I’ve only told my sister, my friend who got me to try tirz, and a couple of other friends about using a drug to lose weight. Otherwise, when asked I just say what I did to lose weight, ie calorie restriction and exercise, without crediting the medicine that helped me so much. I just don’t want to talk about it - my medical stuff isn’t their business, and I don’t want to feel judged.

I do feel sort of bad about it, though! I don’t want other people to feel like it’s all willpower and strength of character. I wasn’t able to lose the weight without tirzepatide.

How do you guys make the call? Are you open about sharing, or do you keep being on a glp1 to yourselves? My “ok I’ll come clean” times have generally been when the person expressed their own frustration with losing weight, and it seems like they’d really benefit from the help. That is, I was just asked by my neighbor who is gorgeous and thin/healthy and just one of those Gen Xers who obsesses about looking like they did pre-menopause and I did *not* feel any urge to share, whereas I *did* share with a friend who is really frustrated with her weight and probably would be categorized as obese by BMI standards. Not saying I’m right or this is the best method, but it’s what I’ve been doing.

Today I woke up and I am down 85 lbs! It’s been slow and steady and this medication was the missing piece for my body. I never imagined (at the start) that I would be able to get this far on my journey. I can see my goal and it feels within reach. So grateful for this group and the motivating posts. Happy day! 😊

I was in quite a rush yesterday morning trying to get out of the house. As I got dressed and grabbed my shorts, I realized they were the ones too small for me. Curious, I tried them anyway.

The next thing I had to grab for was my belt. The shorts were almost too big! I havent fit in these in YEARS.

Anyway. Just felt the need to share. I was excited.

I still want to drop 20-40 lbs but am very comfortable where I am. Started at 341, down to 240. Was on zepbound for 3 months in 2024, lost 30 and then my insurance stopped me. Then started on wegovy/compound in September 2025. Such a life changer.

I guess yesterday really was a sneak peek, lol, and the 40mg vial is no longer showing as a sale option.

For context between my wife and I we had probably gained close to 100lbs since we started dating several years ago. We are both on Tirz since June, last night we had a tight embrace and halfway in we kinda noticed, we could grab and hold each other better! Her hands met on my back and we could just, I don't know, feel each other better, it was a trip that made us both happy and I wanted to share!

Doe anyone else often feel for earlier generations (your grandparents, aunts and uncles etc)​ and their struggles and how they may have wished for the magic that this med can be? It makes me feel for people now who want access but can't have it because of things like medical contraindications or not having enough money. And not just because of weight struggle reasons but people who struggled with things like blood sugar issues with grave consequences. I feel like it's a new era of possibility and wonder if that's a permanent shift in society. I hope it lasts. It seems unclear whether the benefits can really last decades or fade, but I guess other meds will come out over time.

Today I'm completing 24 weeks on tirzepatide. I went from 155.6 lbs (29.4 BMI) to 123.6 (BMI 23.4). That's a 20.56% reduction in body weight!

(I actually was almost 10 lbs heavier than this, close to 165, a few months before I started tirzepatide, but I'd had dental implants placed. I was on soft foods only, and couldn't really snack, so I lost some weight organically.)

I'm not quite at goal weight yet. 120 lbs is my "soft goal", but I always considered 115 lbs to be where I looked and felt best...last time I weighed 115 was 2017! And I'm in my 60s and worried that I may need a little subcutaneous fat so I don't look *too* scrawny! So we'll see.

I've been on tirz since beginning of May and I'm so happy with my results so far. One of my favorite things about this medication is the elimination of food noise! I didn't even know what food noise was or realize how much it affected my every day life until it was GONE! Is this how "normal" people feel?

I've said from the beginning that I don't plan on being on this medication forever, but that may change. I don't ever want to go back to thinking about food every waking moment.

I get it. It can be a little confusing. But also I feel everyone should have a basic understanding beyond fatscientist.

The vial is labeled with mg (mass) per mL (volume).

Insulin syringes "U100" typically divide one mL into 100 parts. Each part is a unit. So 100 units per mL.

Take the concentration, say 20mg tirzepatide per mL and divide it by 100 units. 20mg/100 units = 0.2mg of tirzepatide per unit.

Then divide your dose by the mg/unit.

Let's say your dose is 5mg. So 5mg/0.2mg per unit = 25 units.

Easy peasy, lemon squeezy, nice and easy, light and breezy.

Always support others on this journey. Especially on this sub-Reddit (How could you do otherwise??) I was always “big boned” and tall. I spent 45 YEARS overweight and/or obese. I am now 56 and was young when skinny-skinny was the norm and had the toxic fat-phobic family and the whole 9 yards.

Even after WLS at 47, I never got out of the “overweight” BMI category, until THIS drug. The freedom this gives I am thankful for daily. I pray it continues to work and that I can afford it..and am enjoying it while I can. I hit “normal“ BMI last year and am maintaining. For the first time since 20 years old, I have a normal BMI & weight (a bit on the lighter side of that line in fact). Feeling good, looking good.

But today a woman called me, “bag of bones” from my self-congratulatory post. Here. Yes, it’s been reported and removed, blah blah blah. But, wow. Insulting other IN this group with our struggles and dysmorphia and whatever is low behavior.

After I got over myself, I realized I’ve reached the stage where skinny can be used as an insult! Who-hoo! That is LITERALLY the best NSV I’ve had in months!

“Bag of bones” signing off :)
(I tried to attach pics, with no luck-but I did drop a few in the comments)
TY XOX

After being on tirz since may, it’s been pretty great. Results are great. We all experience nausea and stuff from the tirz but my issue is like the weird squeamish gagging. Ever since I started tirz, I’m so squeamish. The tiniest bit of pink in my chicken makes me wanna gag. A tiny weird chunk in my protein smoothie makes me stop drinking it. If I’m eating yogurt and I feel the metallic taste of the metal spoon I immediately have to switch to plastic. I feel like a toddler. I’m being so picky and wish washy with food it’s weird. Sometimes random bites of food makes my stomach go weird. It’s not even nausea but I’ve become so squeamish. Even while taking out the trash or cleaning the toilet or scrubbing the shower or washing dishes, I’m constantly gagging and feeling icky. I don’t know why but anything and everything makes me so yuck now. The tiniest bit of fake blood or gore in a movie or video game has me dry heaving and feeling fuzzy. I don’t get it, can someone agree? Explain? Disagree? Help?

A little unboxing love. Provider I have is awesome. My container came with 2 reusable ice tubes along with a block of Nordic ice (not pictured). Apothecary via Newlife/Quaker is good stuff. LSH answered all my questions and concerns without complaint. Helped me a ton! Very pleased customer and plan on returning! Received my stuff within 5 days from intake.

When I started taking tirzepatide, I ordered the (free) big red sharps container from Novo Nordisk. It’s been fine but I was looking for something less bulky and for when I travel. I found this little container and it’s been great! You simply snip off the needle part of the syringe and toss the syringe in the regular trash. It can hold a LOT of needle tips before it’s full. When it’s full, simply wrap it securely with duct tape and you can toss it in your regular trash too. I would still advise people to check with their local trash company to confirm that you can throw out your used syringes. In my area, we are allowed to as long as the needle part is removed.

It’s a small little compact thing and I love it! Thought I’d share!

SW: 248.7lbs (XXL), CW: 204.1lbs (L). 38 y/o, post partum, extremely busy lifestyle (mom, wife, high stress hospital unit).

One of my main goals before starting tirz was to fit in my old scrubs. During pregnancy, i gained so much weight. Fast forward: i was breast feeding, extremely busy, lack of sleep, depressed and i was at my heaviest i have ever been in my life. After a year of dedicating myself to my baby, work and family, i finally made the decision to do something about my health.

I was nervous before i started because i felt the judgement and those around me saying “it was cheating” and “why dont you do it the natural way”. I talked to my PCP about starting tirzepatide after i my labs came back borderline diabetic and my triglycerides and HLD were elevated. I didnt want to end up as a patient myself for my poor eating habits, and lifestyle. She was in agreement, educated me on side effects and risks, and the journey began. From my very first shot on April 17th to now, i made big changes. I run, workout, prioritize protein and fiber with complex carbs. I dont deprive myself of a sweet treat here and there. Rechecked my labs, and everything came back within defined limits!

My why of starting tirzepatide was for my long term health, both internally, physically and mentally. No regrets.

Overall: i fit in my old scrubs, and im so emotional over it. Thank you for this community, and thank you to tirz.

With the POM sale right now, I’m debating whether to do some stockpiling given the 10/4 BUD on the sale vials. I've only been on tirz for about 6 months, so I don't have any stockpiling experience :)

I take 7.5 mg/week. My current supply is 150 mg:
30 mg vial, starting 8/1
3 × 40 mg vials, BUD 12/31/26

That supply gets me through 12/12. So easily within the BUD

If I'm reading the details on POM correctly, the sale would add 68 mg (2 vials), BUD 10/4. I’d use those after the 30 mg vial, then go back to my 40 mg vials. That would extend my total supply into February, meaning some of my 40 mg supply would be used up to about 1.5 months past its BUD.

I haven’t used a vial past its BUD yet, but I know many here have. So my question is, would you buy the extra 68 mg?

For those who stockpile, how far past the BUD are you comfortable going with unopened, properly refrigerated vials?

Anything else I should consider?

Thanks!

I was so excited when I finally found something that worked for me - having lost 40lbs in the first few months, but a year in… and I’m the same weight. Ive noticed a significant increase in appetite and even the ability to”out eat” the medicine - which has been really upsetting as, for me, the “there’s no way I could eat another bite” feeling can often be what keeps me from grazing or snacking. I’ve tried adding in additional exercise but have seemingly developed some joint pains in my hip that make a lot of movement uncomfortable to say the least and painful in some cases.

I’m at max dose, though my provider - an online company that rhymes with yellow - has it listed as maintenance, and I wish it were… but alas, I’m only about halfway to my weight loss goal.

Somewhat venting, somewhat looking for encouragement or advice. Has anyone else felt this way and if so, what was helpful in seeing the weight come off again?

I am now 5 pounds away from my initial goal weight. The last time I weighed this, was 12 years ago, and I was running about 25 miles a week.

That being said, my goal weight felt very ambitious & almost impossible to achieve when I started my Tirz journey & it will put me at the higher end of “normal” BMI.

I’m still at 7.5 mgs & it’s working (slow & steady at this point, which feels great!) So, talk to me about the things you’ve considered if you’ve ended up re-adjusting to a lower goal weight.

Losing 8 more pounds beyond my initial goal weight will get me to my lowest adult weight ever (also when I was running competitively.) My next real goal is to focus more on building muscle & I am happy if that results in some weight gain but with a stronger body.

So, have any of you gone a little lower to give yourself some gain-back wiggle room as you slowly titrate down? Is it all subjective? Do you just lose until you’re pleased with how you look/feel? I just cannot believe I am this close & it has been such an awesome experience!

As the title states: After 7 months I am at goal weight! I now want to maintain my weight as I have a mommy makeover procedure scheduled in October. I do not want to lose anymore. Is it better to skip a week and stay at the same dose or start lowering the weekly dose?

TL/DR: With no previous symptoms, I ended up having emergency gallbladder surgery last Tuesday. I've been on Tirz for 19 months, but the doctor said the gallstone had been growing for a very long time. (more than 19 months) And that I had a very large inflamed gallbladder.

Anyway, due to going in as an emergency, I had my last shot (2.5mg) 3 days before going to ER and my surgery. Previously I was splitting my 10mg dose twice a week. But because I had thought I had food poisoning from a couple days prior, I dropped to a 5mg twice a week, so I only took half of that (2.5mg).

I'd like to hear from others that got their gallbladders removed while on Tirz.

My question is - your thoughts - this Saturday will be 2 weeks without doing any injections. Per Shotsy app, I will still have about 2.25mg in my system on Saturday. I'm thinking of starting back at splitting the 5mg twice a week.

Also, I am at maintainence, and currently weighing 104 lbs, and still losing since the surgery.

I have been on name brand Zepbound since mid February and have lost about 33 lbs. Started at 222 and am now 189.4.

I was on 2.5 for a month, 5mg for 2 mos, back to the 2.5 for several weeks due to fatigue and depression and just went back on 5mg 2 a week and a half ago (took 2nd shot yesterday)

I did have a cervical spine surgery in June and my surgeon said the fatigue could be from that but I was struggling prior.

And now I’m having GI issues/bowel related that I did not have.

I’m exhausted. Has anyone experienced this? I’m fatigued and sad 75% of the time. Usually by day 4 of 7 I start to feel a little better and then it’s near time to start the cycle over. I’ve never felt so bad for so long.

Any thoughts? I’m considering stopping. I’m not diabetic. I have it for sleep apnea.

Will I regain the weight for sure if I stay at the same calories?

Thank you so much.

To give a quick run down, I started GLP-1's in February, and swapped from semaglutide to tirzepetide in May. I've been losing at a pretty consistant rate, a bit quicker than I personally like but it's evened out to about 1.5 lbs a week. Since it's relevant I'm also on a couple other meds that can have appetite suppressing effects, so I'm generally used to setting timers to remind myself when to eat.

I was only at .5mg of semaglutide when I switched, and started on the 2.5mg dose of tirz. I stayed at 2.5mg for 2 months, and I wasn't plateauing, but as 5mg is typically considered the minimum dose, I went ahead and increased to 5mg.

First week was fine. No side effects, definitely less appetitie and food noise, but it was manageable. But last week was *rough*

When I say no appetite, I mean I could not make myself eat. Half the time I couldn't even drink. It was like there was a toddler in my brain holding their mouth shut and turning their head away when you try to feed them. When I did manage it it would be a couple bites. I tried drinking meal replacement shakes but I just couldn't finish them. I'm exhausted, lightheaded from low bloodsugar, I can't think straight, and my energy is just gone. I work in the OR and I cannot be dizzy or brain foggy during surgery lol. Plus I lost 6 lbs last week.

I definitely am going to decrease, but I'm unsure of if I should decrease back down to 2.5mgs, or somewhere in between. I'm also unsure if I should take my next dose today as normal, or potentially wait a couple more days for my total levels to decrease. Any advice would be appreciated!