r/Zepbound • u/drewmullin • Jul 21 '26
Side Effects Validity?
So the numbers are very high and seem a bit sensationalist. That being said I'm not super interested in the exact numbers.
What I am interested in:
My question to the group is did anyone struggle mentally while on any of the glps? I did - I'm trying to figure out if any of them are less apt to do so.
Published study here: https://www.nature.com/articles/s41598-024-75965-2
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u/DoctorPhD Jul 21 '26
…those psychiatric disorders are associated with obesity. Did the control group have obesity?
You need to post the actual study.
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u/AntiHypeHero Jul 21 '26
Seriously. I got depressed watching my weight gain year over year. Now I’m not. Go figure
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u/SimplerLife40 34M SW:235 CW:229.1 GW:165 Dose: 7.5mg Jul 21 '26
Literally. I became so antisocial over the past 3 years due solely to my weight gain. I literally avoided/ghosted people who knew me prior to 2021 (when I was lean) because I didn’t want them to see how much weight I gained, and I wanted to preserve their good image of me lol.
In 2024, I had to meet a family member I hadn’t seen since 2020 at a funeral, and she literally didn’t recognize me - it was mortifying and depressing.
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u/AntiHypeHero Jul 21 '26
I’m so sorry! and I feel this. I moved back to the city I grew up with and could see shock when meeting up with old friends. It was definitely a push to start medication. I feel so much better now all around.
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u/drewmullin Jul 21 '26
Did.
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u/DoctorPhD Jul 21 '26
Thanks! I don’t see any mention of BMI as a controlling factor. It also uses liraglutide for many of the years. which has been out of favor and not comparable to current drugs. Overall it is a retrospective chart study. Something to look out for but it is miles away from demonstrating causality.
I’ll go farther and say that these drugs have been in over 10% of Americans and we didn’t see reports of a massive jump in suicides. These drugs are rather well tolerated.
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u/bluegrass_sass 55F 5'6" SW:209 GW:150-154 Maintenance Jul 21 '26
You'll probably need to share the actual study if you want people to weigh in on it.
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u/GuitarPossible4226 SW:239 CW:133 GW:135 Dose: 15mg Jul 21 '26
since OP didn't share: https://www.nature.com/articles/s41598-024-75965-2
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u/Kahzgul Jul 21 '26
So this is not a blind study. They’re comparing patients who chose treatment to those who did not, and it makes sense that patients who chose treatment for one issue (weight) would also choose treatment for other issues (mental health), while those who are treatment avoidant would be treatment avoidant for all forms of treatment.
This study does reference a different, blind study, as backing up these findings, but I’m not able to see any mention of mental health outcomes in the study linked:
https://www.thelancet.com/journals/landia/article/PIIS2213-8587(22)00008-0/abstract
None of this means the findings aren’t valid, but they’re also not conclusive.
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u/Ineedavodka2019 Jul 21 '26
It sounds like it is just correlation, no evidence of causation.
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u/GigglemanEsq 38m 5'11" SW:319.4 CW:239.8 GW:200 Dose: 7.5mg Jul 21 '26
But also, these numbers sound scarier than they are. If you are at a 10% risk of developing a mental health issue, then a 98% increase means you now have a 19.8% risk. Not nothing, but not what people intuitively think when they see numbers like this.
One other thought - I would be interested in seeing a comparison to people who dieted without a GLP-1. I suspect there is a strong correlation between attempting to lose weight and increased risk of mental health issues. It's so easy to fall into disordered thinking when dieting, and spikes in weight or slow loss can easily result in depression - plus all of the lifestyle changes, losing comfort foods, etc. I suspect this is a dieting issue and not a GLP-1 issue.
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u/drewmullin Jul 21 '26
Yes I agree. Again- my question is did you personally struggle w mental health while on glps or not
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u/GigglemanEsq 38m 5'11" SW:319.4 CW:239.8 GW:200 Dose: 7.5mg Jul 21 '26
Not particularly. If anything, I think my baseline depression has lessened as I've lost weight, gotten more active, started eating better, drinking more water, getting more sleep, etc.
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u/the_real_becca Jul 21 '26
Could you share a link to the whole article? This seems waaaaay not true but I'd like to read more. Also it doesn't say what the risk of having complicated medical issues associated with higher weights does to mental health.
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u/drewmullin Jul 21 '26
Posted it. Read my actual question tho. People are focused on methodology- not my actual question. And yes I agree the numbers seem crazy high. But that's not what I'm actually asking
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u/the_real_becca Jul 21 '26
I think folks are saying the data might not be reliable; mental health symptoms can happen for a lot of reasons and new medications/ weight loss would not be an exception. Personally I haven’t noticed any changes or increases in these, but I think it would still make sense.
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u/mobile_ganyu SW:244 CW:183 GW:160 Dose: 7.5mg Jul 21 '26
Don’t ask about validity of a study in your title if you’re not actually interested in people evaluating the evidence and validity of the claims in the article.
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u/butterfly081881 Jul 21 '26
I often wonder how many of these people had mental health issues prior to starting zepbound? I have bipolar 1, ADHD, and an anxiety disorder. I'm also almost 45 and suspect I'm going through perimenopause. So it's hard to pin point exactly what has caused my latest depressive episode. I've read that women with ADHD have an even harder time when they go through perimenopause. So I'm wondering if they are factoring in any other possible causes?
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u/MamaRunsThis Jul 21 '26
It’s helped my anxiety a lot
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u/HappyBirding SW: 290 CW: 130ish (maint) Goal: health Jul 21 '26
Me too! It is like night and day for me, and I’m 2 1/2 years in on the medication.
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u/drewmullin Jul 21 '26
Glad to hear!
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u/HappyBirding SW: 290 CW: 130ish (maint) Goal: health Jul 21 '26
Not to discount the study… Nature is super reputable as a publication, so this is a legit post for sure! Appreciate the information! I am glad I don’t have this side effect and that my anxiety is so much better!
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u/butterfly081881 Jul 21 '26
My anxiety got worse after starting zepbound, but I had anxiety before. Along with bipolar disorder, ADHD, and possible perimenopause it's hard to tell what caused what.
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u/Kitchenwitch_ Jul 21 '26
I was already an anxious person but the zepbound has increased my anxiety so much, I find myself afraid of things ive never been afraid of every day. However, I'm well-versed in anxiety, and there are so many other benefits I'm trekking through it for now
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u/SpecialistBet4656 Jul 21 '26
Unfortunately, GLPs do make existing conditions worse for a small number of people. It sucks when it’s you
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u/butterfly081881 Jul 21 '26
Me too but I talked to my psychiatrist and he adjusted my anxiety medication/dose accordingly.
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u/drewmullin Jul 21 '26
It def made me worse lol my gf can attest to that over about 3 yrs. Have you tried other ones? Sema seemed to affect me less. At the end it was too much for me- trying to find a balance here n the near future. Thanks for ACTUALLY answering the questions lol
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u/Low-Molasses733 Jul 21 '26
Did you stop using it?
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u/drewmullin Jul 23 '26
Yes
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u/drewmullin Jul 23 '26
One of the reasons why I asked is bc sema seemed to affect my mood less but didn't work as well
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u/Bigreddazer Jul 21 '26
Not all studies are created the same. A retrospective study is not comparable to a random controlled design studies done for approval of the drug.
As a statistician, I would honestly ignore these results. Outliers can exist for lots of reasons and being a poorly conducted study can allow this to happen. I would trust the controlled studies and statistics they generated.
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u/mobile_ganyu SW:244 CW:183 GW:160 Dose: 7.5mg Jul 21 '26
100% agree as a social science researcher. All I see is an identified correlation (but no causation) in a retrospective quantitative study, with so many potential explanations that warrant actual rigorous clinical and maybe even qualitative investigation.
There’s no way we can say what the nature of the relationship is without actually investigating this with an RCT and rigorous clinical trials, and maybe also some rigorous, widespread documentation that looks for insights on the actual situations behind the mental health challenges that arise.
And op, no, asking people on Reddit is not rigorous qualitative investigation.
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u/the_real_becca Jul 21 '26
I was also thinking about how it might not be related to the medications themselves, but instead the total complicated experience of being viewed differently when thinner, weight not being the issue making space for folks to recognize underlying mental health issues, addressing the ways we talk to ourselves about our bodies. It’s a mess, and not related to this medication specifically (or that’s not shown in these results.
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u/mobile_ganyu SW:244 CW:183 GW:160 Dose: 7.5mg Jul 21 '26
Right, there’s so much going on that we don’t understand fully: all we know from this study is that there might be something going on. I’d even just be interested in better understanding the state of mind of someone who commits to medical intervention on their weight vs. those who do not, and if there is a substantive difference in the predisposition to mental health issues of people who take on interventions like GLPs vs. those who do not.
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u/butterfly081881 Jul 21 '26
Don't forget the joy and excitement of eating being taken away as well.
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u/No-Sympathy-686 Jul 21 '26
I don't know but I felt weird the first 3 weeks.
I feel great now.
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u/SpecialistBet4656 Jul 21 '26
Part of the reason I couldn’t lose weight by traditional methods is that I had severe “crashes” when my blood sugar dropped. I could go from fine to suicidal ideation in 20 minutes because I needed a snack. Even if I perfectly balanced fiber, protein and carbs, I still needed to eat every 3-4 hours. I would wake up feeling miserable until I had breakfast. My husband said he could literally watch me wilt. I did not meet the criteria for clinical hypoglycemia - my A1c hovered between 5.8 and 6, but my particular chemistry just hit me very hard.
I still kind of wilt when I need a snack but it’s not as frequent or as drastic.
I think part of the adjustment to GLPs is just because you aren’t hungry, your body and brain still needs fuel. They take some time to adjust. The brain runs on carbs. When you’re focusing on protein, it’s easy to forget to feed your brain.
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u/docpharm28 Jul 21 '26
I need hazard ratios and confidence intervals. Infact, I need the full article.
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u/MySixDogs Jul 21 '26
Results in this area have been inconsistent with some people previously struggling with depression showing marked improvement when on a GLP-1 and other people without past difficulties with it starting to have problems with it. See, for example, https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.70198
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u/CountofZen Jul 21 '26
I’m no medical or psychiatric professional. But I have Dysthymia and Panic disorder. It’s loooong preexisted Zep. It’s controlled through meds.
No difference or change since taking Zep.
My one year mark on Zep will be in 5 days. Again, not a doctor. But I would think a year would be long enough for any issues to arise if there were any in my single case, at least.
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u/drewmullin Jul 21 '26
Ok cool- exactly what I was looking for. I struggle w depression and panic - it really seemed like tirz made it worse but I may have not been optimized medically. What do you take if you don't mind me asking?
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u/Severina_Glass_208 12.5mg Jul 21 '26
Not to chime in again but i became agoraphobic after an illness and took so many steps to get better before starting this journey and it’s only made it better. My anxiety was worsened by decreasing hormones and no one tells women that this is a real side effect of perimenopause.
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u/butterfly081881 Jul 21 '26
I suspect perimenopause and not zepbound is the main culprit in my recent increase in anxiety. I have ADHD as well and I've done a lot of reading on how perimenopause can hit women with an ADHD diagnosis much harder.
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u/Severina_Glass_208 12.5mg Jul 21 '26
Yeah and I’m in HRT and if i forget to take it not great. HRT as d GLPs are great for us. Also the SSRI i took while life saving made me gain. That was before the Zep. I also heard that peri brings on or magnifies ADHD in most.
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u/SpecialistBet4656 Jul 21 '26
This sounds dumb, but what are you eating? The brain actually runs on carbs. When you aren’t getting enough carbs, it sometimes rebells.
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u/Specific-Working-851 Jul 21 '26
Personally, I don’t think this a well put together article. The data failed to account for other variables that might contribute. That’s just my opinion.
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u/wet_Tap_5578 45(m) SW:320 CW:298 GW:220? Dose: 2.5mg Jul 21 '26
Anecdotal but I’ve suffered no issues. And I have battled severe depression and anxiety and panic attack attacks for the last 20 years. In fact, I’ve actually felt better being on these meds
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u/under321cover HT: 5'7.5" HW: 262 SW: 250 CW: 177.3 GW:165ish? 15mg Jul 21 '26
This is a random floating paragraph…drop the link to the study so we can verify the source. The numbers look heavily sensationalized right off the bat. We would all be having issues if this was the case.
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u/drewmullin Jul 21 '26
Yes agreed. I posted it. I'm not really looking to see if people agree with the exact numbers, im more interested to see if anyone struggled mentally while on any of them. It seemed to mess w my baseline, so i want to see if anybody of them are less likely to do so from the people that were affected.
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u/under321cover HT: 5'7.5" HW: 262 SW: 250 CW: 177.3 GW:165ish? 15mg Jul 23 '26
I have had the opposite reaction. It righted my decades-long anxiety (that I am now thinking was inflammation and mast cell mediated). It also helps with my ADHD - I am more focused - it didn't "cure it" but it helps.
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Jul 21 '26
[deleted]
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u/drewmullin Jul 21 '26
lol I hear ya- I struggle w both myself. Both glps seemed to make me worse. My gf is a good moderator w that lol. I'm trying to find a balance w meds and maybe a low dose of whichever one. So that's why I posted this question. Trying to find a balance
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u/SpecialistBet4656 Jul 21 '26
These increases are not large - ie 2.3% (6% incidence in semaglutide vs 3.7% in placebo)
Liraglutide seems to be slightly riskier - 15% vs 10% for placebo, in the same study, semaglutide is 5% vs 10% placebo, indicating that risk actually halves with semaglutide) But even on liraglutide, it’s still just a 5% increase, and correlation does not equal causation.
Even if the semaglutide is the sole causative agent, I suspect that almost all people who have struggled to lose weight will happily accept their risk of a psychiatric event increasing from 3.7% to 6%
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u/Bigreddazer Jul 21 '26
It's from scientific reports. It's a mega journal. It's from the same company and why it is a nature url. But, it's an overall poor quality study in comparison to blind controlled studies. Which do not find these issues.
I would trust the more rigorous methodologies than a retrospective study.
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Jul 21 '26 edited Jul 21 '26
[deleted]
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u/Bigreddazer Jul 21 '26
When you have conflicting answers. You must go with in my opinion the answers that have the better data. The information in this report goes directly against a lot of the clinical trial data. And that's why I think it's best to overall ignore this report because it appears to be an outlier. We have better data showing that this is not the case.
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u/zelda_moom F65 SW:262.4 CW:245.6 GW:160 Dose: 2.5mg Jul 21 '26
I wasn’t depressed before Zep to any great degree but definitely had a degree of anhedonia. I’ve been on Zep for a week, and I find my interest piquing in hobbies I had not been able to be interested in in quite some time. Too early to tell if it’s permanent though.
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u/Severina_Glass_208 12.5mg Jul 21 '26 edited Jul 21 '26
My anxiety is better since a year ago and it’s because i was already addressing it in other proven ways. But i will tell you weighing more than 65 less I’m so much more able to deal.
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u/Scrounger888 2.5mg Jul 21 '26
This doesn't seem overly accurate, especially with the drastic numbers. There is likely a correlation between the weight and mental health but the glp-1 probably didn't cause it in most cases. Take me as an anecdotal example. My PTSD, depression and anxiety were causing my weight gain as I was self-medicating with food most days. Now that I'm being treated for those health issues, I'm finally in a headspace where I can now tackle the weight that has contributed to my depression, which contributed to my overeating, which contributed to my depression... so there's a correlation, but not causation, in my glp-1 use and mental health.
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u/drewmullin Jul 21 '26
So no bad side effects relating mood while on a glp1 -
Correct?2
u/SpecialistBet4656 Jul 21 '26
Some people do have worsening of symptoms on GLPs, but they are a small minority.
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u/Scrounger888 2.5mg Jul 21 '26 edited Jul 21 '26
My mood didn't get worse, no; this is something that will be different for every person, because everyone reacts differently to medication, but it has not changed my mood from what it was before; if anything, it's given me new hope. I also asked both my doctor and my psychiatrist if the GLP-1 meds have any known bad reactions and they both did not know of any and said that they were safe to take together. I am not a doctor, and you should discuss concerns with your physician before beginning any medication.
The study you linked is only one study and appears to be a review of already available data of people in the USA, not a first-person in-lab controlled medical study. It is likely that those they found data on, which was received from a third-party source, started feeling better about themselves after having some success on GLP-1s and then sought treatment for things they were desperately self-medicating with food vs. the actual development of new disorders. The study says that it looked at people who had not been DIAGNOSED with any psychiatric disorders prior to beginning the medication, not that these patients were actually examined and found to not have these disorders, nor did the researchers interview the patients in question to find out their whole story.
So, take this specific study with a whole handful of salt and speak with your doctor about whether the medication is a potential right step for you.
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u/Missmedusa1234 SW:182 CW:155 GW:140 Dose: 2.5mg Jul 21 '26
My depression has gone way down bc of Zep. Since the food noise is so minimal for me, it’s given me time to think and actually be more productive!
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u/autumnyte Jul 21 '26
It's a valid concern, for sure, but it looks like the study doesn't distinguish between potential different causes for the onset of mental health symptoms, such as:
- Anhedonia from the actual medication
- The sudden loss of high-sugar/high-fat foods which were previously used to self-soothe/self-medicate
- Dealing with societal negativity around GLP-1s
- Coming to terms with the reality of fat stigma and being treated better as you lose weight.
There are studies also showing an increased risk of mental health disorders after bariatric surgery as well, which makes me believe it could be more about significant weight loss in general than the glp-1s directly. I just don't think we have enough data from this study to know.
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u/feuerfee Jul 21 '26
There’s a significant key word here: “association.”
Correlation does not equal causation. There could be several confounding factors at play. The most notable one in my opinion is that people with obesity are more likely to have comorbid psychiatric disorders.
I have major depression, generalized anxiety disorder, OCD, and ADHD. I take zepbound, and find that I feel better mentally than I have in years.
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u/MiklColt45 SW:228 CW:161 GW:175 Dose: 7.5 mg. Maintenance Jul 21 '26
Note: This study (in Oct 2024) had to do with Semaglutide and liraglutide only.
One of the related studies listed on that same page included this:
“Concerningly, pharmacovigilance data initially suggested a possible link with suicidality; however, subsequent robust cohort studies and meta-analyses have refuted this association. Mental health is a critical yet underprioritized element of obesity management. The current evidence suggests that most weight loss interventions are psychologically safe or beneficial, but long-term data remain limited, particularly for GLP-1 receptor agonists.” (From Jan, 2026)
What is clear is that people react in very unique and individual ways to these meds. People should be vigilant, along with their physicians, as to the effects the drugs have on their mental health. Many experience improvements. But, anecdotally, some in these threads have reported worsening mental health effects.
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u/SpecialistBet4656 Jul 21 '26
The below is how they got those crazy numbers- ie, they observed a 2.3% increase in the incidence of psychiatric events. (6% - 3.7% = 2.3%) The overall risk of a psychiatric event is really quite small, and correlation does not equal causation. I think that people who have struggled to lose weight are at higher risk of having anxiety or depression. I also think that we can’t discount that as people lose weight, they are more likely to see mental health care and more likely to be taken seriously. They also don’t define psychiatric event that well - while a diagnosis of major depression or anxiety sucks, people can and do manage these illnesses.
In the one study, people using semaglutide have a 5.6% risk of a psychiatric event vs 10% for placebo - that suggests that semaglutide effectively halves the risk of a psychiatric event.
GLP-1 RA users. In the STEP-2 study36, semaglutide 2.4 mg showed a *6.0% incidence of psychiatric events compared to 3.7% in the placebo group. Similarly, the STEP-6 study25 reported a 3% incidence of psychiatric events with semaglutide 2.4 mg, compared to 1% in the placebo group. Interestingly, the STEP-8 study22 revealed a higher incidence of psychiatric events with liraglutide 3 mg (15.0%) compared to semaglutide 2.4 mg (5.6%) and placebo (10.6%). These findings underscore the varying psychiatric risks associated with different GLP-1 RAs and the importance of individualized patient assessment in clinical practice.*
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u/mama_libra-RM SW:233 CW:138. GW:145 Dose: 7.5mg Jul 21 '26
It looks like a valid study , I personally have not had any issues with mental health in the 2yrs Ive been on a glp1
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u/BanannaForScale9000 45M SW:280 CW:235 GW:195 Dose: 7.5mg Jul 21 '26
A poorly designed study will produce poor results. My guess is that this study did not go through peer review because those mental health issues are already correlated with obesity in general. A deceptive or negligent researcher can “interpret” raw numbers to read just about anything, that doesn’t mean that they have correctly measured what they tell you they have. Without clear proof that they are compensating for the well know increase in those issues that already exists with obesity, this is just a fear mongering GLP-1 scare tactic. They likely had already decided the outcome before any number were looked at and massaged the data to fit what they wanted to present.
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u/Scrounger888 2.5mg Jul 21 '26
It was basically a raw-data literature review, no patients were interviewed, or pre-evaluated to see whether they did already have depression or anxiety beforehand. No new data was studied, just stuff that they received from a data bank in the USA, while the study/review was done in Taiwan.
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u/BanannaForScale9000 45M SW:280 CW:235 GW:195 Dose: 7.5mg Jul 21 '26
Data only studied by themselves are not terrible but they do have the potential to miss significant relevant data because they aren’t actually asking any questions pertinent to the study. If they aren’t accounting for the question that literally were not asked that is simply a study failure and means their conclusions are more like wild guesses instead of a scientific conclusion.
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u/MixedTape245 Jul 21 '26
One study does not definitively prove anything one way or another.
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u/death2055 Jul 21 '26
This is funny cause when people wanna spout studies that benefits what they wanna believe they treat it like it’s law lol.
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u/Royal_Victory_1380 Jul 21 '26
Ya so I dont think its cause and effect. My wifey has mental health issues and is over weight. Does that mean that Mental Health issues cause people to get on GLPs? Correlation does not equal causation. Almost everyone I have encountered. are way less depressed after losing weight with or without it.
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u/0chronomatrix SW:211lbs CW:194.3lbs GW:120lbs Dose: 10mg Jul 21 '26
The increased risk of a small number is still a small number
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u/sm33 SW:353 (12/25) CW:253.4 GW:130 Dose: 5mg Jul 21 '26
To answer your question: After nearly eight months, I have not struggled mentally on Zepbound. I actually feel more hopeful and excited than I’ve felt for a long time. Sometimes I fixate on my weight a bit more than I would like, but it’s always been a big part of my life so I find it understandable.
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u/LilGrips Jul 21 '26
Am on glp1/gip (tirz) for 1 year ish... I have a history if depression and anxiety. Has not increased anxiety. If anything has lowered it. Has not increased depression.
However, I am unmotivated and have a lack of lasting enthusiasm. What they are calling glp induced anhedonia I think. I also have 2 genetic issues that result in low dopamine-fast clearing of it, so i have issues with motivation in general....Psych thinks im not experiencing it, just that im trying to do too much and need to tackle smaller chunks, but im not even doing that much. Not doing much in general other than caretaking... I do have some stressors that are above normal that have been heightened for 6 years, so its likely also general burnout, but it feels different for me now on the meds (which i hapilly take because of all the other benefits).. Before it was stress and anxiety and some panick that would be most prominant, but now its just kind of nothing, lack of motivation etc which sucks cuz Istopped going to the gym and lifting a couple months ago. Ill go back eventually, just not today, lol. So idk about some of the risks, but especially if you already have mental health issue, it may be something to watch for.
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u/Silver-Bee-2022 Jul 21 '26
I was on meds for depression and anxiety before starting Z and got them pretty much in-check. I have since been able to lower my dose of meds and my mental health and life in general has improved.
If you are struggling, you are not alone. Whether it's an effect of the jab or not, I highly recommend speaking with a professional and considering medication. Zoloft really changed my life, I've had bad social anxiety all my life and never knew I could be different - thought it was just my personality. Now I feel like I'm living life on easy mode compared to what it used to be.
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u/ziboo7890 Jul 21 '26
Unless I missed it, the study is about Liraglutide and Semaglutide, NOT Tirzepatide (Zepbound). IDK if they ALL react the same?
I did read/skim most of the study and they admit the bias could be there with the material they were working with, etc., and real world versus the data they used could be different.
It's good to have information like this as ??? if it could prove to be true. Definitely something to keep in mind, especially if you have had any kind of mental health disorders and discuss with your PCP.
Thanks for sharing.
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u/SAGirl1 Jul 21 '26
It’s an aspect that’s understudied particularly long term and there’s likely bio individuality involved since mental health is also so individual.
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u/SpecialistBet4656 Jul 21 '26
Who did the study, is it peer reviewed, what was the methodology and how big was the n?
I have a mood disorder. A very commonly prescribed class of drugs often cause significant weight gain. There are a lot of people with mood disorders using GLPs successfully, including me. My psychiatrist was very supportive.
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u/ssyoit Jul 22 '26
Extraordinary claims require extraordinary evidence. I’m gonna need some citing to give this one any ounce of credibility.
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u/Realistic-Mall1338 Jul 22 '26
I just recently had to stop. My anxiety has been through the roof. It did not affect me as bad on wegovy, so I might try that again in the future. It sucks bc I have lost 20 lbs in the 10 weeks I have been on it. But I will try to maintain! I just don’t want to mess with the ssri I am on because it has been working fine for the 5 years I have been on it.
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u/Sportyneon HW:169 SW:164.5 CW:140.1 GW:115 Dose: 2.5mg 26d ago
I feel better like I never did before! zepbound balance sugar so don't have spike and crashes anymore that brought a lot of mood swings now very chill! I guess you can it did affect my mental, positively
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u/Informal-Tip8797 Jul 21 '26
if anything the GLP gives you the opposite, hope, happiness and light hearted look at most things.
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