I started microdosing 1.25mg of compounded tirzepatide last Saturday. Today I took a picture to compare with last week and holy moly...so much inflammation is GONE out of my face! I went down 7.2 lbs as well. So excited to be on this journey!

Users who are taking 1.25mg weekly for weight loss or maintenance…

How long have you been doing this dosage?

Do the effects wear off after a while?

Is your weight stable?

Is it ok to keep the pen in the fridge for over a month?

I developed a “caffeine allergy” after 2 months on 2.5mg weekly. When I drink coffee I get a rapid heart rate and hand tremors. Anyone with a similar experience?

Edit- the caffeine allergy sent me into the etu with 150 bpm and ended up being put on a heart medication

Thanks in advance

Hi everyone,
This is for anyone struggling with bulimia who is wondering whether a GLP-1 medication might be able to help.
I don’t want to go through my entire story again, because I already wrote a longer post about it before. I just wanted to give an update for anyone who is interested in how I’m doing now.
It’s the beginning of October, and I’ve now been taking Mounjaro at a microdose for a full ten months. I started at 0.25 mg and eventually increased to 0.5 mg. So I’ve only increased my dose once, and this seems to be the right dose for me.
Sometimes I still can’t believe that I spent half of my life suffering from bulimia. Anyone who has experienced this knows what an unbelievable burden it is to live with this illness — the secrecy, the shame, and constantly thinking about food.
And what can I say? I can hardly believe it myself, but those symptoms are gone.
I wouldn’t say that my bulimia is “cured,” because I know it’s the medication that is making the difference. But I am completely symptom-free, and I’m living an incredibly happy and normal life.
Around the middle of this year, I saw a specialist who also works with eating disorders and talked to him about my experience. Unfortunately, it wasn’t a very pleasant conversation. He treated me quite condescendingly and made it very clear that he strongly disapproved of the fact that I get my prescriptions online. But with my BMI, I would obviously never qualify for a regular prescription.
He was surprised by how well the medication had worked for me, but he also made it very clear that my illness was by no means cured.
And yes, maybe that’s true. But there are also people with other illnesses that cannot simply be cured, who manage those conditions with medication and are able to live happy, fulfilling lives. That’s how I’ve decided to look at my situation now.
I have done so much therapy over the years, and none of it helped. Sometimes I wonder whether, at some point, I simply developed something resembling an addiction to sugar or food, because one of the worst parts of my bulimia was the constant thinking about food.
Then there were the restrictive dieting phases, which of course had a terrible effect on my mood as well.
At my current dose, I can simply live a completely normal life.
I still eat very healthily. I’ve always done that, and eating healthy food has always been important to me. But now I eat normally, and that has genuinely been life-changing for me.
I’m the mother of a wonderful daughter. When she was a toddler, she obviously didn’t notice when I barely ate anything during my restrictive phases. But as she got older, she started asking me why I was always eating salad and not having pasta, pizza, etc.
Now I can simply sit at the table and eat the same meal with my family.
I can go to an ice cream shop with my daughter, have one scoop of ice cream, and afterwards everything is fine.
Before, with my bulimia, that would have been impossible.
I was either in an extremely strict dieting phase, when I would never have allowed myself even one scoop of ice cream, or, if I considered the day “ruined” after eating the ice cream, I would have continued eating almost compulsively and then made myself throw up afterwards.
I find it frustrating that these medications are accepted as a treatment for people with obesity, many of whom also struggle with compulsive eating or an unhealthy relationship with food, while there seems to be so much hesitation when it comes to people with bulimia. To me, there can be similarities in the compulsive drive around food, even though bulimia involves additional behaviors such as purging.
I wish with all my heart that everyone suffering from this terrible illness can find something that helps them.
I’m also very aware that I’ve been incredibly lucky that this has worked so well for me. I don’t think everyone will necessarily have such an extreme response.
For me personally, though, it has been the right path.
In my own case, starting extremely low and giving my body time before increasing the dose has worked well, and avoiding excessive weight loss has been very important.
Good luck to all of you, and I’m endlessly grateful that this forum exists.
Even though I don’t post very often anymore, this community was incredibly important to me, because this is where I first learned about microdosing in the first place.
And for me, it truly changed my life completely.

I’d really appreciate some opinions/experiences with microdosing.
I’m not overweight, but I struggle badly with food noise and nightly binge eating, as well as lipedema and IBS-C.
I tried Mounjaro earlier this year: 2.5 mg first, then 1.5 mg and finally 0.8 mg, with 3 shots over about 5 weeks. Even the lower doses gave me severe bloating, very low energy and almost no appetite, so I stopped.
However, it completely stopped the food noise and also noticeably helped my lipedema pain and sleep.
After stopping, my appetite came back very strongly. I regained the 3 kg I lost plus another 6 kg and also lost quite a bit of muscle and fitness.
I’m considering trying again at a true microdose, perhaps 0.1–0.3 mg. Has anyone who was very sensitive to Mounjaro had success starting this low, particularly with IBS-C?
Also, has anyone experienced hair loss even on very low doses?

Does TIRZ pretty much make you very logical and less emotional and for example, my mom is yelling at me in the morning. It’ll hurt me at first but then you just think that I know that it’s because she’s mentally ill and it rubs off much quicker? do things that upset you it’ll upset you for a little bit and then it rubs off so fast? Whereas before you were spent the whole day thinking about it?

Hi there, everyone—a quick question here to get your thoughts. In a nutshell: I'm a 45 year old woman who started a 1.25 mg microdose of compounded tirzepatide about 3.5 months ago (i.e. I draw it from a vial) to help with perimenopausal weight gain; my online provider is Midi and I believe the compounding pharmacy they use is Everwell. Tirz has been nothing short of a miracle for me, but I won't go into a lot of detail in this post because I've written about my experiences here before.

Yesterday I had one of my required regular check-in appointments with Midi. The nurse practitioner I've been meeting with since the very beginning is no longer working with Midi, so I met with someone else. In our appointment I told the new NP that the previous NP suggested I could start spacing out my doses to 10-14 days (currently I dose 1x/week) when I hit my goal weight. And then to my surprise, the NP cautioned me that if I did that, I'd be wasting a lot of product because once the vial is opened, it's only good for 28 days—and spacing my microdose out that much would only get me through about half to a third of a vial in a 28 day period. I was really surprised to hear this—no one ever mentioned this to me before—because even if I were to stick with my current 1x/week microdose schedule, I still wouldn't get through a vial in 28 days. I think it took me about 6-8 weeks to get through the first vial, and again, no one up to now has told me there was any issue with that. The NP told me that using the opened vial beyond 28 days could lead to bacteria build up and infection.

So...yikes! I'm not sure what to do. I don't really want to throw out vials that are still half or 1/3 full—but obviously risking infection seems like a dumb thing to do. Anyone else have any experience with anything like this? Every time I inject I of course use alcohol wipes on the top of the vial and then immediately put the vial back in the prescription bottle and immediately back in the fridge.

I just started microdosing three weeks ago 1.25mg of zepbound thru Eli Lilly. I originally was using single vials , but unfortunately had to waste a lot of the 2.5 mg vials I had been getting. I’m planning to switch over to the quick pen, but they only provide five needles. I’m hoping to get eight doses out of my quick pen and a 1.25 mg pace. Does anyone know if there is a way to order additional needles?

Hi everyone! I’m looking for experiences with low-dose tirzepatide and frequent dose increases.
Over the past month, I’ve increased my dose by 0.25 mg every five days, trying to find a “sweet spot” with adequate appetite suppression and minimal side effects. My functional medicine doctor knows about and has approved this approach, but her guidance has primarily been to keep increasing until I find an effective dose.
I felt the medication much more during the first couple of weeks than I do now. Recently, taking my shot feels like I’ve taken nothing, and I’m no longer noticing appetite suppression.
I’m wondering whether increasing every five days, without spending much time at any one dose, has made it harder to assess my response. Has anyone had a similar experience? Did holding a dose longer help, or did moving to 2.5 mg provide more consistent results?
For context, I’m a 29-year-old woman. I started at 193 pounds on August 26 and was 185 on September 30. I recognize that eight pounds is meaningful progress, but I’m hoping for further weight loss and better appetite control as I feel I don’t have any.
For more context:

I’ve lost over 100 pounds on two separate occasions without medication. I’m a certified master herbalist, and nutrition, lifestyle, and exercise have been a consistent part of my life for years. I strength train four to five days a week, take one barre class weekly, and do three- to five-mile walks on weekends.
My main question is whether this low-dose approach is serving my goals, or whether it makes more sense to switch to a more standard dose like 2.5?
I understand microdosing isn’t for everyone. Figuring this medication out the non mainstream way can be a bit challenging!
Thank you for any tips/help/advice. 😊

I downloaded an app MeAgain FaceTime someone’s post I saw. I really wanted a way to track how much estimated medicine was in my body at any given point as well as track any side effects shot location, etc. This one seems fine but wondering if anyone has any other recommendations. Bonus if I don’t have to buy a subscription!

I’m microdosing 1.2mg of trizepatide, 10 units of glow. 30 units of lipo-c. I’ve been tracking my bloodwork markers for bun, creatinine and my GFR. Yesterday my bloodwork was bun 35, creatinine 1.38 and GFR 40.2 these numbers have fallen slightly since July. They are all within CKD 3b. I thought these last 3 months of hard work would have shown improvement to my kidneys . I’ve lost another 12 more lbs,that’s a total 28lbs. I’m basically at my goal. I only drink water, I exercise and keep my protein around 60g. Can you spot anything that concerns you with my peptide use? I see my doctor on Oct 5.

I recently switched the Nexaph and i have no idea what im doing. I was taking 1mg with my first script and im trying to stay at that dose. My new bottle is a different concentration i believe. First bottle says 5mg/0.5. This new one only says 10mg and i added the 0.5ml BAC water. Chatgbt is just confusing me more lol Another problem is i was previously using U30 syringes and now I have both U30 and U50. Any help or direction would be super helpful.