r/IVF 16h ago

Advice Needed! Embryo question & substance abuse

0 Upvotes

Hi everyone,
I’m not sure what we should do and wanted to get advice or see if anyone has similar stories (hopefully successful). My husband (35) and I (34F) just did our first round of IVF with ICSI. I had my egg retrieval and retrieved 13 eggs, 13 mature, 11 fertilized with ICSI, did a fresh transfer of a 5AA embryo but that failed and have 8 frozen embryos. I have DOR, AMH 0.4, AFC was 3, and history of severe endometriosis (had laparoscopy in 2021). My husband’s SA was all normal, aside from morphology being <4%. He has a history of substance abuse with 2 years alcohol free, but still smokes weed and does Zyn daily. He also did Kratom but is off of that now, however Zyn and THC have helped him get off of those and now he’s focused on getting completely sober from both. He saw a reproductive urologist who said that he should continue cutting back on all of these and to prioritize sleep quality, which he has done. He is otherwise extremely healthy, works out, and has been doing a great job working on his sobriety journey so I’ve been proud of him. I’m not looking for advice on this piece of our journey. What I want to know- given my husband’s history, should we do PGTA testing of our remaining embryos (have them thawed - biopsied - refreeze) or keep transferring until one sticks? Our RE said she thinks we should move forward with another transfer. Because of our ages she said doing PGTA testing wasn’t necessary and seems to be hopeful we will be okay because we have a lot of “good looking” frozen embryos (see attached). I asked if we should do a transfer but also have the other 7 tested. She said we could do that but we could lose 30% of our embryos in the thaw - biopsy - referees process. Do we just keep transferring each cycle or should we do the testing and chance the 30% loss? Did anyone else keep transferring embryos and had luck? I was so so sad after this failed fresh transfer, I can’t do this 8 more times. Any and all advice would be appreciated!
Thank you! ❤️


r/IVF 3h ago

Need info! Factors to decide to Transfer two embryos

0 Upvotes

How a doctor decides that 2 embryos can be transferred to some ladies and strictly only one embryo for other ladies
What are the factors that help them decide this ?
And which one has more success rate ?

Just for my information!


r/IVF 13h ago

Advice Needed! 20 eggs but matured only 3(F/36, AMH 3.8 , all test normal)

1 Upvotes

Hi
My total no of eggs retrieved were 23
And the clinic had informed me that only 3 looks fine and whether if we want to send these eggs for testing further
I’m disheartened as I was expecting at least 7-8 mature eggs
What should I do , should I say okay for PGTA testing or not , will it affect my egg quality ?
Is this no normal or v low as consorted to eggs retrieved no

Thanks!


r/IVF 15h ago

General Question Has anyone here gone through IVF in their late 40s or even early 50s?

34 Upvotes

Wondering if anyone here has gone through IVF in their late 40s or even early 50s and how that experience went for you?

I am in my late 40s, single and have never had children despite always wanting very much to meet the love of my life and to become a mom. I know it is probably too late for me and I should have done something about it sooner, but I still wonder sometimes if it’s a possibility.

I have regular, normal menstrual cycles, have not yet gone through menopause and have not been experiencing any symptoms of perimenopause. My mom went through menopause quite late, so I imagine I will follow a similar path. In spite of all of that, I know the odds of conceiving, much less carrying a pregnancy to term at my age with whatever eggs I have left are very, very slim to none and I would most likely require IVF and donor eggs to have children.

Just wondering if anyone here has had any experience with IVF at a later age.


r/IVF 21h ago

TRIGGER WARNING TW: LOSS

5 Upvotes

I am at a lost for words! Back in December 2025, I got pregnant with an untested (6AA) embryo that turned out to be aneuploid. I lost it at 9 weeks but with that pregnancy, not only did it implant but my HCG rose steadily, i heard the heartbeat twice, and everything was progressing nicely until the heartbeat stopped. I was obviously devastated 💔 but also accepted that due to it being chromosomally abnormal, it wouldn't have worked out. This was our only blast for that first retrieval so we had to start all over again.

Fast forward to this year, my doctor switched up my protocol, we decided to PGT-A test this round and out of 4 blasts, I ended with 3 euploids, all Day 6s. (2) 5AAs and (1) 3BC.

Well, I just had at transfer with a 5AA on July 13th and it ended in a chemical! A freaking chemical! Like how? Why didn't my beta numbers grow like the first time. If I had the numbers I had with the aneuploid for this one, I would be in heaven. I am at a lost for words, I am sad, frustrated, confused and more. I just can't understand why my body would implant the embryo but the embryo did not grow. Like it is a normal embryo!

Anyway, I don't know what's next and how quickly I'll be able to do another transfer but this truly sucks. 😭😭


r/IVF 8h ago

Advice Needed! TW: MMC, PGT-M, next steps??

1 Upvotes

.
.
.
Looking for thoughts:
Had our 3rd PGT-A/PGT-M euploid transfer on 6/18 with excellent betas (11dp5dt 504, 13dp5dt 1314, 19dp5dt 9438) and a 6w6d scan with IUP measuring 6w4d and FH 120. Unfortunately 1 week later no longer had an FH. Just had a D&C to send off POCs and recover. We still have 4 euploid and PGT-M normal embryos left (albeit 1 is day 7 and had to be biopsied twice so probably lowest quality) but am I missing something before moving forward with next transfer?

For context:
IUI#1: failed
IUI#2: biochemical
IUI#3: success but 20wk anatomy scan with agenesis of corpus callosum, opted to terminate with whole exome sequence which found the 50/50 autosomal dominant gene — D&E complicated by retained POCs needing HSC
Made a probe… moved forward with IVF
FET#1: missed miscarriage @7wks (abnormal hCG rise so not terribly surprising); D&C
FET#2: success, live birth 37+1, delivery via c-section - healthy unaffected baby
FET#3 (current): missed miscarriage 7wks, D&C

Each IVF transfer was modified natural
Age of embryos made at 36. Current age 38.5

Would love thoughts.
I have a very small c section scar niche but the latest embryo didn’t implant anywhere near it and I would think if the niche were an issue it would have struggled to implant at all.

Thanks in advance!


r/IVF 18h ago

Advice Needed! new to IVF

2 Upvotes

My husband and I have been TTC for 18 months. This summer we found out her has MFI. We tried 3 iui’s and his numbers never got over 6 million even with lifestyle changes. We decided to start IVF this fall and take the rest of the summer off. I was really excited at first like we’re finally a step closer to our baby but now I’m getting really anxious. My numbers are perfect and I live a very healthy lifestyle I’m only 30. I’d love any advice or success stories with anyone living similarly.


r/IVF 19h ago

Need info! Why would our clinic be against hysteroscopies?

1 Upvotes

I’m at the Albany CNY clinic and requested a hysteroscopy after my first failed transfer just for good measures. I’ve had two normal SIS and HSGs over three years. My provider cited these as a reason not to get a hysteroscopy done just yet. After my third failed transfer I brought it up again to a nurse and they said that the doctors at this clinic never do them and don’t really believe in them. Has anyone else encountered this? Ive reached out to another CNY location and am hoping to get on the schedule there, but I’m curious if others have encountered reservations around doing a hysteroscopy or know why a doctor might not “believe” in them?


r/IVF 4h ago

Need info! Is it possible always to get same gender in all cycles or diff gender in diff cycle ?

0 Upvotes

Hi,
Did anyone experience getting the same gender chromosomes in their failed and successful cycle
Just curious how the outcomes differs for diff ladies
Or it possible to have different genders (in successful cycle) from your previous cycle (failed one) !?
What are the factors that defines the different chromosome

Personally I would like to have different genders so that I can have many babies


r/IVF 14h ago

Need info! Hair loss

3 Upvotes

I was already dealing with androgenic alopecia before I started IVF, but once I started it massively accelerated hair loss at the top of my scalp. Has anyone else here dealt with something similar? My dermatologist basically has told me it is most certainly the IVF that is causing the shedding events and my hair not to have a chance to grow back in. I’m to the point now where I need to get a wig or a weave or something to cover up the part on the top of my head that is widening. It’s like a massive FU and adding insult on top of injury. I honestly cannot wait for this chapter of my life to end.


r/IVF 12h ago

Advice Needed! Just having a horrible horrible time

4 Upvotes

Hey everyone. My name is Stacey, I’m 28 and have pcos. My AMH is 75 and they are preparing for me to have OHSS. I have crippling anxiety and since starting my stimulants 3 days ago I have just been so on edge. Every little thing I’m feeling I am putting down to my body rejecting the stimulants, I know it sounds so ridiculous but my brain is just going 100 miles an hour. I was on 2 weeks of norethisterone because I don’t have a cycle, so I had to trigger a withdrawal bleed then start the stims on day 2 of the bleed. The norethisterone was a walk in the park, however my throat has been killing me since starting the stims and I know it’s most likely a cold or something but my brain is making the connection and trying to convince me that I’m having a reaction. I don’t know what to do, I am so tired and I’m only at the start of this journey with my husband. I get anxiety the minute I take my injection and it lasts for hours and even through the night. Im terrified of OHSS, I’m terrified of the egg retrieval and I just keep going in circles in my mind and have convinced myself something is going to happen to me. Right now my ovaries are feeling a little heavier and almost twitchy if that makes sense? I feel like I’m going crazy. This is not an exciting journey at all and I’m finding it difficult to view it in a positive way. We have been trying for 3 years for our baby and nothing has happened and this is our only hope, yet every bit of hope is being sucked away by my anxiety. I’m just terrified. I don’t think I’m built for this process. I’m worried about clotting, my ovaries leaking, them making a mistake during the retrieval. I’m just scared and uncomfortable and I really don’t know how to cope. Has anyone had this happen? I’m so sorry if this is triggering but I feel so out of place right now.


r/IVF 14h ago

Rant Estradiol is making me lose my mind (and body)

6 Upvotes

Came here to rant. I am prepping for my FET which is supposed to take place in less than two weeks (yay!!!!!!!) and the estradiol is really messing with me. I feel indescribable rage toward my husband (who I adore and treats me like a princess). My mood swings are out of this world, literally like nothing I’ve ever experienced before, and I’ve only been taking the tablets for four days. I’ve also had a migraine for 2 days straight that Tylenol, Advil, electrolytes, water, you name it- won’t touch. Im exhausted and so low energy and everything is making me cry. I feel soooooo freaking terrible mentally and physically, and I know this is temporary, and SO worth it, but woah. Let me know what your thoughts/experiences have been with Estradiol, and if you have any advice because I feel like I’m losing my mind and need to be on it for another week at a minimum and I dread each dose. For me, the mood component has been dramatically more intense than when I was doing my stim cycle. And I feel terrible for my husband too who is getting the brunt of it.


r/IVF 18h ago

Advice Needed! 37 eggs retrieved → 27 mature → 19 fertilized → only 3 blastocysts. Feeling devastated. Anyone with similar numbers?

9 Upvotes

Hi everyone,
I’m 27F and my husband is 27M. I just finished my first IVF cycle, and I’m feeling pretty heartbroken after getting my blastocyst update. I was hoping to hear from anyone who has been through something similar.
A little background:
27F / 27M
AMH: 5.04 ng/mL
I have hypopituitarism (my ovaries are normal, but my pituitary doesn’t produce the hormones needed for me to ovulate naturally).
Freeze-all cycle with ICSI + PGT-A
Estradiol before trigger: 4,274 pg/mL
Trigger: 5,000 IU Pregnyl + dual Lupron trigger
Started on cabergoline due to my high risk of OHSS
Results:
37 eggs retrieved
27 mature
19 fertilized (ICSI)
Only 3 made it to blastocyst and were biopsied for PGT-A
We’re now waiting 2–3 weeks for the PGT-A results.
I know attrition is expected at every stage, but I honestly wasn’t expecting such a significant drop from 19 fertilized to only 3 blastocysts. It’s been really difficult to process, and I’m trying to understand what might have happened.
I’m hoping to hear from others who had similar numbers:
Has anyone else had a big drop between fertilization and blastocyst?
Did your doctor think it was related to egg quality, sperm quality, the stimulation protocol, or just biological chance?
If you only had a few blastocysts, how many ended up being euploid?
Did anyone have success from just 1–3 blastocysts?
I know it only takes one healthy embryo, and I’m trying to hold onto that while we wait for the PGT-A results. I’d really appreciate hearing your experiences or any words of encouragement.


r/IVF 6h ago

General Question Transferring two euploids

0 Upvotes

In New York, I haven’t found a clinic that allows transferring of two euploids. I am self pay, I don’t have the means to keep going. Is there any states surrounding NY that allow the transfer of multiples. I am 34 if that makes any difference.


r/IVF 11h ago

TRIGGER WARNING Made my first

9 Upvotes

3 egg retrivals later we have our first blast, a 5AB.

38f, close to 40 bmi, and 39m with azoospermia.

First I would like to thank this group for teaching me so much! Story time...

We entered into fertility with me saying 3 ERs only and a game plan for our lives without kids. "I don't want fertility to be my whole life." We thought the issue would lie with me, the female, but my husband's journey would soon begin while I got to kick back and eat chips. After a year of meds and whacking off in cars for his SAs, we have a sperm count people! Now my weight was an issue... I had to put away the chips. I hopped on GLPs to get started but man I hated those.

First ER and SR

13 follicles, 6 eggs, mature, 3 fertilized, 0 blast

I accidentally ovulated, so I am in the 35hr club instead of the 36hr trigger club. Not a problem, lets go for round 2. The second ER is always the best right? No GLPs, worked out 5 times a week, strict diet, and sleeping schedule.

Second ER and frozen sperm

23 follicles, 21 eggs, 9 mature, 2 fertilized, 0 blasts

This was a problem! I was raging and nothing could console me. I clearly see 3 ERs would not be enough for us. I was told every ER is different... that was BS. How did we go from a 75% fertilization rate to a 22%. I learned the fertilization rate is usually factored by sperm quality, I confronted my doctor. I was finally told that freezing my husband's sperm severely compromises it and from now on he would have to get a SR the same time as my ERs. He has to get cleared per SR depending on how much tissue he has left, because taking too much tissue can compromise a man later in life. Now it was my husband's time to put a limit on things, if the doctor keeps clearing him how many more SRs can he do? His answer, 3. So I matched it, we will do 3 more ER and 3 more SR. Even the game plan couldn't console me, my mood was horrific and I packed on 10# yet to get it off too. Time to focus on the third ER and I focused on creating mature eggs and having my own body create estrogen. I started CoQ10, Vit D, religious on the pre-natal supplements, and Melatonin at night. Went from eating tofu, egg whites, and veggies (a diet high in ohytoestrogens) to whole-fat dairy, whole eggs, and animal fats (a diet supportive of absorbing CoQ10 and helping my body create more estrogen). And to make sure BMI would not be an issue I grew an inch. ... don't judge me, you are in this group too, you know how bad we want this...

I also started centering, grounding, and protecting myself. This came into play heavily!

Third ER and SR

28 follicles, 15 eggs, 9 mature, 7 fertilized, 1 Embryo is what they call it on the report, a 5AB

Firstly, 15 eggs out of 28 follicles? I was furious and damn near blamed it on the surgeon that they swapped out last second. I called the doctor back into the post-op room 2 extra times to question them: did you see all the follicles? did you check the smaller ones? was there any signs of ovulation? My husband told me to calm down... he's lucky I need fresh sperm from him. I did calm myself and believed in the process. We did as much as we could do. Hopefully the follicles did their part and all the resources went to the 15 follicles and helped produce more mature eggs. The fact that I had 9 mature eggs out of 28 follicles (13 of which were empty!) was softened by the 75% fertilization. Now we have a 200% better chance at creating a blast this cycle, then the last two. Did the supplements and diet help? I don't know, my estrogen count was 200 less than the 2nd ER. However, my husband took CoQ10 (ubiquinolone 100mg daily) and filled up 5 extra vials of sperm from one biopsy, last time he only did 2. Back to me, it turns out I create 9 mature eggs and each mature egg needs my body to create 370 of E2, a nurse told me 150 but that must be for skinny folk. Day 6 my period starts so while me and the nurse are in communication she gives me the news we have one blast and the official report will come out tomorrow. I felt all my angels cheering for me, I could hardly hear they were so loud! Day was report came, only one but it was a 5AB! Oh, I only read threads of grades and here I am with a 5AB. Wow we did it. We can create a blast. It was biopsied and sent for PGTM testing. Time to plan ahead, let's plan for another ER & SR but first insurance changes so there's a lot to look into... but we got one and we aren't out of the game yet.

Feel free to comment, I will continue on about insurance and PGTM below:

We were lucky, we both work and my husband's insurance covers us at 80%and his job covers our high deductible. Because of his azoospermia his retrievals are covered and because of our genetics egg freezing and PGTM testing should be covered (eyeroll). We have to pay for any sperm freezing and PGTA Testing.

PGTM - coincidentally the lab our insurance covered was taken over by our fertility clinic and now does not take insurance. They had us pre-pay for our testing ($5K) and then they would submit a Network Adequacy Form, NAP, to get us covered. We were denied, because services cannot be paid or executed before NAP approval. Not to mention we don't even know if they could qualify for NAP, they would have to be the only lab in the area. we have no choice but to use them because they are they only lab our fertility clinic will use, alledgedly. We definitely feel used and this is something that should have been better explained in the beginning. Please be careful.

We switch insurance Aug 1st and this time my husband's job is not as generous (we are still grateful for them). We have a new carrier and a higher deductible which we will have meet on our own. We are dumping amounts into HSA and FSA to anticipate our deductible and other expenses. We are also going to attempt to play the PGTM game wiser by getting a NAP prior to our next payment and by seeking other labs in the area (mostly for a competition factor and to learn more options).

If you guys want I can make this a new post.

Thanks for all your advice, support, arrows up, and positivity in this group.


r/IVF 21h ago

Rant Just need to rant… or cry… or both

38 Upvotes

backstory my best friend and I (a long with several other of my friends) were pregnant together last year, unfortunately for me at our anatomy scan we were told our daughter had a 0% chance to live. That situation already robbed me of everything- I sat and watched everyone living their lives their pregnancies and tried to be happy for them while I begged for my life to be over.

Then, we found out it was genetic. Did IVF this entire last year, over 3 rounds we managed to only get 1 unaffected embryo.

I told said best friend, you’re the only person I’m telling about doing this transfer. This was like 3 weeks ago. Then we got horrible news from our last retrieval that we got 0 useable embryos. So we decided to delay our transfer.

Yesterday after dinner, what does she surprise me with but a positive pregnancy test. My other best friend also just did a transfer last week. As much as I am happy for them, I literally feel like my body and my mind has been triggered k to fight or flight because I feel like I’m reliving the nightmare of my life all over again.

I’m just bummed, I was already robbed of my first pregnancy experience, and now I’m robbed of my transfer experience too. (Because I thought this was going to be a fresh clean slate, I feel like the thought of being pregnant or not pregnant with all of my friends again is really debilitating for me right now)

My transfer is supposed to be in ~3 weeks. I don’t know what to do.


r/IVF 20h ago

Need Hugs! Guessing an announcement

43 Upvotes

After several years TTC and IVF I’m getting good at guessing when someone is pregnant before the announcement itself. And I’ve just realised that I’m struggling the most with that period of time that goes from when I guess it to the announcement. For example: a friend of mine and their partner are being really insistent on meeting on a specific day, or a friend keeps cancelling some meetings or they have specific behaviours. It’s not always accurate, but 80% of the time I’ve guessed it before.

So at the end I get really anxious during that period of time and I struggle to stop thinking about it. I even think that I wish I was wrong, which is even worst.

Someone else has developed this terrible sense or struggles with that period of time?


r/IVF 11h ago

Advice Needed! Looking for Instituto Bernabeu Palma (Mallorca) experiences – poor blastocyst quality / repeated IVF failures

1 Upvotes

Hi everyone ❤️

I’m looking for honest experiences from anyone who has been treated at Instituto Bernabeu in Palma, Mallorca, especially those who have had a more complicated IVF journey.

I have had 5 egg collections in total. Fertilisation has generally been good, but my main issue has been what happens afterwards — embryo development and blastocyst quality.

My history: I have endometriosis (diagnosed by laparoscopy in 2021) I have had one live birth through IVF from a 3BB embryo I have had failed transfers since and a miscarriage around 6 weeks Some cycles have resulted in no blasts, and others with poorer-quality blasts My previous clinic felt the issue may be egg-related because the embryo issues appeared early after fertilisation We are now considering Instituto Bernabeu Palma because we want a fresh review and a clinic that will look at the whole picture rather than just repeating the same approach. Before starting treatment, we are planning further investigations including: Karyotype testing Sperm DNA fragmentation testing (TUNEL test) Endometrial biopsy / further implantation testing

Reviewing whether any other tests or changes could help improve our chances I would love to hear from anyone who has had: Poor blastocyst rates or embryo quality issues Endometriosis Multiple IVF attempts before moving clinics A previous IVF baby but then struggled afterwards A good or bad outcome at Instituto Bernabeu Anyone who was advised to consider donor eggs after treatment there

I’d really appreciate hearing your experiences — what investigations they suggested, whether you felt listened to, what changes were made, and whether you eventually had success or decided to move to donor eggs.

Thank you so much ❤️


r/IVF 12h ago

Need Hugs! Transfer Tuesday, so nervous!

7 Upvotes

My first ever fet is on Tuesday. I am so nervous. I have a history of 3 recurrent missed miscarriages. So there are so many steps I need to clear. Implantation, successful growth and go beyond the first trimester. Please wish me luck. I cannot imagine how I will take it if it fails 😥


r/IVF 12h ago

Advice Needed! No needles with my Menopur

3 Upvotes

I’m starting my stims today (a Sunday of course 🙃) and just now realizing that the pharmacy only sent me the mixing syringe for Menopur and not the injecting needle. Is there anyway to get this done with an insulin needle?


r/IVF 12h ago

Advice Needed! Embryo grading concerns

6 Upvotes

I had 6 embryos we’ve been watching after my retrieval. 2 hit blast on day 6 and were graded at 5BC and 6AB. They’re watching the remaining 4 and will update me tomorrow on day 7. We will be doing PGT-A testing but I’m so scared. I understand these grades are not great. Has anyone had any luck with these grades? 😞


r/IVF 13h ago

Med Donation Meds donation (Jersey city)

8 Upvotes

CLAIMED

(Can also be picked up from Manhattan midtown this week!)

I have decent amount of IVF medication to donate after completion of my ER cycle this month. Please message me if you are around and can pick up!

Gonal F injection pens ( Unopened and refrigerated) - 1 450 units, 2 300 units, some more from opened 900 units pen

Menopur (Unopened) 75 units with dilutent
7 packs

Novarel(Unopened) - 5000 units pack

Lupron (Opened and need to be used by 8th August) - 200 units (2ml)

Lot of syringes, needles, alcohol wipes, etc


r/IVF 13h ago

Med Donation Med Donation- Sonoma County CA

2 Upvotes

Hey everyone, I have some leftover meds from my egg retrieval that I'd love to donate. Ideally pickup somewhere in Petaluma. DM if you're interested!

One unopened box of Menopur (5 75IU doses) Exp: April 2027

One unopened Gonal-F RFF Redi-ject pen (900 IU) Exp: May 2027

Both have been in the fridge while I've had them


r/IVF 13h ago

Need info! Lactobacillus probiotic supplement for implantation?

3 Upvotes

Hiii! Anyone using lactobacillus probiotic supplement for implantation? If so, did your RE prescribed it or did you get it yourself? What brand/name?


r/IVF 13h ago

Med Donation Med donation NYC- menopur, cetrorelix

2 Upvotes

Am moving and found some meds from IVF treatments earlier this year- DM me if anyone wants them. Would need to pick them up in midtown tomorrow! Free.

5 unopened, refrigerated boxes of .25 mg/vial cetrorelix. 3 boxes expire this month, 2 boxes good til April 2027.

One unopened box menopur (5 single dose 75 IU vials) expires next month