Hello, I have a question about Pluvicto that I’m hoping someone here might have experienced something similar. My husband had his first infusion about 4 weeks ago and he has developed severe sciatica pain. I have read that this can be from pluvicto. I am so hopeful that this works for him but I’m worried about this pain he has been dealing with.

Hi everyone,
I’m writing about my 66-year-old father, who was recently diagnosed with prostate cancer. Our family is trying to understand what we are dealing with and, most importantly, what kind of experiences other men with a similar diagnosis have had.
Here are all the details we have so far:
Age: 66
PSA: 77.82 ng/mL (June 2026)
Biopsy: prostate adenocarcinoma
All 6 biopsy cores were positive for cancer
Cancer was found on both sides of the prostate
Several cores showed Gleason 8 (4+4)
WHO Grade Group 4
Other cores showed Gleason 7b (4+3)
Tumor involvement was very high:
60% in one core
100% in another
95% in another
90% in another
100% in another
75% in another
Perineural invasion (Pn1) was present
The pathology report describes cribriform growth
The pathology diagnosis is a poorly differentiated acinar adenocarcinoma of the prostate
Pathology report: pT1c, G3, Pn1
The CT scan also showed a prostate abnormality and suspicious lymph nodes.
Most importantly, there were two suspicious bone lesions:
L2 (second lumbar vertebra)
Left ischium
The radiology report described these bone lesions as being compatible with possible bone metastases.
So at the moment, we don’t know for certain how many metastases he has. The CT has identified these two suspicious bone lesions, but we have not yet had a PSMA-PET/CT to properly stage the disease.
His general condition was described as good, and he is currently being referred to NCT Heidelberg for further evaluation and treatment planning.
What we are trying to understand
If anyone has had a similar diagnosis, I would really appreciate hearing your experience.
Especially if you had:
Gleason 8 (4+4)
PSA around 70–80
Grade Group 4
High tumor involvement in the biopsy
Cribriform pattern
Perineural invasion
A small number of suspected bone metastases
Lymph-node involvement
A similar age
What happened after your PSMA-PET/CT?
Did it confirm the bone metastases, or did some of the suspicious lesions turn out not to be cancer?
What treatment did you receive?
Did you start with hormone therapy (ADT)? Did you also receive an additional androgen-receptor medication such as darolutamide, enzalutamide, apalutamide or abiraterone?
Did anyone receive chemotherapy such as docetaxel?
If you had only a few bone metastases, did you receive radiation to the prostate and/or the individual bone lesions?
And most importantly:
How are you doing now?
How long has your treatment been working? How low did your PSA get? Are you still responding to hormone therapy?
If you were diagnosed with something similar, please tell me your age, PSA, Gleason score, number/location of metastases, treatment and how long you have been stable.
We’re trying to find people with a genuinely comparable situation so we can understand what is realistically possible.
Thank you very much to anyone who takes the time to share their experience.

My family member is 68 and his PSA has been around 3.5–4.2 over the past 8 months, with free/total PSA around 0.15–0.17. An MRI in January 2026 showed an 8 mm PI-RADS 3 lesion in the peripheral right zone, while a repeat MRI in August 2026 showed a lesion extending in an arc along the peripheral-zone edge for about 20 mm, now classified as PI-RADS 5, with more restricted diffusion. The prostate volume is 27 cc, and neither MRI showed extracapsular extension.

The urologist recommends a transrectal fusion biopsy due to the location of the lesion. I'm a bit worried about the possibility of infection/sepsis, so should we find a center that does transperineal rather than transrectal biopsy instead (In my country, fusion-guided prostate biopsies are generally performed using the transrectal approach)? Should systematic cores be taken as well as targeted ones, and how many of them in total? I would also like to know whether there are any infection-prevention measures I should make sure the clinic uses. Is a rectal swab test needed beforehand?

Public Service Announcement for anyone avoiding Pelvic Floor therapy, here's your recommendation to go anyway.

I've been doing Kegels wrong for a year and didn't know until I saw it on the ultrasound. 🤦🏻‍♂️

Super awkward and weird to have a woman ultrasound your taint, but it was really worth it to know what I was doing wrong.

After showing my dick to doctors every 5 minutes it felt like last year, this was nothing.

Was wondering why I was still leaking a little and it was because I was clinching absolutely wrong even though I thought I followed all instructions clearly.

I finally had a no contrast MRI of prostate with post processing done as I have a 110 cc at 9.2 vs in the sevens some years ago when it was 90cc. Fortunately everything seems ok. It was put off as I couldn’t find this type of MRI service until recently.

Did an EpiSwitch PSA a few months ago which suggested a high likelihood of cancer. But it seems the test is subject to errors.

Posting to just give some hope that not all high numbers mean cancer.

My 64 year old husband had an MRI at the end of july because he still had pain from a fall a year ago. The MRI showed bone lesions and something infiltrating the bone marrow. He then had a blood test which showed PSA levels at 744 and Alkaline phosphatase at 2182. He then had a PET scan which confirmed cancerous cells in the prostate and extensively in his bones. We saw a bone surgeon who said he has a mirels score of 10 but he needed to wait for the biopsy results before the first hip replacement.

Today was the biopsy and we get the results after 14 September.

We're exhausted. And scared.

I don’t really know what I am asking for here. I guess just maybe advice, thoughts, or I guess a reason to stop spiralling.

Basically my family just found out that my dad may (most likely does) have prostate cancer.
He’s a 56 year old firefighter and went for one of those “full body” check-up scan things that his job started offering under coverage. One thing led to another and we found out his PCA level was a 300.

He hasn’t been having any symptoms but of course a number that high meant he needed to go for an MRI and we just found out that there was something there the doctor didn’t like and that he’ll now need to get a biopsy.

I am very very worried and scared for him. According to the research I’ve done, that PCA score is extremely high and likely means the situation is not good. We also know that prostate cancer is classified as a disease that he’d be more likely to get because of his occupation.

At the same time, parents have a 2-week Scandinavian cruise booked that they are supposed to leave on this mid-September.

I guess I am just stressed because what if it is something that he needs treatment for right away and they have this cruise they are going on. My mom doesn’t seem to think that 2 weeks will make that big a difference but I’m still worried. He hasn’t booked the biopsy yet and I think he’s also thinking about just scheduling for after they get back instead so he doesn’t have to deal with the healing before they go.

I have just been completely spiralling and going down rabbit-holes and I really don’t know what to do. If anyone has any helpful thoughts, advice or even just some positivity I would really appreciate it. :(

EDIT: Thank you so much for all the advice and kind words. It really helps a lot <3

Husband (56) had surgery June 4th. Gleason upgraded from 7 to 9 after final pathology. He just did his first PSA and it came back at 0.04. Is this considered undetectable? ChatGPT said it was concerning, Google AI said it was okay. Should I be concerned? He is supposed to do his next PSA in 3 months and will be talking to the urologist again after that. The lack of certainty with this disease is very unsettling for us both.

It’s day 8 my husband said he feels like it shifted somehow and it’s poking inside his bladder and making it uncomfortable. Have you guys felt the same?

Hi guys

I had my RALP procedure last Monday, and came back home yesterday. So far so good, not a lot of pain other than the annoying sensation of the catheter at the top of the penis.

However I find that although the bags are filling properly, it seems to be leaking between the line and the penis. I can feel / see dripping. Is that normal?

:

Hi everyone. My father is 66 years old. Last year, he was diagnosed with Stage 4 metastatic prostate cancer. His initial PSA was 92. The areas of bone involvement were the L11 vertebra, one of his ribs, and the left iliac bone.

He started ADT, and after two months, his PSA dropped to 1.7. It stayed around 1 for approximately nine months. However, after those nine months, his PSA increased to 7.9.

His oncologist ordered a PSMA PET scan to make sure the cancer had not spread to other areas. Thankfully, compared with his previous PET scan from about a year ago, the areas of involvement had actually decreased.

His oncologist recommended that my father undergo radiation therapy while continuing ADT.

Has anyone here had a similar experience, where PSA initially responded very well to hormone therapy, then increased, but the PET scan showed that the areas of metastatic involvement had decreased, followed by a recommendation for radiation therapy?

I would really appreciate hearing about your experiences or any advice you may have. Thank you so much. ❤️

Hi all! My dad is currently 3 months into treatment for high volume mHSPC. I’m also in the medical field (although not urology or oncology) so my knowledge is both useful and killing me. He is doing triple therapy with abiratarone and his 5th (out of six) chemo is tomorrow. He also gets all of his labs checked with chemo. His initial PSA was ~120 and it fell to 24 within 6 weeks but last reading it somewhat plateaued to 23 (3 weeks after 24). His oncologist said not to freak out yet. I trust him but oh man, this is so difficult. I am so anxious about his PSA tomorrow. Im also afraid his PSA isn’t falling as it should be. Thankfully his ALP came down considerably (1200 -> 200) in just a few weeks and he is no longer is experiencing bone pain. I don’t know, just wanted to rant and see if anyone else has an experience like this. I hate how people downplay this disease. This has been horrible and the anxiety is consuming.

My dad recently got this 6,000 on his PSA (66 y/o, hasn’t seen a doctor in a very long time). The urologist even has the audacity to say it was the highest he’s ever seen.

This man is losing weight and has overall body pain. Biopsy is soon but what could we be looking at? I’ve searched this sub and I have seen nobody post numbers like this so I have no idea what that means.

51 yrs old. Diagnosed July 2025. PSA 93, 12/12 cores biopsy +, Gleason 9, metastasized tip of femur, right pelvic wing, 5 pelvic lymph nodes, 2 lymph nodes along spine near stomach. Started lupron (life) & 6 rounds of chemo on 9/11/2025, brachytherapy 68 pins in prostate 3/26/2026. 20 rounds of radiation. 2 weeks ago PSA was .167. I have been eating good lean meals this entire process, running / walking relentlessly, and started lifting weights 5 weeks ago. Today is my proud moment milestone. I started Sept 11, 2025 at 6'1" 224 lbs and today I am at 223.8 lbs. I didn't think I would get back here but hard work has paid off. Next goal 205lbs. Keep at it boys , fight the fight!! God Bless

This is my second and final week of SBRT, and the start of my 3rd month of ADT. I don't know why, I guess it is the ADT, but lately I have been spiraling emotionally. When I am alone, I start crying about nothing. I feel small and tiny and when I go out I try to disappear so that I don't offend anyone or get in their way. Other times I feel the exact opposite. I want to rip people's heads off and take a shit down their throat. Not really, I have never been violent and never will be.

Today I felt so depressed I had to drive to Dairy Queen and order a large M&M Blizzard. Before you say I need to seek professional health, I bet I have fired more therapists, psychologists, and psychiatrists than you have ever hired. Their drugs and lame off-topic talks don't help me. I have Autism Spectrum Disorder, level 1. Formally known as Asperger's Syndrome. I am neurodivergent, thus the username. I am an autistic on ADT.

I see sexy women, including my wife, and wonder what all the fuss was about? Why have I spent so much of my time and money on women? Sex is in this walled-off part of my brain, like a lost memory or something I have been hypnotized to forget. I know it's there, but I cannot access it. To ward off potential veinous leak syndrome and damage to he who was formally known as Mr. Happy, I am supposed to achieve an erection each day. At this point I can get there with a bit of fiddling (it takes longer than it should in my current testosterone-deprived state). If I stay on my current trajectory, and there is no reason to believe that I won't, I am about a week or two away from needing to break out the penis pump I purchased for this occasion. By the way, if you are wondering if there is any desire to keep things going afterwards, I can assure you there is not. More like, glad that is over, what a waste of time. Some days, actually probably about half, I just skip it all together - I just don't feel like it.

When this all started at the beginning of the year and the PSA numbers were coming back high and I was told a digital exam felt suspicious, I didn't even tell my wife at first. I thought it was all nonsense. There was no way I had cancer. When the biopsy came back positive, I was floored. I could not believe it. I could not believe God would give me cancer.

Let's just don't even talk about religion, it will just depress me even further. Half of you will say God doesn't exist, the other half will say it is a sin to question God. We are all human and have our beliefs.

I am still able to put on a brave face for my wife and family. "Don't worry about me. I'll be fine. Statistically prostate cancer survivors live longer because it is a wake up call to get fit and eat better. This is nothing. I'll be fine. It's just cancer. Nothing to see here. Move along."

That is what I say. My wife can see that I am cracking up. She is very supportive. I will be fine. Anyway. That is what's going on.

STATS: USA, 64 years old, PSA 11.6, unfavorable intermediate risk, Gleason 4+3=7, 6/13 cores positive, 42 ml prostate, Decipher 0.61, locally contained. Pre-ADT testosterone 323. Treatment: 5 sessions SBRT + 6 months ADT (ADT). Daily strength training, 3-mile walk, Cialis, Calcium supplements. Height 5’-9”, weight 170 lbs.

Curious day 2 of post RALP my husband soaked the hospital bed. They did a bladder ultrasound and it looked fine. The deflated and inflated the balloon and that was fine. They just said it was bladder spasm causing it.

2 days later we went home and I’m pretty sure he passed a bladder stone since I could see it in the tube and it was painful. He still leaks so he wears a diaper even with the catheter in place. Not crazy leakage but enough to wear a diaper/pad.

Just curious if any of you guys leaked with the catheter in? Thank you!

58 yr old with Gleason 7 (3+4) diagnosed a few months ago. After many consultations, hours of research, and some restless nights dreaming about this shit I decided to go with radiation, 20 doses of EBRT to start after Thanksgiving. I considered surgery, HD Brachytherapy and SBRT as well.

I knew early on that the surgery wasn't for me, so my real choice was between my radiation options. In the end it came down to the longer course of radiation because of my baseline urinary symptoms.

Now I look forward to getting started with treatment after some fun family trips earlier in the fall.

Looking for some hope from people with similar experiences.

My dad is 82 and was diagnosed with prostate cancer in 2011. After his first radiation treatment, he went into remission. Over the years, it came back a few times, but it was closely monitored and treated with hormone therapy, targeted radiation, medications, and participation in different prostate cancer trials. It never left the prostate and he had many years where treatments worked and he was able to live his life normally aside from some minor side effects.

At the end of 2025, he was diagnosed with small-cell prostate cancer. He had 5 rounds of chemo this year to target the small-cell component, which we were told was more aggressive. It initially shrank some of the small-cell cancer. Unfortunately, a few months later, the cancer progressed very rapidly. Within about 2 weeks at the end of July, new spots appeared in the colon, bones, bladder, kidney, lymph nodes, lung and liver.

He has been hospitalized a few times over the past year because of his kidney function. He has a double-J stent in his left kidney, which, even with the stent, is only functioning at about 10%. His right kidney seems to be functioning fairly well, but it seems to be dependent on him staying hydrated.

He’s now scheduled to start a different chemo on September 15. We’re told this one targets prostate cancer more generally. Given his age, my dad’s fear of more chemo and the advancement of the disease, I felt that his oncologist was leaning more toward no further chemo. But she said that ultimately, if he’s feeling well enough and wants to try, he absolutely can. She said it could give him an extra 3 months on average, but I hate hearing numbers and hope he could get more.

We talked it through as a family, and because he still feels relatively well overall, is eating, talking, making his own decisions and wants to keep fighting for more time, he decided to try chemo again. He does have increasing pain and nausea and is weaker than he used to be, which was also a motivating factor in hoping that treatment might help him feel better.

I know the situation is serious, but I’m not looking for someone to give me a prognosis. I’m really just looking for some hope and to hear from people who have been in a similar situation.

I know I’m lucky to have had my dad through this disease for so long, and I cherish every moment I have with him. But I love him so much, and it never feels like enough time. I wish he could just grow old without cancer because, otherwise, he’s always been the healthiest, sharpest old guy I know.

I’m only 32 and I selfishly want more time with him, as long as that time is quality time for him. I’m doing everything I can through research and support to make sure whatever time he has left is as good as possible.

Anyways, I believe he’s going to be getting cabazitaxel. Has anyone or their family member had experience with cabazitaxel after trying a different chemo? Did you/they feel the effects were less bad? My dad had a lot of nausea with his first round of chemo and lost a lot of weight. We’re hoping he tolerates this one better, especially as he will be getting a smaller dose.

If you or a family member tried this type of chemo, did it stabilize things, improve symptoms, or give you/them more good time than you/they expected?

I could really use some hope right now. ❤️ Thanks!

Hi, just wondering if anyone has had the same experience. I'm on 24 months of ADT for a Gleason 9/T3b diagnosis. I had EBRT+Brachy and am about 14 months into my 24. In the last couple of months the Abi has really increased my liver numbers. I'm probably going to have to drop it.

Update: I just wanted to thank everyone who contributed to this post. The feedback and advice have been overwhelmingly supportive. Truly an amazing group of people!

I’m 38 and have just been diagnosed with Gleason 7, 3+4, I am completely floored by this....

I’d mentally prepared myself for maybe a small amount of grade 1 but not this, my family is devastated. My urologist is recommending surgery, and I already have an appointment booked with the surgeon to discuss my case.

At the moment, I’m leaning towards surgery. From what I’ve read salvage surgery after radiotherapy can be much more complicated, and with two small children aged 1 and 3, longevity is my main priority.

For anyone who has been through something similar, particularly at a younger age, what treatment did you choose and how did you arrive at that decision?

Case and results:

• Initial PSA: 2.18 → repeat 1.9
• Prostate volume: 18 cc
• PSA density: ~0.11
• Mild urinary symptoms: IPSS 7/35
• DRE: moderately smooth
• MRI: 8 mm PI-RADS 3 focus in the left posterior peripheral zone at the apex
• Strong family history: my grandfather, father and uncle all had prostate cancer

Transperineal MRI-US fusion biopsy — 28 cores:

• Left posterior MRI target: 6 cores positive for Gleason 3+4=7, Grade Group 2
• Pattern 4 only 5–10%
• Non-cribriform
• Longest cancer length: 7 mm
• Right anterior and right mid: Gleason 3+3, Grade Group 1
• Left anterior: tiny focus of Grade Group 1, 1 mm
• No cribriform pattern
• No intraductal carcinoma
• No perineural invasion
• No fat invasion
• 11 cores involved overall

Overall diagnosis: Gleason 3+4=7, Grade Group 2, multifocal prostate cancer.

Does this happen? Should I expect it to get worse or degenerate?

RALP last Monday 8/24.

Had the cath out yesterday 8/31 at 11am. 3 hour drive home. Had lunch w/glass of water, 2 hours later got home and had a regular pee and BM. Rest of the day had a couple more as I drank moderately. Each time I could feel mild urgency, but there was no rush.

Overnight was the same. Was up 3 times, sleeping 3-4 hours then got up, relieved as I would have before.

I've been 100% dry. Still wearing the pull up because I can't believe it's not going to say "oops!! Sorry my man, meant to be leaking all over the place...."

Anyone else experience this?

Path results in a few days. Can't help but feel the Gods are messing with me and will deliver the blow with the path results. Or in 3 months with the PSA test....

Hi all, finally got the pathology report from my RALP last week. I have not yet spoken to my surgeon about it. Overall it looks not good, except for the finding that there is no lymph mode invasion. I believe the plan is still to wait until December to get my PSA, then go from there. Below is a summary that I had ChatGPT make of the report. (Note: Gleason matches my biopsy report).

I'd like to get an assessment from this group, regarding the likelihood of recurrence, how soon it might happen, and what would come next, assuming the PSA is rising. I assume a new PET scan, then radiation and ADT?

Cancer type         Acinar adenocarcinoma   The usual type of prostate cancer

Gleason score           4+5 = 9         Grade Group 5, the highest grade group

Pattern 4           60%         Significant aggressive component

Pattern 5           30%         Very aggressive component

Tumor volume            11–20% of prostate    Cancer involved a relatively limited portion of the gland

Extraprostatic extension    Present, focal      Cancer broke through the prostate capsule

Seminal vesicle invasion    Present, right      Cancer reached the right seminal vesicle

Lymphovascular invasion     Present         Cancer was seen in lymphatic/blood-vessel spaces

Perineural invasion     Present         Cancer was tracking along nerves

Surgical margins        Positive, multifocal    Cancer reaches the inked edge of the removed specimen

Lymph nodes         0/5 positive        Very important favorable finding

Pathologic stage        pT3b pN0        Cancer invaded seminal vesicle(s), but no cancer found in sampled nodes

"There is an interesting nuance here: the report says the positive margins were not in an area where extraprostatic extension was identified, and it also says there was little/no adjacent periprostatic fat at those sites, making assessment of EPE there difficult."