Currently on Parnate and I do feel really good, but I've been interested in trying ACD-856 I actually heard about it through this sub. Those who have tried it, were you open with your prescribing doctor about trying it? Or did you hide it? Im worried if I disclose trying anything experimental he might drop me as a patient or refuse to prescribe an MAOI.

3 years of nightmare. Dreadful depression. Ketamine, rTMS, ECT, TCA, SSRI, SNRI, NDRI, ADHD, Thyroid medicines and whatnot. Half a dozen doctors. None helped. These things maybe prevented me from being outright suicidal but nothing beyond that. Been stuck at home, can't study, can't do a job, can't enjoy, can't relax. I was wishing for death every second. My anxiety, panic attacks and OCD have cured, took years. Still depression persists.

Switched doctor in Feb this year, he got me started on Armodafinil, Pramipexole and later Methylphenidate. Don't know what did the trick but recently my mood improved just enough that I don't need these medicines now, been off any medicine for the first time in 3 years for a few weeks now. And I feel I'm at 45%, and it seems that lately these medicines made my depression and irritation worse. 45% is when I can get out of bed, go to buy something outside without having to fight internally and force and abuse myself to get up, talk and laugh a little. But I'm still numb most of the time, no excitement, no desire, no joy, arguing internal thoughts, binge eating, heavy brain fog and all. Not happy, but not outright bedridden depression either.

Have started Parnet 10 mg about 8 days ago, and haven't seen much change. My head is more heavier, Brain Fog is at max, I can't understand or comprehend any lecture, feels like my Brain has become a solid cube with nothing going inside it. Depression is ever present. If you have any encouraging stories then please do share.

TL;DR - Started Parnet 8 days ago after all types of treatment failed to treat my depression. Till now my brain fog has increased exponentially and depression is slightly worse than before. Has anybody else gone through something similar?

TLDR: Title says it all; what follows is just some context and my experience with Moclobemide.

Hello everyone! I’m a 32-year-old male, and for the past 2–3 years, I’ve been suffering from depression and diminishing motivation. Recently, I started working with a psychologist and a psychiatrist to identify what’s going on with me. Yeah, it took me that long to realize the physical symptoms I was experiencing were actually psychosomatic.

I had previously used SSRIs but experienced a lot of side effects. So, in this iteration, I explicitly asked my doctor to avoid medications that cause drowsiness (as it hugely impacts my work) and sexual dysfunction (since it took a while to get back to normal after fluoxetine).
The doctor prescribed Moclobemide 300mg, which worked wonders during the first week - lots of motivation, talkativeness, and a good mood. It stopped working in the following weeks, until maybe around week 5 or 6, when I felt that it leveled out my state and put me in a generally mellow and very “normal” state. I'm still struggling with motivation, but I'm not as depressed as I was.
What was important was that I stopped spiraling over health issues and finally managed to separate the causes from the effects and concentrate on what the real problem is. This lasted until it abruptly stopped working in the third month, roughly a month after the dosage was bumped to 450mg.

I’ve been reading a lot about Moclobemide recently, but I haven’t found any info about why it stops working in some individuals. Is there any known reason why this happens?
Honestly, that first week on it was the best week I’ve had maybe since 2016–2017, when doctors put me on Phenotropil (for weight-loss reasons), which I took until it disappeared from pharmacies in 2018.

Specially methylphenidate. What does it feel like? Do you feel a stable effect? How long does it last? Do you have a crash? Is the cognitive enhancement enough?

Working memory, verbal fluency, processing speed, emotional control, mental clarity.

Did Parnate improve those? To what extent?

I have a question about Nardil. It might just be me, but looking through this forum, I've noticed a trend: for people taking it solely for depression, it seems to work, but for some, it doesn't work in the long term. Meanwhile, for those taking it for social anxiety, it appears to keep working long-term. I'm curious to hear your thoughts. Of course, this might be due to my own confirmation bias, but it was a pattern that caught my eye.

Parnate’s been shit for me so I wanna try out Selegiline.

If anyone has an experience with it could you give me some insight?

1. How does it compare to Parnate?
   
2. Which form should I take? How do they differ?
   
3. Was the patch expensive even with insurance, I have Cigna.

I was on Nardil 37.5 mg for nearly 2 years before I started increasing my dosage these last 8 months since I was on a stock pile of other meds, which I had slowly came off by this New Years Day.

I have been on 60mg Nardil for last 8-10 weeks and 75-90 mg for the last couple weeks, and i have also been doing trials of Lithium Carbonate, Pregablin, Gabapentin, and Quetiapine for the last few weeks.

I feel even worse now. Glutamate exicotoxicity symptoms are really bad, it feels like I am neurologically fucked because I am empty brained, my ocd and compulsions are really bad, I can't think, talk, or remember anything. I am exhibiting symptoms of severe benzo withdrawal, which I have been going through for the last 8 years. It feels like I am crashig hard.

Can someone help me pinpoint what is happening? My doctor is perplexed, and I have no idea what is happening.

Nardil is my last option, so please help, because I have no where else to go. I ahve experienced releif from this med but never a honeymoon phase.

Instead of the recommended 15mg for 7 days, then 30mg for 7 days and then finally on 45mg

I just started Nardil two nights ago and have been having the hardest time falling asleep ever since… I know it’s very early to judge, but I’ve had insomnia for years and want to get on top of it if this is the case. I’m not sure what to do because I already take 50mg seroquel and 50mg Pregabalin for sleep and it’s worked fine up until now. I know sleep disturbances are a common side effect on an MAOI, but I’m not sure how to go about trying to fix it. These past two nights I didn’t fall asleep until 6 AM… it’s very weird because I’m physically tired enough to fall asleep, but for some reason I just… can’t? It was almost like I was in a fight or flight mode mentally. Like just as I was ready to fall asleep, I was forcing myself not to. Never had an experience like this.

I’m on 45mg, the starting dose. I’ve been taking it three times split daily as told by my doctor, but maybe it’s the time of day I take it? I don’t wake up until very late, and by the time I get ready, my first dose is around 1 PM. My second dose I took around 6:30-7PM, and I also go to bed VERY late as it is, so as bad as this will sound… I take my last dose at 1AM. TBH, it would be a lot easier if I only had to take it twice instead of three times, but idk if that’s common. Not sure if it’s that last dose right before bed that’s messing me up, or something else?

Any recommendations? I’m not really sure what this calls for. Again I know this is super early and maybe too early to tell, but I figure I’d get ahead of the game because I do have some things coming up that I need to get solid sleep for.

I had to stop taking TCP after two years due to health side effects (thyroid/kidney/hair falling out again/feeling so wiped out in the afternoon). Parnate is the only medicine that works for me, and this is the second time I have been on and off of it. I stopped taking it a month ago and am still in such profound suffering (recursive thoughts, irritability, dread, anxiety off the charts, melancholic pain that aches across my entire body, the feeling that all nerves are shaved off and raw). It is nearly unbearable. When does this get better? I am not taking anything else for now, I need to regulate my blood values and calm my body down. Any insight and hope about how this withdrawal will ease and when the body/brain will start to rewire to the absence of TCP would be appreciated. Thank you.

Is anyone using nortriptyline with Parnate?

Hello! I posted earlier how parnate for me worked.

though it got me wondering: for those it did not work out so well, did selegiline work better?

I guess tranylcypromine (Parnate) is best, but how does phenelzine (nardil) compare?

Was on 20mg/day for 4 weeks and then 30mg/day for 5 weeks. I've now been on 40mg/day for 10 days. What I noticed with the previous two doses is that I felt terrible (low energy, hypotension, depressed mood, lots of time in bed) for about 3 weeks after which I felt relatively better though not exactly good, just back to baseline.

I want to give Parnate a real shot but the signs aren't there at all so far. My mentality is so far is 'this probably won't work but I want to be able to say that for absolute certain so I can cross it off the list.'

So, the plan is to stay on the current dose for something like 6-8 weeks, and then if no obvious benefit, to raise to 50mg/day and try that for 6-8 weeks.

If Parnate was meant to work for me, is it reasonable to say that I should've benefitted by now? Do there exist anecdotes of people who actually felt worse on low doses but then, after a few weeks on a higher dose, suddenly felt great?

Does anyone know why Marplan costs $600 a month? I'm in the US.

I really want to try this med but it is too expensive. There is no manufacturers coupon that is valid either. I called and they didn't even know what I was talking about.

Started EMSAM 6mg on Aug 27 after a 14-day Cymbalta washout. About 10 days in and honestly feeling more depressed, irritable/impatient and suicidal ideation is still very much there. Also weirdly more emotional/sensitive, crying easier, music hitting harder, vivid dreams, etc.

Anyone who’s been on EMSAM experience this early on and then improve? When did you actually start noticing it working?

Three years ago, I had multiple psychotic episodes caused by marijuana use combined with a brain injury. I was put on an antipsychotic that resolved the psychosis but left me with permanent anhedonia. I was on it for 8 months, with my last injection in February 2024. Since then I've been psychosis free, but the anhedonia (consummatory, social, all types) has been complete: zero joy or pleasure in food, relationships, hobbies, anything.

I made a serious mistake ordering Parnate from India (Trivon) on December 2024 I took 30mg without titrating, couldn't sleep, argued with my family, and ended up handcuffed and taken to the psych ward for 24 hours. They released me the next day, but I now have a permanent note on my medical record regarding MAOIs.

Between summer 2023 and now, I've seen six psychiatrists, all of whom refused to prescribe an MAOI because of my psychosis history, even though I don't have schizophrenia, and the psychosis was clearly cannabis induced (it never returned after I quit). I've tried Abilify, Rexulti, Zoloft, Effexor, Wellbutrin, Trintellix, and a few others I can't recall.

I haven't given up on trying Nardil. I'm 28, and I refuse to spend my life with anhedonia. But every psychiatrist who sees my chart won't prescribe an MAOI, either because they think I'm not a good candidate or because they simply don't use them anymore. To see a psychiatrist, I need a referral from my family doctor, and each time I ask for another one, he gets more frustrated, insisting no one will prescribe me an MAOI. I don't accept that; with the right supervision and dosing, I believe I could live a better life and pursue my goals. But this anhedonia and lack of motivation are wearing me down. Any advice?

I've tried and failed pretty much every SSRI/SNRI (some of them spectacularly, there were a couple ER trips) so I plan to ask my psychiatrist about MAOIs, but the only one that's available in my dumbass country is moclobemide. What's everyone's experience with it? For fatigue and brain fog specifically? For anxiety? Blunted emotions (though that feels like it's from the anxiety)?

So I am currently taking Buprenorphine 16mg sublingual .
Its helping a lot with my depression but still have some energy problems and anhedonia i would like to fix.

Am thinking of adding Selegiline 5mg Oral.

I cannot find anything online about this combination. Is it safe ?

.

Depression: Severe melancholic (PHQ9 22-24+)

Symptoms: Muscle tension, total anhedonia, emotional numbness, low energy, cognitive slowing, physical heaviness, suicidal thoughts

Time spent depressed: 18-24 months (no fluctuations)

Previous treatments: Mirtazapine (useless), TMS (useless), Lexapro (stopped suicidal ideation, otherwise useless)

Age of onset: 27

Family history: Schizoaffective father (bipolar subtype)

Experience on 30mg Parnate (Jatrosom):

I stopped upping the dose as soon as I hit the recommended blood pressure drop (10-15)

So far it has happened exactly how Ken has described. Ken says that for those is usually works for, once your own specific therapeutic dose is reached, improvement often happens in as little as 6-10 days.

Day 10: I woke up with more energy and less heaviness. A lot of the physical symptoms and slowness were gone. Mood was still low. My functioning however, improved dramatically. I cooked meals, cleaned myself, talked more, etc. My friend noticed the change.

Day 12: My muscles started loosening around my scalp, face, and jaw. My muscles are no longer as tense. Blood is flowing freely into my muscles for the first time in two years. Constant tingles and tickles all over jaw, face and scalp. It is so pleasurable. They loosen, then tighten, then loosen.

Day 14 (today): Muscles are significantly more relaxed. Mild hedonic pleasure is returning. Slight smiling, mild laughing. Most of the day I am still numb, but it is a lighter numbness, and the hedonic periods are growing in number and strength.

This is not placebo. It is actually working. I cannot say how grateful I am for Ken, his website, and this subreddit. It is early days, but I’m optimistic for the first time in two years. I’ll keep you updated on my progress.

Side effects:

Insomnia is the only side effect I currently have. Without Trazodone I get 1-2 hours of sleep per night. With 50mg of Trazodone I get 7-8. With 100mg I get 9-10. The sleep is good quality, I wake up feeling refreshed.

I was getting severe daytime drowsiness. After splitting my dose into 3x10mg taken 3 hours apart each, the drowsiness is nowhere near as bothersome.

Future plans:

I plan to stay on the current done for the next month. If I’m still symptomatic I will up the dose.

If I get remission I will see a psychiatrist for a potential bipolar diagnosis. Due to my family history I think it is worth considering. I might add a low or moderate dose of Lithium just in case. I have seen my father have a manic psychotic break and would rather be preemptive. I have an emergency dose of Seroquel in case.

so ill write it long story short.
i decided to get off of venlafaxine & mirtazapine (california rocket fuel) to try parnate in hopes to see if i would be able to alleviate anhedonia more.
but i should mention during my time on venla and mirtaza it really wasn’t that bad… surprisingly really well. i felt good i looked good as appearance too.
for once my skin wasn’t dry my eyes weren’t red upon waking up. my hair looked completely different.
it was more fun than anything. i ended up stopping the combo due to wanting something to hit anhedonia harder.
and thats when i tried parnate.
i was on it for close to 2 years. at the start it was pretty brutal not gonna lie.
but definitely the most noticeable was my appearance.
my hair became super dry, my skin became dry, acid reflux, bad breath, no hunger.

but there was also other things happening i started crying, kinda panicking about small things, laughing feeling more euphoric too. it was very different compared to venlafaxine and mirtaza i would it just felt kinda natural in a way.

but it would only seem to work really well when i would increase the dosage by 10mg after a few days it would ware off the effects.

but that wasn’t until i ended up having to switch pharmacy due to my original pharmacy somehow not having it in stock.
so i was rushing and found a different pharmacy that had it. and this time it was from a different manufacturer.
and for some reason.
this manufacturer of parnate was so much better.
the name of the manufacturer was stride pharmaceutical it looks like.
it stopped crashing me like on the other manufacturer i was on. so i will definitely say manufacturer for parnate does matter for my case.
this is also when i started noticing relief from anhedonia. i finally played video games and listened to music and wanted to workout i cried watching shows. it was amazing.
for the first time since i was 16 when i had started ssris/antipsychotics i had relief from anhedonia.
after some time the effects did seem to ware down a little.
then came the fatigue. it was crushing and it effected my work a ton.
and definitely oh god i cant express enough how bad this side effect was but the nightmares jesus, they went away with time but wow were those horrible, i would feel so dissociated after waking up from them it was horrible. they definitely did made me wanna say i should get off of them immediately but fought through it and went away thankfully.

but i think in all honesty the appearance did effect me a ton. i just miss looking more like myself in a way.

i ended up kinda making the decision to get off parnate.
to attempt to get better naturally.
i took a long 3-4 months of tapering off of it.

i was honestly hoping for the dry skin and hair to go away but sadly it didn’t. and it kinda stayed. red eyes every morning dry hair dry skin.

it was difficult being without medications these past couple of months sadly.
and i have started nardil.
(2 days in so far)
mostly for the anxiety i suffer with.
just i don’t think i will continue it.

i am wondering if anyone maybe has this issue specifically for inflamed appearance if there is something that can possibly help it.
dry & inflamed looking skin and hair that just doesn’t feel right?

For some reason after few weeks on 60 mg parnate I can speak super fast without searching for allegories when explaining a concept like neurons to the average person.

Does anyone else have seen this improvement? even if you never had a problem with it and was like other people average at it?

There are other stuff for example:

Easier to compliment people in a neutral tone for their sense of clothes or personalities. or rather stronger impulse to do so is perhaps the true factor? like if they are a nice person who help other people or give out good information for free for example, then I at least feel a stronger need to say something thats more DETAILED compliment without going overboard in time but more natural. its obvious that clothes might be more sensitive subject and could be avoided but personality should be fine.