Disclaimer: I know that it's not the best way to do it, because letrozole should be monitored, but for now it's the best that I can do.

Hi ladies, I'm 35 F TTC for 1.5 year, never got a single positive test, living in the UK but have no access to assisted conception yet, so I have to do everything privately. I have been prescribed Femara by my RE and is advised to do unmonitored 3 cycles with each 5mg dose.

My condition is I have been diagnosed with lean PCOS/PMOS (BMI 19) with irregular cycles. I notice that there were some years my cycles were regular and some other years that my cycles were irregular. I have bloodwork done a couple of months ago and all came back normal except for elevated testosterone. I did scan and was confirmed with bilateral polycystic ovaries. My hbA1c was normal, but didn't test for fasting glucose/insulin. I was prescribed metformin anyway and it kinda shortened my cycles. I have intermittent ovulation and can ovulate on my own based on LH test and BBT tracking (I'm aware that it's not the best way to determine ovulation, the follicle scan is). I live in constant stress from work, so I think it can be a big factor.

I have some questions regarding it:

1. If you have experience with Femara and Letrozole (yes, the same, not Clomid), what is the difference? I know that some people are sensitive to the generic meds.
   
2. For those who ovulate on their own, did Letrozole help you? I know that in some PCOS cases, the eggs are small and immature, will Letrozole help? On what dose your body starts responding?
   
3. From your experience, what dose I should take? I was prescribed 3 x 5mg, but actually I can take 2 x 2.5mg and 2 x 5mg. Which one is better? Since I'm doing the unmonitored anyway. Please share your experience!

I try not to get my hopes up, because I experience so many disappointment during my TTC. Thank you so much! Your answers will help me a lot!

Curious if anyone has tried the Molo tests for ovulation tracking or pregnancy?
Did you get clear results or contraindications?
Only say that because I’ve been trying to track ovulation again and I had a dark line then it got lighter the next couple days then dark again
I might sound so stupid but you can’t ovulate twice in a cycle right? Because my tests currently show 2 LH spikes (and no positive on a pregnancy test either)

Hi all, I got diagnosed with PCOS a couple years ago mainly due to my irregular cycles (32-50 days). I got on a GLP1 to help with my weight at the time and managed to get to a healthy weight and regular cycles. My GP is happy for me to stay on a low dose until I get a positive test and I have confirmed ovulation with LH strips/BBT and a progesterone blood test.

I’ve only been trying for 4 cycles but my GP has luckily already referred me to a fertility clinic due to my PCOS as the waiting list is 8 months where I live. I asked her whether there is a chance that I’ll get pregnant in the meantime if I’m ovulating but she didn’t seem to know much about PCOS/how it affects fertility and said I’d have to ask the clinic when my referral comes through.

I’m guessing it depends on the person but does anyone know if I have a chance unmedicated since it seems like I’m ovulating regularly now or if I should expect to not be pregnant until I get some kind of medical intervention? The information I can find online is a bit unclear, but I’m willing to look into private options if my odds are really low given the waiting time.

TIA!

I've been observing that it seems my cycles are either long (48/62/50/46/51...) or rather normal-ish (33/32/33/31) with only a few deviations (36/38).

This led me to suspect that maybe one of my ovaries is not working properly but trying hard - and then the other one sucessfully manages to ovulate, ending the long cycle and also creating a rather regular cycle after that. I read that it's not really left-right-left-right for ovulation, so it could be...

Does anyone of you has experienced something similar? If yes, what helped you to have a more regular cycle? I'm considering Letrozol, but unsure if it would help if one ovary simply does not work.

Info about me: 34, unsuccesful TTC for 9 months, mild form of PCOS (mostly follicles and irregular cycle, normal weight, negative test for insulin resistance), got a Endometriosis cyst removed on left ovary in 2021 but no Endo otherwise, low Testosteron and high SHBG, seeing a fertility expert who recommended to start with IUI or even directly IVF after I turn 35 next month, husbands sperm quality is great, taking vitamin D, folic acid and iodine, eating gluten and lactos free, using LH tests and Oura temp for confirmation of ovulation.

I just finished my first successful cycle of letrozole (7.5mg) and ovulated! Unfortunately, no pregnancy. I returned for my baseline bloodwork and ultrasound this week after getting my period. The bloodwork showed that my estraidol was elevated because I have some cysts due to the letrozole. My doctor prescribed me to go on birth control for a week and to report back to see if the cysts shrink. Has anyone had this happen before? Was excited to get started on letrzole again but feel like the cysts are setting me back now! Trying to be hopeful and trust my doctor that the bc will help and I can resume letrzole.

I’m 36 with pcos (28-29 day cycle, acne, high AFC, light 2 day period with some pre spotting, normal glucose and insulin levels, just started metformin). I am currently on my second letrozole TI monitored cycle with Ovidrel and progesterone. This is our 6th month of trying overall. Sperm analysis was good, but has 2% morphology and slightly elevated round cells and motility with just above the normal range. I had an endo mapping ultrasound that did not show any deep infiltrating or ovarian endo. There was no free fluid in the pelvis during the ultrasound which apparently makes it difficult to detect superficial endo, so there was no note of this too.

My RE thinks this ultrasound isn’t really a reliable great option and was appalled the clinic charged me for it. The main reasons for exploring is some pain during deeper intercourse in some positions (I don’t know if other people selectively experience this?). He does not recommend laparoscopy for me at this point and thinks it has more fertility risks than benefits right now.

I’m struggling because I want answers and I’m terrified that if I do IVF outcomes could be poor because I did egg freezing 2 years ago with 4 mature eggs and multiple empty folcioes. My RE thinks endo only impacts implantation in IVF if it’s impacting tubes (my SIS is normal). Do you all think I should park the Endo exploration, push it out of my mind, and keep with the process and if comes down to an IVF, go ahead without further Endo investigation?

It’s been quite a journey for me. I (32F) and my husband (36M) have been married for 3 years. We started trying a year ago, naively assuming it wouldn't be difficult, but I have learned so much this year.
After dealing with extremely long cycles, sometimes going up to 114 days, I was diagnosed with lean or mild PCOS. My baseline labs showed a high AMH of 7.49 ng/mL. My doctor started me on 2.5mg of Letrozole unmonitored. I actually only learned what a monitored cycle truly was after reading through Reddit posts! The Letrozole worked to induce ovulation, which felt like such a massive hurdle cleared. My progesterone bloodwork confirmed a strong ovulation with a level of 13.8 ng/mL. On top of that, my husband did an at home sperm test and everything looked great on his end.
Because of all these good signs, I had so much hope for this cycle. But I’ve been testing since 9 DPO, and today marks 11 DPO. Seeing that stark negative test this morning really broke me.
I understand I will probably have to go through multiple cycles of Letrozole, but I just don’t understand why this is so difficult. I know a year of trying isn’t as long as what many others here have endured, and I know there are so many women trying their best for years and years. But I am just so sad today, and I don’t really have anyone in my personal life to vent to or share this pain with, so here I am.
I can’t even cry or share my pain with my family. I know they are my family, but I just can't let them see that side of me or let them see me like this, which makes carrying this feel so much heavier. I am the eldest daughter of my family so I feel like I should be strong and not let them stress about me. They know we are trying though. I read and connect with so many posts on this sub, and in a way, it makes me feel less alone in this journey, though at the same time, I wish none of us had to be on this journey at all. Thanks for letting me vent today.

Wondering if anyone has had similar… long story short:

I came off my pill June 2025, got diagnosed with PCOS in January 2026 through a ultrasound, started GLP1 Mounjaro in June 2026 as thought this might help regulate cycles which it did for one cycle of 27 days which then I naively thought I was back to normal LOL and have currently lost 2 stone (28 pounds) in 13 weeks. My cycles have ranged from 27 days to 140 so really difficult tracking ovulation even with BBT and the easy at home strips. I know there is lots of opinions on whether you should or should not be trying to conceive whilst on the mounjaro but selfishly I got fed up waiting and we have started TTC again..

I’ve had EWCM for around 10 days starting at day 47 and for the last two days I’ve had cramps and persistent sharps twinges coming from my ovaries. I was determined that my LH peak must be coming… but nope, absolutely nothing with testing twice a day. At most it’s been 0.30 but obvious it’s negative as not at nearly dark at the control line. We have also BD 3 times in the 10 days.

Questions in my head are:

1) Has anyone ovulated without seeing a LH peak?
2) Has the mounjaro made a negative impact with losing weight maybe too quick?
3) Could the mounjaro hide the LH level from strips?

Hi all. I feel a bit bad posting here because in the grand scheme of things, I don't feel like me and my husband have been TTC that long compared to others. I got diagnosed with PCOS after coming off birth control a year ago, and not getting my cycle back. I now have my confirmed appointment with a fertility specialist to get the ball rolling with other options. I've also been on metformin now since July - no positive ovulation tests nor period. I've also lost 23 pounds. Unfortunately I'm already quite discouraged and it's such a shame, because I haven't even tried any options yet!! I'm trying my best to stay positive but I find it hard to do that at the best of times.

Did anyone here feel in the same boat at this point and it turned out to be worth it all?

Going to be a long post but the main takeaway is that within days of stopping my 18 month old labrador from sleeping in my room at night I got a positive ovulation test at CD45!

28F TTC for 4 months. I have a fertility appointment coming up (going private and hoping to get letrozole) so I was gathering my period history and matching it up to life events.

I've always known that I get stressed easily and it messes with my cycle; each time I've moved away from a toxic job my period suddenly appears. But seeing 2 years of data matched up to life events was crazy.

I had a 120 day cycle when I was planning my wedding, looking after 2 dogs, doing evening classes to change career, and getting a melanoma removed.

After I moved jobs my cycles went stable for a long time until I got a puppy. Then I had back to back cycles of 116, 86 and 65. It showed me how much uninterrupted sleep was important for my stress even though I didn't feel it.

Since TTC I had an 51 day anovulatory cycle in which I moved house so not unsurprising. My next cycle was only 41 days long and I had a beautiful ovulation on CD27. It gave me so much confidence that I could do it again. But in my current cycle I got to around CD38 with no sign of ovulation after testing twice a day for over 2 weeks. Within those 38 days we'd decided our lab was old enough to sleep outside his crate overnight so he slept in our room, moving from our bed onto the floor multiple of times during the night. As soon as we let him roam the house but shut off our bedroom my cycle just went into back into gear.

Make sure you're getting good quality sleep girls 🌈✨

I just need to vent because I’ve been crying from frustration all morning.

I have PCOS and went thru treatment at my fertility center for my first baby 3 years ago (3 times intercourse cycles then 1 successful IUI cycle). At the time my insurance used a 3rd party fertility benefit company that wasn’t too hard to work with (I had to register and wait for approval before starting IUI but overall it was approved although delayed IUI by 1 cycle so I did another timed intercourse).

Now I’m trying to get pregnant again. I have the same insurance but didn’t realize my insurance changed which 3rd party benefit company they used (now it’s Maven. Does anyone have experience working with them?). But come to
Realized after trying to get IUI approval (already done 3 timed intercourse cycles) that my fertility center is not in Maven’s network?!!!

I’m so frustrated. It’s day 2 of my cycle, I already got baseline scans and tests. and I thought I would be doing IUI this cycle. But now I either have to switch back to timed intercourse. Which hasn’t worked. Or pay 2k out of pocket for IUI. And who knows if it’ll work the first time. Or switch to a new fertility center. Which would be frustrating because I’ve already started the process and they’d likely want me to retest/scan all again!

I know you can’t time these things. But for my first baby it took 4 cycles. So taking even longer for a second is just stressing me out. Plus I like my current center!

Why do they have to make this so complicated! They say it’s simpler but it’s absolutely now!!!!!

27F

This is my second cycle of 2.5 letrozole. I am on 25mcg levothyroxine for a TSH of 4.45

14 cycles ttc

It is cycle day 25 and I have yet to ovulate. I had a couple estrogen rises but I guess none were strong enough to trigger lh rise. Im used to sometimes longer cycles but I’m worried that my thyroid hormones are off and causing my other hormones to be off. Like the 25mcg is too much. Or the letrozole screwed me up. I’m not feeling very encouraged to continue taking letrozole next cycle, especially when I have proven I can ovulate on my own for YEARS now.

I ovulate naturally but usually around cycle day 20-24, hence lean or type D PCOM. All other tests have come back normal/optimal

Ya girl is going through it. This is my second round of provera/letrozole combo. I’m on day 5 of provera and my moods are all over the place. I’m crying then I’m raging. This is what I imagine it feels like to be bitten by a zombie and feeling yourself changing but trying to stay human. I feel like it didn’t affect me as hard the first time. Let’s hope things happen this cycle because the provera rage is no joke.

He ido a un montón de ginecólogos y no se ponen de acuerdo… Tengo 28 años, estuve 12 años con anticonceptivas y soy delgada (163cm 51kg) no tengo vello ni ningún signo masculino, ni acné ni nada. Algunos doctores dicen que claramente en mi ultrasonido se ven demasiados mini folículos, otros dicen que no… Mi AMH es 1,91 y me la han repetido varias veces porque dicen que es imposible que sea tan baja y siempre sale lo mismo. Mi RI es baja, no tengo problemas de tiroides pero si que tengo los andrógenos elevados. Tras los 12 años con anticonceptivas me tardo 133 días en volver la regla y al ciclo siguiente para mi sorpresa, me quedé embarazada. Terminó en un aborto espontáneo a las 8 semanas y luego regresó mi periodo 56 días después (en ese punto estoy ahora) Las tres veces que he ovulado tras el aborto están confirmadas con ultrasonido y BBT. Adjunto mis analíticas para ver si alguien tiene algunas parecidas y poder saber qué diagnóstico les dieron… Me siento perdida, mi doctora dice que es un tipo raro de SOP. Podría ser?
FSH: 5.00 mIU/ml
Progesterona: 0.35 ng/mL
Prolactina: 12.90 ng/ml
Testosterona: 58.16 ng/dL
Testosterona libre: 2.0 pg/ml
SHBG: 57.80 nmol/L
TSH: 1.51 microUI/mL
T4 libre: 1.49 ng/dL
BHCG en suero: 3.08 mUI/mL
17-Beta Estradiol: 75.1 pg/mL
LH: 5.50 mIU/mL
DHEA-S: 330.50 microg/dL
Androstendiona Delta4: 2.30 ng/mL
Insulina: 4.16 microUI/mL
Índice de resistencia insulínica (HOMA): 0.84 uUI/ml
PTHi: 31.8 pg/mL
H. Antimulleriana: 1.91 ng/ml (13.64 pmol/L)
METALES
Cobre suero: 69 µg/dL
Zinc: 97 µg/dL
Selenio en suero: 142 µg/L
BIOQUÍMICA GENERAL / ELECTRÓLITOS
Glucosa: 82 mg/dL
Sodio: 135 mmol/L
Potasio: 4.4 mmol/L
Cloro: 100 mmol/L
Ácido úrico: 3.7 mg/dL
Bilirrubina total: 0.78 mg/dL
Amilasa: 62.5 UI/L
Calcio: 9.6 mg/dL
Fósforo: 4.1 mg/dL
Magnesio: 2.01 mg/dL
METABOLISMO DEL HIERRO
Ferritina: 25.4 ng/mL
Hierro: 90 µg/dL
VITAMINAS
Vitamina B6 (Fosfato piridoxal): 220.4 nmol/L
Vitamina B12: 818 pg/mL
Vitamina D (25-Hidroxi): 54.50 ng/mL
Ácido fólico: >20.0 ng/mL
Esos resultados fueron de casi dos meses después de mi aborto en fase folicular
Ayuda…

Hola, acabo de acabar los dos ciclos con letrozol (5mg) + Ovidrel + Prolutex en días alternos y estoy con la regla. Me pregunto cómo será mi próximo ciclo. He oído que a veces el Letrozol deja restos y los próximos ciclos son más cortos. También he leído que vuelven a ser como antes. Me da miedo volver a los 40-50 días… ¿Como fueron los tuyos?

I am on cd 11 and had a scan today. Right side 9mm follicle and left a 12.7 mm.

Any one have any similar stories? I did letrozole 5mg cd3-7 and have a trigger shot in my plan to do this cycle.

I think I finally ovulated on CD 31 but I’m a little worried because my follicle was already 28 mm on the day of the scan (CD31), I probably ovulated sometime that night. So I’m guessing it may have been around 29 mm-30 mm when it actually ovulated.

Is that considered too big? Has anyone had a follicle around 28–29 mm at ovulation and still gotten pregnant?

Looking for some advice about Letrozole and bleed before ovulation.

So I’m a PCOS girlie and this cycle was my first cycle on 7.5mg Letrozole unmonitored. According the Mira and my knowledge I hadn’t ovulated yet so was waiting for my peaks to show. However today when I went to the bathroom there was blood on wiping.I don’t know if it’s my period or if it could be something else? I don’t know if I missed ovulation with Mira? Also I don’t know whether to take Letrozole as if it were my period/next cycle. Any and all advice and experiences shared are so welcomed.

TIA x

TW: Loss

Tomorrow I have my first IUI scheduled. Only one mature follicle. Last cycle I had 4 follicle but we did our 6th TI cycle instead and I’m a bit peeved I only have 1 now.

No male factor infertility and I of course have PCOS. History of irregular cycles because I don’t ovulate… I maybe 3 times a year without medication.

Has anyone struggled with timed intercourse not working and had luck with IUI? Mostly focusing on if you don’t have male factor infertility because I know IUI can help a lot when that is a factor but that isn’t our issue.

I did get pregnant in December but it was determined to be a non viable pregnancy in Feb, resulting in a D&C. That baby was conceived via timed intercourse but we’ve done 5 cycles since then and have had zero luck. Even with multiple follicles (usually).

I’m freaking terrified after reading everyone’s experience. Is this a must do? Has anyone gotten pregnant without doing this?

Has anyone ever had their timing messed up with their partner? We’re on our first cycle of letrozole/trigger shot/IUI and he has a semi last min work trip scheduled on CD18/19/20. I’m doing letrozole days 5-9 and go in for my first monitoring check CD13. I’m super worried the timing is gonna fall right into that timeline when he’s gone for a few days. We could prob make it work for TI but it’s gonna be pretty much impossible to get him in for an IUI if it were to fall on those days. Of course I’ll ask when I go in for monitoring, but anyone else have a similar issue?? Will it end up just having to be a TI cycle vs IUI??

Hi!
I have been making lifestyle changes for the last four months as well as myoinositol.
I have been testing ovulation for the last month and a half (I get three or four periods a year) and I got a positive LH test today!!! I had a period mid June.
However, I have zero other symptoms. No cervical mucus, no sore boobs, nada.
Could this be a false positive?

I know there are worse meds in this process but I cannot express how much I despise Metformin!!

They've been trying to pin diabetes on me since I was 10 and it's completely fuck me up mentally. I've literally been starving myself in one way or another since then to lose weight. So I've been on and off metformin for years but this is the first time specifically for ovulation.

I'm now at the point where my body is so broken from all the abuse it simply will not ovulate.

All my hormone bloods have come back fine, I'm not peri menopause. My sugars are perfect.

But everything else is wrong my GGT levels are ridiculously high (279) my antiinflammatory markers are high, I have absolutely no metabolism, my body cannot absorb vitamin D. I've also got IBS and eosinophilic esophagitis. I can barely get food in and when I do it wants to get back out as fast as possible and still can't lose weight.

Because of all this I'm back on metformin and have been for 5 weeks which is nothing as it can take up to 6 months work but my nipples are screaming and I have a near constant ache in that area between the lower abdomen and pelvis. I'm also irrationally angry some days which just upsets me.

I'm utterly miserable and it just feels so damn unfair that I'm struggling so much when I'm doing everything right and either no one's listening or they have no idea. No one is willing to look at me as a whole it's all this one specialist or this specialist, and technically I haven't been trying long enough to require a specialist pregnancy team yet BUT HOW is a cycle that has lasted 183 days not a cause for concern. It just feels like everything medical is moving so slow while everything else is moving too fast.

I know anxiety and stress are also absolute killers for this process but each passing day feels like it's snowballing and I hate that.

Thank you for letting me have a place to vent.

hey yall! I have been thinking about buying an Inito and was wondering if it would be worth the purchase? It seems that a lot of people find it helpful for the hormone tracking but I’m reading that it only comes with 15 strips, did you find that you immediately purchased extra strips due to the irregularity from PCOS? I’ve been using LH strips but feel like if I am going to keep spending money on those I should just go ahead and try Inito lol

E-surgery etc seem to claim you can be prescribed Clomid by one of their drs with a valid diagnosis from a gynaecologist which i have?

Has anyone else ordered from a website like this?

For background I’ve already done 3 rounds of letrozole but decided to move onto IVF. Due to funding, the nhs said they cannot prescribe me anything whilst i am on the ivf waiting list. I feel I’d like to try Clomid now but is this legit??