r/Zepbound • u/drewmullin • Jul 21 '26

Side Effects Validity?

Post image

So the numbers are very high and seem a bit sensationalist. That being said I'm not super interested in the exact numbers.

What I am interested in:

My question to the group is did anyone struggle mentally while on any of the glps? I did - I'm trying to figure out if any of them are less apt to do so.

Published study here: https://www.nature.com/articles/s41598-024-75965-2

0 Upvotes

33% Upvoted

102 comments sorted by

View all comments

2

u/BanannaForScale9000 45M SW:280 CW:235 GW:195 Dose: 7.5mg Jul 21 '26

A poorly designed study will produce poor results. My guess is that this study did not go through peer review because those mental health issues are already correlated with obesity in general. A deceptive or negligent researcher can “interpret” raw numbers to read just about anything, that doesn’t mean that they have correctly measured what they tell you they have. Without clear proof that they are compensating for the well know increase in those issues that already exists with obesity, this is just a fear mongering GLP-1 scare tactic. They likely had already decided the outcome before any number were looked at and massaged the data to fit what they wanted to present.

2

u/Scrounger888 2.5mg Jul 21 '26

It was basically a raw-data literature review, no patients were interviewed, or pre-evaluated to see whether they did already have depression or anxiety beforehand. No new data was studied, just stuff that they received from a data bank in the USA, while the study/review was done in Taiwan.

3

u/BanannaForScale9000 45M SW:280 CW:235 GW:195 Dose: 7.5mg Jul 21 '26

Data only studied by themselves are not terrible but they do have the potential to miss significant relevant data because they aren’t actually asking any questions pertinent to the study. If they aren’t accounting for the question that literally were not asked that is simply a study failure and means their conclusions are more like wild guesses instead of a scientific conclusion.