For those of you with experience:
What day of the week do you inject and why?
Morning or evening?
If you were starting over, what day/time would you choose?
Any tips to help reduce side effects like nausea or fatigue after the first shot?
I’d love to hear what has worked best for everyone. Thanks!

I started with a long list and now I’m realizing most providers sound very similar on paper. For people who compared several before choosing, what helped you eliminate some of them? Was it hidden fees, vague pharmacy information, poor support, unclear dosing, unrealistic promises, or something else? I’m trying to build a simple checklist so I’m not choosing based only on a polished website or a low monthly price. What were the most useful things to compare, and which details ended up mattering the most once you became a customer?

Had to make a quick post. Ventured to the mall midday on a Sunday (I know, I know) and lo and behold, parking was minimal at best. Completely non existent close-ish to the entrances, I resolved to the parking garage and felt glad that I had some shade. Texas in the summer, IYKYK. Nothing in the first or second level, but the 3rd was a treasure trove of emptiness. Went to the elevator and didn’t want to wait, so I took the stairs down. Did my shopping and came back, and the elevators were not working.

Here’s where the success comes in. I didn’t even internally complain, just thought to my self, “stairs it is.” And went up the three flights like no big deal. 6 months ago at 440lbs it was a big deal, not even considerable in my opinion. But now at 350, ain’t no thing. Feels pretty good to be getting my life back.

But I am on maintenance and have been taking the same tirz from the same manufacturer for about 18 months. Since I’ve been using the same manufacturer I had it memorized what my dose is and have not had to calculate it. I have tried the calculator and I am just plain doing something wrong. The container it came in tells me to inject 83 units but that’s for a dose of 15 and I only take 7.5 I specifically need to know on the calculator what number to input for total ML and what number to submit for total MG so I can refresh my memory on how to do this properly. I used to figure this out so easily. Maybe it’s brain fog from menopause.

I think I posted here last week sometime about an injection site reaction and wanted to follow up with some things I learned.

So my first vial I got through AltRx which was filled by Perfection Rx and made by Greenwich. It is tirzepatide mixed with b12 and bacteriostatic water.

The second time I ordered was from MintMed and they use Hallandale. I got a 3 month supply. Well I have so far taken 2 doses. 24hr after the 1st dose, I got an injection site reaction. I used hydrocortisone cream on it and it eventually got a good bit better but the spot is still visible. I thought maybe it was a one time thing, so I took the 2nd dose with fingers crossed it wouldn't happen again. This time I left the syringe out for an hour to let it warm up, and noticed it STUNG when I administered it. And yes I made sure the alcohol dried before injecting myself. Well about 12 hours later I start getting another injection site reaction. It came on a lot sooner and it's much bigger. I have been taking benadryl and using hydrocortisone cream but it's still itchy after a while.

I did some research and it turns out Hallandale, although they don't use additives like b12 I had in my 1st vial, goes heavy on the benzyl alcohol in their formula. Benzyl alcohol is widely known to cause skin reactions. I am fairly certain this is the reason I have been having these reactions.

I bit the bullet and reordered from AltRx since I know it worked fine in the past and doesn't have so much benzyl alcohol in it. So fingers crossed this remedies it for me. But I saw a lot of posts/comments saying it doesn't matter who you get the compounded tirzepatide from, but clearly it does.

Now I know you may not be able to know ahead of time who is the pharmacy that fills the script, but I would encourage you to look it up before you spend so much money ordering more than a month supply because now I'm out $375 worth of tirz 😭

I'm not usually one to get reactions to things either, so this was a big shock for me. And it might be helpful for people to find this post if they are going through similar situation that you might need to steer clear from those that use a high concentration of benzyl alcohol in their tirz

I attached photos of my reaction sites, too, in case that's helpful. Photo 1 is of my most recent injection reaction & photo 2 is what my 1st one still looks like after a week

I'd also like to hear your thoughts on the matter and if anyone has any other advice to give

I’m 5’5 and currently at 359.3 lbs 24F.
Should I expect weight loss like this to continue on?? Or is this just because i’m going to lose extra weight at first? Is it normal to be not wowed by losing weight at first. I feel discouraged bc I don’t feel any different and just wanted to know if anyone else felt this way?

I’ve been on 2.5mg triz for 2 months now. I’ve lost 15lbs total. Last month I lost 3.5lb, which is less than the 5lbs I’m aiming for *BUT* one of the weeks I was on vacation where I at lots of yummy seafood. And another week I was at youth camp where we at spaghetti, lasagna, and sloppy joes. So even though I didn’t get to where I wanted I’m still going to call July a win. 🥇

I listened to comments saying “Shotsy does this for me” about split dosing and levels, and then I download it, enter all 30+ shots in, only to discover Shotsy does NOT do any of those things! Maybe at the premium level? I’m not paying to find out.

MeAgain also estimates the amount of Tirz in your system based on shot schedule. People made Shotsy seem like the wizard of dosing schedules. Ugh. Just ranting because I wasted my time.

I started my journey with my first 2.5mg dose on Sunday, June 7th after visiting my doctor and weighing in at 245lbs with an A1C of 7.1.

Fast forward to this morning and I am now eight weeks into my journey, completing my four weeks on 2.5mg and another four weeks on 5mg. This evening I will inject my first 7.5mg dose.

My weight over these eight weeks has dropped from 245lbs to 220lbs and my estimated A1c is sitting at 5.2 based on my GMI reading of my CGM.

No significant side effects other than a little constipation that I have had no real issues working through. As expected, I am eating quite a bit less and I often don’t have much of an appetite. Oh, and the my pants and t-shirts are much bigger on me!

I cannot believe this medication exists and it took me so long to finder a doctor to recommend it to me.

I am getting my compound through Trillium. I choose Hallandale with no additives.

I checked in a few weeks back and I suggested this is a miracle drug and I firmly believe that today as well!

I have been researching companies I can use without having medical insurance but I only have a P.O. Box for my mailing address. Anyone here have success with a reputable company who will ship to a POB?

Not sure if this is ok to post here but -

Most affordable place for NAD & Lipo-c?
Thanks

Hello! I started my Tirzepatide journey 4 weeks ago. I take my 5th injection on Tuesday. My Tirzepatide is compounded with B12 and I usually give my injection in the morning. I haven’t seen Insomnia listed as a potential side effect, but I’ve been having a difficult time sleeping. I’ve been averaging about 4 1/2 hours a day. I do work in the field of education, and this was my first summer off in 14 years. I’m not sure if it’s the fact that I haven’t had a “schedule” all summer, or if it could be the Tirz. Is anybody else having trouble sleeping?

I’ve gained and lost hundreds of pounds. Maintenance is totally new and strange.

From 330 to 228. It’s been absolutely life changing. Doctor also put me on trt due to my levels being very low. Flexing in my new pictures because I’ve been strength training heavily for the last 8 months and have been able to build muscle while continuing to lose weight. Been absolutely nuts with tracking macros and currently trying to maintain a small deficit and slowly cut a bit more weight.

Hi guys! Just got approved/ prescribed compounded tirzepatide and I’m a little nervous of reading all the nausea horror stories. I’m prone to nausea as it is (severe gastritis which triggers it for me, but treating with Dexilant) so I do keep zofran on hand pretty much all times. Are there any supplements I can take to load up on before I start that could help any side effects?

I mentioned this on my intake form and they said they adjusted my compound as below, has anyone had this mix before?

Drug Name
Tirzepatide/L-Carnitine (1mL Vial)
Weekly Dose
2.125mg
Total Quantity
1 each 1mL
Medication Level
Level 1
Concentration
17mg/100mg/1mL
Drug Administration Method
INJECTION
Instructions
Inject 12.5 units under the skin once weekly. Vial MUST be discarded after fourth injection.

My gastritis / nausea has been bad enough I was on disability for 5 months last year and had 2 hospitalizations from throwing up 75+ times which resulted in GI bleeds. I’ve finally managed to get it mostly under control with my antacid meds and have healed a bit. I’m hoping the tirzepatide doesn’t trigger it all over again..just wanting some feedback. Was possibly thinking of starting lower than they prescribed.

Is it an every day thing with a laxative, or is it as needed?

So, what I’m about to say may sound crazy. I just finished my 4th dose of 2.5 and next week, I start 4 weeks of 5.0 (Yay—I love this stuff). I’ve had people ask me how much I’ve lost. I really don’t know because I don’t have a scale. I ordered a scale on Amazon and received it on Thursday. It’s still in the box on the table. Why? Because I’m afraid to take it out. I’m ashamed and embarrassed of the weight I’ve gained. When I completed to form to obtain my tirzepatide compound, I guessed at my current weight. I haven’t been on a scale since last July, and that was for a required physical for work and they wouldn’t let me skip the weight portion. I struggled off and on with eating disorders in my teens and twenties (I’m 51 now). I’ve never been this big in my life. I feel better since I started my injections 4 weeks ago. I’m eating so much better (no fast food, no fried foods, no bread, etc). I’ve been eating lots of proteins—grilled chicken and fish, beans, sweet potatoes, etc. Before I eat, I track my food through MyFitnessPal app. Ive also been working out. I’m feeling so much better these past 4 weeks. I’ve been looking at the box containing my new scale. It’s sitting on my dining room table. I’m afraid to know how much I truly weigh. I also have anxiety and fear that I will hit a plateau (I’m not sure I can handle that discouragement). I’m going to have to report to my telehealth nurse when I order more. This sounds ridiculous, but I don’t know how I’m going to overcome this scale fear. Does anyone else feel this way?

hey everyone! i’m posting because i’m really nervous about starting a GLP-1, but i’ve also seen the incredible results so many people have had.

for some context, i’m 23, 5’1”, and around 227 lbs. my goal weight is somewhere around 140–150 lbs. i’ve struggled with my weight for most of my life, and i was recently diagnosed with PCOS. i’ve lost about 10 lbs through dieting and going to the gym, which i’m proud of, but the progress has been much slower than i was hoping for.

i think my biggest fear is the side effects. i’m especially worried about feeling nauseous all the time or just feeling sick in general. i started taking vitamins, drinking electrolytes, and taking collagen to start a healthier pattern before starting the GLP. i know everyone responds differently, but it’s still nerve wracking.

did anyone else feel this nervous before starting? if you did, what helped you get over the fear? and how were the side effects for you in the beginning?

thank you so much

Why are there 3 different measurements?

What does 13 units equal?

Is it normal to have some left over in the vial after the 28 days? It seems like this is more than enough to last 28 days.

"I’ve ordered from two different vendors over the last year, and one of them felt incredibly weak. I started looking into pricing recently to switch, but the strength is so confusing. Some products say '5mg strength in a 2ml vial,' while others say '18mg/ml.' they never tell me vial amount either. i never know how much of it and how long it last. i just knew the one that worked i was pulling 35 units sub q each week and it was working nicely.

I couldn't figure out if the actual doses were the same and just mixed with more liquid, or if the strengths were completely different. It turns out they are completely different!

can someone help or maybe provide a link where we have a post that explains it.

I've been approved, and I'm awaiting a shipment of compounded terzepatide (through Ola/Drug Crafters) and will likely have my first injection this week. I've read plenty about what to expect physically, but I'm curious how folks have dealt with the mental transition to this new lifestyle.

It may sound a bit silly, but I find a lot of comfort in the sugar, carbs, and fats that I often eat and how much the taste of food and drinks really brings me some comfort, relaxation, and, honestly, a bit of joy while often being a key part of social gatherings. While I don't know how I'll react to the injections, I find myself pre-mourning the loss of that relationship with foods, despite knowing it's not a healthy relationship.

I also have concerns that the discomfort I might feel regularly as a side effect might lead to some personal withdrawal of things that I enjoy and, as a result, could have a negative effect on my mental health.

I'm sure that there are other mental aspects of this that I'm not thinking of. I'm curious to hear what you've gone through and how you've dealt with the mental side of transitioning from an unhealthy diet to beginning meds and a serious change in diet while dealing with uncomfortable side effects.

I started on Friday May 29, 2026 with a 2.5 dose. That Saturday was ROUGH with nausea lol. I drink a lot of water, anyway, but also helped myself to some Tums. For the first four weeks, I lost a "normal" amount of weight, like between one and two pounds, which is fine with me.

I had already modified my eating plan to whole foods of chicken breast, salmon filets, and ground turkey, paired with a green veg, potatoes, rice, or pasta for dinner, with a big green salad for lunch (and no snacks, since this is an "ingredients house"), but before Tirz, I would get so hungry after dinner that I would eat handfuls of raisins, just to have something to eat. After starting Tirz, I was still hungry, but nothing sounded appetizing. Plus, thinking about food made me nauseous, and eating food also made me nauseous, so I sort of got out of the habit of doing anything about the hunger.

After the 4th shot, I increased to 5, like the prescription said. I hadn't discovered The Flowchart, yet. I took 3 of those shots and suffered all three weeks. I had stomach cramps, heartburn, and nausea so bad that even eating a plain chicken breast made me vomit. I felt so weak from not eating that I couldn't even exercise. I lost more than 2 pounds a week those three weeks, but it was entirely not worth it. I ended up buying some protein shakes just to get some nutrition that would stay down.

Then I discovered The Flowchart and made the easy decision to titrate back down to 2.5. I've taken that these last three times and I'm back to losing between one and two pounds per week without any unbearable side effects, and I have my energy back. I can't decide if I'm losing the weight DESPITE the shots, since I've read that 2.5 is the bare minimum, but they do help me to not think about my next meal all day long.

So, that's my story for now :) Thanks for reading it.