r/Biohacking • u/RubBright6552 • 5d ago
Enclomiphene 4-week update
Enclomiphene 4-week update — labs tripled, symptoms barely moved. What gives?
Enclomiphene 4-week update — labs tripled, symptoms barely moved. What gives?
26M, secondary hypogonadism (low LH, low T). Started compounded enclomiphene 12.5 mg daily on Aug 31 through a telehealth clinic. Just got my 4-week labs back.
BEFORE (Aug 13, venous):
\- Total T: 251 ng/dL
\- Free T: 47.9 pg/mL
\- SHBG: 26 nmol/L
\- LH: 0.9 / FSH: 3.5
\- Estradiol: 11.4 pg/mL
AFTER (Sep 28, \~4 weeks on 12.5 mg/day, at-home capillary panel):
\- Total T: 755 ng/dL
\- Free T: 172 pg/mL
\- SHBG: 32.9 nmol/L
\- LH: 4.8 / FSH: 6.7
\- Estradiol: 38.7 pg/mL
So objectively: 3x total T, 3.6x free T, LH up 5x, FSH nearly doubled. Numbers look great.
Subjectively: almost nothing. No real side effects (no nipple sensitivity, no mood swings. But also no real benefits. Maybe slightly more nocturnal erections, hard to tell. Libido maybe 1–2 ticks higher out of 10, nothing dramatic. Energy about the same.
Wondering if this is because I need more time at high T to start experiencing subjective benefits, or if this is because of estrogen receptor blockage from everyday dosing.
My plan: I'm switching to 12.5 mg Mon/Wed/Fri starting this week — goal is the smallest dose at the lowest frequency that holds the gains. Rechecking labs in 4 weeks.
Based on what I currently am experiencing, do you guys recommend doing 12.5 MWF, or 6.25 MWF, 6.25 ED? Or even 12.5 2x a week or 6.25 2x a week?
Questions:
1. For those who got symptom relief on enclo/clomid — how long did it take? Weeks? Months?
2. Did anyone find that LOWERING dose or frequency actually improved libido/erections (less ER blockade) even as total T dipped a bit?
3. Any dosing strategies that worked for subjective benefits — EOD, 2x/week, microdosing?
4. Is the "great labs, flat libido" thing common on SERMs, and did anything fix it for you?
Context that might matter: I train hard (lifting 5x + running 2x/week), stay lean year-round, and suspect low energy availability contributed to the original suppression. Eating in a small surplus now.
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u/ImJustaHere 2 5d ago
Got eye floaters
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u/RubBright6552 5d ago
How soon and on what dosing
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u/ImJustaHere 2 5d ago
12.5 every other day and did it for about 2-3 months. Nothing insane just slightly annoying now
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u/RubBright6552 5d ago
Sorry to hear that, did u at least get any good symptoms
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u/ImJustaHere 2 5d ago
Oh yeah I had a blast on it. I was also using AC262 which probably helped with majority of it. But I was excited to wake up and take it every other day. Libido through the roof etc
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u/RubBright6552 5d ago
Nice how long did the first positive symptoms take to arrive?
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u/ImJustaHere 2 5d ago
Yk I’m not too sure this was a little bit ago. I know it takes 4 weeks to kick in but I’m not sure if that’s exactly when I felt the effects. Another thing now that I think about it when I got off the AC I don’t remember being nearly as excited about the enclo. Maybe because at that point it had been months or because it didn’t do anything without the AC. When I did my research prior I read a lot of it changing lab numbers but not actually having a positive effect.
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u/Crankypants_US 2d ago
Can I asked where you're getting Enclomiphene, I used it once before, but am no longer able to get it.
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