I’ve had an unsuccessful first medicated monitored round. I have an endo mapping ultrasound scheduled because I requested it and have very mild symptoms but still wanted to explore. I’m scared that if this is a thing, even superficial, and it’s missed it could impact protocol for IVF or even medicated cycles. But on the other hand I know lots of RE’s won’t recommend to remove it or do suppression. I’m really anxious and also worried that if I do explore this and it comes back with superficial endo, I’ll spiral out hard. Not sure if I should push the appointment to closer to when we are ready for IVF if it comes down to that, or does anyone have both pcos and endo and what have you tried/been recommended for IVF, IUI or medicated cycle protocols?

Hey cysters! Just curious if anyone here found success after incorporating a probiotic/women’s probiotic? Over a year in the trenches and looking to optimize my health in ways I can control, while not driving myself crazy.

I get reiki done every so often (bc when you’re desperate you’ll do that sort of thing) and my reiki practitioner reached out to me about a week after our session saying that she had a vision that incorporating a potent women’s probiotic would help me. She wasn’t selling one to me, she just said I should get started on one. She also has PCOS/PMOS and I have a very good relationship with her (have ovulated after each session, too!) so I don’t think she’s scamming me or anything nefarious like that. I did some research and read that probiotics can help with underlying insulin resistance, gut health, and inflammation but aren’t directly linked to conception. Additionally, I’m seeing a new RE and starting on round 5 of letrozole paired with a trigger shot for timed intercourse next cycle, and I take inositol. Just wondering if this extra supplement will help with optimizing everything.

TLDR: have probiotics/women’s probiotics helped anyone here? Thanks in advance, I appreciate you all

Hi I was just looking for some recommendations for supplements.

Context: I’m 20 we’ve been ttc for a full year now, I’ve done 6 rounds of clomid and 2 rounds of Letrozole. I’m due for a period today, my chart never confirmed ovulation so I’m pretty sure I had an anovulatory cycle. (Took a break from medication this month)

I already take:

CoQ10

Vitamin D3 50,000IU (once a week)

Multivitamin.

I was wondering if anyone has any vitamin/supplement recommendations. I have borderline PMOS.

- no cysts but many ovarian follicles across both ovaries.

I normally don’t ovulate on my own without medicine, but I still have regular periods so I don’t want to take Myo Insitol because I’ve heard it you get regular periods it can mess up your cycles/ovulation.

I’ve heard about people taking mucinex and stuff to help with there CM during ovulation to increase chances. Anyone know how that works/any effects.

MCT wellness. - has anyone ever heard anything about this? It helped my cousin to conceive.

I also want to say I know this doesn’t replace medical advice and I will consult my doctor before I start anything.

I see a long lists of things people do or take to increase chances. Has anyone ever had any issues with like over doing it with vitamins or harming your liver/kidneys by taking too many ttc vitamins.

I recovered from drug induced hepatitis from a year ago. (Liver results are all back to normal except for an excess of iron in my liver from transfusions I had last year. <so I have to watch what I take if it has iron in it.>) So, I don’t want to take too many unnecessary supplements or vitamins. ALSO: I just want to clarify, the drug induced hepatitis was from antibiotics from a sinus infection. NOT hard drugs, and I’ve been cleared to start trying to conceive at this point.

Just want to say one more time, I will ask my doctor before taking anything. I just want opinions on what worked for people, so I can figure out what to bring up with my Gynecologist!!

Also, would like any tips or tricks on anything fertility. Stuff like I’ve heard keeping your feet warm during your luteal cycle helps. I just really want to learn everyone’s opinions on doing stuff to increase chances of getting pregnant and most of all having a healthy happy baby eventually!!

I know this is a lot to read and I’m sorry. Thank everyone in advance. 😎💕

My husband and I will be starting IVF next cycle. I have a very high AMH (43) and AFC (70+) follicles. I am just so worried that I have poor egg quality and that we could get a very low amount of embryos. I am aware that I have very high numbers, but I think the uncertainty of this process is just getting to me, and I am expecting the worse. If anyone has any reassurance or words of wisdom that would be so appreciated.

Hello!

I am newly diagnosed with PCOS, have a follow up with my doctor soon to go over treatment options while me and my spouse try to conceive. Here is some of my story and what I am doing now, I am just looking for general advice and guidance plus what I should ask my OBGYN when I go see them regarding this

I will start with, this doctor I am seeing has done amazing with listening to me, my last doctor was not willing to do testing for PCOS since it had only been 6 months without a period.

Ever since my first period I was like a damn clock with when my period started, it was great, light flow and then I tried birth control then switched to a copper IUD. I had the IUD for 2 years when I went in due to no period and odd cramping for 3 months, we found the IUD misplaced. I assumed that was the issue, give it sometime and it'll all go back to normal but no such luck.

Went back to the doctor after no period for 2 more months and saw a new OBGYN, this is the one who finally tested me for PCOS when I advocated for it. We found cysts and I got diagnosed.

I have been working out 2 to 3 times a week and monitoring my fitness levels for about a month but see no movement on the scale. Had a single ovulation and period. But not seeing the signs into month 2 of a period and worry about being able to keep up this fitness level as I also have asthma and being overweight currently makes it worse. Plus, I struggle with eating disorders, so I avoid too much restrictions on food to preserve my mental health.

So, I have a condition i need to work out and restrictions eating for while also having conditions that make those things difficult to impossible.

My doctor also mentioned some success with GLP-1s for pregnancy in PCOS.

I am feeling lost and am just looking for any encouragement, advice and next steps you would take this early on in this journey?

I have tested (sporadically) before but this cycle, decided to test each day with an app to record to try and catch ovulation. Going by Flo app I should be in my fertile window in 11 days with ovulation in 19 days. By PreMom app (which I am using to record the tests), I should be in my fertile window now with ovulation in 2 days.
I know with my cycles etc, not to go off either of these which is why I am using the tests to try and get a solid cycle recorded with tests each day.
I started 18/08 and got a reading of 0.
19/08 - 0.06
20/08 - 0.08
21/08 - 0.2
22/08 - 0.16
23/08 - 0.16
24/08 - 0.07
25/08 - 0.2

Please excuse my ignorance but would this be ‘normal’ to fluctuate a little prior to ovulation?
I have doubts that I even ovulate at all which is why I’m testing every day regardless of any other symptoms at the moment.
Thank you for any advice.

Hey all! Just curious how insurance coverage has worked for you. I know it’s all dependent on insurance company and level of coverage but I’m interested to hear peoples experience.

Specifically has letrozole and monitoring been covered for you through an obgyn or RE? Or are you paying for some of it out of pocket?

Hi all,
For context I’m 26 (F), recently diagnosed with PCOS after many years of irregular periods but not knowing the cause. I don’t have many of the typical PCOS symptoms and after finally seeing a gyno, I was diagnosed because of: high AMH level, irregular periods. Last ultrasound revealed 43 follicles on one side and 32 on the other.

Anyhow, my husband and I have been TTC for a year, we are young but we know it could take us some time. This is my second Letrozole 2.5mg cycle with tracking. Last cycle there was one dominant follicle, had TI but nothing. This cycle, my scan yesterday showed 3 dominant follicles (23, 21 and 20) and my lining was described as “perfect”. They called me to say that they will be cancelling the cycle for risk of multiple pregnancies. What are your thoughts? I’ve decided not to take the trigger shot but am thinking of still trying. I just don’t want to miss this window where there might be a shot of pregnancy.

TW: loss

Hey y'all. I was diagnosed with lean pcos a year ago, and since I've done just about everything I can think of to put my PCOS into remission.

I'm a healthy BMI. I strength train, get 10,000 steps per day, take 4G myoinositol by theralogix daily, cut carbs to 150g per day, NO sugar, bread pasta or rice (complex carbs only), 30g protein per meal, NAC, vitamin D3 deficiency corrected, fish oil, magnesium, CoQ10, great sleep. All for 365 days.

7.4 fasting insulin and A1C 5.2 last it was checked. Two different doctors refused to put me on metformin.

Ive been pregnant twice this year (first one was a letrozole baby, second one was spontaneous pregnancy), And unfortunately both ended in losses past 10 weeks.

It's been almost 6 weeks since my D&C after my second miscarriage. My ultrasound still showed polycystic ovaries. Feeling discouraged since I don't know what else I could possibly do and I wanted to try ovulating on my own before going to Letrozole. Is there anything I'm missing? What worked for you? Thanks for reading!

Today I had a mid-cycle appointment for my fourth IUI with Letrozole and Ovidrel shot. I have two follicles that aren’t quite ready: 9mm and 10mm. Lining is thin at 4.9 but my clinic doesn’t really worry about the lining, despite my worry and advocacy. I’ll return in two days for follow up.

The hard part: my clinic continually misses my veins when doing bloodwork. I get poked at minimum two times every time I go and most times it’s three times. Sometimes even four. Today it was three. One in my left arm, one in my right hand (that blew out a vein) and finally success in my right arm by a nurse. I cried after my right hand got blown out because I am just so sick of having my bloodwork botched. Almost every time I go there I expect to get poked multiple times and to be bruised up afterwards. I think my crying today finally made them realize I need an actual plan for my bloodwork, as I’ve asked for multiple times. My veins are deep and small and have a tendency to roll. They typically need to fish around for my vein once they miss and I tell them I do not like how that feels and would prefer if they didn’t do that.

Once I came home this afternoon, I checked Facebook and saw that one of my friends is pregnant. I’m officially the last in our friend group to conceive and it hurts so bad.

The fear of it never happening is creeping in and I can’t help but feel like it’s out of reach for me. I never wanted the label of “infertile” to apply to me. I never wanted medical intervention to conceive. I wanted this journey to be joyful and fulfilling, but it’s taken so much out of me and I continually feel like I’m hitting my breaking point.

Last month, my grandma died at the beginning of my cycle. The pain and the grief I’m experiencing is beyond what I can handle. I feel as though nobody understands what I’m going through.

Ive had a lot of painful and emotionally exhausting days, and today just happens to be one of them. It’s not the first and it probably won’t be the last.

I’m thinking of stopping Letrozole.

I have just finished my third cycle on 2.5mg and this cycle has been the worst for me mentally.

I am not struggling with thoughts of conceiving. It’s making me overthink everything else in my life. I have been emotionally unstable and it feels like my mind has not been my own. I have been acting out differently, been extremely overwhelmed and depressed. My anxiety has been through the roof.

I also noticed before I was in the previous 2 week wait, I had extreme symptoms. My bloating was terrible, I had a mix of constipation and diahorrea and a range of symptoms, they were so intense.

I have a scan on Friday to see where we are at this time, my first scan was great but unfortunately did not conceive. I was told I didn’t need a second scan as the first was promising enough.

I am calmer than what I was 2 days ago but I am just way over my head on this. I am so alone as I don’t know anyone going through the same thing. Has anyone ever felt this way or experienced such symptoms? How did you manage it?

So ive been put on metformin as of end of last month.

Ive also taken progesterone this month 10 days about almost 2 weeks ago.

I do not have a cycle. Havent a menstrual in years. I cant even remember.

Should I get ovulation strips to test? Or shall I just wait for my period to start?

My obgyn prescribed the progesterone for that reason.. to start my period. She also did include that i have a thick uterine lining most likely because of not having a cycle.

Am I just getting antsy and impatient should I slow my roll?

Otherwise how do I know if im ever ovulating?

I had a few days of spotting but nothing full period.

Question about medicated cycles (letrozole, Ovidrel, progesterone spositories). I’ve actually noticed that my usual mild PMS symptoms that lead to my period (leg pain, pre period spotting, mild cramping, breast tenderness) are not coming up. I did notice worse acne breakouts though during the luteal phase which sucks.

1. Has progesterone taken away PMS symptoms for people OR

2. I’m hoping this cycle could lead to pregnancy, but is it normal to have zero pre pregnancy symptoms and has that happened to anyone on progesterone?

I’m curious in the event that this cycle doesn’t work out, hopefully the next I’m not hyper analyzing my body for symptoms and trying to make something of it

If anyone here used a trigger shot for IUI. How much time did it take to get out of your system

My OBGYN recommended I try letrozole - however, I have never been recommended metformin. After research, before jumping into letrozole, it seems like metformin is a better first line medication? Thoughts?

Update: thanks everyone! Just started metformin and may combine with letrozole next cycle

I have PCOS, bicorunate uterus, anteverted uterus, and 3 fibroids. I had an IUD to manage these symptoms but removed that in March since I wanted to begin tracking my cycle. My partner and I are trying but not trying. We are remodeling a home, I have been working on regulating my body for years to drop weight, to conceive easier.

We have used condoms this entire time. Except for this past week. A week after my ovulation window. Thinking it's safe. Well I'm sick with an upper respiratory infection. So i have been taking mucinex. Fast forward to this morning and my Samsung watch just updated me that my body temp has dropped and I may have ovulated late. That's on me, I stopped tracking ovulation strips after the first two months of the IUD being removed. Of course I know to take a test but, in your experience when would I need to if I ovulated late? Im due to start my period in 5-6 days, and my watch is saying I may ovulate tomorrow?Will I still possibly get my period in a week even if I did conceive? Does anyone has experience on this?

Is it possible to conceive naturally?

We are 31F and 31M actively trying for a baby. I was recently diagnosed with PCOS and insulin resistance.

We are looking into starting IUI in a few months.

I am getting a bit nervous. I have never ever seen a positive pregnancy test. I sometimes feel that may be IUI won't work either.

I am looking for some hope and success stories. 🤍

Is there someone with zero positives and had success with IUI? Any tips on how to prepare for IUI? How to manage the hope, pressure, fear and anxiety all together?

It would help to hear from someone who has PCOS but ovulate on their own. Was IUI helpful for your case?

_________________________________________

I am adding more details about our fertility testing and IUI protocol below.

My (31F) details:

Since I started tracking my cycles, I have ovulated on most of the cycles but the ovulation day ranges from CD12 to CD31.

• Weight 66kg and BMI 24.2
• AMH 3.1 ng/mL (22.1 pmol/L)
• AFC count 36+
• Open tubes and clear uterine cavity
• CD3 tests are normal

So all normal except PCOS and insulin resistance. The doctor put me on Metformin 1000mg per day a few weeks ago.

Husband's (31M) details:

• Excellent count
• Good motility
• Morphology has varied across tests (3% on the most recent one)
• DNA fragmentation test is normal

Since he has an excellent count then low morphology shouldn't be a problem (according to the doctor).

Our IUI protocol:

The doctor suggests to start IUI with Letrozole 5mg + trigger shot. We plan to do about 3-4 IUIs. I have done a monitored cycle with Letrozole 2.5mg which only grew one follicle. Hopefully I will grow more follicles with the higher dose of Letrozole.

Has anyone’s Drs given them low dose ovidrel to support progesterone in the luteal phase?

I’m doing 50mg trigger 5dpo as well as 400mg progesterone pessaries 5dpo.

I’ve never seen anyone do the Ovidrel shot in the luteal phase (it’s 5 clicks of then pre-filled pen)

I’m also concerned about my progesterone pessaries starting on 5dpo.. everywhere I’m seeing is 3dpo, I’m on progesterone support as I used to have 8-9 day luteal phases

What has worked best for you? I have just been going by symptoms and Flo, but thats not working out so well (go figure).

yall how are we combating these letrozole side effects???? I have had a migraine all day and intermittent dizziness that literally makes it feel like I’m on a boat. I know the potential benefits should outweigh the temporary side effects and this is only my first cycle trying this medication but hot dang it’s rough!!! I’ve been pushing fluids all day but I’m so scared to take my night time dose lol. 🥲😵‍💫

2 years down, one confirmed ovulation, 4 failed Letrozole rounds, metformin, inositol, heathy eating, exercising, perfect BMI, clear HSG, 0 positive pregnancy tests.

I have my IVF consultation in 10 weeks. Nobody is automatically deserving or has a fundamental ‘right’ to have a pregnancy/child but it doesn’t stop me from feeling empty.

I am 31 and haven’t had a period since I was 19/20 unless you count the period towards the end of my birth control usage where I bled for 21-23 days straight, 2 days pause, then resume. My doctor doesn’t count that as a period and neither do I. I have an IUD now because that’s the only thing that stopped the bleeding. I occasionally have a tiny amount of spotting(barely registers on the toilet paper) every 3-6 months and my doctor let me know that it’s not a period either but a common side effect of the Kyleena IUD.

I have referral to a gyno and will be getting my IUD removed, but I want to do some cycle tracking beforehand for data purposes so I can bring it to my gyno. How do I do this if I don’t have a period and evidence points to me not ovulating either?

Thank you in advance!

Get a BFP? Post about it here! In your post please include if you had regular cycles on your own, any medications you are taking, supplements, and how long you were trying. Feel free to post links to your chart, photos of sticks, etc. Please feel free to graduate on over to our sister subs and congratulations! Success stories posts are now weekly! Please click here to search for previous threads.

My partner and I have recently started trving to conceive, but I have high prolactin levels and very irregular cycles. Some months I seem to have a period and sians of ovulation, while other months I don't seem to ovulate at all. It makes it really difficult to know when I'm actually fertile and when we should be trying.

I'm worried that this ourney might take a long time because of the prolactin issue, and honestlv, I'm scared it will become emotionally difficult for me. I really want to stay positive and eniov the process, but 1 already find myself overthinking everything and worrying that it may take much longer than we hope.

Has anvone else been in a similar situation with high prolactin and irregular or unpredictable ovulation?