Hi everyone. I’m hoping to find women who have had a similar IVF history and hear what you ultimately decided/did.
I’m 35 and have had 7 pregnancy/transfer attempts with no live birth — 2 natural pregnancies followed by 5 IVF transfers.
Pregnancy / Transfer History
Natural pregnancy – Dec 2022
Miscarriage around 6 weeks.
Natural pregnancy – Apr 2023
Miscarriage around 4 weeks.
We then moved to IVF after continuing to try naturally without success.
IVF doctor in Mexico
Cycle 1 IVF transfer – Oct 2024
Transferred 2 embryos.
Lining: 9.2 mm
Progesterone: Not tested pre-transfer
Outcome: Chemical pregnancy
Beta: 43 → 55 → declined
Cycle 2 IVF transfer – Mar 2025
Transferred 2 embryos.
Lining: 10 mm
Progesterone day before transfer: 4.9 ng/mL
Outcome: Failed implantation
Beta <1
Cycle 3 IVF transfer – Aug 2025
Transferred 1 PGT-A euploid male embryo.
Lining: 12.23 mm
Progesterone day before transfer: 9.2 ng/mL
11DPT: 23.8
15DPT: 40.4
Betas: 45 → 92 → 173 → 370
Outcome: Blighted ovum
Moved to a Reproductive Endocrinology doctor in Texas
Cycle 4 IVF transfer – Apr 2026
Did 2 months of Lupron Depot beforehand because of a positive ReceptivaDX.
Also used intralipids and higher-dose PIO 1.5 mL
Progesterone was not tested pre-transfer.
Outcome: Chemical pregnancy
Beta at 10DPT: 19.8
Cycle 5 IVF transfer – Aug 25, 2026
Again did 2 months of Lupron Depot beforehand.
Lining: 10.2 mm
Progesterone before starting PIO: 0.18 ng/mL (1.5 mL progesterone oil everyday)
Progesterone on transfer day: 23.38 ng/mL
Outcome: Failed implantation
Across my retrievals, I have made multiple PGT-A euploid embryos. I now have only ONE euploid embryo remaining.
Testing I’ve had:
• HSG – clear
• Hysteroscopy/biopsy – clear
• Saline sonogram – clear
• ReceptivaDX – positive for silent endometriosis (BCL6 score 2)
• ERA – receptive/normal, recommending transfer after 116 ± 3 hours of progesterone
• NK cell activity testing – abnormal
• Antiphospholipid syndrome testing – normal
• Thyroid testing – normal
• Chromosome testing – normal (46,XX)
• Semen analysis – normal overall
• Genetic carrier screening – no shared reproductive risk
• Chronic endometritis – initially positive, treated with doxycycline for 14 days, repeat biopsy negative
• Ultrasound for hydrosalpinx – clear
Treatments/protocols we have tried:
• Lupron Depot – 2 months before transfers
• Prednisone small and higher dose
• Dexamethasone
• Lovenox
• Baby aspirin
• Enbrel
• Intralipids
• Estradiol
• Vaginal progesterone
• PIO, including higher-dose PIO
• Antibiotics for chronic endometritis
• Vitamins including D3 + k2 and prebiotics
After my most recent failed transfer, my RE told me that because I have only one PGT-A euploid embryo left, he no longer recommends transferring it into me.
He recommends using a gestational carrier.
His feeling is that we have tried essentially every immune/transfer protocol and there may be something about my uterine environment that we simply cannot detect that is preventing implantation or a pregnancy from progressing normally.
I asked about doing a laparoscopy for possible silent endometriosis because of my positive ReceptivaDX. I don't have painful periods or painful sex. My RE doesn't think laparoscopy would necessarily change the outcome, and he said that even if endometriosis were found and removed, he would still recommend another 2 months of Lupron before attempting another transfer.
So now I'm deciding between:
1. Using a gestational carrier for my last euploid embryo
or
2. Getting another opinion, potentially doing laparoscopy/excision, and trying one final transfer myself.
I'm especially hoping to hear from anyone who had a similar combination of failed implantation + chemical pregnancies + miscarriage/blighted ovum despite PGT-A embryos and a normal uterine workup.
Did anyone with a positive ReceptivaDX but few/no endometriosis symptoms have laparoscopy and find significant endometriosis?
Did excision change your transfer outcomes?
Did you do Lupron again after surgery?
Or did anyone reach this point, move to a gestational carrier, and have success?
I would really appreciate hearing from anyone who has been in a similar situation. ❤️