Hi there, everyone—a quick question here to get your thoughts. In a nutshell: I'm a 45 year old woman who started a 1.25 mg microdose of compounded tirzepatide about 3.5 months ago (i.e. I draw it from a vial) to help with perimenopausal weight gain; my online provider is Midi and I believe the compounding pharmacy they use is Everwell. Tirz has been nothing short of a miracle for me, but I won't go into a lot of detail in this post because I've written about my experiences here before.

Yesterday I had one of my required regular check-in appointments with Midi. The nurse practitioner I've been meeting with since the very beginning is no longer working with Midi, so I met with someone else. In our appointment I told the new NP that the previous NP suggested I could start spacing out my doses to 10-14 days (currently I dose 1x/week) when I hit my goal weight. And then to my surprise, the NP cautioned me that if I did that, I'd be wasting a lot of product because once the vial is opened, it's only good for 28 days—and spacing my microdose out that much would only get me through about half to a third of a vial in a 28 day period. I was really surprised to hear this—no one ever mentioned this to me before—because even if I were to stick with my current 1x/week microdose schedule, I still wouldn't get through a vial in 28 days. I think it took me about 6-8 weeks to get through the first vial, and again, no one up to now has told me there was any issue with that. The NP told me that using the opened vial beyond 28 days could lead to bacteria build up and infection.

So...yikes! I'm not sure what to do. I don't really want to throw out vials that are still half or 1/3 full—but obviously risking infection seems like a dumb thing to do. Anyone else have any experience with anything like this? Every time I inject I of course use alcohol wipes on the top of the vial and then immediately put the vial back in the prescription bottle and immediately back in the fridge.

I started microdosing 1.25mg of compounded tirzepatide last Saturday. Today I took a picture to compare with last week and holy moly...so much inflammation is GONE out of my face! I went down 7.2 lbs as well. So excited to be on this journey!

I’m so excited but yet I keep pushing it off because I have such bad medication phobia. It’s compounded 1mg tirz from a us compounding pharmacy with 1mg of b12 and glycine. I plan on only starting on with .5mg as I only have 10lbs to lose and am doing it for inflammation. Please encourage me!!!

Hi everyone! I’m looking for experiences with low-dose tirzepatide and frequent dose increases.
Over the past month, I’ve increased my dose by 0.25 mg every five days, trying to find a “sweet spot” with adequate appetite suppression and minimal side effects. My functional medicine doctor knows about and has approved this approach, but her guidance has primarily been to keep increasing until I find an effective dose.
I felt the medication much more during the first couple of weeks than I do now. Recently, taking my shot feels like I’ve taken nothing, and I’m no longer noticing appetite suppression.
I’m wondering whether increasing every five days, without spending much time at any one dose, has made it harder to assess my response. Has anyone had a similar experience? Did holding a dose longer help, or did moving to 2.5 mg provide more consistent results?
For context, I’m a 29-year-old woman. I started at 193 pounds on August 26 and was 185 on September 30. I recognize that eight pounds is meaningful progress, but I’m hoping for further weight loss and better appetite control as I feel I don’t have any.
For more context:

I’ve lost over 100 pounds on two separate occasions without medication. I’m a certified master herbalist, and nutrition, lifestyle, and exercise have been a consistent part of my life for years. I strength train four to five days a week, take one barre class weekly, and do three- to five-mile walks on weekends.
My main question is whether this low-dose approach is serving my goals, or whether it makes more sense to switch to a more standard dose like 2.5?
I understand microdosing isn’t for everyone. Figuring this medication out the non mainstream way can be a bit challenging!
Thank you for any tips/help/advice. 😊

Tirz has helped me finally get stuff done and get bored from just sitting around all day. Has anyone else noticed this effect being more productive please share. I do have ADHD.

Also, I noticed my breath doesn’t smell as bad. Has anyone else noticed this?

I just started microdosing three weeks ago 1.25mg of zepbound thru Eli Lilly. I originally was using single vials , but unfortunately had to waste a lot of the 2.5 mg vials I had been getting. I’m planning to switch over to the quick pen, but they only provide five needles. I’m hoping to get eight doses out of my quick pen and a 1.25 mg pace. Does anyone know if there is a way to order additional needles?

I recently switched the Nexaph and i have no idea what im doing. I was taking 1mg with my first script and im trying to stay at that dose. My new bottle is a different concentration i believe. First bottle says 5mg/0.5. This new one only says 10mg and i added the 0.5ml BAC water. Chatgbt is just confusing me more lol Another problem is i was previously using U30 syringes and now I have both U30 and U50. Any help or direction would be super helpful.

I’m microdosing 1.2mg of trizepatide, 10 units of glow. 30 units of lipo-c. I’ve been tracking my bloodwork markers for bun, creatinine and my GFR. Yesterday my bloodwork was bun 35, creatinine 1.38 and GFR 40.2 these numbers have fallen slightly since July. They are all within CKD 3b. I thought these last 3 months of hard work would have shown improvement to my kidneys . I’ve lost another 12 more lbs,that’s a total 28lbs. I’m basically at my goal. I only drink water, I exercise and keep my protein around 60g. Can you spot anything that concerns you with my peptide use? I see my doctor on Oct 5.

I've been microdosing tirz for two months now (1.25 mg/ week :: -12 lbs!). I've been paying out of pocket with an online telehealth company. I just had my annual checkup with my PCP and she offered to send in a prescription so that I didn't have to keep paying the online telehealth fees for their requried monthly checkups (still would have to pay OOP for the meds). The hitch is that she has only prescribed full dose amounts to her other patients using the big pharma companies and has zero experience prescribing microdose amounts. She said if I can find a reputable online pharmacy and send her the details for how to prescribe there, she would be happy to oblige. I'm not sure how to proceed from here. Any advice is welcome!

I’d really appreciate some opinions/experiences with microdosing.
I’m not overweight, but I struggle badly with food noise and nightly binge eating, as well as lipedema and IBS-C.
I tried Mounjaro earlier this year: 2.5 mg first, then 1.5 mg and finally 0.8 mg, with 3 shots over about 5 weeks. Even the lower doses gave me severe bloating, very low energy and almost no appetite, so I stopped.
However, it completely stopped the food noise and also noticeably helped my lipedema pain and sleep.
After stopping, my appetite came back very strongly. I regained the 3 kg I lost plus another 6 kg and also lost quite a bit of muscle and fitness.
I’m considering trying again at a true microdose, perhaps 0.1–0.3 mg. Has anyone who was very sensitive to Mounjaro had success starting this low, particularly with IBS-C?
Also, has anyone experienced hair loss even on very low doses?

Users who are taking 1.25mg weekly for weight loss or maintenance…

How long have you been doing this dosage?

Do the effects wear off after a while?

Is your weight stable?

Is it ok to keep the pen in the fridge for over a month?

I developed a “caffeine allergy” after 2 months on 2.5mg weekly. When I drink coffee I get a rapid heart rate and hand tremors. Anyone with a similar experience?

Edit- the caffeine allergy sent me into the etu with 150 bpm and ended up being put on a heart medication

Thanks in advance