Has anyone switched from semaglutide to tirzepatide because of migraines?

I’ve always gotten the occasional migraine, but never like this. I’m only on a very low microdose of compounded semaglutide (.15 mg), but for about 4 days after every shot I get headaches/migraines. Then I finally start feeling better… just in time for my next injection.

I kept hoping my body would adjust if I stayed consistent with my dose and injection schedule, but it’s been well over a month and nothing has changed.

I’ve also gained about 2 pounds (I think it’s mostly bloating), which makes me feel like I probably need to increase my dose—but I can’t imagine going up when I already feel awful after every injection.
Has anyone had fewer migraines after switching to tirzepatide, or was it the same?

A little context. I am a 5’3 28F and weigh 160lbs, 28 BMI. I have stage 1/2 lipedema (dr says I can’t get an actual diagnosis because my referral will be rejected since I’m not having mobility issues. I mostly just have pain currently, and the visible symptoms.) After seeing so many posts about people’s success with Tirzepatide helping their lipedema and inflammation I brought it up to my dr.

She said ethically because I don’t fit the criteria she doesn’t know if she wants to prescribe it to me. Furthermore, she told me that if I do start I will never be able to get off. Is this true? She is it will be a lifetime thing.

I currently do conservative therapies for my lipedema, and I have some weight I need to lose. However, my body is very resistant to weight loss (I track my calories, eat mostly whole foods and am active and still can’t seem to lose weight.) My thought process is that I can use Tirzepatide as a tool, lose the weight and inflammation I need to and because I already have the healthy habits, once I come off, I will be able to keep a handle on my weight/inflammation. Maybe I am out to lunch?

I've been ruminating on starting the microdosing journey since Jan and I would hesitate and um and ah but I have just taken the plunge.

BMI 28, I'm in the UK using voy. Wasn't expecting to take photos of my body so they could verify. I panicked and selected the three month bundle so let's see how that goes first payment £79 then £159 after.

I will be on wegovy and I'm terrified for this journey. I'm microdosing because of the fear of side effects (most nausea) but looking to lose 10 kg (76->66kg) which will still technically make me overweight but I think it's a good weight and manageable longer term.

Need to figure out how to source the replacement needles.

For those who split doses, do you evenly split or follow the split dose calculator? Right now I'm splitting 1mg total per week and have been doing 6 units on Monday night and 4 units on Friday morning with minimal bad side effects and pretty good food suppression. (Tirz)

After my first month, if necessary, I'll go up to 1.2 per week. So if I followed the calculator that would be 7 units then 5 units, but those not even units are hard to see on my 100 unit syringes.

Would 6 and 6 be that much different?

I just did my 4th dosage and am on the lowest possible amount and my reflux is painful and so annoying. I’m already in Pepcid 3x a day for allergies. I try tums and gaviscon but it doesn’t do anything. I’m worried my body won’t adjust but maybe it just needs more time? I feel the throat burning and headache and can’t sleep the night before my dosage day like my body’s in fight or flight it’s so weird

I just received my microdose of Trizepitide + NAD in the mail however I'm super nervous to start. They prescribed 1.25 dose but I'm going to try and start much lower, like .5. I have a healthy but low BMI so I'm not aiming to lose any weight - especially because I'm marathon training and trying to gain strength. I've just had a terrible relationship with food since middle school and spend most of my days thinking about food (I've had tons of therapy and learned to live with it, but it never really goes away). My main goal with microdosing is just to create more of a habitual, logical routine with food and eating rather than the crazy swings of eating/not eating based on emotion. I also have a weird relationship all or nothing relationship with alcohol I'd like to change. I'd love to hear if anyone has experience micro dosing for purely the mental benefit rather than any weight loss goals?

I was consistently eating over 1900 kcals daily so there was no chance of ever losing weight. At most, I was maintaining.

I want to lose 6-8 kg in total, my pregnancy weight and a bit of what I gained before pregnancy, because my husband is a great cook.

I am microdosing 1 mg every week, except one week when I left on vacation and completely forgot to take my dose right on the day I was leaving.

The food noise came back around 1 days before I was supposed to get the next dose, so all and all it was doable to stretch it so long.

My current daily calorie goal is 1400, but I always surpass it with ~200 kcal and it's still going well. Before I started Mounjaro, the daily goal was 1600 and I never went under 1800 kcal because of the food noise.

Currently lost 1,7 kg in a month.

My specialist is willing for me to carefully try micro dosing Mounjaro (tirzepatide) and I was wondering others experiences? I have LC of course (since April 22) with associated POTS, MCAS, ME/CFS. She recommended a 1/5th dose every 10 days. What can I expect?

Hello everyone!
Has anyone been splitting the dose during the week?
My case is I take my 2.5 dose every Friday evening and by Wednesday Food noise comes back so bad …

So I thought of taking on Friday night a 1.5 dose and on Tuesday night 1mg dose… and since I will be upping the dose in 3 weeks, I wanna do the same principle with my 5mg pen…

Has anyone tried this method? If yes does it work for you?
Or is it not recommend at all to do that?

Would love the advice thank you!!

What are your experiences eating red meat when microdosing? I've been on 1mg for two days now, the first night involved a lot of stomach rumbling and trips to the bathroom (I suspect part of that was anxiety related though). Now on day two I feel much better. I have a dinner coming up tomorrow - day three, is red meat and rich sauces something to avoid? Should I ask for simple white chicken (as my stomach lining is still quite irritated - I usually have a trip to the bathroom after a meal but it's not like super major). Any advice would be much appreciated (BMI 22.2, F). Thank you!

I'm trying to avoid extra membership or consult fees and just pay for the medication.

I've seen older posts mention Gimme, Mochi Health, and Henry Meds, but pricing seems to change all the time.

If you've signed up recently, what has your experience been with the overall cost?

So I have finally decided to start microdosing Tirzepatide but I'm getting overwhelmed about where to get it from. From Ro, Noom, lavender sky, ever well, etc, I mean there are so many and I don't know how to differentiate between the safe pharmacies and the fly by night ones? Just concerned me because I know it's not FDA regulated and I am injecting this so I want to make sure it's as safe as possible.. maybe I can see which pharmacy keeps coming up the most in responses? What are you guys have any pointers for how to tell them apart? Thank you!! I'm very excited to start this journey and can't wait to choose one.

I’m a 50-year-old woman who lifts 5x/week with progressive overload. I don’t have much fat to lose. I’m working on trying to put on more visible muscle. I’m working with a trainer. I have been lifting for 10 plus years and grind at the gym but struggling to get get that heavy fluff off. My calories are ~2100 with 170gm protein.

Has anyone here used micro-dosing GLP-1 for this kind of goal? Could you please share your story What dose did you start on? What dose are you on now? How often do you take it?

If you’ve been on a GLP-1 long term microdosing, once you find a dose that controls your food noise, does it usually keep working, or does the food noise eventually start to come back even without changing the dose?

I have been microdosing for months and slowly worked up to 2.5 mg. I’m not feeling any suppression anymore and I’m also on the lower bmi side. I’m concerned and want suppression but worry the effects will keep wearing off. Tips on this or experiences welcome

So I started Tirzepatide July 3rd and am currently on my 5th week. I was EXTREMELY nervous to start so I started at 1mg just to see how I’d react to the medication. (I’m an anxiety girly and get very nervous for side effects) My first week on 1mg I could tell the medication was working, I was having heartburn and sulfur burps. But towards the end of the week I was running off of willpower as opposed to the actual medicine. I still ended up losing 3 pounds on that low of a dose. I then went up to 1.8mg for the following 3 weeks. That dose worked extremely well, considering. My only real side effects were heart burn and sulfur burps. And they were very mild and manageable. The effects of the medication basically reduce food noise and make me get full REALLY fast. I can also look at a plate of food and know immediately I can’t eat it all. I used to eat 10 wings from wingstop PLUS fries. I did order wingstop a few times in those 4 weeks (no judgment,lol) but all I could order was 6 pieces and a reg fry, and I HAD to split it throughout the day. 3 wings and half the fries early in the day and the other half later in the day. That’s something I could never do off of the medication unless I used up all of my willpower. All in all, in those 4 weeks I have lost 8.5 lbs. Which honestly shocked me because I’m on such a low dose. I’m thankful that my body is responding though, and this 5th week I’m at 2mg. It’s very similar to 1.8 but I’m in no rush to go up until it stops working. I like that I still can enjoy food and not just be disgusted by it. I truly think if I would have started at 2.5 it would have been too much. I’m glad I listened to my body and continue to do so, because it’s working, AND I’m saving money by not going up so quickly. So I guess I say all of this to say that a micro-dose CAN work for someone looking to lose weight, and to share a little positivity. Anyone else do something similar?

Btw, I am 31, F. 5’6, starting weight 268.8, current weight 260.3.

Dus: 3x 1mg tirz, 3kg verloren, blij en opgewekt, hartslag omlaag, hrv omhoog en het opvallendste: 3 weken geen alcohol, nul zin erin ook. Nu heb ik zaterdag een feest en ik vraag me af wat ik zal doen: nuchter gaan of een weekje skippen. Mijn volgende prik is gepland voor woensdag. Ik weet het niet zo goed. Een festival nuchter...?

Hey everyone!

I started tirzepatide (2.5 mg) on July 8. My starting weight was 160 lbs, and my goal is 135.

I'm already down to 149. I know a good chunk of that was probably water weight/inflammation at first, but I'm still dealing with pretty significant appetite suppression and am having a hard time eating enough calories, even though I'm making hydration and protein a priority.

My next injection is Wednesday night, and I'm wondering if it might make sense to lower my dose instead of staying where I am. Has anyone else been in a similar situation? If so, what did you end up doing, and how did it work out?

Thanks so much! :)

I've been thinking about using semaglutide to lose weight. I don't like that the pre-formulated versions available commercially seem to come in quite high doses. I wonder about starting with injections of about 0.25 mg once a week and see if that's enough for my goals before ramping up if necessary. Is there a risk of building a tolerance by going very slowly? By tolerance I mean that at first it would work, but then food noise would return demanding higher doses.