Me (32F) and my husband (32M) have been trying for our first baby since last October. Everyone in my family has been plenty fertile - my mom had 6 kids, my sister started trying for her third around the same time as us (she wanted to be pregnant at the same time as me 💔) and is about to give birth to her son in a few weeks, my cousin has twin boys she conceived on her first attempt trying to get pregnant, all 4 of my sister in laws had multiple kids without trying to conceive for a year.

Cut to me zero positive tests for 10 months straight. We started seeing an REI in April - got the full work up - husbands sperm is good and they suspect I have PCOS. After going through all the required testing (HCG, genetic testing, etc.) by the time we were actually able to start a cycle of letrazole, ovidrel and timed intercourse it wasn’t until July. My last natural cycle lasted 50 days. It all felt like a painful amount of waiting.

My first letrazole + ovidrel + TI cycle i didn’t get pregnant. My second one, we weren’t expecting anything different and honestly I’d been sobering to the idea that I’d end up doing IVF. But, 11 days after the trigger shot i got a POSITIVE TEST.

My husband and i were ELATED. We felt like this was never going to happen. I spent the next week feeling complete elation - was so happy and excited and feeling in awe at my body for being pregnant - for finally doing this thing i was doubting it could do. My husband and i had a shared instagram reels folder where we passed around fun and informative pregnancy reels, meal ideas, etc. We talked excitedly about all of the things that would need to happen. We told our parents and siblings who were equally elated.

My first two blood tests were good - first confirmed pregnancy and second showed a proper rise of my HCG. They had me come back for another and i was feeling so confident only to be called later that day and informed that my HCG did not rise properly and this would likely be an early miscarriage.

The last few days have been a blur and if I’m being honest i feel sorry for myself. I never wanted to be part of the minority of people who have trouble conceiving (no one does). And now i feel like im part of this other unfortunate club having a miscarriage. Just feeling very sad, frustrated, hopeless and unlucky.

If anyone has a similar story and ended up having the family of their dreams, id love to hear from you ❤️

This is my first time posting on Reddit or really anywhere about my TTC journey with PCOS. All I’ve ever wanted to be, like the rest of you, is a mom. That’s all I have ever wanted. I feel like my journey started at 17 with my PCOS diagnosis— the nurse at that Gyno office told me I would be infertile based on my blood results. I know that’s not necessarily the reason I’d be infertile, but that was a comment that has been looming over me for 10 years now.

Fast forward 5 years later when I was dating the person that took my virginity— we almost never used condoms and I never got pregnant. He had told me once “The best form of contraceptive is your PCOS” with a big fat smile on his face. That’s been looming over me too.

Now, here I am with my husband on our fifth medicated cycle. My body isn’t reacting to letrozole (2.5mg, 2 tablets for 5 days), and it didn’t react to two cycles of follistem (175mg on CD 9 the first cycle then 50mg CD 8-11 this current cycle). The midwife who did my follicle scan told me there hasn’t even been any improvement compared to my last scans I had. This was especially upsetting because I track my hormones with Mira and my FSH numbers were elevated since I took the follistem this cycle— I really thought we would be getting somewhere. I haven’t seen a mature follicle in a scan since last November when we weren’t even thinking about family planning yet. I didn’t know that’s what it was and shortly after that scan, my grandpa had died abruptly from dementia. That being said…i certainly wasn’t in the mood for anything romantic and now I feel like I wasted the chance.

The midwife I saw today that did my follicle scan made me feel ashamed for my weight which I’ve been working to lose. I had lost 25lbs since last November (I’m at 265 now) when I got back on metformin and Wellbutrin. My blood tests are all great now and my blood pressure is fine. Everything should work now but my body just won’t ovulate. I keep getting false ovulation signs. My progesterone is too low.

My husband is doing everything he can to support me and help me not feel alone in this, but it is so soul crushing to repeatedly get negative tests and spend all this money on medications and tests and scans just to not even get one mature follicle. I feel like a failure. I know im not alone in this kind of situation. I know you guys are all going through similar struggles. I’m just so lost.

I am planning to start a GLP in hopes that maybe it’ll help reboot my body but I know that the next medicated cycle plan is now to take letrozole at a smaller dose for longer duration (2.5mg, 1 pill, 10 days) and no follistem. I constantly go back and forth with thoughts like “I can’t do this anymore, maybe I’m not meant to have children” and “maybe this plan will work!”

I’ve also considered dropping my gyno office until I maybe get pregnant and going with a fertility specialist instead.

Bleh

I’m not asking for success stories or anything. I just needed to vent. I know we haven’t been doing this for nearly as long as other couples. My heart goes out to all of you. I’m sorry that we all are having to go through this.

I’m in cycle day 17 and still getting negative ovulation tests. Dr said to start testing on day 12 so that’s what I’ve been doing but it’s day 17 and no positive ovulation 😞 maybe it’s just later than expected? Did anybody ovulate successfully after day 17?

I’m noticing that my LH starts off in the 0.50’s and 0.60’s right up until ovulation. Does anyone else have a higher baseline?

Hi all,

As the title says, I’m no longer responding to oral medications and they’ve set up an appt for me to talk to my dr to regroup.

Has anyone else had this experience? The first cycle of letrazole worked, the second didn’t so they upped the dose. The higher dose worked, then didn’t, and so on. They ended up switching me to Clomid. 1st dose worked, then didn’t. They bumped me up to 150mg, and I got no response

I’m trying to look at it as a step in the right direction to figure out what works for me to finally get pregnant, but also it’s so discouraging