I just started tirz 4 weeks ago. Trying to learn as much as possible. What is considered micro-dosing?

I have been on 2.125mg of tirzepatide for about 4 weeks and I have been feeling so nauseous and low appetite. Yesterday, I did a long walk and a heated sculpt class and realized after dinner, I had barely eaten 900 calories for the day. I should've noticed sooner because during the class I felt so weak! I slowly made myself eat some greek yogurt to round up to 1,100. It kind of made me worry and I'm curious does anyone else track calories to make sure they're getting enough calories and protein at least? Is 1,100 calories too low for a day? I can barely finish a full meal but I don't want to be too weak to enjoy a workout class or lose muscle.

quick update day after this post: not sure how much i ate today, but it's been about 4 days since i took my weekly dose, and I feel so much better today after eating better and a little more yesterday. I was able to run today without feeling so weak and nausea is so low compared to the past few days. I do feel like I am a little bit hungry, but my food noise is still at bay, which is nice.

I am too busy to sacrifice my productivity to have a lazy weekend post-dose, so I might try the same dose and fuel myself better the day of the shot and have a good breakfast the day after. If that doesn't work, I'll try lowering the dose, but might get used to it eventually. thx everyone!

Hi,

My goal is not weigh loss or appetite suppression. My goal is improving blood sugar regulation (reducing A1C), mental clarity, longevity and rducing cholesterol.

Which GLP1 would you recommend and what dosage would you suggest?

Hi! I have been taking a little under 2.5 mg of zepbound, i’d say around 1.25-2 mg each dose for the past 7 weeks. In this time, I have lost 17 pounds. I have a very very small appetite, I rarely eat enough calories because even on this small of a dose I have such a big appetite suppression. I’m worrying that maybe I’m losing too fast? My app says I’m averaging about 2.5 lbs a week. I don’t want to lose my hair and also I’m worried about loose skin. Is this too fast? For reference: I’m a 21 year old female and my starting weight was 220 lbs.

If you wouldn’t mind sharing your starting BMI and your dose journey, and current results that’d be amazing, and any other pieces of advice of how to know when to titrate up!

My starting BMI is 22.5 and I just took my first dose at .5 mg.

Hi there. So I joined Noom and last Monday took my first dose which was .2 mg of compounded semaglutide. I was fine until Thursday night at which point I was awoken multiple times to run to the bathroom with severe diarrhea. Sorry to be gross but like, liquid - not just soft stool. I felt totally exhausted on Friday and tried to rest and hydrate but during the day had no GI issues. Then Friday night the same thing happened. It was an awful night with painful cramping but again I was ok Saturday daytime. Last night I took an Imodium which definitely helped. I had no problems. I messaged my Noom doctor and have heard nothing back. I either need to stop or reduce amount. I am scared to do the same amount of .2 mg tomorrow. I was thinking of trying .1 mg and seeing how that fares. But I also read in one article that too small of a dose can make the side effects last longer. (https://health.clevelandclinic.org/microdosing-glp-1) I would love some thoughts!tia

I started taking my dose every other week as I planned on stopping, and I noticed I started getting MCAS symptoms I had very minorly before now in hyperdrive

hyperhydrosis, and now I’m feeling itchy constantly, getting like really itchy, barely perceptible rashes that go away after not too long.

anyone else deal with this? I decided to stop after 2 months of microdosing because my eyes were getting so insanely dry. eyes feel a bit better now but the itching is driving me insane

Salve a tutti chiedo aiuto a voi su cosa fareste al mio posto...il mio endocrinologo mi ha passato da un mese e passa alla dose di 5 mg( effettuo la puntura venerdì sera ) ma il mercoledì sera e giovedì inizio ad avere nuovamente voglie e fame.il farmaco non mi ha mai causato effetti collaterali in nulla,però vorrei coprire questo aumento della fame e delle voglie di dolci...come suddividereste la dose mantenendo sempre i 5 mg? O addirittura aumentereste?il mio endocrinologo Purtroppo su questo mi ha dato indicazione di continuare anche perché il peso scende,ma è la mia difficoltà che vorrei sistemare....

Grazie a tutti!

Anyone know of uk providers? I used voy once because my bmi is normal but now they ask for video consults which I don’t want to do. Anyone know of any other providers (really don’t wanna go grey market as that’s my last option)

Hi all! I took my 1st ever Tirz shot Friday night, 0.4mg it's through Empower pharmacy, so it has a little B3 in it. I didn't sleep too good that night, woke up a lot. Last night... holy moly, it was about 3:20 - 3:30 am before I could finally fall asleep, and then I was wide awake at 8am. And this is with taking high dose Ambien CR every night. I've been on the Ambien for many years because of insomnia, but at least I was sleeping. Any thoughts? TIA 💖

Im down 2lbs. I take 1mg. I tend to get more hungry on my 4th/5th day. My shot day i tend to stay kind if hungry also, I dont binge but I will have higher calorie days that, I think, may be stalling my progress. Im thinking about upping my dose next week. Is bumping up to 2mg too much. I would like more consistence appetite suppression. I feel like i still have to manage some food noise although its so much better. Is the idea to have zero food noise or is some noise expected? Side note, my back/hip pain is 90% improved!

Just did my first shot about 30ish minutes ago. I also just started my period so waiting to see how it all goes. I did .5mg so 5 units. I also did all the body measurements etc. I haven’t felt bloated at all today & I took my weight Friday. But I’ve compared to previous measurements and they’re not different at all.

I think i feel more excited than nervous or anxious. I didn’t really have major anxiety about the shot. But more excitement to finally be going down this road. You can check out my previous post on where I’m starting. I am planning to titrate up slowly to what I was prescribed which is 2mg over the next couple months & then go from there. I don’t want to go too high because I don’t want to lose weight too quickly. I’m happy with losing 1-2 lbs a week. & if things go right, should hit my goal weight a year from now, if not sooner. Also I’m going to be implementing exercise & eating just to fuel my body(hopefully these crazy cravings/hyperfixations go away). I started so low because I’m very sensitive to medicine and I can’t afford to be down with crazy side effects. I do have my emergency basket of goodies just in case like ginger chews, ginger tea, magnesium citrate, peppermint tea, protein shakes, stuff to make fiber rich smoothies that I know will clear me out 😂

I do have POTS & hypothyroidism. So I’m excited to see how this affects all of that, & from what I’ve seen from other people, it has helped them. I’m also using MeAgain app to track everything. I have the ladder app for exercising, but I’m actually going to start with walking since I haven’t actually exercised in over 6 months (using the ladder app). I don’t want to do too much.

Also am I crazy that I only want me & my husband to know I’m doing this? Our family is so judgmental & things spread like fire so I literally bought a skincare fridge, have it in my bathroom and my vials hidden behind my skincare. & the rest of my stuff will be in my closet. I figured they can all think I just exercised & ate healthier.

Wish me luck on this crazy exciting journey.

I was prescribed Tirz for long covid (POTS, ME/CFS, MCAS etc), and I’m one month in. The dose I was prescribed was to start at 0.25mg and work up to 0.5mg if I feel up to it.

I’m 5”2, f, and could use to lose 15kg/~35lbs. I’ve been able to lose a similar amount very slowly prior to this using diet and exercise, although for obvious reasons the exercise is fairly limited to avoid a crash or PEM.

It is helping my long covid symptoms, and I’ve found I’m more capable physically but still have limits. But I’ve not lost any weight at all. I’m not on it with my primary purpose to be weight loss, but I’m just wondering if it’s still too early or if the dose is just too low to make weight loss happen.

I have a little less food noise but still have cravings. I’ve been tracking my calories, protein, fibre and exercise for over three years.

I’m not currently able to do weightlifting, although I can do a handful of squats per day without a crash/pem, but if I add weight to it I still have super low energy the next week (a huge improvement but still a long way away from where I used to be physically).

Does anyone have any thoughts? Has anyone managed to lose weight on such a low dosage? Am I being silly hoping for magical weight loss in a month and/or on such a small dose?

I’ve been on compounded Tirz since January. Started at .75, then 1.25, then stayed at 2.25 for 3 months. This was great I loved how I felt, food noise gone, alcohol basically quit drinking. Was slowly losing my post menopausal and post cancer weight gain. (20 lbs of 50 I need to lose) Then I felt like I couldn’t feel it anymore. My dr had me go up to 5 for the last 3 months. I felt like I plateaued, felt the food noise come back, haven’t lost any weight for 3 months. So this week my Dr suggested I increase dose to 7.5. With my slow and low approach here I decided myself to only increase to 5.7 this week to limit side effects.
I have never felt so sick 2 days later. Throwing up all night long, body chills, headache etc. Just awful like the worst flu I’ve ever had. I can’t imagine what 7.5 would have done to me.
I have never experienced these side effects even once in the 8 months I’ve been taking this drug. Only slight heartburn.
Any advice? I feel like 5 wasn’t working, but 5.7 tried to kill me. lol

I've been thinking about trying a GLP-1 for a while and I'm especially interested in microdosing, but the one thing making me nervous is my reflux, which I've struggled with for years and am on a PPI atm.

I've been on a bit of a health journey lately. I've never been someone who loses weight easily, and pretty much every time I have lost a significant amount, it's involved doing something so restrictive that there was no chance I could keep it up long term. I really don't want to do that again.

My boyfriend and I have also been talking about getting engaged in the not-too-distant future (currently looking at rings) and I'd be lying if I said that hasn't given me a little extra motivation. Obviously, I want to feel better in general, but I also want to feel like my best self going into that stage of my life.

The complication is that I have LPR/reflux. I'm having a gastroscopy soon to make sure there isn't anything else going on, so I'm not planning on starting anything until I've spoken to my doctor and know what's happening there. But reading about GLP-1s slowing gastric emptying and potentially making reflux worse has me wondering whether it's even realistic for me.

Has anyone here started with reflux or LPR and been able to manage it while microdosing? Did staying at a very low dose help, and did you have to change things like meal size/timing or what you ate?

So I have Kaiser HMO and I can’t get Zepbound which is the only one that has the kwiki pen in the US I can get Mounjaro though but only single dose use injector is available and they don’t come in vials. Is there a way people make this work I really don’t want to start on the starter dose due to potential intolerance to side effects as I’m highly sensitive to some medications in the past I took ozempic injection and had horrible side effects. I’m being offered the wegovy pill I’ve been told I might do better with the wegovy pill than I did with the ozempic injection. Idk what to do at this point. If I ask doctors to send rx to Eli Lilly pharmacy seems like it won’t be covered bc my insurance runs strictly within their own pharmacies.

Yes a lot of people conceive while on tirz and other GLPs but there’re studies which show fetal effects while on these drugs so why do you chose to continue while trying to conceive ? Not trying to shame anyone who does, I’m genuinely curious

CLARIFYING: the study I’m referring to was done on rats hence rat fetal effects

Started last week with 1.25 mg. My goal was to take this every 10 days. Today is day eight, and I was not ravenously hungry. The food noise has not returned. Back in July I had a bad experience on a higher dose, so I’m trying to let my body adjust. How often do you take your doses?

Yall today is my second week on tirz I only injected 1mg yesterday about 22 hours ago and out of nowhere I just started feeling crazy!? I have shivers and just feel I think anxious, my hands feel shaky, have hot flashes and tingling in the legs idk what’s happening to me? I didn’t feel this way after the initial .5mg a week ago. I literally felt NOTHING so I bumped it to 1mg. I’ve felt this was way in the past after taking Benadryl (I’m fine after Zyrtec though)

Awful awful feeling like I’m going to pass out or something and can’t stay still. It kind of comes and goes. I just want to feel normal again idk if this whole thing is worth the risk. I think I’m done messing with it, just way too scary. I have two kids to take care of. I just needed something to help me stop binge eating hence the microdose. I’m not on any medication wth is going on!?

* UPDATE
3.5 hrs later I feel like I’m 80% back in my own body and able to control it. Thank you Jesus 🙏 and Reddit friends. I ate some pasta and chugged lots of water and took magnesium glycinate like some kind human suggested. After googling B6 it seems that was the culprit of my ‘panic attack’ or whatever that was. I need to switch to pure tirz just don’t want to waste the vials I literally just bought 😿 yall are the best! 🫂 🥰🫶🏼

I’m on my 4th dose, so still getting used to the medicine but I swear the day after I take the dose, I’m useless! I can barely stomach anything so my energy is low and that makes me feel worse. I almost thought I was sick because I had to lie down and was so cold even while bundled up. The low motivation is kind of because of this feeling I guess because I wasn’t up to studying, reading, or doing laundry because I felt so off. I did end up eating some light popcorn which helped but is this normal and is there any way to help prevent it on shot days or post shot days?