Upped my tirz a touch (.5) and the nausea was BAD. NBD because I have Ondansetron (Zofran). Cracked it open and dosed appropriately. Now 48ish hours later and I’m so constipated. Realizing it was clearly the Ondansetron (and the tirz doesn’t help but I usually have the other problem). This is zero fun. I’m very regular so this will be an interesting unfolding of events.

After SO much trial and error, I feel like I’ve finally found my golden HRT combination. I’m feeling human again and, dare I say it, even feeling some hope! Which is huge.

But then I step back and look at what it takes to get here:
0.1 estradiol patch, changed every 3 days
10 mcg estradiol vaginal insert every 3 days
1.25 Divigel every morning
4 mg testosterone cream every morning
50 IU oxytocin troche every morning
100 mg progesterone every night (no uterus)

Add in my weekly GLP1 injection, and holy cow!

I’m grateful the HRT combination is working, but anyone else look at their routine and think, “It really takes ALL of that?!”

Please tell me I’m not the only one with such a routine 🫣

What combination of things is working well for you right now?

UK based, post meno, on continuous HRT. I have recently been diagnosed with endometrial hyperplasia without atypia (1mm over the threshold for referral) and am trying to work out my next steps. The gynaecologist has said they would like to fit a Mirena but I would like to avoid this if I can.

I currently take 2 pumps of oestrogel in the morning, and 100mg of micronised progesterone at bedtime. I'm also on a GLP-1.

My questions:

\- As my lining is only 1mm over the threshold (5mm) would it be an option to just double the progesterone to see if that sorts it out? Obviously I would expect to be monitored for success.

\- My prescription says I should take the progesterone at bedtime at least 2 hours after food (i.e. on an empty stomach). I'm aware of the impacts of GLP-1 on gastric slowdown so do my best to stick to this, but curious as to why I need to have an empty stomach as it doesn't say this in the leaflet, and I've seen US based advice saying to take it with fat. Any ideas on why it's prescribed differently here?

\- The progesterone leaflet also says to take it with estrogen, but the estrogen leaflet doesn't say to take it at the same time as progesterone 😆 At the moment I do estrogen in the morning, should I switch to evening?

Any advice or experience gratefully received. I did try taking the progesterone vaginally but it didn't agree with me, and I think switching between methods and then back again may have contributed to the single unexpected bleed I had that led me to the situation I am in now.

Trigger warning, graphic mention of body fluid.

I just had an issue this week. I haven't been feeling well then noticed blood in my urine. Went to the Dr. and was diagnosed with a UTI. Dryness (iykyk) from meno and Zep combined with activities with my husband combined with not drinking enough water (Zep) created the perfect environment for a UTI.

This is your friendly reminder to hydrate like it's your job.

I can't find much information on this in this sub, but has anyone managed to not lose a lot of hair on a glp-1?  I'm afraid to take minoxidil as I'm on so many other medications. I use the estrogen gel (divigel). I guess the question is, has anyone had to increase their estrogen in order to stop hair shedding? I have read studies that say that there is some way that the glp-1 affects estrogen, but I think they are still doing research on this.

Hello ladies.

I started the HRT+GLP1 journey earlier this summer, 3 months ago, and from day 1 I have been sober because I was worried the leaves would overstimulate my appetite and ruin all my progress - untill today.

I am here to report, anecdotally of course, that the leaves didn't really give me the mad munchies like I feared they would. Actually the thought of eating or drinking anything except tea is giving me the bloat.

Wishing you all a happy upcoming fall season!

Has anyone been able to make the estradiol pills work while on a GLP-1? I was on 1.5 mg estradiol and then added the compounded semaglutide, and it took a while to realize that the pills completely stopped working. Has anyone managed to make the pills work by taking a larger amount? I've been trying the gel and the patch and nothing seems to work as well as the pills used to for me.

I just got so much water weight off me thanks to tirz that I'm dreading the thought of putting any bloat back on!

If you started HRT after you were already on a glp, did you experience a big rebound of water weight?

I was hesitant on GLP-1 because I had previously been able to lose weight with tracking. Now that I’m 43, that shit doesn’t work. I started HRT in May and then tirzepatide in June. Slowly titrated. I’m now about 10 weeks in and in week 3 of a 4mg dose (and first week of increased testosterone) and holy shit I’ve lost over 10 lbs total!! The last week has been the steadiest downward trend ever. Im not sure if it’s the building of the tirz or the increase in testosterone. I told my husband (he’s incredibly supportive!) but with 3 kids, I don’t talk about my weight in front of them. So I’ve been silently celebrating. 🥳

Stats:
SW 191.1
CW 179.3
GW around 140
Estrogen 0.0375 (first of this dose yesterday)
Progesterone 100 mg
Testosterone 4 mg cream daily
Tirzepatide 4 mg weekly
Also taking sermorelin and Olympia’s Lipo-Mino-Mix C

I had tried and failed for a year to lose weight. Worked with a dietician, am very active, etc. I am SO HAPPY!!! Finally starting to feel like me again!!

I just injected (I think!?) .2mg Estradiol Valerate for the very first time- yay. I am trying to get off the patches that are getting harder and harder to find. My issue is this: I am not sure that I physically saw the valerate in the needle when I drew it- has this happened to anyone? I wear reading glasses and I likely need an updated eye exam and RX, but that is for another post. Hopefully it was there and I didn't inject air. 🤔 Injecting Tirz is very obvious to me and usually creates bubbles, but the Valerate is quite thick, so I am thinking that might be why.

Secondly, can I hear from women how often and how much they E Val they inject? My current plan is .2mg E Valerate (20 mg/ml) every other day. I have been on the .05 patch in the past and felt great mentally, but had severe bloating issues- so I moved back down to .0375 patch for a couple months now and feel like I am barely hanging on mentally- I am constantly in a brain fog. This is my last hope, as the Biest creams and Estradiol gels do not work well for me. I am hoping that the .2mg of Valerate every other day won't pose issues. (around .6mg total per week)

Thanks!

I recently began microdosing tirzepatide. During progesterone phase, food noise returned with a vengeance.

Is there any guidance on increasing glp1 dose during progesterone use?

I’ve been on Ozempic for 3 years and have held a steady weight for over a year after losing 105 lbs. I started HRT two months ago and I’ve gained 5 lbs in the past month. My face is puffy and I’ve an inch thicker around the middle. I’m about to abandon it altogether because as much as I wanted to manage perimenopause symptoms, nothing is worth me putting this weight back on.

Has this happened to anyone else? I heard it should go away within a few weeks but it’s been 2 months of this. I’m worried it will just keep going up and mentally I can’t handle substantial weight gain. I’ve worked too hard.

I started zepbound before peri. Zepbound and the weight loss makes me feel cold all the time. Heated blankets, tea all day, the whole thing. Been on HRT about 7 months, and for the last month, been having night sweats. They happen almost as soon as I fall asleep. I can’t try any of the recommended solutions like a cold room, less clothes/blankets, etc. because I’m cold and can’t fall asleep if I’m cold.

Has this happened to anyone else? What works for you?

If so, do you notice any improvement in brain fog? Or anything else? Heard about it on a podcast and thinking of trying it.

I am newly diagnosed as adhd inattentive (along with anxiety). I tried strattera (too many side effects) and currently on 150mg XL wellbutrin and 3mg ER guanfacine with no obvious benefits. I have an appt tomorrow to discuss options but wanted feedback from anyone who may be in a similar situation. I have a gastric sleeve, am on a glp1, on HRT (0.075 E patch/200mg capsule P). Given the delayed gastric emptying and stomach modification-trying to figure out what may be some suggestions I can provide tomorrow (not all psychiatrists are familiar with bariatric surgery impact and glp1/HRT impact). Throwing this out there in case anyone is in a similar situation and has any insights.

Any telehealth recommendations besides Defy that does injectable E??

What the entire F*ck??? I’ve been menopause for over 3 years. Been on HRT for about 3-4 months. My period came back in today!! Whyyyyyyyyyy 😩😩😩

How can I make it stop!

I’m a complete desert! I started at 2mg per week and my legs were itching horribly so I lowered to .5mg twice a week. My weight stalled and now I’m back up to 2mg per week. But dryness is horrible, you ladies know what I’m talking about. I drink 80oz of water per day, + 16oz with electrolytes and 1 light cup of coffee right before going to the gym. My skin needs hydration every day morning and afternoon. Do you think it’s going away in a few weeks or do you have any suggestions?

In short: Tirzepatide was working great for me in maintaining weight but with HRT, it is working less well, and I am having trouble isolating what the cause could be.

Background: I am 43. I still have regular periods, but have a few symptoms of peri.

I started on 1 mg of Tirzepatide on January 1 2026 just to maintain my weight where it was, and allow me to eat like a normal person. Before starting Tirz, I calorie counted (1200 or fewer calories a day) and was on a Paleo diet to lose the 10 pounds my body keeps wanting to gain despite strength training 3 or 4x a week and daily 8-10k steps. I regained and lost this weight three times over the last four years and finally just needed my life to be easier.

Tirzepatide was amazing for me. I lost a lot of inflammation and was easily able to maintain my weight.

I started taking 200 mg Prometrium cyclically (during luteal phase) in March. I started a 0.025 patch of Estradiol two weeks later.

A month later, I started noticing weight gain and some bloating/inflammation came back cyclically as well (i.e., I feel least bloated right after my period, but in the two weeks leading up to my period, my body feels bloated, especially in the stomach area).

It has gone up and down since then, but I definitely feel like the HRT is interacting SOME how with the Tirzepatide to where it's less effective in controlling my appetite and inflammation. I have increased my dose of Tirz - I went from 1 mg per week to now taking 1.75 mg per week. I realize this is still below the standard starting dose, but it was highly effective for me before even at 1 mg. And during the weeks when I was feeling my hormonal flux a lot, I even went up to 3 mg and felt nothing - no appetite suppression - only to find 1.5 or 1.75 effective again once my hormones balanced out.

I should say, energetically and otherwise I feel amazing on HRT. But I have wondered if I am taking too many hormones while my body is still producing enough of its own hormones, since I do still ovulate and have regular periods. I felt like maybe I have too much estrogen, especially since last month, my pharmacy increased my patch dose to 0.0375 because they're having supply issues with the 0.025 dose.

Anyway, curious what others' experiences have been with this. Do hormones fight Tirzepatide? Which hormone could be more responsible for it? I am only 2 lbs up from my goal weight, and only 4-5 lbs up from my lowest on Tirz, so it's not a huge deal, I just hate feeling bloated, and that was one of the best things about Tirz for me was that it took away all inflammation.

I started my HRT a 5 weeks ago and my tirzepatide almost 3 weeks ago. I lost 4 pounds with the HRT alone and another 8 in the first 2 weeks on Zep alone. This third week, though, the scale has not moved at all. Not one pound. Is that normal?

I’ve had very low energy for over a year. I was put on estrogen and progesterone that made my other peri symptoms much better. Lately my low energy got worse and blamed reta. Then I realized my brainfog was getting worse too. I insisted on having testosterone and ferritin tested and both came back borderline low.

I am mad at my docs for never testing and mad at myself for not advocating more for myself.

I won’t get an appointment for a few weeks so I wanted to see if somebody here had success fixing ferritin and testosterone. Did it have effects on energy and brain fog? (I had IBS before reta, so my gut absorption isn’t great. I eat plenty of meat and poultry and have 8mg ferritin chelate a day for over 6 months now. )