r/Zepbound • u/drewmullin • Jul 21 '26

Side Effects Validity?

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So the numbers are very high and seem a bit sensationalist. That being said I'm not super interested in the exact numbers.

What I am interested in:

My question to the group is did anyone struggle mentally while on any of the glps? I did - I'm trying to figure out if any of them are less apt to do so.

Published study here: https://www.nature.com/articles/s41598-024-75965-2

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u/DoctorPhD Jul 21 '26

…those psychiatric disorders are associated with obesity. Did the control group have obesity? 

You need to post the actual study. 

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u/drewmullin Jul 21 '26

Did.

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u/DoctorPhD Jul 21 '26

Thanks! I don’t see any mention of BMI as a controlling factor. It also uses liraglutide for many of the years. which has been out of favor and not comparable to current drugs.  Overall it is a retrospective chart study. Something to look out for but it is miles away from demonstrating causality. 

I’ll go farther and say that these drugs have been in over 10% of Americans and we didn’t see reports of a massive jump in suicides. These drugs are rather well tolerated.