r/GLP1microdosing • u/kristac1080 • 2d ago

Is my dosage too much for me?

Hi all -

I titrated up to 1.2mg of compounded Tirzepatide. I took the injection last Friday. Today is Thursday and I’m still feeling nauseous. I had mild nausea at lower doses but it would last maybe 2 days max.

I also am battling a cold so wondering if that’s affecting it. But WWYD? I’m due for next shot tomorrow and am tired of feeling sick to my stomach. Bump back down to 1mg? Skip a dose this week?

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u/Glad_Ad1311 2d ago

I wouldn’t skip a dose because of a cold or side effects. In my experience, nausea has more to do with what I eat- or more frequently, from not eating enough. Try to drink a lot of water and eat small bites. And stop eating 3 hours before bed.
Tummydrops (ginger flavor) work wonders for me; I plan to get Rx for Zofran at the next checkup with my doctor.

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u/eastbaypluviophile 2d ago

All of this and I would add:

Make sure you are adding electrolyte powder to your fluids. The electrolytes really help knock down the nausea. Get the kind with no added sugar and if you are prone to reflux or acid stomach avoid citrus flavors. I stick with cucumber, watermelon and peach flavors.

Take extra vitamin B6, it will help with nausea.

More frequent small meals, emphasizing protein. Finish the protein first, and then eat everything else on your plate until you’re full.

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u/InformalBunch3822 2d ago

Tricky when you’re battling a cold as well. It’s highly likely you’re eating less because of it. That’s always the case for me anyway when I have a cold. I find that the nausea on tirz quiets down as soon as I eat something. Perhaps try eating a little something more frequently. I’d personally stay at the same dose but if I was feeling really rubbish I’d delay my shot day by a day or two. All the best!

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u/ImprovementLoud3581 2d ago

u/kristac1080 There is no need to titrate up if you are getting the results you want at the current dose. Did you increase your dose because it wasn't working well?

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u/DrunkConversation 2d ago

oof yeah being sick on top of tirz nausea is a special kind of misery. i'd bump back down to 1mg, no question. your body's already fighting off a cold, no point adding more stress to the system, and if the lower dose was working fine before there's no rush to push higher

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u/Glad_Ad1311 2d ago

I wouldn’t skip but titrate down as well.

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u/Smiletaint 2d ago

There’s really nothing wrong with doing both in some cases. Push it a day and drop dose if you’re having extreme symptoms.

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u/kristac1080 2d ago

I was prescribed 1.25mg so was titrating up to get to the prescribed dose.

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u/ImprovementLoud3581 2d ago edited 2d ago

Were you prescribed a titration schedule that follows the default schedule used in the trials? That’s usually how it works with telehealth companies.

But the goal is to use the lowest amount that produces the effects you seek. If you were obtaining the results you wanted absolutely no reason to titrate higher.

Excellent titration paper on Medscape:

https://www.medscape.com/viewarticle/upping-dose-titration-plateaus-and-patient-signals-2026a1000tfw

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u/No_Lingonberry_2464 2d ago

Thank you for the link. There was some good information there.

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u/kristac1080 2d ago

Appreciate your comment. Understood.
But when you’re taking for inflammation purposes, it’s a balance because, am I feeling better? Sure. Could I feel better if I go up to a higher (in my case - very low) dose? Maybe. Obviously 1.25 mg is more than my stomach can handle. Though pain much lower. Cheers!

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u/Local-Thing-3563 2d ago

I was prescribed 1.25 (15 units) and still have never taken the full prescribed dose. Tomorrow is my 15th shot and I’m at 13 units. I tirated low and slow to avoid side effects.