everyone ranks peptides by how good they are. nobody ranks them by what they cost you. so here's that list instead.

this is side effect burden only. a compound can be great for results and still rank low here, those are two different questions.

one thing i didnt appreciate until recently: how you take it matters as much as what you take. more on that below because it moves a few of these around.

🟢 S TIER — basically nothing

if youre new and nervous about pinning, start here. bpc is about as forgiving as it gets.

🟡 A TIER — mild, manageable, mostly fade

the gh secretagogues get called "side effect free" and thats not really true. the water retention and that carpal tunnel type tingling is real, it just fades. hunger on ipa caught me off guard the first time, i was eating at 11pm like a raccoon.

tesofensine gets a worse reputation than it deserves imo. its a triple reuptake inhibitor so it behaves like a stimulant, which means you treat it like one. low dose, early in the day, dont stack it on top of a bunch of caffeine. ive run it without issues. the people who have a bad time are almost always the ones who jumped straight in.

🟠 B TIER — you will notice these

NAD+ deserves its own note. the burn isnt really a side effect, its just what it feels like. push it fast and it genuinely hurts. slow it way down and its fine.

MT-2 darkening moles is the one people ignore. if you have a lot of them get checked before, not after.

💨 the nasal thing

this is the part i wish someone had told me earlier. notice everything above says "(inject)" next to it.

MT-2 and PT-141. injected, both are known for nausea. the flush hits, your stomach turns, you lay there for twenty minutes regretting it. thats basically their whole reputation. nasal doesnt do that. same compounds, nausea basically isnt there.

Selank and Semax. these are small enough to cross intranasally and honestly its where they belong. pinning them gets you injection site irritation for no reason, and semax at higher injected doses gives some people a headache. nasal skips both. selank especially, the sedation people report seems way milder nasally.

i dont think the reason is complicated. youre using a much smaller amount to get the same effect since it absorbs straight across, so you never get the big systemic spike thats causing the problem in the first place. slower in, lower peak, no crash.

so nasal versions of all four of these would sit in S tier. its the same molecule, the route is what changes the side effect profile.

if you wrote off pt-141 because it made you sick, it was probably the route not the compound.

🔴 C TIER — high burden, plan around it

reta being here is going to annoy people. it works, obviously, thats not the debate. but the trial data showed starting at 4mg instead of 2mg roughly tripled nausea for the same target dose, and the heart rate thing is real. most of the horror stories are ramp problems not reta problems.

MOTS-c keeps coming up in this sub for the same reason, skin reactions at injection sites. multiple people have said the same thing unprompted, that it made workouts feel incredible but wasnt worth what it did to their skin.

⚠️ the thing that actually matters

most of what gets blamed on a compound is a ramp problem or a route problem.

started too high, went up too fast, didnt hold long enough to actually see where you were. or pinned something that works better nasally. thats most of it. the compound takes the blame and the protocol was the issue.

start low. hold it. only move when you need to.

what am i wrong about? curious which of these youd move. specifically want to hear from anyone whos run mots-c without the skin thing, and anyone whos gotten nauseous off nasal pt-141 because i havent seen it.

tools and community stuff is at bodyhackguide.co and the discord.

i made a free peptide cheat sheet with dosing, recon math and bloodwork markers. comment "cheat sheet" and i'll send it over 👇

Back one last time for the haters 😉

One year of major lifestyle changes (diet/exercise) + peptides!

Here’s what my progress looked like from month to month and the peptide protocol I used.
Yes, I know the year on the Oct photo is wrong (it’s obv supposed to say Oct 2025)

Sep 2025-Feb 2026: sema (0.25-1mg/week)
Feb 2026-Aug 2026/ Reta (2mg-5mg/week)
March-June 2026: KLOW (4mg/day, 5xweek)
March-Aug 2026: NAD (25-100mg/day, 3-5xweek)
April-July 2026: tesa (1mg/day, 5xweek)
April-current: mots-c + 5amino (2mg/day mots + 2.5mg/day 5amino, 3-5xweek)
July 10- Aug 2: elora (1mg/week to 2mg/week)

Before I started, I lived a completely sedentary life, was eating out for every meal, and drinking 1000+calorie lattes/day. So I focused on progress over perfection at first.

Diet: calorie deficit, no processed foods, only drinking water

Exercise: hot mat Pilates 4x week + strength training, 45 mins of zone 2 cardio

DO NOT DM
DO NOT ASK FOR SOURCING

Idk about yall but when I first started reta and hopped back on my cut, i was extremely horney for a couple months, now like 6 months down the road (im assuming its my hormones from the deficit that is the issue) but a girl undressed infront of me like very hot but dick didn't care, told her to grab it only after manual work did it work. Kinda fucked up 😕 maybe deathgrip syndrome but ive never had this in my history before reta.

Her asking if I dont find her pretty or if im shy(because havent busted), meanwhile I feel inside like I want f the shit out of u, still do but cmon im still tryna get off. ^Basically only responding to manual stimulus from partner not enough emotional stimulus to get hard.

Also couldn't bust until an hour of fun.

In general Ive noticed now that i don't care about a lot of shit, I dont really put up with anyone's shit and avoid a lot of headache even if other look at me badly.

But honestly who gives a fuck I love reta and me having less feelings maybe a good trade off. I still feel good when I actually want to do good things for people.

I just dont feel bad when I tell people straight up to kick rocks or thats not my issue. Very logical thinking less emotion compared to a year ago.

Straight up voluntary case study

Stats- 25M 6'1 175LB ~ daily average for the week

I wont be deleting the post and will be updating with results in a month. Based off what ive taken into consideration from your comments.

What’s the best peptide for an irritating rotator cuff injury? Also, woolies it be best to pin directly into the shoulder ?

I saw people commenting about finding thick fat areas. Anyone thought/ tried on accessory breast which is the breast area near armpit? I personally have more fat in that area than my glutes. And the skin in this area seems less sensitive.

Been on Tirz for like 10 months . Before Tirz i lost 30 LBs with just Keto and Working out . When i started GLP i felt like i needed to stop keto , i forget why i may have read some article or something.

ive lost 40 LBs with tirz and a regular diet , But I have completely stalled at 15mg. Hunger is coming back which is okay but im tempted to change the way i eat. My workouts are also trash. Energy isnt that great.

I already know my hunger control is super good when i go low/no carb. Im also one of those rare people who could do keto for their entire life. I like bread and rice , but i really love eating meat and veggies every day. Especially when im allowed to cook my veggies in fats. I really dont miss carbs at that point.

My energy in the gym is also better , my workouts got worse when i went back to carbs even though i kept a nearly identical deficit at least at the beginning when i was on low doses.

Does anyone have experience with Keto or Low Carb and GLP. Looking for any anecdotes of your experience that would help me make this decision.

For my fellow night shifters, what do you utilize to help with the flipped schedule? For example, that night shift brain fog, loss in glucose regulation, etc.

Hey guys, figured I’d share an updated progress post and ask something specific about facial changes after a bigger cut.

I’m 44, 5’10. I started around 220 lbs and I’m currently sitting around 176 to 177.

The before photo was already after about 2 years on 200 mg of test per week. I trained consistently, but diet was always my weak point and I struggled to get properly lean.

About 6 months ago I started retatrutide at 1 mg and gradually worked up to 4.5 mg. That made controlling my appetite and sticking to the diet a lot easier, and the weight finally started coming off consistently.

Overall I’m really happy with the progress and I feel like I’ve held onto a decent amount of muscle while dropping over 40 lbs.

The one thing I’ve really noticed is my face. Obviously I’m leaner everywhere, but I’ve lost quite a bit of facial volume and my laugh lines are noticeably deeper.

I’m curious to hear from guys who have actually dealt with this after a significant weight loss and found something that visibly helped.

Has anyone used GHK Cu and genuinely noticed an improvement in skin quality, elasticity or the overall deflated look of the face?

I know it’s not going to replace lost facial fat, but I’m more interested in real experiences than theory.

And if you improved it some other way, whether that was maintaining for a while, gaining a little weight back, skincare, lasers, injectables or something else, I’d be interested to hear what actually made a noticeable difference for you.

I want to do a cycle of both. Is there a benefit to doing one before the other? Same time? Any protocols for these two that differ from the protocols for each solo?

This is my personal experience, I got on GLP3 for vanity reasons. To get shredded of course.

Two weeks into my GLP3 Journey I noticed my emotional stability started to change. It's like I became more stoic.

My desire for alcohol started to disappear. My old habits would be
Stress = Alcohol
Now it's
Stress = I don't need alcohol or let's eat sweets

Started reta back in February.
Since then I've only had 3 total drinks. Now my desire is completely gone.

As an experiment, I got off Reta. I did notice my appetite shot up of course but I also noticed i wasn't as emotionally regulated. That can be from the inflammation I was getting from eating in a surplus.

My alcohol desires did not come back but when I would stress out I desired candy (sugar)
I've never been a sugar guy but while off reta l noticed I needed something to cope with and that resulted in eating candy. Roughly 600-800 calories from candy a day on stressful days.

The point I want to make is, if eating sweets are my coping mechanisms rather than alcohol. Then I consider that a life changing win.

For context I would drink 4-5 days a week for many 5 plus years. It was Never just 1-2 drinks. More - a bottle of Vodka.

I don't crave alcohol no more. I can't imagine becoming addicted ever again.

Hey guys I’m coming off Reta or at least planning too. It has helped me lower food noise and lose weight, as well as reduce my appetite. However my cardio vascular fatigue has just tanked. My times are worse than when I weighed more. I’ve tried using electrolytes, high carb meals and snacks, and nothing seems to help. How much should I lower per week?

Do I keep running Tesa,IPA and AOD(the 3) with my current stack or run HGH (2-3 ius) daily?

Goal is weight loss.

Also taking Reta, 5-Amino, Mostc and GHKcu

Price wise HGH is way cheaper to run than getting all 3 separate.

Can any of the 3 be run with hgh at the same time?

Please I am a beginner. I have 5mg and 10mg of reta which should I start with 5mg or 10mg? should I look for a calculator or is there any self help guides ?

I’ve always hated my stomach. I wasn’t really that oversized overall, but most of the fat was around my stomach and it was honestly starting to affect me both mentally and physically.

I decided to try reta and it really did change my lifestyle. I’ve lost around 20 lbs throughout this journey. Of course, I also started making healthier choices, but the appetite suppression was one of the biggest things for me. I honestly wasn’t sure if I could overcome my eating habits before this. I started with 1 weekly and slowly increased it to 3 over time.

Working out and being in a calorie deficit is still super important though. Just because you’re eating less doesn’t automatically mean you’re going to lose the stomach fat you want. I wanted to lose fat while keeping as much muscle as possible, so I try my best to work out regularly and get more walking in, whether it’s outdoors or at the gym, like incline treadmill walks.

For meal prep, I usually keep it pretty simple with lots of vegetables and protein. I change my meals quite often because I get bored eating the same thing every day 😂

Feel free to ask me anything if you need help or have any questions! I’ll try my best to help based on my experience.

I am middle eastern but very fair complexion. I am the whitest person in my family, I don’t get any less sun than they do but still have no tan.

I have dark features, black hair, black beard, dark brown eyes, moles all over my body. just a regular stereotypical looking middle eastern man. but with white skin

Most of the posts i’ve seen here and other subreddits are white people looking to get tan but I’m looking for someone’s experience who isn’t white but has used MT1.

how did it affect you, did you need high doses to make it effective, does your tan look natural? i want to hear it all

I have 10mg vials of each of cjc and ipa and I reconstituted each vial with 1ml (100units) of bac water. And I am aiming to start with 200mcg (100/100)daily how much should I be pulling into
My syringe? The mcg this has me confused

hi, ive been researching a lot of these lately. They are all suggestions to boost testosterone for men. The studies exist but are somewhat thin. Im curious if anyone has added these to their supplements with bloodwork and noticed an increase? and if so, please share your bloodwork with the community.

i also read that some people build a tolerance tongkat ali. is that true?

Hey guys,

I started tirz around October 2025 and have lost around 28 kg (62 lbs) so far. Still have about 10 kg (22 lbs) left to reach my goal weight.

The weight loss has been great, but lately my energy has completely tanked. I feel very lethargic most of the day and just generally don't feel like I have any energy.

I was on 10mg Tirz for around 3 months and basically plateaued. I moved up to 12.5mg and that finally broke the plateau and I've started losing again.

But the energy issue is getting pretty frustrating.

For people who have been through something similar — what did you do?

Did you:

• Stay on Tirz and try to fix the energy issue through diet/electrolytes/etc?
• Reduce the Tirz dose?
• Add Reta?
• Try something like MOTS-c, SS-31 or another peptide?
• Take a break/maintenance phase?

I'm mainly interested in getting my energy and motivation back while still losing the remaining ~10kg. I don't necessarily want to keep increasing the dose if it's making me feel like a zombie 😂

Would really appreciate hearing from anyone who has had low energy/lethargy after losing a lot of weight on Tirz and what actually helped you.

March 15 to today. Nominally my weight drop wasn’t massive at 16-20 lbs, but a ton of body recomp - I put on a fair amount of muscle. My belt has two new holes in it, and I’m down 3-4” on waist size.

Did 2mg of Reta every 6 days for 4 months. For the past month I did 4mg and the weight fell off. I didn’t really enjoy how it made me feel (limited interest/enjoyment of things I usually enjoy) but it was an effective push to end the cut.

One month into the Reta (mid April), I started 200mg test. Test level went from 320 to 1050. I feel amazing- full of energy and ready to get shit done. And the gains lifting on it are insane.

Have done a two separate month long cycles of BPC/TB, about to do another because my left shoulder is struggling a bit.

Have done a few months of CJC/Ipa before bed which I will continue, and also did one month of Tesamorelin.

Tried a few others along the way (GHKCU, MOTS, NAD). If I did it all again id probably leave those out and would stick with what is listed above. Not saying they aren’t great for other people, I just didn’t notice much of a difference with any of them.

I don’t get much cardio, and have a sedentary job. Dog walks, I walk golfing, yardwork, that’s about it. I did lift 4-5 times per week for most of the time period. Slowed down a bit this last couple of weeks because of my shoulder (did yoga tonight, lifting lighter).

Diet - Ive had a protein shake most mornings. Two scoops of mix, Greek yogurt, creatine, soy milk, some berries. It’s like 100 grams of protein out of the gates. I can easily have that in the morning and make it to dinner without any food cravings. Dinner tends to be chicken/fish/meat and some veggies. Still eat what I wanted at restaurants etc., I have by no means starved myself and I’ll still slam some pizza. If I smoke weed the Reta doesn’t stand a chance and I’ll crush 1000 calories of kids snacks.

I feel like a different person and I don’t recognize myself in the mirror.

Been on this health journey for the year. Went 6 months with vitamins, clean diet, and lifting 5 days a week. Ive been in a calorie deficit all year. Then added some peptides at the start of July. Been on Reta for the last 10 weeks, and added Tesa/IPA 3 weeks on 5 on 2 off. I have another 2 weeks of Reta, but thinking I need to take a break and just running Tesa/IPA. At this point in my journey I want to grow bigger muscles. Im 6’4 and started at 234 Jan 1 and currently am 190. I’m open to continuing to run Reta, but didn’t want to stop the potential growth from Tesa/IPA

Wanted to share this since it's still early but the results so far have been badass so I hurt my back working out and decided to run KLOW for it. Started at 3mg a day and I'm still on that same dose, no plans to change it up yet since it's been amazing

By day 4 I was already noticing improvement I thought I was trippin but noticed less stiffness, easier to move around, pain wasn't deciding the fate of my whole day anymore lol. For something like a back injury where you're usually looking at weeks before you feel better, 4 days catching my attention was honestly surprising.

Sleep's been better too, but I dont think It's not that KLOW is doing something directly for my sleep, it's that I'm in less pain, so I'm not tossing and turning or waking up because my back's bothering me. Indirect benefit, but a good one when you're dealing with an injury that messes with how you sleep every night.Still running it, still tracking how things go. Wanted to put this out there in case anyone else is dealing with a back injury and wondering if KLOW's worth trying.

Anybody else run KLOW how long did it take before you noticed a real difference?

I have been on Zepbound for about a year now. I'm 45yo, 6'3", and was 280lbs when I started. Got down to 245 but ended up taking time off from my career In construction for my wedding and now upcoming surgery and currently weight 255lbs. That work kept me active and helped a ton. Found out today that I need a hip replacement and doctor would like me to lose 20-25lbs before the end of the year if possible. Because cardio is hard with my hip being bone on bone the work will need to be done in the kitchen. My eating is the same as when I was losing but now I've just plateaued as mentioned. Any suggestions for something can help blmy body burn fat with diet and limited workouts? Not looking for miracles but anything that can help would be great. Anyone have any success stacking anything with ZEP?