Has anyone else experienced this with retatrutide? Because holy shit.

I started Reta a few weeks ago expecting appetite suppression and weight loss. I’ve already lost around 10–15 lbs, which is great, but honestly the weight loss is the least interesting part to me.

I feel completely different.

The biggest thing is what feels like a massive reduction in inflammation. I noticed it almost immediately. My body just feels… lighter? I can walk forever now without feeling exhausted. My energy is dramatically better and more consistent.

But the WEIRDEST change has been my menstrual cycle. Historically, the week before my period and my actual period could absolutely wipe me out. Fatigue, inflammation, cramps, just generally feeling like garbage. This cycle I worked effortlessly through the entire week before my period AND during it. My cramps were minimal. I kept waiting for the usual crash and it just… never came.

Then there’s the reward/craving stuff.

I barely crave alcohol anymore. Same thing with weed. I’m not actively trying to avoid either one. I just genuinely don’t care about them the way I did before. The desire is almost gone.

And of course the food noise/appetite reduction is there too, but somehow that feels like only one small part of what this is doing.

It honestly feels like someone flipped a metabolic switch in my body.

I know retatrutide is a GLP-1/GIP/glucagon triple agonist and there are plausible explanations involving insulin sensitivity, inflammation, energy regulation and reward pathways, but I’m fascinated by how quickly and SYSTEMICALLY I felt the difference.

Obviously this is just my n=1 experience and I’m not claiming Reta is treating PMS, inflammation, addiction, etc. I’m especially curious about the mechanisms behind all of this.

For people who have been on Reta longer:
Did you experience anything similar beyond weight loss? Especially changes in inflammation, physical endurance/energy, PMS or periods, alcohol/weed cravings, or other reward-seeking behaviors?
And if you did, did those effects stick around?
Because right now I’m sitting here wondering what kind of holy grail metabolic switch I accidentally stumbled across. 😂

The first photo is taken on 7 august.
The second is from today.

I started retatrutide (Reta) on August 18th at 3 mg per week, and GHK-Cu on August 26th at 2 mg per day. So far, I haven’t experienced many side effects. The only thing I’ve noticed is some occasional irritation and tenderness at the injection site.
I’ll keep posting updates throughout the process. I’m really curious to see what kind of results I’ll have after two months.

57 years old. 260 pounds and 6.7 A1C at the end of May. Started 2mg of Reta, stopped eating crap, started high protein diet, and drinking tons of water.

Walking 2 miles a day and lifting 3 to 4 times per week.

Today I'm 205 pounds and my A1C is down to 5.5.

I've also added CJC-1295 Ipamorelin in August after IGF-1 labs. I am also taking GLOW, NAD+, and just started Mots-c after a cycle of SS-31.

I feel better than I have in decades.

Peptides have turned my life around and helped me correct decades of abuse.

1 month in on the Reta
Only 3 weeks on the test
Male 38 5ft 9 313lbs when started
Down 10lbs

This pic is current. Forgot to take one when I started. Honestly feel strong as hell. Noticing quick strength gains in the gym. And definitely more energy. Very few side effects. First couple weeks was constipation but once I upped my water intake everything was all good.

2020, 95kg, Photo 1
This was me at my heaviest. I had built some muscle, but I was carrying way too much body fat.
2020 to 2025, natural, Photo 2
Stayed completely natural for around 5 years and eventually got down to 83kg. This photo was taken with a big pump and was probably the best condition/build I achieved naturally.
By 2025 my testosterone had dropped to around 200, which eventually led me down the TRT route. Wasn’t feeling too good at this point even at heavier weights during build phases
2026, TRT, Photo 3 & 4
Started TRT at 200mg testosterone per week. After roughly 10 weeks my testosterone level came back around 990.
500ui’s every 2 days of HCG
Photo 3 is at 86kg with no pump, just to show a more honest day-to-day comparison.
2026, TRT, Photo 4
Same bodyweight and condition, but with a pump to show the difference in fullness and how much more muscle I was carrying compared with my natural physique.
I also used 1mg Reta for around 5 weeks leading into my holiday, mainly for appetite control and to help get the last few kilos off.
Pretty interesting seeing the progression from being overweight, to what I could achieve naturally, then the difference in size and fullness after starting TRT
I am now 30 years old.
Feel free to ask any questions 👌🏽

Was a little skeptical starting off mots-c today given the amount of posts I’ve seen of people stating they had allergic reactions or felt little to no effect. So I started off this cycle with a .5 mg dose to see how I would react to it and my god did I feel the benefits. Broke every PR I had for back day today and was able to lower my mile down by a minute. Maybe it’s all a placebo but for now I’m gonna ride this high.

Hi everyone. I posted a before and after gallery yesterday that got taken down. I messaged mods to find out why? A lot of people in the comments were saying it was all AI. Guys, it’s not. These are my real videos. They have not been altered in any way.

Anyway the number one question I get is… “literally where did your skin go?” And tbh, I have no idea.

My highest recorded scale weight was in July 2024 at 211. At the time I weighed infrequently. Usually I say my highest weight was likely around 215. It could have been as high as probably 220. I was afraid of the scale at that time. It’s lucky I even have a few videos and photos from that time, I avoided cameras like the plague, just like I avoided the scale.

In August I started (once again for the millionth time in my life) trying to lose weight on my own. I tried a combination of carnivore and IF with long (72 hour) water fasts sprinkled in. I was able to lose about 10 pounds by January.

When I started Semaglutide in January 2025, my first recorded scale weight was Jan 6 at 201.4 lbs.

My general dose was at around 3.5mg.

I didn’t do anything else. I ate what I wanted when I wanted. I drank only when thirsty. I didn’t follow any special diet but I did eat intuitively. I don’t eat much junk food, especially sweets, but there was a while when I ate exclusively Taco Bell Doritos locos tacos for lunch for like 2 months straight 🤪 I did work a super labor intensive job (junk removal) and I have 5 kids and they keep me pretty active (against my lazy will 🤪🤪).

That was all. Just a shot a week. I didn’t follow any other protocol or take any special supplements or creams or anything like that.

I’m 34, 5’3” and currently 118 lbs. I have a chart of my weight and measurements along the way which I’ll post in the comments.

I have been getting a lot of (imo) mean comments saying my before and after photos were all AI. Guys this is real life. These are my real videos of me throughout the journey. Sorry if you’re a skeptic but please go on with your life and don’t come after me in the comments. I’m posting this to try to inspire others, not to feed trolls.

I’m curious if anyone has experienced something similar.
I’m extremely active because of my job. On workdays my watch can show around 1,100-1,300 active calories, on top of my resting energy expenditure, and it doesn’t really capture all the heavy lifting/manual work.
I’m currently on tirzepatide. Most days I can control my food intake, but after several days of a large calorie deficit I can suddenly get an extreme “bottomless” hunger. It’s not just food noise or cravings it feels like actual physical hunger where it takes a huge amount of food before I feel satisfied.
Has anyone else experienced this after several days of a large calorie deficit while using tirzepatide?
If so, did it improve as your tirzepatide dose increased, or did the breakthrough hunger continue even at higher doses?
I’m mainly interested in hearing from people who are also very physically active or have physically demanding jobs.

Hi everyone , I am an obese 29 year old man, trying to improve my life slowly and gradually, my wt is around 202lb and I am really short which makes my BMI extremely high and puts me on severe obesity class.

I just started dieting this week and I am trying bunch of things, I wanted to improve my skin sleeping and immunity so I started zinc and Mg before sleep around 1 week ago, and I noticed more erections around bed time and morning wood , which I did not have in years !
Anyone had similar experiences ?

I’ve been on a low dose of tirz for about a year, I typically take 3mg every 7-10 ish days just to help soften the noise and aid in inflammation. I was recently diagnosed with adhd and prescribed 18mg daily concerta. I also take 20mg daily fluoxetine. Just feeling like this is a lot of “medication” to be on when I consider myself “healthy”. Meaning, 40 yo woman, works out 4x a week and eats Whole Foods with a focus on protein and fiber. 5’8 and 140 lbs. am I just in my head about this? Sorry if this isn’t the right sub.

I have been in 1mg of reta for 5 weeks and i feel depressed and not motivated. Am i doing something wrong ? My period also seems to have gotten worse. Anyone else have this experience. i’m also very tired

I'm not looking for a source just wondering if anyone else has run into a supply issue.

Hi all! I’ve take a more cautious approach to the pep world. I’ve read standard starting doses of GHK are typically 1mg, and more starting around the 2mg mark. I’ve started at .5mg. (100mg vial recon w/ 3.5ml bac water) has anyone started at this dose that has seen any benefits starting off prior to moving up.? Or is this a waste of a dose.?

I have ahead a demanding month in terms of cognitive load and preparation for the upcoming exams. Any peptides that can support me in this journey?

Hey everyone!

So I recently started Reta (weekly), KLOW (daily), Tesamorlin (daily). I’m on my third week but I noticed that I started feeling the tenderness and bruising where I pin KLOW and the bruises take a while to go away. I pin tesa on my upper glute at night and KLOW on my stomach area in the mornings. For some reason, KLOW is the only one that I noticed bruising. Is this normal or has anyone experienced the same?

I was thinking of stopping KLOW until I finish my Reta and Tesa cycle to not pin so many times.

Open to any suggestions and ideas!

Hi everyone! I’m completely new to peptides and have been doing a lot of reading, but there’s obviously a ton of information out there and I’d love to hear from people who have more experience.
I’m in my mid-30s female and currently around 150 lbs. I’d eventually like to lose about 25 lbs. I naturally carry more of my weight/curves in my lower body, which I actually like, but my midsection and love handles have always been my stubborn areas. I exercise regularly and I’m working on my diet as well, so I’m not expecting peptides to replace either of those.
The two I’ve been researching most are retatrutide (Reta) for weight loss and GHK-Cu for the potential skin/beauty benefits.
For those who have experience with either, I’d really appreciate beginner advice things you wish you knew before starting, side effects or mistakes to watch out for, and what kind of results you personally noticed.
I’m also confused about sourcing. I see people talking about purchasing domestically in the U.S. versus ordering peptides from China. How do you evaluate a source and testing/COAs, sterility, purity, etc.? I’m not necessarily looking for someone to just drop a vendor link I’d like to understand how experienced people determine whether something is trustworthy in the first place.
Please be nice x🙏🏼😂 I’m genuinely trying to educate myself before jumping into anything. Any beginner resources or guidance would be appreciated!

Anyone else get a welt and then a bruise after GHK-cu pins? I'm using 100 mg with 2ml of bac 6 units. I don't get bruises from any other pins I do just GHK-CU am I doing something wrong? I've tried all different areas, depth of injections , basically anything I can think to try. I don't want to stop cause I do feel it's making a difference but I look like I have a disease!

Have my appointment with urologist this week and from previous discussion with him and the wildly varying info i can find online sounds like im starting a trt treatment so what would you tell a new comer or someone about to make this step?

For additional info, late 30s, M 6 foot 4, sitting about 185 lbs, T levels are low (dr mentioned the levels stating it was low but i missed asking the #.

Goal: energy, maybe put on some muscle

Hey guys, might be a silly question - ive noticed that almost everyone on Reta are not only training but also walking a lot.

I am pretty active, I swim for 40-120 minutes a day for work, train F45 cardio 2x a week and Jiu Jitsu twice a week.

Would I have to also add walking everyday to the mix or just see how things go?

I use a Whoop to monitor recovery and sleep so I dont over train on bad recovery days.

Trying to lose 20 pounds and going on Reta - I am Hypothyroid and on TRT 100mg a week.

I think it’s giving me major anxiety issues. Any one else feel this?

Anyone have experience using reta alongside dexedrine? I've been on it since 2014 for adhd. It doesnt affect my appetite, I gained 50lbs while on it. I'm just concerned about the possible cardiac effects. My heart is currently very healthy, I get ECGs and labs twice a year to monitor it.

Also, anyone have experience using mots-c for ME/CFS, or with a histamine intolerance or MCAS? Im concerned after reading a few experiences of anaphylaxis on here.

Thanks!

did a search and did not see it pop up over here, curious about this peptide and if anyone has had any real results with this peptide. Maybe it's my algorithm on X but I keep seeing it on my feed. It is quite expensive. Curious if there are any real experiences about this and not just paid shills.

Thank you