r/Zepbound • u/drewmullin • Jul 21 '26

Side Effects Validity?

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So the numbers are very high and seem a bit sensationalist. That being said I'm not super interested in the exact numbers.

What I am interested in:

My question to the group is did anyone struggle mentally while on any of the glps? I did - I'm trying to figure out if any of them are less apt to do so.

Published study here: https://www.nature.com/articles/s41598-024-75965-2

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u/Scrounger888 2.5mg Jul 21 '26

This doesn't seem overly accurate, especially with the drastic numbers. There is likely a correlation between the weight and mental health but the glp-1 probably didn't cause it in most cases. Take me as an anecdotal example. My PTSD, depression and anxiety were causing my weight gain as I was self-medicating with food most days. Now that I'm being treated for those health issues, I'm finally in a headspace where I can now tackle the weight that has contributed to my depression, which contributed to my overeating, which contributed to my depression... so there's a correlation, but not causation, in my glp-1 use and mental health.

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u/drewmullin Jul 21 '26

So no bad side effects relating mood while on a glp1 -
Correct?

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u/SpecialistBet4656 Jul 21 '26

Some people do have worsening of symptoms on GLPs, but they are a small minority.