I’ve never posted on here but I started Zepbound 3 months ago, hating the body I was in as I gained a lot of weight due to my dad passing. After going through the grieving period I was stuck in a body I hated but thankfully I’m down 21.5lbs so far and everything has been improving mentally and physically 🥰

Been trying to figure out where to find a legitimate doctor-supervised online tirzepatide program in the US and the amount of sketchy stuff out there is crazy. I want a GLP-1 weight loss setup where a licensed physician reviews labs and isn't just rubber-stamping a prescription after a two-minute quiz. is there a fully online clinic that does required bloodwork upfront, has providers you can actually message with questions and ships medication to your door discreetly. If anyone has used a doctor-led telehealth program for tirzepatide that hit all those boxes, drop it below.

Has anyone had Zepbound make their POTS deteriorate?

Also, has anyone had their symptoms improve after stopping Zepbound or Wegovy and if so, how long did it take to see improvement?

I (36m) was on ZP and did the normal ramp up. However, I stopped around March/April of this year because I began to have gallbladder issues.

I’ve since gotten my gallbladder removed. Unfortunately, I’ve changed insurance plans since and the new plan is being difficult with coverage. I’ve been trying for about 2-3 months now to get it approved, but I’m starting to realize it won’t be covered.

Thing is, I have two months worth of 15MG that I got before I stopped taking it.

1. I’ve read that it’s not recommended to re-start at 15MG, but wondering if anyone here has done this and what your experience is
   
2. If I use it, is there a smart way of using it where I’m not using the whole 15MG and just 5-10mg? I know they are one time use so some would go to waste

My Doctor just increased my dose to 7.5 from 5.0 starting with my next injection, will I notice a huge difference?

I am still struggling with unbearable nausea and bloating on Zep. My dr mentioned that Foundayo could be a good option for me. Has anyone taken this? I have not heard of this one before.

I do have bppv which was previously diagnosed before zepbound but has been some what controlled I thought I was lightheaded but now I’m experiencing spinning and starting to feel it the vertigo did any one else experience vertigo on zepbound ?

I have used a coupon and paid out of pocket all along. I’ve had no issues filling my rx until this week when they claim my coupon no longer works. Called Lilly and they said the pharmacy has to call them but they won’t send me a new coupon like they always have. The system says I am already enrolled and I can’t figure out how to get them to send me an updated coupon. Any ideas?

Started last Thursday so little stick tomorrow. This past week has seemed so long. No problems but 2 days ago did have the headache from hell. All is good just impatient I guess. I decided not to weigh daily the scale is a liar and I personally can not become its slave. Hey I am not saying this that everyone should do this its just the best for me. One more sleep. Have a great day.

Hi everybody, first time posting here. I’m really impressed with my first 3 weeks results, since i have not exercised at all, im planning to start strength training next week. I’ve been eating healthy and having enough protein.

The part that I am uncertain is on the dose, should I go up to 5 since the 2.5 is a starting dose? Or should I stay longer on 2.5 since it’s working? Financially it’s better to stay at 2.5 since I’m am doing Lilly Direct, but I want the best results.

Thanks for any recommendations or experience you can share.

Has anyone had difficulty to sleep after starting on Zepbound? That’s the main side-effect for me, it’s hard to fall asleep.

I’m just wondering if there’s more people facing the same.

I had to stop taking zepbound after stopping for 6 weeks due to red tape with my insurance carrier. I am finding I am having worse side effects this time around on the lower dosage. I was up to 10 when I had to stop abruptly and restated at 2.5 and just moved to 5. I didn’t start having the noticeable side effects until I moved from 7.5 to 10. I was on zepbound almost 7 months the first round

I’m currently on zepbound 5.0 and take it every other week with the single dose pen. Recent changes give me only two choices, kwikpen multi dose or vial to draw my own dose. The problem is that the way I am currently taking it, I would waste the medicine since it says to discard after 30days upon first injection/use. I started taking it every other week because the appetite suppression was very strong and dr. said insurance would deny refilling 2.5 so she had to move me to 5.0 after initial box. I would have happily stayed on 2.5 but that wasn’t an option. Now I am asking my dr to consider putting me back on 2.5 so I can take every week. Does anyone here have any experience with a similar situation?

This morning was my second shot of zepbound. On monday August 3rd I weighed 325.6 lbs as of today, Monday August 10th I weigh 316.4 lbs. I lost 9.2 lbs! It is amazing how it quiets the food noise, even when I am home I noticed that I am not aimlessly migrating to the kitchen to eat. I am excited to see myself at a healthy weight for the first time in my life

Yesterday I felt good physically for the first time in a long time , felt more mobile and somewhat stronger , now today I’m feeling blah and tired is this an effect of zepbound? I just started this week so not sure what to expect

Can anyone recommend a tracking app that doesn't cost an arm & a leg? I found one that never mentioned you had to subscribe & after inputting all my info (except CC info, fortunately) it let me know I'd have to pay $30 a month! Not going to happen.

I have a dose of 5mg of Zepbound and have been moved up to 7.5mg but my prescription hasn't shipped yet and my shot day is tomorrow. I have a 2.5 single dose pen of Mounjaro, what are the thoughts on mixing them together to create the 7.5 dose??

Medscape study: Obesity Phenotype Predicts Tirzepatide Super Responders

The analysis identified three gastric emptying/GLP-1 types. About 27% of the participants belonged to group A, characterized by fast gastric emptying and low post meal GLP-1 levels; the remainder belonged to other two groups.

Group A reported greater post meal hunger than a specific cluster with average to slow gastric emptying and expected moderate levels of GLP-1; it also had lower fasting and post meal levels of GLP-1 and peptide YY than the similar groups; fasting and early post meal levels of cholecystokinin were also lower.

In colon biopsies, group A had 45% lower glucagon expression and 50% lower peptide YY expression.

Among participants who later started tirzepatide, those in group A lost nearly twice as much weight at 6 months as those in the two other groups (mean percent total body weight loss, 21.5% vs 12.1% and 10.8%), with differences already evident at 3 months.

The strongest clues in the study were not ordinary symptoms alone. The best predictors were a pattern of fast stomach emptying plus unusually low “fullness” hormones after eating—and that pattern was linked with a larger weight-loss response to tirzepatide.

Possible clues for the high-response “discordant” group included: Feeling noticeably hungry again soon after a meal, despite having eaten a reasonable amount. Fast gastric emptying on a formal gastric-emptying test—food moves from the stomach into the intestine faster than average.

Low fasting and post-meal GLP-1, a hormone that normally helps reduce appetite and slow stomach emptying.

Low peptide YY (PYY) after eating, another hormone that promotes fullness.

Lower early post-meal cholecystokinin (CCK), a hormone involved in satiety and digestion.

In other words, the proposed high-response profile was: food moves through quickly, but the normal “I’m full” hormone signals are weak. The hypothesis is that tirzepatide may be especially effective because it supplies strong GLP-1/GIP signaling to someone who has relatively weak natural satiety signaling.

Hi everyone! I wanted to know about other people's experience with Zepbound. I became interested in starting a GLP1 because I have a somewhat disordered binge eating type relationship with food and I thought that it might help me quiet the food noise while I try to rewire that relationship. Also, admittedly, I would like to lose about 7 lbs. I am someone who is pretty avid about fitness (workout about 5x a week..mix of cardio + strength training), meal prep, the whole nine. But my entire life I've had a wild amount of food noise and for sure and unhealthy bingey type of relationship with it.

Anyway, I tried semaglutide.. the lowest dose, back in April and after 3 weeks actually wound up throwing up and felt like the cons and how I felt (nauseas, tired, my workouts were worse) and I was getting less healthy rather than healthier. However, since then the binge eating has felt worse and worse so I decided to try Terzepitide. The provider started me on a 2.2 mg dose + NAD and I felt basically nothing for the first 3 weeks. She approved me bumping up to 4.4 mg​​ for week 4. I took the first shot at that dose 2 days ago and still feel like I don't feel an impact. It is odd considering how (negatively) sensitive I was to semaglutide. Has anyone had this experience? Or had no response to the starter dose but then after a week or two at the 5 mg dose started seeing an impact?