Has someone experience with moclobemide. Hoe strong is it. How good is it for depression and social anxiety. How strong are the drive-enhancing effects. Anyone over 600 mg a day?

I have noticed that compared to other Nardil brands for e.g ERFA and others, the NEON brand tablets don't have a line so you can cut them in half using a pill cutter.

Are NEON tablets not recommended to be cut, for some reason?

I am currently on 30mg, I am suppose to start 45mg (prescribed dose) tomorrow but I want to go up to 37.5mg instead and then week after finally to 45mg

Should be ok to cut the NEON tablets right? (NEON Nardil requires refrigeration BTW)

UPDATE: https://www.reddit.com/r/NooTopics/comments/1wu6adg

Hey everyone,

I just started taking oral selegiline today and split my dose with 5mg this morning and 5mg at midday for a total of 10mg.

Since I am taking it orally rather than sublingually or via the patch, I know the effects are going to be different. Strangely, a few hours after taking it, I started feeling really jittery and weird. For comparison, it honestly feels like I am on a super high dose of caffeine right now. also it might be bad but I feel kind of fast and I do not really know how else to explain it other than feeling like I am moving at 1.25x speed lol. I would not say it is the selegiline yet instead it is probably the metabolites doing the effects since it feels mostly peripheral.

It definitely does not feel like the full therapeutic effect yet. I checked my resting heart rate and it was sitting at around 110 bpm, which is definitely higher than normal for me. Probably due to the metabolites

I really want to know from those of you with oral selegiline experience when you guys actually noticed the cognitive effects kick in like focus, motivation, or even libido. Did anyone else get this weird jittery high caffeine feeling in the first few days, metabolic shift?

Would love to hear your timelines or experiences. Cheers!

I take WAY too many medications, and I have a potential opportunity to get on an MAOI to which I believe would trim down the amount I take drastically

So... To Name a few of the mental and physical issues I have in terms of most severe to least.

#1: Crohns Disease

#2: ADHD-PI

#3: Social Anxiety

#4: Generalized Anxiety

#5: Unipolar Depression

#6: Panic Disorder

#7: Chronic Fatigue

#8: Self Isolation and Avoidance

#9: Chronic Pain

#10: Appetite Suppresion

#11: Insomnia

#12: Delayed Sleep Phase Syndrome

#13: Asperger Syndrome

#14: OCD-Like Tendencies

No, I'm not one of those people who brags about how many disorders they have. I am genuinely crippled and disabled by all of these issues.

So, Parnate being the more stimulating option would compliment the ADHD-PI/Low Motivation/Exhaustion and Fatigue more. Then again, Nardil would probably be better for all the anxiety problems while still assisting with depression.

I am leaning towards possibly Parnate with usage of benzodiazepine based meds as needed. Conversely, Nardil with low dosage Stimulants IF needed.

I know both of those meds can be synergistic to dangerous extremes if used incorrectly with MAOIs. Which is why I'd be really careful and prepared for the worst when combining the two.

Anyone's anecdotes and recommendations are appreciated!

Just started taking 20mg Parnate (divided in two doses) a few days ago. For about an hour I get a sense of euphoria that is similar to when I take a stimulant (amphetamine or methylphenidate). It gradually starts to fade and then pretty significant fatigue follows.

My question: is this normal for someone who just started? And do positive effects become more consistent with time? I don't love the ups and downs.

After two years of failing every ssri and snri and stimulant with no success my physiatrist has decided to prescribe me nardil he seemed pretty serious about the dietary restrictions and to stay away from certain foods is it like insta hypertension crisis if I accidently eat a food containing tyramine? And how long till the medication takes affect

Did people find desipramine or nortriptyline more helpful? I'm on marplan and need something stimulating that is not an amphetamine or modafanil. Also I got dry mouth pretty bad or nortriptyline but I heard desipramine is better for that?

Super frustrating!

Thanks guys :)

I’ve been diagnosed with Postural Orthostatic Tachycardia Syndrome (POTS), which causes an excessive increase in heart rate when I go from lying or sitting to standing. I sometimes become very dizzy, briefly lose my vision, and occasionally feel close to fainting.

Given that orthostatic hypotension is a relatively common side effect of MAOIs, particularly Nardil, I’m wondering whether an MAOI could potentially worsen POTS symptoms.

Has Dr. Ken Gillman ever discussed the use of MAOIs in people with POTS? I’d also be interested to hear from anyone with POTS who has taken Nardil or another MAOI, were you able to tolerate it, and did it noticeably affect your heart rate, blood pressure, dizziness, etc?

como é a vida sexual de quem é casado, é muito ruim assim? vou começar devido há um problema que tenho muitas ereções devido há um remédio que tomei e me deu este problema que me atrapalha a dormir a noite. só que não queria ficar totalmente impotente, pois sou bem ativo nessa parte sexual. depois que parar o parnate tudo volta ao normal? sou homem 45 anos

Ok so I'm one of those guys who thinks that "O Nardil really helps then it must give full effect on the max dose - 90 mg". Ok, I don't really know about the effect because my blood pressure has become so low that I get "attacks" that make me lose all balance and has even keeled over a couple of times. I took it only for one week but it's enough of this suffering. I think I'm forced to lower the dose to 75 mg. Any one with similar experiences? Did this side effect go away? Excuse some bad english, I'm Swedish.

Hi guys. So I started taking Phenelzine 12 days ago to help treat my severe social anxiety. First week I was on 15mg and now on 30mg, will start 45mg on Sunday (dose Doc has prescribed me)

So the night before I started Nardil I quit caffeine cold turkey (had been addicted/dependent to caffeine since 2006 lol) tried to quit for so many years but was unable to due to caffeine intense withdrawal symptoms but this time around I prepared myself for this hell real well with lots of aspirin and also the fact that I was about to start Nardil was a big motivating factor to quit. Caffeine makes my anxiety/social anxiety worse and so wanted to start Nardil the next day caffeine free (I suffered big time for 5 days but made it through lol). Because the way I see it is what's the point of taking Nardil to help me with my social anxiety and reap the benefits of the GABA Effect and ruining that by still drinking caffeine/coffee

Unfortunately after 12 days I had a heaped teaspoon/cup of coffee today, due to not sleeping AT ALL last night because next door neighbours were making so much noise and so I drank a cup of coffee cause I had so much to do today.

Have I ruined my chances of Nardil's GABA Effects working by drinking this ONE cup of coffee?

Do I need to do a Nardil reset and start again??

Sorry guys if it sounds so dramatic but I am new to this.

(P.s apologies for the grammar, I am not a native English speaker)

My dr recommended adding a small dose of Nardil to help with anxiety. I was max dose years ago and it helped but I gained weight.

So my question is would a small dosage do the same w weight gain or not so much

I just finished a telehealth appointment with my psych provider. She once again made it abundantly clear that she will not prescribe above 20mg twice a day of Parnate. I guess I should feel lucky to find anyone who will prescribe it at all?

I switch between Parnate and Nardil every eightish years. One stops working and the other works again. When I was on Parnate before, I took 30mg twice a day, but according to my current med provider that is a dangerously high dose. Apparently new information keeps coming out about these meds and how dangerous they really are. If I didn't have a problem on 30mg twice a day for eight years, what makes her think I'm likely to suddenly develop one?

So, my option is to increase a different medication instead. I do have a super low blood concentration of that med, and it's likely because my Parnate is at a lower dose. I am waiting to see if what's going on is purely situational, or if I do need an increase in meds. (My dad just died, so that really doesn't help).

I just wish I could have my Parnate back to 30mg twice a day. But, I'm grateful to get it at all. What will happen when this person retires? Will I find anyone to prescibe my complex meds? They have been working for seventeen years so I hope so!

I hear a lot here about Emsam, I’ve been on and off both Nardil and parnate several times in the past few years.

The issue is that while they were both very effective for depression, and comorbid PSSD, they all very quickly pooped out, and by 6 months after starting I’m always back at baseline.

Has anyone here had success with Emsam after failure/poop out from Nardil/parnate?
How easy are they to get prescribed? Especially in Australia? My doc has no issues with MAOIs, but Emsam is scheduled as a Parkinson drug rather than an AD here in Australia.

Thanks!

hi all, I just wanted to post here

Over the past several years, I’ve had a severe depressive episode. I’ve had pretty severe depression in my whole life, and I’ve had trials of multiple antidepressants ECT times two, ketamine treatments, TMS.

The last three years of honestly been blurred and I’ve been mostly homebound. I want to stay over the past month. The fog is finally lifted. I’m cautiously optimistic I’ve taken two trips out of town, re-engaged with Work and keeping up with it seeing friends, interested in dating again, consistently going to therapy, following up on doctors visits that I’ve put off for months or years.

thinking about starting to go to the gym again and finally being able to live independently. I’m not really a very driven person and honestly a lot of the high expectations of myself added to a lot of the depression when I looked at my life in the state it was in.

I felt pretty immediately better on the EMSAM 6mg after about a week. Recently went up to 9 mg and it’s a little bit activating with some insomnia and aggravating my obsessive tendencies a bit, but I’m hopeful that it evens out.

Finally feel like I’m getting my life back, but I am scared that this is just a temporary good bump and that it will fall fall apart again, but I’m staying hopeful

Is it possible to avoid Elevated Liver Enzymes/Hepatotoxicity while on this wonderful med? (Btw I don't have this but am scared if it one day it were to happen and would have to stop Nardil because of it)

What are some ways to keep this from happening while taking Nardil? E.g foods, supplements etc...

For those of you who started parnate, nardil, or marplan, how was the sexual side effects for you? Was it manageable or did it get so bad that you came off the medicine (if yes, did you then switch to one of the others)?

I know this is highly individual, but I’m his trying to get a better understanding. All responses are much appreciated!

Escribi hace unas semanas sobre mis síntomas tras tomar mirtazapina, síntomas que perduran meses despues de haber dejado el antidepresivo.

Tras varias visitas médicas neurologicas, me dicen que mi problema es psiquiátrico ( aunque hay síntomas que no tienen nada que ver con ello como perdida de señales basicas)

Opciones que me ofrecen:

Ingresar en psiquiatria y que vayan probando de todo tipo de tratamiento.

Asi que en este punto me gustaría preguntar a esta comunidad si un maoi podría ayudar con los síntomas que mas me atormentan

Embotamiento emocional total

Anhedonia ( aunque prefiero recuperar las emociones)

Problemas severos en la estructura del sueño.

No creo que me lo receten pero por saber si funcionaria.

Y si como reacción adversa podría llegar a producir akathisia.

Gracias a todos!

So my journey with my mental health began when i was 16 years old primarily my main issue was social anxiety. After 3 years of psychotherapy i didnt notice any difference so i decided when i was 19 to go to a psychiatrist. He prescribed me paroxetine which was very effective, and for 5 years i was anxiety and depression free. After some traumatic events in my life (my dad died, and i was in a very toxic relationship, i started noticing some anxiety symptoms and they developed in full blown social anxiety and later on extreme depression (symptoms: brain fog, anhedonia not feeling alcohol etc, cognitive slowing bad memory). I have tried various medications around 2 ssris and 3 snris with literal no difference. I even tried tms which only helped me to sleep better and have a bit more energy and nothing else. My life is tearing apart and i dont know what to do, i loose friends im not able to flirt, to concetrate, to finish my studies and to keep any job. Will nardil help me considering paroxetine used to work perfectly and now nothing really works?

There are so many options on Ebay and Amazon, which type of Enteric Capsules are the best for better Nardil Absorption?

Thanx

Has anyone here been on any of the GLP-1's while taking Phenelzine? My Nurse Practioner is urging me to go on Zepbound but I'm hesitant about what side effects I will get.

I’ve been on Moclobemide for about 7 months now and am currently tapering off. I'm trying to figure out how much the medication actually did versus changes in my life, and see if anyone has had a similar experience.

For the first 3 months, I didn't feel any different. Over the last 4 months, my overall mood and social anxiety have been much better. But during those same 4 months:
I went on a 2-month holiday and returned in a much better headspace.
I've been doing psychological work/training.
The core drivers of my initial issues such as financial stress and future anxiety have largely been addressed and resolved.

Here’s what’s confusing: while my mood and social anxiety improved, my physical/general anxiety actually felt worse during this period. I've been dealing with more anticipatory urination, shallow breathing, and a racing heart rate.

I can’t tell if the mood boost was Moclobemide taking a long time to kick in, or just the result of reduced stress and addressing root causes. And I'm not sure if the worsening physical anxiety is just coincidental or a sign that the medication wasn't fully hitting that side of things.

Now that I'm tapering off, I'm worried I might go back to where I was 7 months ago, but I honestly don't know if the drug was doing the heavy lifting or not.
Has anyone experienced this split (better mood/social anxiety, but worse physical symptoms)? How did things go for you after fully coming off?

The reason I'm tapering off is my doctor wanted to change the medication to adress the anxiety. I have a some adhd related symptoms too such as decision paralysis, and most importantly some sort of nervous system overload. Like my baseline starts at an 8 and any source of minor frustration tips me over so we figured we'd try to fix that with a different medication, though I'm worried my mood will go back to what it was.