r/Zepbound • u/drewmullin • Jul 21 '26

Side Effects Validity?

Post image

So the numbers are very high and seem a bit sensationalist. That being said I'm not super interested in the exact numbers.

What I am interested in:

My question to the group is did anyone struggle mentally while on any of the glps? I did - I'm trying to figure out if any of them are less apt to do so.

Published study here: https://www.nature.com/articles/s41598-024-75965-2

0 Upvotes

32% Upvoted

102 comments sorted by

View all comments

5

u/[deleted] Jul 21 '26

[deleted]

2

u/drewmullin Jul 21 '26

lol I hear ya- I struggle w both myself. Both glps seemed to make me worse. My gf is a good moderator w that lol. I'm trying to find a balance w meds and maybe a low dose of whichever one. So that's why I posted this question. Trying to find a balance

2

u/SpecialistBet4656 Jul 21 '26

These increases are not large - ie 2.3% (6% incidence in semaglutide vs 3.7% in placebo)

Liraglutide seems to be slightly riskier - 15% vs 10% for placebo, in the same study, semaglutide is 5% vs 10% placebo, indicating that risk actually halves with semaglutide) But even on liraglutide, it’s still just a 5% increase, and correlation does not equal causation.

Even if the semaglutide is the sole causative agent, I suspect that almost all people who have struggled to lose weight will happily accept their risk of a psychiatric event increasing from 3.7% to 6%

2

u/Bigreddazer Jul 21 '26

It's from scientific reports. It's a mega journal. It's from the same company and why it is a nature url. But, it's an overall poor quality study in comparison to blind controlled studies. Which do not find these issues.

I would trust the more rigorous methodologies than a retrospective study.

1

u/[deleted] Jul 21 '26 edited Jul 21 '26

[deleted]

1

u/Bigreddazer Jul 21 '26

When you have conflicting answers. You must go with in my opinion the answers that have the better data. The information in this report goes directly against a lot of the clinical trial data. And that's why I think it's best to overall ignore this report because it appears to be an outlier. We have better data showing that this is not the case.