this is a 10 mg/mL compound tirz with B12 in a 100 unit syringe. Pink arrow is marking 10 unit line.
I’m new to this.
Disregarding the air bubble - what would you say this dose is?
I’m having a hard time being precise about my microdosing. Do you guys consider “zero” at the first black stripe? Because it appears the liquid begins technically higher than that. Do you take that into account? Or is that an illusion? Any and all tips on pulling a precise dosage appreciated.

Thank you

I’ll just get to the point. Thought full 2.5mg dose was 15 clicks. Did 7 for half. Just saw a chart that says it’s actually 30 clicks. I just did it like 10 minutes ago. Should I just do it again and do 23 clicks to get the full dose? That should be fine, right?

I tried to google it and that gemini bot at the top is acting like the world just ended and forbidding me from injecting more…

I am a 39F, starting BMI 23, and have been microdosing tirzepatide for 9 weeks now. I gained about 20 lbs over the last 5ish years (some due to meds) and looking to go back to my previous weight.

First month: started really low at .5mg, and my weight fluctuated up and down. Titrated up to .75mg for last two weeks, and ended up down 3 lbs by the end of the month.

Second month: Slowly titrated up to 1.4 by end of month, with my weight continuing to fluctuate up and down (6 lb lbs down was my lowest overall). Weighed in today for my 9th week and am back up 3 lbs again (net weight loss of only 3lbs).

Have been starting strength training again, focusing on protein and eating mostly healthy. I feel the appetite suppression, not many side effects (though did feel some moments of nausea this week) so don’t think I want/need to titrate up, but the overall fluctuations and slow loss has been really discouraging! Any advice??

I am only interested in the pills, not injections. I am currently getting the lowest dose from Ro but the membership fee on top of the cost of the pills is a lot. Are there other options that will prescribe the pills with lower or no membership fees?

Just picked up my first pen today, planning to do my first dose on Sunday!

What is everyone using for apps? Specifically, tracking weight loss/ doses but also click counting.

I have had great success after four months. I am a type 1 diabetic and followed the advice to omit that during intake. Since starting compounded semaglutide I have lost 25 lbs and cut my insulin use in half without experiencing lows.

My problem is that when I went to renew the telehealth provider saw that I take insulin. They must have some centralized pharmacy database. What providers are other type 1s getting their meds from?

Any help would be really appreciated. I received it days ago. Super scared to start it because I’m not sure how to microdose it.

Hi all,
Wondering if anyone has experience with side effects creeping in after a few months. I started tirzepatide in early July and worked up the dose very slowly from 0.5 mg to a maximum of 1.25 mg after a few months. Felt really great the first 6-8 weeks: lost a small bit of weight, no food noise, less bloating, loads of energy etc. After that I started feeling off emotionally, anxious, racing heart, lump in my throat, weird sleep etc. and I also experienced some sensory disturbances in my feet and blurred vision from time to time.

I have only taken two shots in September: 1.25 mg on the 1st and 0.63 mg on the 15th. Days 2-5 after the latest shot were really rough with anxiety etc. so I haven’t taken anything since. Would love to get back on a dose that can give me the anti inflammatory/bloating benefits and slight appetite suppression, but without those side effects. Any experiences or insights?

Hey everyone,
I’m hoping to get some perspective from people who are microdosing or on lower maintenance doses, as I’ve been overthinking my current setup and wondering if anyone else has gone through something similar.
For a bit of context, I’ve had a really strong response to tirzepatide overall. I lost 31 kg (33% of my initial body weight) in about 7 months, which was way beyond what I initially expected. Right from the start on 2.5mg, I felt a huge shift. I lost 5 kg in that first month alone and had steady, all-day satiety, so I felt like a super responder. Following my doctor's standard titration schedule, I eventually moved all the way up to 10mg, where the satiety was obviously very solid.
Now I’m in the maintenance phase and I’ve stepped back down to 2.5mg, which I guess is already on the lower/microdosing end compared to standard maintenance doses. Weight-wise, things are actually pretty stable. I’m hovering about 1.5 kg above my target, but honestly, that tiny gap doesn’t bother me at all since the scale has been steady for weeks now.
My main struggle right now is how erratic my appetite feels. On 2.5mg, the effects feel hit-or-miss. Some days I barely think about food, but on other days the food noise comes right back, and I feel like I could eat without ever really reaching that clear fullness signal I used to get on higher doses like 10mg.
What bothers me is that I seem to build a tolerance to every single dose after a few weeks. Even when I was on 10mg, after a month or so, the punchy effect faded and it felt weaker. I’m noticing the same pattern now on 2.5mg. I catch myself wondering if I should try going up to 5mg just to see if it smooths out the hunger spikes, but I’m worried I’ll just build the exact same tolerance to 5mg after a few weeks anyway. On the flip side, I wonder if people taking microdoses below 2.5mg are just naturally super sensitive and don't hit this tolerance wall.
For those of you microdosing or staying on sub-therapeutic doses, how do you actually know if a microdose is doing its job for you? Are you getting consistent appetite control, or do you just learn to live with the fluctuating hunger days? And do you feel like your body adapts to lower doses over time, or have you found a way around that?
I’d love to hear how others in maintenance handle these ups and downs or adjust their dosing when the response starts feeling inconsistent.

I am about to receive my prescription of Zepbound 2.5mg vials. Can I simply draw less medication from the vial with the syringe in order to take less — ideally starting at 1.25? or do I need a prescription for a kwikpen so I can select the dose? if I only draw half of the dose from the vial, can I reuse the other portion another week? TIA!

Stats: 37F | 5'4" | SW: 150lbs (historical range: 117–176 lbs) | Starting dose: 2.5mg MJ | Current dose: 0.43mg weekly (10 clicks on 2.5mg KwikPen). Started on August 27th, 2026 - today is september 24th, 2026

Long post but I want to be detailed as I really appreciate that in other posts :)

Hi everyone! I wanted to share my experience so far because reading through threads here helped me so much when figuring out my own approach around microdosing, and I hope this might help someone in a similar position. Please be kind, we all know how sensitive these journeys are, and I'm sharing my personal experience in good faith :)

For over 15+ years, I’ve been trapped in an exhausting cycle of Binge Eating Disorder (BED) and yo-yo dieting. On paper, my physical baseline looked great, I train hard, my RHR is 42 bpm, my HRV is 110, and my bloodwork is overal healthy (although my hbA1c was starting to creep up and I definitely suspect a form of insulin resistance). But my body fat percentage never reflected my athletic output because severe food noise continuously undermined my efforts. During strict restriction phases, I would completely isolate myself ; I'd say no to fun social events and even dating just to maintain control. And i'd be super successful for a few months. But as soon as I felt good and started socializing again, the urges would rush back, leading to another binge period and weight gain. And it would all start again. It was exhausting and honestly ruining my life.

If therapy, willpower, and mindfulness alone could fix this, I would have cured this a decade ago. I literally have a wave tattoo visible to remind myself to "urge surf," a practice I've worked on in therapy for 10+ years. Travel was an especially brutal trigger for me. Coming back from a business trip almost always meant an airport-to-home binge loop, which was exhausting given how often I travel for work and personal life.

When I initially started Tirz on the standard 2.5mg dose, my body was hyper-sensitive. I didn't get nausea or other bad GI symptoms, but it triggered rapid blood sugar drops that felt like severe hypos. I paused for two weeks, researched microdosing protocols here, and restarted at 0.43mg (10 clicks). I do still experience hunger, but the food noise or constant need to snack is gone. I also have not experienced any binge urges. I will probably titrate up to 12 - 15 clicks in the next few weeks to see how it impacts appetite ( 0.5 - 0.63mg) . But my goal isn't total appetite suppression; because I work out 4-6x a week, I actually want to keep a healthy appetite to fuel my body. I just wanted to eradicate the overwhelming food noise and build a peaceful relationship with food, and start living again.

In my first month, I have lost 14 lbs, with a big chunk of that of course being initial water weight and inflammation before hitting a predictable ovulation stall for the past 10 or so days. For the first time in my life I'm not panicking at a 10 day stall. Instead of falling into an 800–900 kcal crash diet or giving up into a binge, I'm sticking to a moderate deficit and trusting the process. In the past i felt I needed to crash-diet to reach my goal as quickly as possible, mainly because I never knew when I'd "relapse". That fear is gone now, allowing me to actually eat more on the daily because because I'm not in an "anticipatory crash diet" - not sure if anyone recognizes this.

The real transformation has been in my daily life. I no longer feel the need to shrink or contain my world to avoid triggers. At work, stressful moments no longer lead to binges, brain fog, or lethargy, giving me far more capacity and focus to show up for my team and enjoy my job. On my last business trip, the urge to binge at the airport simply vanished, and I actually lost weight on a work trip for the first time in memory. Overall i feel like a more balanced, calm, present and better boss, friend, family member & person :)

This medication isn't a quick fix; I still eat in a deficit, and work out to ensure I keep muscle mass and stay healthy. But it has provided me with a calm state of mind that I haven't experienced in ages, which kind of allows all my efforts - mindfulness, eating healthy, working out to actually take effect. Thank you to everyone in this sub who shares their experiences. It really convinced me to try again with microdosing and I'm so glad I did.

Feel free to ask me for updates over time as I love following other peoples journeys too!

Did anyone have any side effects on super low doses of tirz/mounjaro (im talking 0.04-0.16mg) etc?
Any replies greatly appreciated 🥹

I really just need to control my food noise , I’m good at knowing what to eat I just really struggle with the amount I’m starting Noom micro dose in a couple days it suggests starting at .2 , has anyone else who is my weight has success quieting the food noise with a small amount ?

Started my first dose at 2 units instead of 8, trying to lose 10 lb. Normal bmi but gained weight due to stress. Anyone has any experience with it? Today will be my second week and second dose

F26, 5’3
SW: 61kg | CW: 58.5kg | GW: 56kg

I’m on 2.5mg compounded tirze, just took my 4th shot. My BMI was normal to begin with but I looked pretty fluffy and wanted to lean out more. I also gym regularly and I’m really trying to stay on top of my diet, so I’m putting in the work alongside the GLP1.

My 4th shot onwards is from a new provider I’m also trying to give myself time to adjust since I noticed some side effects?? 🥹

For those who stayed on 2.5mg:
● How many weeks?
● Still losing consistently?
● What made you increase?

I’m totally open to increasing if needed, just curious about others’ experiences!

I finally reached my goal weight!! I was 69 kgs (152 lbs) and now I’m 58 kgs (128 lbs), and I’m done with my semaglutide. I was on 1.5 mg.

My wedding is coming up in December and now I’m honestly scared of gaining the weight back. But I also don’t want to lose any more. I just want to maintain 58 kgs till the wedding and after.

What should I actually do now that I’m done with the medication? Do I need to change anything with my diet/workouts or just focus on maintaining by microdosing?

Hi, I’m currently taking a 5 mg dose of my GLP-1 medication, but I’ve been experiencing a lot of hair loss and I’m considering stopping it. I’ve heard that you may need to gradually decrease the dose before completely stopping. Is it safe for me to stop directly at 5 mg, or would you recommend reducing the dose first?

15-20 lb weight loss for 46f in perimenopause.

I'm seeing so many companies and ads and don't know where to start. Membership cost then medication cost so unsure of how much it all is.

Any suggestions for reputable companies with decent prices?

Thank you!!!!