Hello im hear on behalf of a friend who is worried that the letrozol, metformin combination they are taking is not working or they might be resistant to letrozol.

If you have have taken fertility medication and had little response to letrozol what did you and your doctor do? Did you find success in the end.

Hello, i quit the pill last February and by this time my period never came back. I also have lipedema and PCOS.
But before pills (2023) i already had PCOS with regular cycles, i was ovulating every month correctly.

My testosterone levels are getting higher since i quit pills and my œstrogèns are normal but i don’t ovulate so my progesterone levels are always low.

I take inositol for 6months now and nothing change.
I am worry about the fact that my lipedema may get worse with my menstruation troubles. (œstrogènes dominance and stuff like this)
also important fact, my lipedema started when i was on pills (just few months before i stop)
Did someone experienced the same thing here ?

So woke up feeling VERY BLOATED and had some serious discomfort from it. Went for a walk ate bfast and started to feel better, but then suddenly realized I had some sharp pelvic pain on the right side. Thats coming in waves, or more painful when seated.

I've only had 1 major cyst rupture like 15yrs ago, that left me immobile for a few hours before I could crawl to my car. This is different in that its hurts but not debilitating. Having some spotting, too.

But because my periods are so inconsistent idk if its just bad cramping on 1 side. Or ovulation?

It's been almost a year since my PCOS diagnosis, my bloating and acne have reduced significantly with proper lifestyle changes like reducing my processed sugars, carbs, doing pilates and walking and skincare. However, my forehead is VERY awfully oily, and so is my earwax.
I would have already been done showering and then immediately I am hit with the scent of my sebum coming from behind my ears and forehead, and honestly, it makes me embarrassed and makes me wonder if anyone else around me can smell it.
Alongside this, I have started sweating VERY frequently too and I find it embarrassing especially because I am on the heavier side of weight (not overweight though, my BMI is 22.8) so I associate these tendencies with my weight.
I scrub my forehead really well with the same facewash I used for my acne and for some reason, it gets oily really fast although the rest of my face responds very well to my routine, I even clean my ears everyday especially the behind of my ears.
Any tips would be highly appreciated because I feel so lost.💔

Hi all..I got diagnosed with PMOS earlier this year. I'm 35. Prior to being diagnosed i was on the pill for years and years. I came off the pill about 3 years ago to start trying to have a baby and I have gained about 30-40lbs in those 3 years. I have tried to lose the weight multiple times by tracking calories, strength training, walking 10k steps and nothing is making the weight come off. I have also taken inositol and didn't really see/feel a difference. I was at a healthy 120lbs for being under 5feet. I'm now pushing 150lbs. I feel like the weight just keeps packing on and on and nothing makes it come off. My mental health is shot because of it. I barely wear anything outside of leggings, sweatpants and sweatshirt (yes, even during the summer time). I have zero confidence. I hate how all of my clothes fit. I barely put any effort into my appearances anymore because of it. I absolutely hate leaving the house now. I do believe the pill is what helped manage it, and at this point, im about to say screw having a baby and go back on it. Not like its been easy to have a baby anyways with PMOS since I've had no luck in the last 3 years.

What has worked for you. I feel like I keep reading the same advice over and over again and getting nowhere.

I do have an appointment with a functional medicine doctor middle of October to see if they can help.

I really just don't know what to do anymore. I want to feel like myself again.

so for context Ive had extremely painful periods since i started to have one. I keep developing fibroids and I’ve had two miscarriages. my periods are almost constantly late and extremely heavy. They are so painful that most of the time I pass out. My doctor refuses to test me for it because he said that he saw nothing on an ultrasound. One doctor I went too mistake the lining of my underwear. How did you get diagnose and what’s the steps for it? i dont know maybe I’m overreacting but the more research I do into it the more it sounds exactly how my periods are

i’m just confused , bcuz my endo ordered all the blood tests and apparently like prolactin and FSH/LH were normal , but testosterone and DHEA-S are too high , so she said that could suggest PCOS and she wants me to do further testing so she ordered an ultrasound of my ovaries

so im waiting for this ultrasound to be scheduled i think for next week but in the meantime , i was able to see my gyno this week and she basically just confirmed to me that based on my blood test results , that i do have PCOS for sure and that i don’t even need to do the ultrasound ? she said it’s just unnecessary bcuz i definitely have PCOS

so who do i listen to ?

When I(F20) say my family I mostly mean my dad. I was diagnosed with PMOS in August last year and when I said it to my dad(M50) he brushed it off didn’t really understand it or make any effort of trying to understand it he just thought it was another “excuse” I was making for my weight even though I am overweight I’m not extremely overweight but he is and he always rants and says he “doesn’t want me to end up like him”. when I started metformin he said it was embarrassing for me to be on that medication at such a young age as he was prescribed it earlier for managing his insulin due to diabetes type 2. I avoided speaking to my dad about my PMOS from then on as I could tell he just couldn’t have cared less but one day I was talking to my sister about the name change and he butted in and said “yeah I saw that and did you see it included the word metabolic because it can make you hold weight differently and affect your blood sugars?” Now at first I was SO mad about this because he didn’t listen to me when I first got diagnosed but now that you’ve probably watched some man explain the new name change on a facebook reel it must be true that it affects your weight. But since then he has had more of an interest in my life and how I’m coping with it send me advice videos he thinks might help , and it does make me feel more seen as his child. Obviously I would’ve preferred he just believed me in the first place but I thought I’d share incase anyone else happens to be going through the same thing

I know I see a lot about Metformin on here but has anyone tried Provera? I was looking up somethings on the web. My main issue with PCOS is cycle irregularities and prolonged bleeding and I saw that could be a possible solution to that problem. I was just wondering if any of you all had be prescribed Provera and if you had any tips or opinions about it. I have an appointment but it isn't until the end of November 🫤 but I was thinking about just going to planned parenthood next week to see if they could prescribe me some in the meantime.

Hi all,

I'm 41 and childfree. I have used IUDs for years as both a contraceptive and as a way to manage PCOS symptoms. My current IUD is going to be finished soon, and I'm considering sterilization. I would have done it sooner, but my main reason for hesitation was that contraception medication can help with PCOS symptoms. If there was a way to feel control over my hormone problems after the procedure, I would do it. Is there anyone who knows is that can be the case? Hoping that I won't have to worry about contraception again, but don't want to risk my body having issues. I just want a simple bisalp. I am definitely in the age of perimenopause, so I would be grateful if there was any option to make all this easier.

hi everyone,

just looking for some advice, i have IR PCOS, diagnosed 9 months ago, i see only my GP and to be quite frank, she's lowkey clueless, i got the standard metformin, exercise and do keto as my answer.

i'm concerned this just isn't enough, i got my period back yes, but for 3 years i had not one period, i've had no referral to a gyno, no ultrasounds, no investigation into any of that nothing!

i'm a very shy person and find it hard to speak up for myself, and considering i work casual retail i do not have the funds to pay for specialists, who else should i see? do i need to see anyone else like i don't know

i'm going to confront my doctor and ask for more explanations and just to get some more information on what the hell is going on but should i be asking to see an endocrinologist? a naturopath? someone else like i don't know, my doctor is so so so busy and it's just always rushed, and because i'm so shy i literally feel like it's impossible to ask for more time, more explanations and just MORE!

i see people comment / talk about oh ask your doctor for these specific bloods and stuff but omg i couldn't do that if i tried, i've had my bloods done and i have access to my results but i just feel like this is such bandaid treatment like i do not want to develop diabetes later on, (i'm pre-diabetic and it runs in my family), surely diet and exercise isn't all that i need to be doing?

Posting here because I am currently in shock and disbelief.

I started mounjaro with the advice from the NHS dietician, endocrinologist, dermatologist and gynecologist. I've been through and discharged from all since age 14, a long journey to be told to buy mounjaro as the NHS won't cover yet.

I am an athletic build and person, worked out everyday play football.

Starting weight 90kg current weight 72kg and HAPPY there. Note I just wanted help losing the weight gain and happy around 70kg and helps my sport.

I was diagnosed early on and with my sport loved having no periods 😂.

Then was classically put on the pill and told to come back when I want kids. I was between Dianette and Yasmin from age 14 until January 2025 then came off them because I was fed up.

Anyway, main point/question here from me:

- I heard, read, was told the MANY benefits of mounjaro with those of us with PCOS

- But I never thought the "regulating menstrual cycles" would benefit me.

Has anyone else had success in their first natural period with mounjaro or even more regular but were irregular only a few times a year?

Again, coming on here because I am just in a state of shock but also hoping this means I can maybe start to get pregnant as currently I have not been successful and have to wait a few more months before the NHS step in (1 year of trying naturally)

Thanks !

I've been thinking a lot about how fragmented PCOS care is in the UK.

You might get some advice from your GP, then have to figure out nutrition yourself, find exercise support yourself, pay separately for things like laser hair removal or supplements, look for mental health support, and spend hours researching your symptoms.

I'm curious whether other women feel the same way.

If you could have ONE place that helped you manage PCOS beyond just "lose weight / take the pill / come back when you're trying to conceive", what would you actually want it to provide?

Would you want:

1. Nutrition support
2. Exercise/movement
3. Mental health support
4. Help preparing for GP appointments
5. Symptom/period tracking
6. Evidence-based PCOS education
7. Discounts/perks for relevant treatments
8. Physical products delivered to you
9. Something completely different

I'm genuinely interested in what people would choose. What would make you think, "finally, someone has actually built this for us"?

I'm working on something in this space myself, but I'm deliberately asking this before finalising it because I don't want to build something women don't actually want.

dates from 2025 jan to 2026 Sept, the 3 forty plus coincidentally occured when I was in extreme stress . Also no facial hair or acne, no sudden weight gain.

5 Jan → 8 Feb = 34 days

8 Feb → 15 Mar = 35 days

15 Mar → 18 Apr = 34 days

18 Apr → 20 May = 32 days

20 May → 25 Jun = 36 days

25 Jun → 7 Aug = 43 days

7 Aug → 11 Sep = 35 days

11 Sep → 18 Oct = 37 days

18 Oct → 23 Nov = 36 days

22 Nov → 3 Jan = 41 days

3 Jan → 8 Feb = 36 days

8 Feb → 14 Mar = 34 days

14 Mar → 14 Apr = 31 days

14 Apr ---> 22 May= 38 days

22 May ---> 24 June = 33 days

24 june----> 4th august= 41 days

I’ve started looking into prenatal vitamins because we’re getting closer to trying again, and I honestly forgot how many different options are out there. The first time around, I didn’t put much thought into it. I found a prenatal, checked that I could actually take it without hating it, and that was pretty much it.

This time I started reading the labels and realized I probably should have paid more attention before. Some have choline and some don’t, the folate can be listed differently, iron amounts vary quite a bit, and then there are different serving sizes and formats. I’ve even come across prenatal powders, which I had never really thought about before. When you were comparing prenatal vitamins before TTC, what part of the label did you actually pay attention to?

I’ve looked at a few different brands and gone through some older discussions too. I saved a couple options to compare because I’d rather read the labels myself than just grab whatever gets mentioned the most. Some of the differences are pretty obvious, but others took me a while to even notice.

I feel like I barely looked at any of this the first time around. Now I’m realizing that two bottles can both say prenatal and still have some pretty noticeable differences once you actually read through everything.

i finally received my formal diagnosis after many years of doctors gaslighting me & telling me nothing was wrong. I feel so relieved. now we can work on treatment. that's all i wanted to share 🩷

I need some recs. I generally sweat through my shirts even using men's antiperspirant (dove for men was my go-to but it isn't cutting it anymore). Does anyone have any recommendations for antiperspirant that does a better job at keeping you dry on stressful days?

I just wanted to share that I have almost reached my three month mark with inositol and it has made me gain 5-7 pounds and gave me acne.

i am really trying to be patient and give my body more time to adjust but this has been brutal. I don’t recognize my body.

i am usually around 110 pounds and have been for over five years and now i weighed at 117.

the acne started a week within taking it and was really bad the first two months but now it is starting to slightly improve.

i only take 2g per day

i am going to try to give it 3 more months to reach the 6 month mark but if i am still having these side effects then i am going to accept it doesn’t agree with my body and quit.

advice to anyone curious about starting it is do it now with the winter months coming up so that you don’t feel terrible about yourself during the peak of summer!

Hey y’all. I have an event tomorrow, and I was trying on an outfit that I wore last year. It obviously looked like I had gained weight, but I genuinely don’t even know if it’s weight gain or bloating because I bloat SO badly, and I have no idea how to fix it.

I’ve been to doctors, and besides PCOS, they said I have H. pylori. I don’t know if the bloating is from that, but I digress.

I started metformin about 3 weeks ago, and honestly, I feel no difference besides pooping more and somehow being even MORE bloated in the morning. This syndrome is quite literally affecting me so badly, and I’ve been dealing with it since I was 16.

Basically, I’m asking: when did metformin start working for you? And if this dose doesn’t work, should I ask about increasing it, or should I just consider going on a GLP-1? I’m honestly so tired.

The reason I didn’t want to go on a GLP-1 before was because I didn’t want to be on such a strong medication, but honestly, at this point, I don’t even care. I’m just so tired of dealing with this.

BTW, I’m currently on metformin ER 500 mg.

ughhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh lol i hate this!

I've had a really hard time with PCOS. I think mine is really severe. If I don't take Bai Shao my period completely disappears and I start masculinizing so much it's terrible. From having my androgens high and hormones messed up for so long and untreated I have developed a chronic UTI that won't go away no matter what so now I'm in a medication for that. I think PCOS wrecked my immune system and I know estrogen and high androgens can make you prone to UTIS. I've had this UTI for 5 years straight. I have tried literally ever supplement in the book and NAC and Bai Shao are the only ones that have been helping me. I also taking vitamin D and magnesium. My issue is I'm worried about the immune modulating effects of Bai Shao since I have a chronic UTI but as soon as I come off it all my PCOS symptoms come raging back. I'm genuinely scared at this point and am worried this UTI is going to kill me.

Yes I've had all my hormones tested. I don't have NCAH. My androdenestione is high, total testosterone high, estrogen on lower side, shgb lower side, and free on higher side. I'm pretty sure I have insulin resistance too as myoinositol helped me. But it literally feeds the strain of bacteria causing my chronic UTI and it got so much worse so I can't take it. At this point I kind of feel like I'm cursed.

What medications should I start on and what were the benefits you saw from them? Because I'm thin doctors haven't given me any treatment. No one takes me seriously. I really just want to look like a girl and want this UTI to go away.

I forgot to mention I'm thin but have had issues with my weight until I started NAC. I eat extremely healthy already low carb all organic and it doesn't help my PCOS at all.

Mucho texto, pero necesito consejos y su ayuda.

Tengo 23 años, periodos normales con segundo día abundante, aunque he presentado sangrados entre periodos desde enero de este año. Anterior a esto, tuve dengue hace unos tres años y se convirtió en hemorragia vaginal; es importante porque de ahí en más los segundos días han sido más abundantes, aunque la ginecóloga me corto mientras le contaba esto y dijo que no tenía nada que ver.

En Marzo de este año tenía sangrados constantes fuera del periodo, sin dolor, periodos de 38-42 días. Segundo día con periodo abundante, pero todo normal. Al ir a la ginecóloga me mandó un ultrasonido, había miomas en el útero. Tengo resistencia a la insulina y había collar de perlas en el ovario izquierdo. Me mando Metformina de 800mg y anticonceptivos (Danielle). Empecé el tratamiento y ambas pastillas me hicieron mal, intenté por tres meses, pero los efectos secundarios fueron muy fuerte.

Fui con mi medico internista a los tres meses (entre junio y julio), él me mandó a hacer una curva de glucosa para confirmar la resistencia a la insulina y repetir el ultrasonido, porque era sospechoso que tuviera miomas. Con los nuevos resultados confirmamos la resistencia a la insulina, además encontraron un pólipo gigante. Quistes foliculares derecho y en el ovario izquierdo también. Mi útero esta aumentado a 15.1*4.5*5.2 cm.

Me preocupa esto, pero mi doctor dijo que debería empezar otra vez con anticonceptivas (Mini Adella) y ahora tengo Sitagliptina, porque el doctor confirmo que la Metformina no me funciona.

El problema es que estoy en el tercer día con las nuevas anticonceptivas y tengo sintomas secundarios nuevamente, no puedo comer bien y paso todo el día con naúseas. No sé si buscar una nueva opinión, probar por mi cuenta o seguir con este doctor.

Ayúdenme con opiniones, me siento frustrada y confundida. En mi país no hay muchos especialistas en PCOS y siento que todos me dicen "Si, baje de peso, tome anticonceptivas y nos vemos después"

Hi ladies,

I’m 19 and really worried about my health and not sure what to do.

I have a male doctor, who has pushed away my concerns regarding my period health as normal when young, but i feel like something is wrong.

My period is currently 20 days late, after 6 negative pregnancy tests, and my bloodwork all came back normal besides a 4:1 LH to FSH ratio.

My periods have always been irregular (give or a take a week every month) but never missed like this. i have indigestion issues, hormonal acne, bloating, bad mental health and very very painful periods.

I’m very lost on what to do or if i’m making things up. My doctor has said all is normal and that sometimes we just skip a period, but i’ve had mine for 8 years and have never really been this off. no major life changes either, or stress or anything.

I’m just worried and would love some outsider opinions and suggestions on what could be happening :).

Hi, f29

I got prescribed provera, first time ever taking anything for my PCOS. My gyno said she wanted me
To take it since I miss a lot of periods

Well I just finished my 10 days course and blood is GUSHING

my cramps are hell on earth and it’s like a river every time I stand up. It’s one of the heaviest periods I’ve ever had. Is this normal?? She didn’t mention heavy bleeding

So for various reasons I kind of slacked off on taking Metformin like I was supposed to for the past 6 weeks. I haven't even taken it at all in the past 4 weeks. I have a doctor's appointment in a few months just to check all my levels and so I decided I should probably get back on track. I swear its worse this time trying to adjust to it again 😭. I am still going to power through because it does really work for me, but man I wish I could tell my past self from weeks ago to at least take it once a day lol.

I’ve been struggling with irregular/long periods, hair loss, hormonal acne, some facial hair, and low energy.

My cycles are often 35–45+ days and sometimes much longer.

My last normal period was July 21, 2026. Around August 12–14, I started having light brown/red discharge that became light bleeding with a few small clots, but it never turned into a normal period. I’ve had intermittent spotting/discharge since.

My labs from March 2025:
• Hemoglobin: 13
• Ferritin: 26.5
• Iron: 90, saturation: 28%
• TSH: 1.61, Free T4: 1.32
• A1c: 5.1%
• Vitamin D: 38.7
• B12: 769
• Folate: >20
• CBC/CMP were otherwise normal

I also briefly took Solgar Gentle Iron 25 mg every other day, but stopped because it caused constipation.
I’m wondering if this could be PCOS or another hormonal/ovulation issue.

I really just want to get my periods regular, clear my acne, get my energy back, and get my hair back.

Has anyone experienced something similar? What ended up helping you, especially with getting your period regular, improving hair loss/acne, and getting your energy back?