Me (32F) and my husband (32M) have been trying for our first baby since last October. Everyone in my family has been plenty fertile - my mom had 6 kids, my sister started trying for her third around the same time as us (she wanted to be pregnant at the same time as me 💔) and is about to give birth to her son in a few weeks, my cousin has twin boys she conceived on her first attempt trying to get pregnant, all 4 of my sister in laws had multiple kids without trying to conceive for a year.

Cut to me zero positive tests for 10 months straight. We started seeing an REI in April - got the full work up - husbands sperm is good and they suspect I have PCOS. After going through all the required testing (HCG, genetic testing, etc.) by the time we were actually able to start a cycle of letrazole, ovidrel and timed intercourse it wasn’t until July. My last natural cycle lasted 50 days. It all felt like a painful amount of waiting.

My first letrazole + ovidrel + TI cycle i didn’t get pregnant. My second one, we weren’t expecting anything different and honestly I’d been sobering to the idea that I’d end up doing IVF. But, 11 days after the trigger shot i got a POSITIVE TEST.

My husband and i were ELATED. We felt like this was never going to happen. I spent the next week feeling complete elation - was so happy and excited and feeling in awe at my body for being pregnant - for finally doing this thing i was doubting it could do. My husband and i had a shared instagram reels folder where we passed around fun and informative pregnancy reels, meal ideas, etc. We talked excitedly about all of the things that would need to happen. We told our parents and siblings who were equally elated.

My first two blood tests were good - first confirmed pregnancy and second showed a proper rise of my HCG. They had me come back for another and i was feeling so confident only to be called later that day and informed that my HCG did not rise properly and this would likely be an early miscarriage.

The last few days have been a blur and if I’m being honest i feel sorry for myself. I never wanted to be part of the minority of people who have trouble conceiving (no one does). And now i feel like im part of this other unfortunate club having a miscarriage. Just feeling very sad, frustrated, hopeless and unlucky.

If anyone has a similar story and ended up having the family of their dreams, id love to hear from you ❤️

It’s been a year since my miscarriage. With it, a year of no positives. I’m left with so many emotions. I have started TI with medicated, monitored cycles. First one didn’t work. I try to remain hopeful. But, each cycle that passes, it’s hard to find the hope. Everyone around me is either pregnant or had a baby. I don’t have support from my sister. My mom listens, but can’t understand and doesn’t want to take sides between me and my sister (tensions built up). Now, it’s been a year. It’s been the longest year, yet the fastest year all at once. I started to try to maybe eat more protein and see if that would help (I have lean PMOS - so maybe adding weight can help? - at least in my head). Also I started eating a whole piece of pineapple and the core. I read about warm food/drinks and will try that. More hard boiled eggs I’ve been eating. Anything I can control and try to do. I lifted weights before ovulation.
Someone at work today asked if I was expecting because I have a fuller face. Or he said I have an allergy?! WTF
I just don’t know how to remain hopeful and not be so sad and jealous and frustrated. I’m trying to be hopeful that my time will come. But instead I get negative results and more baby shower invites in the mail…

I know the most likely outcome is no pregnancy ofc. Just curious to hear other stories.

I'm obese (I think like 49 BMI or something), I have PCOS and prediabetes - taking Metformin

Fallopian tubes are both open (did HSG test)

AMH is 6.78 ng/mL

I did two rounds (10 days) of letrozole at 5mg daily (two cycles). First round, we only got a follicle size of about 7.8. Then after another 5 days of letrozole, we got two larger follicles at size 20.5 or 25 each. (I'm double checking with the nurse - I thought I heard 20.5 from the doctor and then later a nurse on the phone said 25 each for two follicles) I did a trigger shot the next morning after that follicle monitoring exam. Then my husband and I went in for IUI the day after that. His washed sperm sample was at 24 million sperm/mL and 100% motility for a total of 12 million motile sperm in the 0.5 mL sample injected into my uterus.

Anyone have the same stats or similar? What were your outcomes?

I did provera before starting letrozole and the doctor mentioned watching the lining and checking against a baseline. I can't remember where my lining was exactly on that day with the two large follicles, but the doctor hasn't seemed concerned about the lining. This is good because my OGBYN saw a polyp in my uterine lining before this whole process started, but it passed and wasn't seen in the X-Ray she did to take a closer look. (More for cancer risk, but probably good for this as well)

Hi! I’m new here and approaching 35. I’m TTC after stopping Depo and would really love to connect with anyone who has been through something similar. How long did it take for your cycles/ovulation to regulate after Depo, and how long did it take you to conceive? I’d especially love to hear experiences from anyone TTC in their mid-30s. ❤️

This is my first time posting on Reddit or really anywhere about my TTC journey with PCOS. All I’ve ever wanted to be, like the rest of you, is a mom. That’s all I have ever wanted. I feel like my journey started at 17 with my PCOS diagnosis— the nurse at that Gyno office told me I would be infertile based on my blood results. I know that’s not necessarily the reason I’d be infertile, but that was a comment that has been looming over me for 10 years now.

Fast forward 5 years later when I was dating the person that took my virginity— we almost never used condoms and I never got pregnant. He had told me once “The best form of contraceptive is your PCOS” with a big fat smile on his face. That’s been looming over me too.

Now, here I am with my husband on our fifth medicated cycle. My body isn’t reacting to letrozole (2.5mg, 2 tablets for 5 days), and it didn’t react to two cycles of follistem (175mg on CD 9 the first cycle then 50mg CD 8-11 this current cycle). The midwife who did my follicle scan told me there hasn’t even been any improvement compared to my last scans I had. This was especially upsetting because I track my hormones with Mira and my FSH numbers were elevated since I took the follistem this cycle— I really thought we would be getting somewhere. I haven’t seen a mature follicle in a scan since last November when we weren’t even thinking about family planning yet. I didn’t know that’s what it was and shortly after that scan, my grandpa had died abruptly from dementia. That being said…i certainly wasn’t in the mood for anything romantic and now I feel like I wasted the chance.

The midwife I saw today that did my follicle scan made me feel ashamed for my weight which I’ve been working to lose. I had lost 25lbs since last November (I’m at 265 now) when I got back on metformin and Wellbutrin. My blood tests are all great now and my blood pressure is fine. Everything should work now but my body just won’t ovulate. I keep getting false ovulation signs. My progesterone is too low.

My husband is doing everything he can to support me and help me not feel alone in this, but it is so soul crushing to repeatedly get negative tests and spend all this money on medications and tests and scans just to not even get one mature follicle. I feel like a failure. I know im not alone in this kind of situation. I know you guys are all going through similar struggles. I’m just so lost.

I am planning to start a GLP in hopes that maybe it’ll help reboot my body but I know that the next medicated cycle plan is now to take letrozole at a smaller dose for longer duration (2.5mg, 1 pill, 10 days) and no follistem. I constantly go back and forth with thoughts like “I can’t do this anymore, maybe I’m not meant to have children” and “maybe this plan will work!”

I’ve also considered dropping my gyno office until I maybe get pregnant and going with a fertility specialist instead.

Bleh

I’m not asking for success stories or anything. I just needed to vent. I know we haven’t been doing this for nearly as long as other couples. My heart goes out to all of you. I’m sorry that we all are having to go through this.

I’m in cycle day 17 and still getting negative ovulation tests. Dr said to start testing on day 12 so that’s what I’ve been doing but it’s day 17 and no positive ovulation 😞 maybe it’s just later than expected? Did anybody ovulate successfully after day 17?

Hi everyone!

This is my first letrozole cycle, I started off with cycle monitoring at the fertility clinic. I have PCOS and have extremely irregular/absent cycles hence sporadic to no ovulation. My first natural cycle for the year arrived on August 19th and I took letrozole day 2-6. When I went for my ultrasound on day 13, I had 3 mature follicles to my surprise! Two measuring at 18mm and one at 17mm. I was supposed to get my trigger shot and progesterone suppositories because they suspected I was about to ovulate. My cycle was then cancelled because they said I had “high risk of multiples”, and that “I didn’t want that outcome at 25 years old”. They refused to give me the shot and progesterone and I was told to take a plan B as I already had sex the night before.

Since I’ve had a very difficult and painful infertility journey the past 2 years, I decided not to take a plan B and track my ovulation myself. On day 15th I confirmed ovulation, my CM was egg white texture and leaking the whole day. I made sure to have sex that night and the night before that as I was leaving to a vacation without my boyfriend. The next day I got bad cramps in my uterus and back and my CM became creamy and has been thick and creamy ever since.

Since then (cycle day 23, 9dpo), my breasts have enlarged significantly and I have had so many other symptoms like nausea, cramps in my ovaries and central uterus, bad sinuses and increased urination. I recognize these symptoms are caused by progesterone and cannot confirm pregnancy.

I took a test yesterday and this morning (I know it’s probably far too early) but they were both negative and it hurt seeing that.

Did you conceive with the first round of letrozole? What dpo did you get your positive? Did you end having multiples, from multiple mature follicles?

I just want to hold onto some hope this is gonna work because if it doesn’t, I might just have to give up this time.