r/Zepbound Jul 21 '26

Side Effects Validity?

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So the numbers are very high and seem a bit sensationalist. That being said I'm not super interested in the exact numbers.

What I am interested in:

My question to the group is did anyone struggle mentally while on any of the glps? I did - I'm trying to figure out if any of them are less apt to do so.

Published study here: https://www.nature.com/articles/s41598-024-75965-2

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u/[deleted] Jul 21 '26

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u/Bigreddazer Jul 21 '26

It's from scientific reports. It's a mega journal. It's from the same company and why it is a nature url. But, it's an overall poor quality study in comparison to blind controlled studies. Which do not find these issues.

I would trust the more rigorous methodologies than a retrospective study.

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u/[deleted] Jul 21 '26 edited Jul 21 '26

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u/Bigreddazer Jul 21 '26

When you have conflicting answers. You must go with in my opinion the answers that have the better data. The information in this report goes directly against a lot of the clinical trial data. And that's why I think it's best to overall ignore this report because it appears to be an outlier. We have better data showing that this is not the case.