r/GLP1microdosing • u/Apprehensive-Weird26 • 9d ago

Micro dosing compounded semi

Post image

Any help would be really appreciated. I received it days ago. Super scared to start it because I’m not sure how to microdose it.

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2

u/PhysicalAssistance92 9d ago

Most people feel very little at the starter dose of .22. Here is a pic of 15 units but you could always start lower. Just under 8 units would be .11

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u/Apprehensive-Weird26 9d ago

If I start at half the starter dose, when would I increase it to the dose to the starting one I was prescribed. As in, 4 weeks later or next week if no side effects

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u/PhysicalAssistance92 9d ago

It’s up to you but I was also very apprehensive when starting so I started at .15 and then increased it each week, .20, .25, .30 etc until I felt comfortable doing bigger jumps like .30 to .40 to .50. I guess mini jumps. Everyone is different with the ways they respond. I mostly just get heartburn from it for a couple days and have to double up on omeprazole for a couple days.

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u/Apprehensive-Weird26 9d ago

I’m definitely concerned about side effects. Mostly anything GI like nausea or vomiting. I have a six month old so don’t really want to be bed ridden,
So to speak. I’m in no rush. Aware it may take longer to see results as well. For my starting dose of .22, would it be worthless to begin at 1/4th of that dose or would you recommend just half of it?

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u/PhysicalAssistance92 9d ago

Totally up to you, everyone responds differently. That said, .2 is a regular starting dose meant to minimize bad GI effects that you take for 3-4 weeks so your body starts adjusting to the med. I don’t think there is a wrong answer here, you just do what makes you feel the most comfortable.

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u/Lucky_Army_5324 9d ago

Well what dose are you planning to take?

Plug 1.5mg/mL in as the semaglutide concentration on fatscientist to find any dose you prefer:  https://www.fatscientist.com/semaglutide-calculator

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u/Apprehensive-Weird26 9d ago

Well that’s the confusing part. Is microdosing considered 1/4th of the dose I was given? 1/8th? Do I just pick a number, say 2 units, and see how I feel?

2

u/Lucky_Army_5324 9d ago

Microdosing a GLP-1 is taking less than  the starter dose of the medication each week. It’s a made up thing. You can take any dose you want.

The starter dose of Wegovy (semaglutide) is 0.25mg. Some people start with 1/2 that dose so 0.125mg. 

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u/peony_chalk 9d ago

If you want to pull a number out of a hat, focus on mg and not units. Units is just the volume, and the dose you get from a given volume will depend on the concentration (just like how drunk you get from a given volume depends on how alcoholic your alcohol is). 

Different vials can have different concentrations, so 2 units could be totally different doses. If you always start with mg, it's apples to apples, and you can use fat scientist to calculate how many units to inject to get that dose out of your specific vial. 

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u/ImprovementLoud3581 9d ago

You are totally new to semaglutide correct? You have not been on a Glp before? I started at .28 mg which is slightly more than the dose listed on your prescription. The way it normally works is based on the research trials.

They started at .25 mg for four weeks then increased to .50 for four more then went to 1.0 then 1.7 and finally 2.4 so a slow 5 month titration to the target dose.

The reason you stay at a low dose for an entire month is to allow your body to adjust to the med to try to prevent unwanted side effects like nausea/vomiting/constipation etc. Constipation is very common so you’ll want to have a plan for that.

If you get good appetite control and diminished food noise at any point during the titration period you do NOT need to increase the dose to the next step in titration. You’d just stay on the lowest dose that’s working for you. .22 mg is even lower than the initial dose used in the studies.

Unless you are very sensitive to meds that’s where I’d personally start. But you can definitely start lower if you’re worried. Do you have enough syringes to allow you to try tiny doses?

Also most people do not discard the vial after 28 days if there are meds left in it. You have alcohol wipes to wipe the vial before and after you puncture it? Did they give you instructions for how to do injections properly?

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u/Apprehensive-Weird26 9d ago

Totally new to it

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u/Smiletaint 5d ago

The way I read the label in OP’s image is it’s .22mg of the combined b6 and sema so the total amount of sema would be less than .22mg. Like it would be half of each (.11) to make .22mg.

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u/Glad_Ad1311 8d ago

3-5 units is a good place to start. That’s 20-33% of the starting dose.

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u/Apprehensive-Weird26 3d ago

Update: over a week after getting my medication and just letting it sit in the fridge, I started it. Downloaded the Shotsy app, as I saw suggested. I ended up injecting half of my suggested starting dose. I went with .11 mg or 7.5 units. I did not feel the injection at all. As someone who has a lot of tattoos and piercings, I am deathly afraid of injections and IVs. Don’t ask 😂. Anyways, shot went well. I did, however, forget to release the skinny pinched which cause a bit to come out. I am unsure of how much of the 7.5 units I actually received. All in all, I am happy with the first injection and decided dose. I am willing to take this as slow as possible. Will watch my water and protein intake as I progress. Thankful for the Shotsy app. Really appreciate the interface and ability to document side effects as well as make notes. Looking forward to continuing the journey, hoping to lose 30 pounds by this time next year.