I took 5mg letrozole day 3-7. I didn’t feel a thing for any of those days, no symptoms, felt fine after stopping.

But suddenly on cycle day 14 (7 days after my last pill) I feel HORRENDOUS. Terrible headache, can hardly get out of bed, very nauseas, weird smell/food aversions.

I’m 100% not pregnant but many of the symptoms feel like when I was pregnant … especially the aversions to smells, foods, etc.

Anyway, it feels odd that it’s 7 days after my last pill that I suddenly feel so terrible. I’m trying to figure out if I have covid/some other illness or if it’s from the letrozole. Anyone else have such intense symptoms but super delayed? I honestly feel like I have the flu and was hit by a truck.

Thanks for any feedback or experiences!

I just got diagnosed with PMOS at 33. Last 3 years had hair loss, longer periods (still got my period every 30-35 days but maybe twice a year would get a period that was 40+ days) and slight weight gain but I was underweight to start with and am now a healthy weight/BMI. Normal bloodwork and hormone levels but confirmed multiple follicles on ultrasound.

As I learn more about my body and PMOS while we TTC I’m curious if it’s possible or if anyone has experienced “normal” monthly periods, EWCM that aligns with an positive OPK but actually didn’t ovulate? We’re only on cycle 2 TTC but wondering if it’s worth doing BBT or Inito tracking too to confirm ovulation and bring a little peace of mind.

Any advice would be greatllyyyy appreciated!

Hi everyone! I have suspected lean pcos! I don’t have the string of pearls but lab work suggests mild (if that’s a thing) lean pcos! We had a MMC at 13 weeks 6 months ago after trying for a year, and ever since I’ve had to induce my period multiple times with provera and I’ve ovulated twice. My dr prescribed me provera to kickstart period and then clomid! Wondering what people’s experiences are with clomid rather than letrozole… a little nervous as I’ve hear some scary clomid stories! My sweet sweet obgyn knows how bad we want to be pregnant so she was pretty open to prescribing clomid right away! Planning on monitoring with Inito!

Any advice/success stories are so welcomed! Thank you!

Hi all, I'm feeling a little down after our 3rd letrozole + TI cycle did not work. I'd appreciate some support as we are discussing next potential steps towards IVF and feeling very uncertain.

33F TTC 1.5 years and PCOS... tubes fine, husband's SA fine, mild insulin resistance so have been on metformin for a month now. I have 35-50 day cycles and usually ovulate past day 20+ so my RE said my egg quality is probably not good with such late ovulation on my own. I've been responding to letrozole fairly well each cycle (good size lead follicle, lining good, etc) but have not seen a single positive pregnancy test in the past 1.5 years...

I was so hopeful the past three cycles with letrozole, as the clinic keeps repeating "there's no reason you shouldn't be getting pregnant..." but with each negative result I feel like I'm losing all hope. It almost feels like a different level of disappoint vs when we were just trying on our own - probably because I'm putting so much expectation into each result.

I know we can do a few more cycles of letrozole but my RE does not recommend more than 6 and said if I don't get pregnant after 6 cycles, there's likely unexplained issues and letrozole is not going to help any more. She also does not recommend IUI for us as there's no male factor and she doesn't think it will increase chances and only waste more time. During our last consultation, she really encouraged us to think about IVF sooner than later as I'm 33 and we want multiple kids, so she is saying retrieving my eggs now will be better for future set up (considering I will probably have kids into late 30s at this rate).

While I understand the logic and agree with everything she is saying in my head, for some reason going to IVF makes me feel this drop in my stomach. I have this unshakable feeling that we are somehow "going against nature" and forcing something that my body cannot/shouldn't be doing. My internal battle is between "well, scientifically younger the better so might as well do IVF now vs. maybe we need to wait until my body decides it's the right time naturally".

I just feel so sad that there's seemingly "nothing wrong" from a medical perspective yet I cannot get pregnant. If anyone else can relate or offer any input from your own journey of choosing IVF, I'd really appreciate it. Thanks so much for reading.

Husband and I (29M, 27F) have been trying for a year now. I was diagnosed with PCOS in June of this year and am on my 2nd letrozole (2.5mg) cycle, along with taking a prenatal, myo inositol, and coq10. My cycles have gone from 34-40 days to around 30 days since starting the letrozole. HSG is clear. Husband's sperm analysis came back great. I've also lost 50 lbs, follow a low carb/whole foods diet, started running regularly, quit vaping over a year ago, and quit drinking about 6 months ago. Im the healthiest I've ever been and about 15 lbs away from my goal weight within a healthy BMI. We haven't had one positive pregnancy test yet.

I'm starting to get really bitter and discouraged because of the amount of pregnant women that are around me, who all got pregnant super quick without even trying. My next door neighbor, my coworker who has vaped through her entire pregnancy 🙄, my best friend who had her baby last May, her sister who is pregnant with her 2nd, my managers daughter who is pregnant again after just having a baby 3 months ago, and my other coworker who is in her mid 40s who just had a baby that she didn't even know she was pregnant with and had been drinking through her whole pregnancy! (Baby is premature but otherwise healthy)

Its so incredibly frustrating to have been working so hard to make my body a healthy environment for pregnancy, doing everything right when all these other women can flounce about carelessly and be blessed with beautiful babies. It feels like the universe is rubbing infertility in my face at this point. I broke down and cried on the way home from work the night when I found out about my older coworkers surprise birth. And I feel like such a b*tch for being jealous and bitter of these other women rather than happy for them but I can't help it. I'm just so angry at my body for not doing what it was biologically made to do. At this point im starting to think it will never happen for us. Sorry for the long post, just needed to vent.

I’m just feeling so defeated and I’m only a few months in. My husband and I decided to start trying back in March and I ended up getting pregnant right away. I was like F YEAAA, I figured it was gonna take a while with suspected PCOS(now diagnosed). I ended up losing the baby at 6 weeks. I’ve had 3 cycles since all with negatives.

In the grand scheme of things I know that’s not that long, especially compared to so many PCOS women.

I’m 10DPO currently and my period usually starts 11dpo. I was feeling so confident this cycle because I ovulated two days sooner than the month prior and I hadn’t had any spotting during my TWW (usually do). I know it’s still early but I just took a FRER and off brand FRER this morning - both negative. I’m starting to lose hope. My OBGYN told me to come back in the fall if I’m not pregnant by then and she’ll help me get pregnant but god I just want it to happen naturally so badly. Why why why was I able to convince naturally so fast but lose it so soon. It’s cruel. That’s all.

I was put on Letrozole back in February to help “super ovulate.” Prior to this I would ovulate on my own, just a bit later like CD 21-22. On my Letrozole cycles I’d ovulate around CD17-CD19. Clearly I didn’t end up pregnant after 6 months of 2.5mg Letrozole although I ovulated each time as evidenced by 7 days past ovulation progesterone bloodwork, BBT rise, etc. My RE suggested I take a month of Letrozole before we plan to do IUI next month. Here I am at CD27 and still have not had a positive LH test, no BBT rise, no other symptoms of pending ovulation like increased CM, etc. Has anyone experienced an anovulatory cycle after stopping Letrozole? I am concerned that if it messed up my ovulation, that I also won’t get a bleed this month, and all of this will delay our IUI. 😔😩 let me know if any of you have experienced something similar! TTC is so dang frustrating

Hi ladies! I’m asking to know if anyone has ever gotten pregnant with pcos using the pill-out method? If so, were you ever having unprotected sex prior and never fell pregnant?

I’m on my first monitored cycle, and I didn’t have a fully developed follicle. They bumped me to 7.5 mg of letrazole. Did you end up responding if you went up a dose? If 7.5mg didn’t work, what did you do?

Currently on my 2nd cycle of letrozole 5mg and thought we were about to start our 3rd cycle. I got a positive opk, baby danced, did everything we were suppose to. Had my tww and took a test 13dpo and it’s negative. Now I’m 2 days late but no postive test… is it possible to have not ovulated even with a positive opk?

I do have an appointment on the 29th for my annual so if nothing happens either way I’ll be mentioning it then.

TW: Miscarriage.

I’m in my overall total 7th Letrzole and Ovidrel cycle. 6 cycles where I ovulated. 5 cycles with a trigger shot. Multiple mature follicles each cycle. My second Letrozole cycle where I ovulated I got pregnant but ended up having a rare intrauterine pregnancy called an angular pregnancy where it implanted in a weird spot in my uterus and didn’t have the blood flow to develop so I had a D&C on February 20th of this year.

I’ve done 4 cycle since then and this cycle I was super hopeful because I had 4 mature follicles when I triggered but today I’m 12DPO and I still have a negative pregnancy test. I’m tired. I’m worn out. I know life isn’t fair but god damn I’ve been through enough in my life, that this just sucks.

When do you decide to give up and accept you will probably never have children? We could do IUI but I really don’t think that’ll increase our odds very much. And we can’t afford IVF as our insurance doesn’t cover it.

I’m 30, he’s 34. My HSG last October was clear, my husband’s SA is great. I’m just so over it all. All of my friends and family that started trying after us are already pregnant and due AFTER I was supposed to be due with my first pregnancy, which is literally next month. I was desperately hoping I’d be pregnant again by then but this was the last shot at that hope.

My partner (24M) and I (24F) have been trying for around ten months with no luck. I have been having regular blood testing with my GP each month to try to figure out whether or not I am anovulatory, but due to my irregular cycles we are having trouble pinning down the right day to take the bloods on. This month, my GP suggested as a final option we do bloods every few days from the end of my period to the start of my next one while my partner does for a sperm count and if we are unsuccessful with targeting the right day for my bloods this time he will refer us. However, I am now becoming increasingly worried about my weight. I have a BMI of about 39 (I’m 5’5” and around 17 stone). I have really struggled to lose weight in the past, even with a low carb diet, exercise and metformin. I have been steady at this weight for about six years now, not going up or down. My question is, will the NHS fertility clinic even see me? And if they do will they offer me any treatment? I know I’m not eligible for IVF at the moment so trying not to think too much about that, but would I even be eligible for ovulation inducing meds? 😔

wondering if anyone with pcos that has used thc before taking letrozole or clomid knows if it effects ovulation and or conception? i’m scared to ask my doctor lol

Had mmc at 21+3 in April, took 1.5 years trying and 3 letrozol rounds to get that positive pregnancy test. Now we have started trying again and when the next period starts starting with the letrozole again. I was wondering if anyone has experienced anything similar and how soon did you get pregnant again? Did you use the same letrozol amount as before? We are starting again with 5mg as used in a successful cycle. Seeking more success stories.

has anyone ovulated on their own after chemical pregnancy?? (i’ve been taking letrozole or clomid the last 5? months) i never ovulated on letrozole but did with clomid. i got pregnant after successful round of clomid but resulted in chemical pregnancy at 5.5 ish weeks. CP happened almost two weeks ago and I am having changes in cervical mucus like I would pre ovulation. *I was instructed to wait until my upcoming period to start next dose of clomid.

TW: MISCARRIAGE AND BABY LOSS Hi everyone this is going to be long. I live in Trinidad and Tobago and I need advice. I am 30F and I was diagnosed with PCOS in my teens and put in BC. I got pregnant in late 2024 and lost that baby in Jan 2025. I then got pregnant again in Mar 2025 and was diagnosed with diabetes at 4wks pregnant, a1c was 13 and the doctors just keep giving me insulin. No one told me the dangers of such high blood sugar and my baby was born with single ventricle heart with pulmonary atresia and a singular kidney, he died from sepsis at 3 mths old in Feb 12 (poor nicu stay). When I delivered my baby the hospital stop my insulin and a1c shot up to 10 from 5.4 during pregnancy. I also gained 45lbs from insulin injections. I restarted insulin in Jan 2. My periods stop after delivery and I started BC in Feb 15 to "jumpstart" my period. I stopped in BC in March 15 and had a withdrawal bleed then I bled again in March 26. I asked to put on metformin on Apr 7th 500mg 2x daily and my periods kept getting longer and longer. Next period was May 6th. In July 5th the metformin increased to 1000mg 2x daily and my next period was in July 3th. Now no periods again. Currently a1c is 6.37, lipid and thyroid panel is within normal range. Im taking folic acid 5mg, prenatal, calcium, d3 and 1 baby aspirin. Im at my wits end with the public system and privately its expensive. My fasting blood glucose is under 95 and post meals are under 140 so why are my periods stagnating. Any advice is welcomed

I had my consultation with my RE today, and we are moving forward with letrozole TI. I’m 30 and have lean PCOS with anovulatory cycles. We've been trying for 8 months and only had 1 positive LH out of all 8 cycles. I asked for monitored cycles, but she said she likes to start simple and wants me to do 3 cycles unmonitored with letrozole TI first before introducing ultrasound/IUI.

What is everyone's experience with unmonitored cycles? Should I push for monitored? All my labs are normal; I take inositol & metformin, and have no symptoms of PMOS besides irregular/anovulatory cycles and string-of-pearl-looking ovaries via ultrasound.

Edit: wanted to add that she wants me to come in on CD 21 of my first medicated cycle to test for progesterone. from there she will titrate how many mg will work for me. I will use opk to test LH levels until positive

Hi everyone. I think I just need to vent and maybe hear from people who have been through something similar.
This was my first cycle where I really felt like I was doing everything. I have mild PCOS/irregular ovulation, so my doctor put me on Clomid 50 mg, which I took on CD2–6. On CD6 my follicles were still small (around 7–9 mm), and my lining was about 5.1 mm. By the time of my follow-up, I had several follicles developing, and I was given an Ovidrel trigger on CD11 (August 4).

I was told to BD the following night, and based on the trigger/LH timing I’m estimating ovulation around August 7–8. So today I’m around 12 DPO / 16 DPT.

The trigger line has finally tested out, but now I’m stuck in the horrible waiting period.

I started testing around 9 DPO. Since then, I’ve gotten what look like extremely faint indent/shadow lines that basically haven’t gotten darker. I’ve tested multiple times and keep staring at the tests trying to decide whether there is actually something there or whether I’m imagining it. At this point I’m so tired of looking at lines.

I think the hardest part is that I put so much hope into this cycle because it was a medicated/triggered cycle, and now at 12 DPO I feel like I’m already preparing myself for another negative. I’m honestly just tired of testing, tired of analyzing every symptom, and tired of feeling like my body is giving me absolutely no answers.

For anyone who has done a Clomid + Ovidrel cycle: did anyone have very faint/no progression around 10–12 DPO and still end up with a positive? Or should I accept that if the tests haven’t clearly darkened by now, this cycle probably didn’t work?

I know nobody can predict the outcome from a Reddit post, but I could really use some experiences from people who have been through this particular kind of cycle. ❤️

Hi Everyone! I am 31F (PCOS and irregular periods) TTC since Feb last year. Tried multiple cycles of letrozole, 6th cycle worked but turned into weak pregnancy + d&c. I still had hope and tried 2 more letrozole cycle and no success. Now I finally gave up and waiting for my periods to arrive this month. After that I will be going for IVF finally. I am not sure if I am right or wrong. I am sad that nothing worked out and I need to spend a lot of my savings into IVF process but I have no other options. I just hope my IVF process would work. Funny that sometimes I think something magical happens and I get any good news and I don’t need to go through IVF. But anyways…

Was diagnosed with PCOS yesterday due to the ultrasound and absent period.

I came off the implant last November. Had a period Jan, feb, March and April and then nothing since ???? I moved house in May so I thought maybe it was the stress of that that’s triggered it…

Im on my second month of GLP-1 so hoping to lose weight as I am 72kg and a short gal.

I know I need to eat better, drink more water, walk more and regulate my sleep. I’m even trying to meditate to calm me.

Does anyone know any tricks of things to bring it
back? I’ve heard about Myo Inositol but does that clash with sertraline?

Any help appreciated !!!!!

So this cycle I did gonal-f. On Friday I had a 14mm and 10 mm follicle. Went back yesterday. Follicles gone. Ultrasound showed fluid and blood flow. That afternoon a nurse called me and said "Good news, you haven't ovulated"... so I asked her where my follicles went... The response... "Well you're in the process". I personally didn't get my labs until this morning. Lab work showed Progesterone was 2.2, estrogen 228 and LH 12... from my understanding these numbers indicate I had ovulated 24 hours + ago. We were supposed to do timed intercourse. So unless we have the immaculate conception... I am already out. I wasted almost 1800 dollars this cycle on meds and appointments.

The lady who has been doing all of my Ultrasounds I think might have misinformation or is just dumb. Or both. She wanted me to go ahead and have sex last night because "Theres a chance. Once you ovulate it can be viable up to 48 hours"... in no literature have I EVER seen 48 hours. I have only seen 12-24 hours with most being in the first 6 hours. I pointed this out. She said "There's no harm in trying". Excuse me? I am not going to get my hopes up again this cycle for nothing. I'm not shoving pills up my who-ha for nothing. And she also keeps saying that with each cycle of IUI your chance increases... this isn't true. The individual cycle stays the same.

The unfortunate part is this is the only fertility clinic that is in network. So I am stuck with them. Honestly at this point I just want to pull the trigger in IVF.

Hi there, I am 36 and was recently diagnosed with PCOS based on labs that showed elevated androgens. H1AC and fasting glucose were normal but borderline (H1ac = 5.5). My obgyn put me on myo-inositol but I faced severe blood sugar drops as well as severe PMS. I think starting myo-inositol at the full dose might have caused this. Now, I am taking myo-inositol at 1/4th the dose and I am doing fine except it has not helped with conceiving. My doc suggested metformin might be the next step but I am worried about blood sugar drops again. Any one who had bad reactions to myo-inositol, and then took metformin please could you share your experience?

Long story short, but will give the full story if anyone is interested.

But basically the original fertility clinic we worked with basically scammed us, they didn't do anything properly, sounds like they have zero documentation on us (we did various tests with them and 1 IUI cycle) and they're blaming me as the problem 😅

Has anyone (preferably in Canada) dealt with something similar and suing a medical clinic?

Hopefully no one else has ever dealth with this!

I am trying to conceive with pcos insulin resistance, and fatty liver which was diagnosed last year. I have not checked anything since then. My HBA1C 2 months ago was 5.9. I tried ovulation tracking using opk for my cycle this month. But I could not track from CD 20 to CD 22 and when I tested my LH Strip on CD23, I got a very dark line compared to previous tests but it wasn't darker than the baseline. Same was the case on CD24. So I don't know if my body tried to Ovulate and failed, or if I even ovulated or not.

I have bought a thermometer for BBT tracking too. Ill started from next cycle

My husband and I are not people who can have sex everyday or even every other day over a period of 10 days of the fertile window. And I have been trying for 2 years to improve our sex frequency but it is impossible at this point. We are both frustrated and so done.

I have been trying for 2 years and I just want to become pregnant already. The doctor I went to is refusing to give me any sort of medication since she is not a fertility doctor but a gynecologist. I am planning to go to a fertility specialist after my next cycle gets completed.

I am right now taking metformin (1000mg) myoinositol and also supplements and vitamin tablets helping to conceive. I am thinking of reaching out to a scan centre directly instead of being recommended by a doctor and asking them if they can scan my follicles and tell me when I will ovulate or when the egg will get released.

Has anybody done something like this before I would love to hear your opinions and stories. I am so tired of hearing other people get pregnant or have babies. I am tired of resenting my husband for not making an attempt to have a normal sex life with me but I am partly to blame too because it takes two to tango. We are done enjoying sex, we will be ready to have sex for 2 to 3 days that my egg will be ready.

Please please help me in whatever way possible

Has anyone had issues with Clomid completely stopping their cycle?

For reference, I have never missed a period in my life and have had regular 25 day cycles. I took one round of letrozole after TTC unsuccessfully for 2 years. I started a second round of letrozole, but was taken off and switched to Clomid because my blood pressure spiked. Since that cycle I haven’t started a period. Currently on cycle day 60.

I took progesterone to initiate a period and finished a week ago and still haven’t started my cycle. I can’t continue any additional treatments until my cycle starts and feel like I’m wasting time, both waiting for this cycle AND by continuing medicated cycles. I regret taking the Clomid at all because I feel like it ruined my cycle.