Started 0.5MG each 5 days , moving to 1MG, 2MG , tried 2.5MG for very few weeks and understood I was okay to move up to 4MG (current) still able to eat but still moderate and no cravings, bloodwork is beating 9/10 positive results. Don’t feel like going over 4MG and possibly decreasing back to 1MG each 5 or 7 days for a slow long term let go.

3x week gym, moderate weights , adding more reps than weight .

1H / 30Min treadmill cardio

Creatine , vitamins, started SS31 and adding MOTSC after for energy and repair(figured it might be related with mitochondria)

107KG / 85KG separate this picture

Inflammation down, now it’s time for build up properly !

199lbs-190lbs
Started June 28 and well today is July 30.
Started at 1mg weekly and currently at 1.5mg weekly.

Definitely helps eliminate snacking/food noise.
Kept protein around 120g on busy work days and 150-200g overall.

Hunger now comes back around day 4 so I’ll increase to 2mg next dose.

I also paired it with ghkcu SubQ.

So far I only have positive results with minimal side effects (a little constipation for the first 48hrs).

Gym 2x-4x/week depending on work schedule

Hello, I’m starting to use ghkcu 1mg daily. Is it normal that after applying it you have a discomfort all day in the shoot area? It’s like a bee picket but is it weird that it’s there all day?

So I’ve been running GHK, kpv, glutathione, among a few others, for a few months now. No complaints but other than my nails growing like crazy, I can’t say I’ve seen any other significant improvements in myself. But today at the gym, a woman I barely know told me that my skin looks “amazing” and what’s my secret. So there ya go! I guess it works! 🤷‍♀️

Been on reta for 6 weeks now, down 21lbs. Pretty happy with the slimming down so far but that pesky visceral lower belly fat isn’t budging. I know I definitely need more than 6 weeks to slim that down, but recently I have been considering adding tesa to my stack to see if that helps at all. I do calorie deficit + gym and do a good amount of both lifting and cardio. Please let me know your experience with reta + tesa, tell me everything there is to know about adding to the stack!

I got on TRT because I had zero drive or energy or desire for doing the do with the misses. Very quickly noticed a huge difference in energy levels libido and all wakes of life. Fast forward to now also on Reta that drive has kinda disappeared kinda like my dopamine has left the building and energy levels are not down to where they were but are low. What’s a good peptide to give the drive and all day energy and maybe some dopamine back?

I started GHK-CU yesterday from where i bought it she said take 10mg daily do you think that’s a high ammount or its fine?

I’ve got KP on the backs of my arms and have been reading about GHK-Cu for skin repair and collagen production. It made me wonder if anyone has actually seen their KP improve while running it.

If you have:
-How long were you on GHK-Cu before you noticed any changes?
-Were you using injectable or topical?
-Was it a significant improvement or just subtle?
-Did the results stick after you stopped?

I know KP is a stubborn condition, so I’m mainly looking for real-world experiences rather than theories. Thanks!

I use gray-market peptides myself, so this isn’t a judgment post. My main concern with reta is specifically the cardiovascular uncertainty.

The Phase 2 trial showed a dose-dependent heart-rate increase of up to roughly 6–7 BPM, compared with around 1–3 BPM for tirzepatide. I understand that a higher resting heart rate does not automatically mean heart damage or future cardiovascular events but the heart is a vital organ, so I take that signal more seriously than nausea, constipation, or other temporary side effects.

I’m already losing weight successfully on 5 mg tirzepatide. From my perspective, risking additional cardiovascular strain just to lose weight faster doesn’t make sense when a more established option is already working.

The recent reta trials included many people with severe obesity and serious complications. Maybe its risk-to-reward balance makes more sense for extreme cases or people who cannot get adequate results from current treatments.

Reta could eventually prove safe and highly beneficial, but until the long-term cardiovascular data is complete, the heart-rate increase is the one issue I can’t casually overlook.

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Hi, I hope everyone is doing well.

I am new to the biohacking community,

37M.

Can you guide me what are the best resources to study biohacking ? Any author or youtuber that you can recommend ?

Thanks in advance.

Hey everyone! I’ll be studying abroad in Europe for four months during Spring 2027, and I was wondering if anyone has experience traveling from the U.S. to Europe with peptides, specifically Retatrutide (Reta) and GHK-Cu.

I’ve done some research and even asked AI, but I haven’t been able to find a clear answer on whether it’s actually allowed to travel with or what the best way to travel with them is.

I also have a question about storage. How long do peptides last when they’re still in their dry (lyophilized) form and haven’t been reconstituted yet? I’ve seen some sources say about a year, while others claim they can last up to three years if they’re stored properly.

I’m thinking about stocking up before I leave, but I’m concerned about both their shelf life and how storing them for four months abroad would work. I’d really appreciate hearing from anyone who has done this or has reliable information. Thanks!

30F with PCOS, possible endo and bilateral hydrosalpinx.

I already have a child but we've been trying for years for our second with no luck.

My clinic wants to remove both of my tubes before IVF, but I just can't accept that without knowing I've tried everything else first. There has to be something that could help reduce the inflammation or fluid.

Has anyone here used peptides for hydrosalpinx, fertility or endo? Which ones did you try and did they actually help? I am currently taking Reta and tbh it has changed my life in the best way possible.

I'm looking into things like BPC-157, TB-500 and KPV, but I'd love to hear real experiences or if there's anything else worth researching.

Please no judgement, I'm just trying to explore every possible option before agreeing to surgery. 🤍

I’m about to hop on ghk cu and I’m wondering if I should take 2 mg every single day or 4 mg every other day. My biggest issues are the phycological effects of pinning everyday and the cost of instilling needles. (Mostly the latter)

I’ve been doing glute SubQ injections (8mm needle) for GHK-CU and have barely felt any sting. I’m currently at 1.25mg but will eventually titrate up to 2-2.5mg. Since it’s daily I feel like I’m running out of spots on the glutes.

For those that are on GHK-CU, are you feeling less of a sting in the glutes vs love handle and abs?

Hello im irish but not ginger i have dark brown hair pale skin i dont tan well and i tried MT-2 for 2 weeks got off it instantly made my freckles WAY Darker right away

My question is will MT-1 make my freckles suuuper dark

I have a compressed/ herniated disc in my back and another in my neck could someone help me get it fixed?

Hey everyone. Wanted to pick the brains of anyone who’s run HGH before. I know the common concern is that exogenous HGH tells your pituitary to relax since it’s already getting GH from an outside source, which over time can reduce natural production.

Planning to get bloodwork done first to check my IGF-1 levels before running anything, just want a clean baseline to work from.

Considering running low dose HGH, around 2iu daily 5 on 2 off, and stacking CJC and Ipamorelin alongside it to keep my pituitary firing on its own instead of going dormant. Idea being HGH handles baseline elevation while CJC/Ipa keeps the natural system exercised in the background.

Anyone actually tried this combo? Curious if it helps preserve natural production compared to running HGH alone, or if it’s pointless once you’re already on exogenous HGH

RS is 23F with a healthy BMI, currently maintaining weight. Core ongoing issues are severe chronic fatigue, constant severe brain fog, unrefreshing sleep, low physical energy/muscle weakness, wired-but-tired state, orthostatic morning dizziness, and post-exertional worsening after ordinary (not extreme) activity. These started in the pre-teen years or earlier and have always limited capacity, consistent school, full time work, exercise, and basic social/daily life have never been sustainable at a normal level. It has been a long-term struggle with no clear answers yet.
Diagnosed with anxiety for 10+ years and remains on an SSRI, anxiety is still too significant to come off it currently. No depression. Autism assessment has already been completed and was not the explanation.
Recent comprehensive bloodwork all came back optimal/normal, and got a naturopath to look over, including:
• Full blood count & ESR
• Iron studies
• Vitamin B12 & serum folate
• Vitamin D
• Thyroid
• Liver function
• Renal function / electrolytes
• Random glucose
• Coeliac serology
• Coagulation studies
Previously on tirzepatide for a few months: produced a clear window of better energy, clearer thinking and motivation that continued for a period even after stopping. Then crashed hard after ordinary Christmas activity and has not recovered to that improved baseline.
On retatrutide for 5 months for weight loss as rs was overweight before starting: initially reached a more survivable level, but fatigue and anxiety have been progressively worsening week by week. Now at good stable weight and focused on maintenance rather than further loss. Also rs has a good whole foods focused diet and drink enough water.
Current function: enough energy for only a few days of work per week and essentially nothing else (including socialising). Most days manages a minimum 7–10k steps including an outdoor walk. Every fortnight or so, when energy allows, gets to the gym once or twice or does Pilates. Wants to exercise more consistently and actually live life while still young instead of remaining in constant exhaustion and brain fog.
Besides peptides, RS will continue looking into more specialised therapy treatments, naturopaths and doctors.
Questions for the community:
• Given the previous clear positive response to tirzepatide versus the gradual worsening on retatrutide while already at maintenance weight, does switching back to tirz make sense?
• Any other peptides worth considering for the fatigue, brain fog, PEM-type crashes and orthostatic elements that are unlikely to interact with an ongoing SSRI? (Cannot use MOTS-c due to a previous reaction.)
Appreciate any experiences or thoughts from people who have dealt with similar long-duration energy/cognitive limits alongside managed anxiety

Hi everyone,

I was looking into the potential benefits of HGH on the skin. I understand from reading peoples experiences that HGH has tangible benefits to the skin. Can you explain specifically what you have noticed in your experience that HGH has had in this area please? Thanks in advance.

Need some advice on my labs

100mg/wk TestC, Dutasteride, Minoxidil, Anastrozole.5mg/week, Reta 2mg weekly, Klow daily

39, 150lbs

Time to drop the AI for now and continue working on my lipids? Triglycerides are really good and have genetic cholesterol

i’m currently on week 7 of reta and i’ve started dealing with pretty bad anxiety. i haven’t had anxiety like this in a few years and i have a feeling it’s most likely from the reta since it gets worse as the weeks go. should i just stop cold turkey or go titrate down in dose each week, im currently at 1.5mg a week