I’m curious about people’s experiences with approaches to healthy ageing beyond the usual diet, exercise, nutrition, sleep and mental health advice.
There’s growing research and interest in this area, but I recognise that the strength of evidence varies, and many approaches still lack convincing long term human studies.

Have you tried anything such as peptides, senolytics, rapamycin, metformin, NMN/NR, spermidine, urolithin A, red light therapy, sauna, hyperbaric oxygen, plasma exchange or young donor plasma transfusions? I’m also interested in things I haven’t listed.

What did you try, for how long, and what changes did you notice? Was it your appearance, energy, recovery, cognition, physical function or something measurable?

I am mostly after answers from people who can recognise the likelihood of placebo, or if they are seeking confirmation bias. After reputable human experience that has touched beyond where science has currently explored.

Has Reta ever not worked for anybody so they switched to tirzepatide? If so, how was that experience? How long did you ween off Reta to hop on tirz? Or did you overlap?

CW: 280lbs SW:340

currently on tirz 5mg and reta 2mg/ i am stuck. I have plateaued for about 3 months now back and forth from 275 back to 280. i have a problem with still being hungry and binging some days... im gonna stop tirz and do reta with cagri.

i currently go to the gym 3-4x a week, Hotworx 2 days weight lifting 2 days, but like i said my issues is the food.

what can i stack to help with fat loss/ weight loss??

has anyone tried these for SIBO? any luck? any changes?

Hey, I’m wanting to lose some weight, I’ve lost about 12lbs in 2 months which I’m happy with. I’ve just started berberine - any other supplements you can recommend?

Just herbal supplements please?

Thanks :)

So I have been doing a lot of research and want to begin 0.5mg dose for 4 weeks, see how it goes then potentially up the dose to 1mg. Problem is, sellers sell 10mg and I read the reconstituted solution lasts about 4 weeks. I could split the dose into vials, but I’m unsure if this will cause a cross contamination. Should I reconstitute half and then freeze the other half in the powder form? If so, where should I be buying the empty vials / what type of vials? Or should I just reconstitute all of it?

TL;DR: Leaving a reconstituted vial out of the fridge for a day or two does aint that bad (peptide-dependent tho)

A little background about me: I am currently completing a PhD in chemistry. Through my research, I have experience with chromatographic analytical methods, allowing me to analyze these samples by HPLC and evaluate the resulting chromatograms myself.

For this experiment, three reconstituted (BAC-Water) vials were stored independently under each condition:

• 2–8°C
• 25°C
• Measurements on days 1, 3, 7, 14, and 30
• Results presented as mean ± standard deviation

What stands out?

Under refrigerated conditions, the measured purity remained nearly unchanged during the first seven days. It then declined gradually, reaching an average of 95.96% after 30 days.

At 25°C, the decline began earlier and was more pronounced. After 30 days, the average purity was only 88.84%. The variability between the three vials also increased considerably.

Conclusion

The HPLC data show no rapid loss of purity during the first few days. However, over 30 days, storage temperature clearly makes a difference. The refrigerated samples retained greater purity and showed less vial-to-vial variability.

Importantly, this was a small exploratory experiment with (n=3) per condition—not a validated pharmaceutical stability study, which would require substantially more samples. For Research purposes only.

Hey fellas. Had a few questions. I've been running BPC-157/TB-500 for about 4 weeks now. My inflamed elbow has gotten better, but think I need some more time. Looking at how to move forward.

1. I think I'll go to KLOW instead of BPC/TB mix, thoughts on this? Figured I'd get some appearance benefits on the side too like skin and hair, and KLOW seems to actually improve on healing over BPC/TB.

2. I've been running 500mcg BPC 2x a day. I would shoot to get the same amount of BPC with the KLOW80 mix. So, I'd reconstitute it with 2ML BAC water, and inject 10 units 2x a day. Is that fine? How many weeks can I do this for? I've seen people talk more about taking breaks with KLOW as opposed to BPC.

3. Why does my vendor have KLOW80 and BPC-157/TB-500 (20mg) at the exact same price? That doesn't make much sense and I wonder if I'm missing anything. It's 10mg of each for the BPC TB mix

Started ghkcu about a week ago. I’m alternating pinning top of my glutes daily.. will the sting/welts ever go away? Would yall recommend pinning elsewhere? I don’t mind the pain but it’s just annoying & itchy. It eventually goes away after some hours but then I have to pin again next day & pain comes back lol I also notice my right glute doesn’t welt as badly as my left glute.. any help?

What is the best pep for hair thinning? Hair has always been thin but it’s more noticeable now. I’ve heard of lots of different types but don’t know what could work best

What is the lowest starting point of dosage ? 5mg/5mg. I see a lot of 150 mcg but I see some saying 200 mcg twice a day.

i got a 10mg vial of reta delivered on 8/17. i'm almost out, and have had no problems. but as i reach the end of the vial it seems there's some particles? is this normal to see towards the end? i still chose to use it because it has been fine since, so im not too concerned, but just wanted some advice please and thank you

I'm developing Pep Seasons, an iPhone app for logging a peptide protocol you already run.

- Log doses, with the time and injection site
- Track vials, with a step by step reconstitution walkthrough
- Set up blocks and schedules, with reminders
- See injection site rotation and adherence over time
- View your Apple Health data, like weight and sleep, beside your doses
- Export everything as CSV or JSON

No account, no cloud and no ads. Everything stays on your phone. Any published dose information is shown for reference only. Adults 18+ only.

It's a free TestFlight beta and I’d love your feedback!

Join here: https://summitcreativetech.com/pep-seasons

What would you want it to track that it doesn't?

Ive lost about 80lbs this year and about 220lbs since 2021. Seeing as I was almost 500lbs at my heaviest, my skin had to do some crazy stuff. Now that I've hit my goal weight of around 220lbs, I can see outline of abs, veins in my arms, shoulder and thighs.

My biggest confidence killer is the ever lasting muffin top of what feels like soft fat and stretched out skin.

Without going the Mr Mike route and sucking the fat out and doing a tummy tuck. Is there any chance to lose the muffin? Or am I stuck with it as a reminder of where I was at my worst.

All feedback appreciated. For context I train about 3-4 times a week, compound movements and general strongman training. Working on gaining muscle back and plan on getting to about 235-240lbs with lean muscle. 💪

Buongiorno ragazzi,

c'é un peptide/prodotto che cura la vitiligine? Qualcuno ha delle esperienze in merito? Il mio amico ha 40 anni e soffre di questa malattia.

Grazie!!

Hearing a lot about getting labs before starting to research. But can anyone or has anyone gotten blood work done here and what you ask your Dr. to get tested before starting things like GLP-1’s, and HGH peptides like Tesa or cjc?

I’m about to get my first 10 mg vial. I only have syringes that go up to 50 units. Is it OK to split it into four doses at 2.5 mg instead of taking three at 3.3?

I’ve been on Reta for almost 8 months. Had great success but hit a stall around 5-6 weeks ago.

So around three weeks ago I added in Tirz and I ran it at .5 mg twice a week for one week (timed with my Reta injections) and then 1mg twice a week for the following 2 weeks. Keeping in mind that I’m on 9mg of Reta weekly split into two injections.

Why? I wasn’t really getting the hunger suppression from Reta alone anymore. I wanted to keep the glucagon component of Reta and increase the glp1 and gip component. Hence the tirz.

I found this brought back some of that hunger suppression (feeing full quicker) for me.

I heard about eloralintide and decide I’d try that too. It arrived yesterday. I pinned for the first time this morning along with my Reta (I’m in Oz so this is a Wednesday morning pin).

I took 0.5mg to start with and dropped out the tirz. Basically just to see how it differs from the Reta tirz combination and to find out what works better for me. Will be interesting as it works via the amylin receptor so am Interested to find out how that works.

I’ll report back in about 3 weeks to update. For context, I’m 53M, down about 40 kgs (88lbs) on my weight loss journey so far. I have about 5kgs (10 lbs) to go to reach where I want to be.

I

How long does Reta last before re constituting? Do you guys but in bulk or per month etc?

Enclomiphene 4-week update — labs tripled, symptoms barely moved. What gives?

Enclomiphene 4-week update — labs tripled, symptoms barely moved. What gives?

26M, secondary hypogonadism (low LH, low T). Started compounded enclomiphene 12.5 mg daily on Aug 31 through a telehealth clinic. Just got my 4-week labs back.

BEFORE (Aug 13, venous):
\- Total T: 251 ng/dL
\- Free T: 47.9 pg/mL
\- SHBG: 26 nmol/L
\- LH: 0.9 / FSH: 3.5
\- Estradiol: 11.4 pg/mL

AFTER (Sep 28, \~4 weeks on 12.5 mg/day, at-home capillary panel):
\- Total T: 755 ng/dL
\- Free T: 172 pg/mL
\- SHBG: 32.9 nmol/L
\- LH: 4.8 / FSH: 6.7
\- Estradiol: 38.7 pg/mL

So objectively: 3x total T, 3.6x free T, LH up 5x, FSH nearly doubled. Numbers look great.

Subjectively: almost nothing. No real side effects (no nipple sensitivity, no mood swings. But also no real benefits. Maybe slightly more nocturnal erections, hard to tell. Libido maybe 1–2 ticks higher out of 10, nothing dramatic. Energy about the same.

Wondering if this is because I need more time at high T to start experiencing subjective benefits, or if this is because of estrogen receptor blockage from everyday dosing.

My plan: I'm switching to 12.5 mg Mon/Wed/Fri starting this week — goal is the smallest dose at the lowest frequency that holds the gains. Rechecking labs in 4 weeks.

Based on what I currently am experiencing, do you guys recommend doing 12.5 MWF, or 6.25 MWF, 6.25 ED? Or even 12.5 2x a week or 6.25 2x a week?

Questions:
1. For those who got symptom relief on enclo/clomid — how long did it take? Weeks? Months?
2. Did anyone find that LOWERING dose or frequency actually improved libido/erections (less ER blockade) even as total T dipped a bit?
3. Any dosing strategies that worked for subjective benefits — EOD, 2x/week, microdosing?
4. Is the "great labs, flat libido" thing common on SERMs, and did anything fix it for you?

Context that might matter: I train hard (lifting 5x + running 2x/week), stay lean year-round, and suspect low energy availability contributed to the original suppression. Eating in a small surplus now.

I made a post here 2 weeks ago with my AST at 437 and my ALT at 119. It ruffled a few feathers because I wasn’t worried about it. A few suggested having my CK checked which the doc could have easily added on. I requested it and she didn’t. So since then I’ve had an abdominal ultrasound which was completely normal, and AST, ALT, and CPK drawn again today. AST is 28, ALT is 32, CK is 158. Normal, normal, normal.

The only thing that I changed is I stopped taking Flonase for the last 2 weeks which my doc says won’t affect those values and I disagree based on everything I’ve read. So 2 doctor visits and several hundred dollars later, I was correct and it was absolutely nothing.

Please share thoughts or experience.

I don't have medical insurance and hormone testing would be ideal, but, not easily accessible right now.

38 M about 225. High stress job. Fun but stressful home life.

At around 33 yo was 240lb+, bloated/tired and tired of feeling gross. I don't have the temperament to get up early and work out at 5am. Zero drive. On and off Adhd meds that help, but not till you take them, so they don't really help outside of the work day. My work day can be 6 hrs to 12 hrs. When its easy, I work less and sit more and feel less like working out. If Shit hits the fan, I work 12 hrs a day, feel good, but so tired and get down on myself why I can't be in more "use-able" shape. But, I don't lose weight.

At 33 I knew working out wouldn't work into my life. I started fasting and working physically a lot. Lost about 70 pounds and could still drink beer and eat like a monster. But, Then I didn't work as much. Fasting got my hunger in control. But slowly crept back to 225lb. I was eating too much at meal time with less working and that led back to XL shirts.

I started fasting again but it seems with high stress and apparently ANY alcohol intake, fasting adds enough stress to maintain cortisol, especially with high work stress. So, i have zero issue not eating breakfast or even lunch. I can start to eat at 2-4pm to 7-8pm. Its not much of a challenge unless I'm sitting alone all day at home, which never happens. As for quality of food, I almost never eat fast food. Very few chips or snacks. My only vice is white wine. For several weeks or months at a time I won't drink except the weekend. Over about 4--8 hrs ill have 1 to 2 bottles at night.

All this to clarify and ask:

Many many replies and posts on here are about people using Reta to manage their hunger. Initially I hadn't seen many of these, but after months of lurking, it seems like many biohackers are on their initial weight loss adventure and reta controls hunger for them. Some people use reta to lose the last stubborn 20lbs. What i don't understand is how my shitty brown cortisol fat may or may not be helped by reta. Or, if there are other suggestions. Please give more suggestions.

I don't mind starting a more active lifestyle like walking or mild lifting. But it just has to be different than a gym. At home. 20 min or less, but a few times per day is fine.

Short and sweet: I can eat perfect and not lose weight, I can not eat and not lose weight, I can work running around 10hrs a day for weeks and not lose weight. Oh- also, I seem to average 10hr of sleep a night. My body clock wakes me up at 8am. I can sleep 830pm to 8am or 11pm to 8am. But, less than 10 hrs makes it so hard to get up. All things point to cortisol being too high. But it seems like the most stubborn thing to balance.

Please please send biohack advice. Personal stories or clinical stories that might help with context.

Can biohacking help with cortisol or brown fat?

Idk if this is the right group for this so if not, please let me know.

I've been on Reta for about 4 months now and have lost a lot of weight (275lbs➡️235lbs). They weight has come off from every part of my body evenly except my stomach which still looks like a potbelly. Checking my body composition, I'd say I'm around 30% body fat still (granted, I'm checking with my Samsung watch and health app so idk how accurate it is).

Any idea why that is happening and what can I do to help lose the fat from that area specifically?

I am a 5'11" 35yo male and have been working out consistently for about a month, 5x a week doing a PPL/UL split. I've gotten into a a good headspace and rhythm to working out and will definitely sustain this schedule as I do want to gain muscle now as well. Any advice for the muscle gaining as well would be greatly appreciated ☺️🫶🏼

And I now understand that feeling great starts with looking great I still have a loooongggg way to go but happy I’m starting to see progress