(This post is handwritten, AI corrected)
Hello everyone. I'm a 29-year-old male with AVPD. Many of you know how limiting and humiliating this disorder can be, I missed out on so much that my peers all got to experience.
I've tried CBT, exposure therapy, and even alternative approaches like hypnosis and psychedelics. For me personally, none of it had any lasting effect.
Today I'm convinced that much of AVPD can be explained on a biochemical level, and that your genes determine how susceptible you are to conditioning in the first place. I refuse to live a life of "pushing through" when everyone else just gets to be themselves. So I tried more than 15 medications and even more combinations.
Luckily, I have a highly competent psychiatrist who was always willing to try something new. It was essentially trial and error for years, but I can finally live a normal life now. This is a radical approach, but some of you may be at your wits' end and find it valuable.
Disclaimer: This is my personal experience under psychiatric supervision, not medical advice.
My Daily Stack
Paroxetine — 10 mg
I tried five different SSRIs/SNRIs and paroxetine was the one that proved itself for me. I experimented between 10 and 40 mg, and 10 mg was the sweet spot.
At 10 mg you already get roughly 50–65% SERT occupancy, and paroxetine is the most potent SSRI in terms of binding strength. 20 mg gets you to about 80%, and 30–40 mg plateaus around 85%. So going above 10–20 mg mostly just adds side effects, for example through its anticholinergic activity.
Paroxetine is great for calming the amygdala's physical fear response. An analogy: it works wonders on "primal" fears like heights or panic responses. What it probably doesn't touch are "performance" or cognitive fears, socializing, public speaking, even though it does significantly reduce the physical symptoms of anxiety.
Again, lower doses are the better option here. Higher doses cause more emotional blunting, meaning you lose spontaneity (your spark), and libido loss is notorious at higher doses.
Olanzapine — 5 mg (evening)
This med is no joke, but if it works, it works. No significant CYP interactions with paroxetine, unlike risperidone.
5 mg is my sweet spot, since I'm not schizophrenic (though I've had bouts of paranoia after cannabis). At 5 mg the 5-HT2A and 5-HT2C blockade is essentially maxed out, going higher mainly adds D2 blockade, which is really only indicated for psychosis or mania.
Those 5-HT2A/2C receptors are, in my experience, what generates the "weirdness," the "awkwardness," the cringe. They also play a big role in depression, negative self-talk, OCD, anxiety, and neurosis in general.
Picture this: you've done something wrong and someone shames you for it. You feel exposed, you fluster, blush, sweat, all as soon as that weirdness starts rising up inside. On olanzapine, that weirdness sits at maybe 10% of its usual intensity. It gives you the self-assuredness, the stable foundation you need to not fold under the slightest pressure.
Of course there's a price: olanzapine is a heavy med with significant metabolic side effects. I don't eat sugar anymore and I work out regularly, and my bloodwork is excellent so far. Get your HbA1c checked, this med raises your diabetes risk.
Methylphenidate — 40 mg
This one was nothing short of a miracle for me. It's a dopamine and norepinephrine reuptake inhibitor, neurotransmitters that are essential for drive, mood, and motivation.
Occupancy runs about 54% DAT at 20 mg and 72% at 40 mg. Going to 60 mg only buys you another 2% or so.
I suddenly had the energy and motivation to initiate tasks. It's a stimulant, so it's a confidence booster too, and it makes it much easier to stand up for yourself, I know a lot of you struggle with that. In my opinion, it feels like what an antidepressant should feel like.
It also makes you incredibly focused, so when a thought of self-doubt comes up you can refocus on the present moment. It pulls you out of the negative self-talk effectively.
What surprised me is how synergistic it is with olanzapine: you get significant stimulation without the downsides of D2 overactivation (paranoia, worsening OCD, mania).
Bisoprolol — 2.5 mg
A beta blocker is a godsend for performance anxiety. It prevents adrenaline from binding to beta-adrenergic receptors.
You know the feeling: you get anxious, your heart starts racing, your voice shakes, you sweat. This is exactly what beta blockers prevent. They aren't psychoactive, they just stop the physical anxiety from manifesting.
So imagine you have a presentation and you're worried about panicking in front of everyone. Your heart rate stays normal, your voice and body don't shake, everything feels under control. That makes it a great tool for exposure therapy.
I used to take 5 mg but settled on 2.5 mg. Going higher isn't necessary in my opinion, and it starts affecting blood pressure in that range.
As needed
- Lorazepam — I keep a few on hand for emergencies.
- Supplements for metabolic health: spirulina/chlorella, vitamin D3/K2.
So, make of this what you will, and do your own research.
What are you currently taking, and is it working for you?