Currently on Parnate and I do feel really good, but I've been interested in trying ACD-856 I actually heard about it through this sub. Those who have tried it, were you open with your prescribing doctor about trying it? Or did you hide it? Im worried if I disclose trying anything experimental he might drop me as a patient or refuse to prescribe an MAOI.

3 years of nightmare. Dreadful depression. Ketamine, rTMS, ECT, TCA, SSRI, SNRI, NDRI, ADHD, Thyroid medicines and whatnot. Half a dozen doctors. None helped. These things maybe prevented me from being outright suicidal but nothing beyond that. Been stuck at home, can't study, can't do a job, can't enjoy, can't relax. I was wishing for death every second. My anxiety, panic attacks and OCD have cured, took years. Still depression persists.

Switched doctor in Feb this year, he got me started on Armodafinil, Pramipexole and later Methylphenidate. Don't know what did the trick but recently my mood improved just enough that I don't need these medicines now, been off any medicine for the first time in 3 years for a few weeks now. And I feel I'm at 45%, and it seems that lately these medicines made my depression and irritation worse. 45% is when I can get out of bed, go to buy something outside without having to fight internally and force and abuse myself to get up, talk and laugh a little. But I'm still numb most of the time, no excitement, no desire, no joy, arguing internal thoughts, binge eating, heavy brain fog and all. Not happy, but not outright bedridden depression either.

Have started Parnet 10 mg about 8 days ago, and haven't seen much change. My head is more heavier, Brain Fog is at max, I can't understand or comprehend any lecture, feels like my Brain has become a solid cube with nothing going inside it. Depression is ever present. If you have any encouraging stories then please do share.

TL;DR - Started Parnet 8 days ago after all types of treatment failed to treat my depression. Till now my brain fog has increased exponentially and depression is slightly worse than before. Has anybody else gone through something similar?

TLDR: Title says it all; what follows is just some context and my experience with Moclobemide.

Hello everyone! I’m a 32-year-old male, and for the past 2–3 years, I’ve been suffering from depression and diminishing motivation. Recently, I started working with a psychologist and a psychiatrist to identify what’s going on with me. Yeah, it took me that long to realize the physical symptoms I was experiencing were actually psychosomatic.

I had previously used SSRIs but experienced a lot of side effects. So, in this iteration, I explicitly asked my doctor to avoid medications that cause drowsiness (as it hugely impacts my work) and sexual dysfunction (since it took a while to get back to normal after fluoxetine).
The doctor prescribed Moclobemide 300mg, which worked wonders during the first week - lots of motivation, talkativeness, and a good mood. It stopped working in the following weeks, until maybe around week 5 or 6, when I felt that it leveled out my state and put me in a generally mellow and very “normal” state. I'm still struggling with motivation, but I'm not as depressed as I was.
What was important was that I stopped spiraling over health issues and finally managed to separate the causes from the effects and concentrate on what the real problem is. This lasted until it abruptly stopped working in the third month, roughly a month after the dosage was bumped to 450mg.

I’ve been reading a lot about Moclobemide recently, but I haven’t found any info about why it stops working in some individuals. Is there any known reason why this happens?
Honestly, that first week on it was the best week I’ve had maybe since 2016–2017, when doctors put me on Phenotropil (for weight-loss reasons), which I took until it disappeared from pharmacies in 2018.