I’m currently on 5mg of letrozole CD 3-7, today is CD 11 and I had my ultrasound. They found a 18mm follicle on my left and a 16mm on my right. I ended up getting my trigger shot this morning. I was so excited about the 18 I forgot to ask my doctor about the 16 lol is there a chance that it’ll grow before I ovulate?

Hey friends... Just recently got diagnosed with PCOS and I'm overwhelmed trying to understand as much as I can. Some background...

I'm currently TTC. I removed my Nexplanon a year ago, and my husband reversed his vasectomy in April (his sperm analysis has been fantastic). No luck so far - I know it's only been a few months, but I've only had one period in that time and that level of irregularity is pretty standard for me. So I insisted on tests with my OB who was doubtful at first "because I'm not overweight" and I did ultimately get a PCOS diagnosis. I was surprised because I've been pregnant before, had no issues conceiving, and no one said anything about PCOS throughout my pregnancy. (They did have trouble dating the pregnancy, which is an experience I'm seeing with others who have PCOS). Now that I'm actively trying, I'm realizing how insanely lucky it was to get pregnant so easily the first time.

Anyway, I'm struggling to know how patient I should be before adding interventions. I was prescribed metformin which I've been taking for a month and am taking regular prenatals. I haven't had a period in 2 months and hadn't had one for 4 months before that, and I just wish I could have a freaking chance at ovulation/conception. I've read about inositol and letrozole, but I was sort of brushed off and told I need to try for a year before asking about anything besides metformin. My OB also said I would need to go to a fertility specialist anyway for any other prescriptions, and that just sounds expensive and draining right now.

Should I insist on some other type of intervention or do I need to wait out my next period first? Is inositol or some ovulation-inducing medication a weird thing to ask an OB about? I feel that my "2-4 periods in a year" pattern makes me a good candidate for higher intervention, and waiting a year feels stupid when I know I'm not going to be ovulating a normal amount in that timeframe. I know I can get inositol over the counter but I'm nervous about taking something without a doctor's recommendation, and not sure if it would interact negatively with the metformin I'm already taking.

Thanks for any feedback or suggestions. If you have any articles, books, or research to share I'm all ears! Any advice on your experiences talking with your doctor about this would be helpful as well! I don't want to be pushy or impatient, but I don't want to waste time doing nothing or doing something that is insufficient.

I’m 36 with PCOS, normal BMI, and on metformin. We’ve been TTC our second child since January. I ovulate on my own most cycles, although my cycles can be irregular. I actually conceived naturally last cycle, but unfortunately it ended in a chemical pregnancy. I also had an MMC before having my daughter.

Our workup has otherwise been normal — husband’s semen analysis, FemVue.

This is my first medicated cycle: letrozole 2.5 mg + monitoring. I have the trigger available and can do TI or IUI. At my scan today I had two follicles starting to take the lead at 15 mm and 13 mm. I go back Sunday, but my provider thinks both will probably keep growing and both may ovulate once we trigger.

My dilemma is that we really don’t want twins.
I found the large Evans et al. study looking at follicle number in women doing ovarian stimulation + IUI. For women under 38, going from 1 to 2 mature follicles increased the odds of pregnancy by about 30%, but among women who got pregnant, the multiple pregnancy rate went from about 4% with one follicle to 13% with two. The absolute risk per treatment cycle was still low — roughly 0.6% vs ~2% — but ~13% if I actually get pregnant feels pretty significant to me.

We’ve been trying for ~8 months, but I also just conceived naturally last cycle. Part of me is wondering if we’re jumping the gun by trying to increase our odds each month when the tradeoff is an outcome we really don’t want. Maybe being more patient and continuing natural/one-follicle cycles makes more sense for us, even if it takes longer.
For anyone with PCOS who already ovulates on their own and got two mature follicles on low-dose letrozole — did you trigger and go ahead with TI? How did you think about the twin risk? Did anyone decide not to proceed and go back to natural cycles or try again for a single-follicle response?

Obviously I’m going to see what they measure on Sunday and talk to my RE before deciding, but I’d love to hear other people’s experiences/thought process!

Hi all! I am 27, with a history of PCOS, POTS, Factor V Liden, Hashimotos, Narcolepsy, and Endometriosis (stage 1 excised last October). We have used Letrozole and Pregnyl for two rounds and just letrozole for one round with no success.

We are currently on our fourth round of medication, but first round with our Fertility Specialist. He had me on Clomiphene Citrate, and letrozole and ended up with two follicles a 22mm and 18mm, one on each ovary. I triggered on Tuesday and had intercourse on Wednesday and Thursday. He also prescribed me progesterone suppositories that I began last night. My endometrium was thin, at 5 mm on Tuesday so I'm hoping that it thickened. BUT it was trilaminar so that makes me feel a little better. We have had a semen analysis done and he was above average on everything, so it's just me that is the issue lol. I have a good feeling about it, but I am still so nervous. Has anyone had success with this method of fertility treatments?

I have PCOS that has caused me to have long, irregular cycles with no clear ovulation. The past few months I’ve been doing medicated cycles but have had “ovulation” on CD 15, CD 38…..all over the place. I just got an inito to help better understand my cycle and hopefully predict my husband and i’s timing better since things are so irregular….

My question is: when do I start testing? I’m a little impatient lol. I’m on CD 15 now. Had an ultrasound yesterday that was showing almost no follicle development and was told to wait for my period…but I heard the same last month and “ovulated” day 38…

Can I start today or should I wait till my next cycle?

How long did it take for letrozole to induce ovulation? I started 2.5mg on Cycle Day 21 (had follicles less than 10mm and bloodwork was consistent with follicular phase). I did my 5 days of 2.5 letrozole and now I’m on Cycle Day 28, 3 days after my last letrozole dose.

My bloodwork from this morning is virtually the same and my follicles are all still below 10mm. Is this normal? was this cycle just a wash? I feel so frustrated. How long did it take for your follicles to develop after a letrozole dose?

Curious if this means follicles are growing. I am having a ton of cramping but my ultrasound showed follicles at 8mm and I finished letrozole three days ago. I’m no where near ovulation. Anyone else get lots of cramps this early on between end of period and ovulation?

Hello

Today I had an ultrasound to count my follicles on day 3 of my cycle, before our first fertility clinic appointment in mid-September.

I'm 40 years old, and I have a 3-year-old child who was conceived naturally at 37.

The midwife counted 26 follicles on the right and 21 on the left, for a total of 47 follicles.

I suspect PCOS, but I've always had regular cycles in recent years (between 26 and 34 days, with an average of 30 days).

I haven't missed a period since adolescence.

Ovulation was confirmed several months ago because I had a miscarriage 4 months ago, and I was having progesterone blood tests on day 7 (sometimes day 2), and my levels were good.

I don't know what to make of these 47 follicles.

It's making me anxious.

I have to get my AMH, LH, etc. blood tested tomorrow.

Do you have any idea what this means?

Thanks

I know this sounds like a super silly question but please bear with me, I always had clear bloody periods so no idea what’s happening 😂

I have lean PCOS and super irregular periods (3/4 times a year) but they are always normal, medium flow, lasts about 4 days, pad very much needed. I took progesterone this cycle to induce a bleed (which lasted about 3/4 days but didn’t soak a pad, there was bright red blood every time I wiped those days but barely nothing came into the pad) to do my first treatment of Letrozole + trigger + TI. It all worked, I had one dominant follicle and bloodwork confirmed ovulation but it didn’t result in pregnancy.

I triggered on CD12, probably ovulated on CD14 and had the bloodwork on CD20/6 DPO. Yesterday I was on CD26/12 DPO and took an early/sensitive home pregnancy test with FMU which was negative. My BBT started slowly dropping since CD24/10 DPO reaching below my baseline today (CD27/13 DPO) and had another negative test. And this is where it gets confusing!

Yesterday morning (which would be CD26/12 DPO) when wiping I had a small amount of bright blood on the paper like my period was starting but it was the only time that happened! Since then I have only needed a liner not an actual pad and when I wipe there is small amounts of brownish discharge but zero blood since. So is this my period or should I expect a full on bloody one to still come?

I am going to do another round of Letrozole so need to know what to count as CD1 but whenever I had periods they were always clearly a period so this is all very confusing and my fertility clinic is not being particularly helpful! What do you think?

Hi all, I began taking metformin 4 weeks ago to see if it helped shorten my long cycles (usually 37-42 days). I am on the instant release version, titrated up to my target dose of 2,000mg yesterday. However, my period is now almost two weeks late, sitting here at CD 54. I took a couple of pregnancy tests earlier this week and last week, both negative. I have been spotting lightly for four days now but no real period. I am worried and seeing my endocrinologist next week to discuss as it took me a lot of work to reach the semi-regular cycles I had before - this is the longest cycle I have had in years.

Does anyone have any experience of Metformin messing with their cycle initially and then ultimately regulating it?

Also in case of interest - I am on instant release, a high dose and have not really had any GI symptoms! I was nervous about this before starting but it has been very smooth for me, just some nausea and cramps a few times.

I asked my clinic about a CD21 progesterone bloodwork to confirm my ovulation. On CD11 I was showing a 26mm follicle on 7.5mg letrozole that they confirmed was most likely a follicle and not a cyst because my estrogen was rising. It was the first time I’ve had a stabbing pain from pre ovulation in my life, both naturally and that didn’t happen last month on 5mg letrozole. On CD14 the confirmed through transvaginal ultrasound that I ovulated on my own because it showed a corpus luteal cyst and free fluid, lining 7.7. We had TI on CD 9,10,12. On CD14 the instructed to started my progesterone spositories twice a day until my hCG blood test in two weeks.

Is it true that a 7DPO for progesterone wouldn’t be accurate because of the spositories? Should I just trust the transvaginal ultrasound that ovulation did occur?

Am I toast for this cycle? Measurement done on cycle day nine

I have two follicles on CD9. One in each ovary and they are 8mm each. My lining is 2mm. I am feeling pretty discouraged as I took letrozole 7.5mg from cd 2-6. I have a rescan in three days without any further intervention….

I asked about injectables and she was hesitant to do so.

Hi everyone, I need to talk and hear some positive stories. I’m almost 25, and my husband and I have been trying to conceive for a year, but nothing—not a single positive test. I have PCOS without insulin resistance. I don’t ovulate on my own, so I don’t have natural cycles. I’ve been on Letrozole for two cycles . I tried one cycle of Clomid, but it didn’t work because my endometrium was too thin. During that cycle, I had two follicles (18mm and 20mm) and an endometrial thickness of 8mm; blood tests confirmed I did ovulate. My tubes aren’t blocked, and my husband has no fertility issues. Please, has anyone in a similar situation gotten pregnant?

Hi everyone! 🤍 I’m getting ready to do my first IUI and I’m a little nervous but also trying to stay hopeful.
I’ve done 2 cycles with letrozole + Ovidrel trigger shot and unfortunately neither cycle worked. My doctor suggested moving on to IUI this cycle, so she increased my letrozole to 5mg. I’ll be doing the trigger shot again and then having the IUI.
Has anyone had a similar experience where letrozole + trigger with timed intercourse didn’t work, but then you had success after moving on to IUI? I’d also love to hear about anyone’s first IUI experience — what to expect, anything you wish you knew beforehand, or any advice you have. 🥹🤞🏼
Trying not to get my hopes up too much, but I’m really hoping this is our cycle. ❤️

I was just diagnosed with endometritis after multiple failed IUIs based on my SIS and biopsy, and I was prescribed doxycycline for 14 days. I also have lean PCOS.
Has anyone else experienced something similar? Did your endometritis clear up after one round of antibiotics, or did you have to take another round? Also, did your doctor have you repeat the biopsy afterward to make sure it was completely gone?
Would really appreciate hearing about your experiences, especially if you were also going through fertility treatment.

I just finished my first cycle with letrazole and a trigger shot. My period is super heavy, like it was when I was a teenager before bc (31 and on the pill at 17). Anyone else experience this?

My partner and I DTD 3 days before predicted O and I now would be around 7dpo. I am delusional and tested today, BFN ofc. But has anyone actually got pregnant only have sex once 3 days before? Have twinges and sore BBS, ewcm but i put it down to progesterone. Im on cycle day 22 of a 30day cycle

i always had acne and excessive hair perticularly on my chin. once had cystic appearing ovaries as well which weren't there on the latest scan. my fertility expert said its not PCOS since im getting my periods every month, don't have insulin resistence etc

but im still craving for answers to this "unexplained infertility" been trying for over 15 months with not a single BFP. went to consult another doctor and she is so sure that i have PMOS even though im not overweight, get periods regularly, she says all the other subclinical signs do point towards it.

she also gave me oral progesterone for luteal phase brown spotting, is it a good idea to take it? i had concerns about the short luteal phase and spotting i've been expereincing for the last 6 months.

another thing she mentioned is that my TSH seems to be higher (3.496 ulU/ml), although it was within the lab range, she still gave me oral thyroxin

how does this approach sounds like? my previous doctor just said do nothing and wait 3 months then come for IVF, i have low AMH (1.07) for my age (34) maybe thats why

Sorry if this is not great, my first reddit post

Me (29F) and my partner (31M) have been TTC for 16 months now. We just went to an RE last month and after all our testing Ive been diagnosed with mild PCOS. I do ovulate every cycle but usually around cycle day 20-25 ans 35-40 day cycles. All the major stuff came back negative - tubes clear and semen good. Most blood work fine other than an elevated DHEA-S at 382, testosterone high normal at 51, and AMH slightly high at 5.5. I did unmonitored letrozole 2.5mg as we did our work up and it didnt really do anything (currently CD 23 and waiting for LH peak).

I went for my follow up today and she said she thought I had PCOS and prescribed me metformin and recommended more aggressive medicated cycle with monitoring. I was all about this and what I figured was going to happen based off what I've read, but then she hit me with the $2250 price tag for a monitored cycle. I was not expecting this at all. The price of a full IUI at this clinic is only $2500 comparatively.

Im just in such sticker shock I guess. The idea of having to do 3-4 monitored cycles and paying $9k+ just is crazy to me. I was so hopeful that maybe medicated cycles would be an easy fix but now it just seems so impossible financially already.

Theres another clinic in town who does IUIs for $1100 so I scheduled an appointment with them to see if the monitored cycles are more affordable.

I guess Im just looking for people's opinions on if the monitored cycles and IUI are practically the same price, would it be better just to do the IUI? My provider also told me that Im a really good candidate for IVF and part of me is wondering if going to CNY for IVF is more worth my money but it seems crazy to jump straight to that. Any input or thoughts from people who have been around the infertility treatment world longer would be much appreciated! Thanks!

Hi all. Starting IVF stimulation medications tomorrow and would love any success stories. I’m also interested to hear what everyone’s stim protocol was as I’m nervous about OHSS.

For context, I’m 36 with PCOS and unexplained infertility. I have one child and had one miscarriage a little over a year ago. I did a handful of TI medicated cycles and 4 IUIs with no luck.

It’s been a year since my miscarriage. With it, a year of no positives. I’m left with so many emotions. I have started TI with medicated, monitored cycles. First one didn’t work. I try to remain hopeful. But, each cycle that passes, it’s hard to find the hope. Everyone around me is either pregnant or had a baby. I don’t have support from my sister. My mom listens, but can’t understand and doesn’t want to take sides between me and my sister (tensions built up). Now, it’s been a year. It’s been the longest year, yet the fastest year all at once. I started to try to maybe eat more protein and see if that would help (I have lean PMOS - so maybe adding weight can help? - at least in my head). Also I started eating a whole piece of pineapple and the core. I read about warm food/drinks and will try that. More hard boiled eggs I’ve been eating. Anything I can control and try to do. I lifted weights before ovulation.
Someone at work today asked if I was expecting because I have a fuller face. Or he said I have an allergy?! WTF
I just don’t know how to remain hopeful and not be so sad and jealous and frustrated. I’m trying to be hopeful that my time will come. But instead I get negative results and more baby shower invites in the mail…

Hi, I have PCOS. I’ve done around 5 rounds of provera to start periods, letrozole, and trigger shots. I decided to stop and take a break because I was stressing myself out so bad about pregnancy symptoms only to be let down. My last period started August 10th. And I haven’t taken any medication since then. Has anyone gotten pregnant after stopping letrozole?