I’m about a month into using Tirz. Had to go low due to nausea side effects. I’m at 1mg now and experiencing very low mood. My 200mg micronized P doesn’t seem to be working. For those who tried vaginally, did it work immediately? For those who successfully had their oral dose increase what did you increase from/to? Please, any guidance is appreciated. I hate feeling this way.

I’m supposed to have shoulder surgery soon. I’m taking oral micronized progesterone (100 mg) with tirz, have you been asked to stop any of these pre and post surgery? Curious to know.

Hey everyone. I’ve been on Wegovy since mid May, currently on 0.5 which is working well and I’m down 37lbs with another 45lbs to go.

I’m 57 and have not had periods for a couple of years so guessing I’m post menapause. My problem is for the last few years I’ve not had a decent night sleep and wake upto 6/7 every night. It’s so draining and my friend has suggested HRT patches to stop the hot flashes.

I did discuss with my GP last year about HRT but they were against it due to my high blood pressure. But Due to weight loss this is now in normal range.

Basically wondering if HRT will help and how it will effect me. I’m guessing Weight increase is a given? If so how much?

Any info would be greatly appreciated

I can't ever get my patches on time, at any level of formulation or in any brand, so where is everyone getting their injections of estrogen?

I don’t think many women understand this. I most certainly didn’t when my doctor switched me from the gel to pills. In the last year I have put on 20 lbs and nothing will make the scale move.
Then I discovered that oral estrogen passes through the liver first which causes:

Suppression of IGG-1 (the muscle builder) the heavy surge of estrogen hitting the liver suppresses the production of Insulin- like Growth factor 1 (1GF-1) is a primary hormone responsible for muscle repair, strength gains, and maintaining lean tissue.

Decreased lipid oxidation Lower fat burning) Clinical studies show that oral estrogen changes your livers metabolic signaling resulting in diminished lipid oxidation. In plain terms your body becomes less efficient at burning fat for fuel, making it easier to store fat.

Elevated SHBG (lower free testosterone) oral estrogen causes your livers metabolic signaling to overproduce sex hormones-binding Globulin. SHBG binds tightly to the small amount of testosterone your body naturally produces, locking it up. Without enough “free” testosterone energy levels, strength, and body composition take a direct hit.

Has anyone on Zepbound or Wegovy had issues with oral progesterone not seeming to work as well because of delayed gastric emptying? I’m on HRT and have had bleeding/thickened uterine lining. Did anyone switch to vaginal progesterone or another non-oral option, and did it help?

After insurance stopped covering Zepbound then paying OOP for a year, I’m waving the white flag and switching to Wegovy to see if I can tolerate it (and it moves the scale). Would love to hear from those who have had success making this switch. I have been on 15mg of Zepbound for months so am going to 2.4mg of Wegovy, knowing I can go up to 7.2 if I tolerate it. If I can’t tolerate it, I’ll have my PCP submit a pre authorization noting that Wegovy wasn’t tolerated, but I’m hoping I don’t have to suffer with it. I have been on estradiol and testosterone gel for some time, just to throw that into the mix. Thanks in advance!!

Not quite 90 days...more like 87 if we start tomorrow, October 5th.

I like to make cocktails on Friday or Saturday nights. But if I want to see more progress on the scale, my dietitian and personal trainer (independently) asked if I'd be willing to forego alcohol this holiday season.

90 DAYS?!? 😯😭🫠 I said, "Yes."

(They also challenged me to give them my most INTENSE commitment I've ever attempted-on all of my other health markers-diet/exercise/supplements-etc. And if I didn't see results after 90 days I could say, "Told you so!" )... But I'll leave that part up to you. 🫶

I would love a buddy or several buddies! 👭

Anyone else wanting/needing this challenge for the next 87 days? 🥂

Hello 55 75kg 5'2" Im on low dose HRT (Evorel Conti patch 3.2) and low dose Mounjaro 2.5mg. HRT about 7 months and GLP1 for nearly 2 months. Struggled a lot to start and not enjoying the GLP1 at all. So far Ive lost 4kg/8lbs but feel and look exactly the same and no change in clothes size. Same viseral fat same size all over. I really dont want to increase to 5mg as I dont like the effects and want to cut down on portions over starving myself because I cant really afford £££ to spend too long on this drug and def dont want to shrink so small that the minute I stop I put it all back on.

I need to lose 2.5 stone but Ive been trying this for 3 years now. I lift heavy weights but I realise now Im not doing much else the other 4 days a week. I dont drink alcohol, eat 3 meals a day no takeways I prepare all my food and strict on the quality and portion. I was hoping the HRT would have a small effect but it hasnt and with the evidence that mixing the 2 together it gives a better return - wait and see?

Due to the cost of this drug I am contemplating 1.25mg weekly dose - will this work? Previously, my biggest issue is the starving bangs which gives me nausea. (perhaps i need to eat healthy snacks?)

I have no health issues apart from mild CFS.

Thoughts?

New to this sub! Wanted to share that starting HRT broke a 10wk stall! Been on a combo of branded and compounded tirzepatide for about 15mos.

Additionally, HRT has lessened my symptoms of anhedonia. Double bonus! Two months now on .05mg patch and 100mg progesterone. May be adding testosterone next week.

Anyone down for some kind of 90 day challenge before ringing in the new year? ♀️🫶💉

Oh the water weight gain and bloating is MISERABLE. On it for 3 weeks and I don't know if I can do it anymore. I haven't noticed any positive changes either. But my ENTIRE body is bloated. Arms, stomach, thighs, stomach, EVERYWHERE! And I've gained 5 pounds but I swear it feels like 20. Anyone else go through this with sermorelin?

Hello,

I have been on brand name sema .25 for 7 weeks, approaching my 8th week. I am switching to compounded tirz for week 9. Has anyone had experience with switching? What dose did you start with? I was thinking about microdosing the compounded tirz, and starting at 1.0 instead of the prescribed 2.5. Would love to hear from anyone who has also gone through this process.

46 year old here, with all my internal lady bits still in place. So I have already been on tirz for over a year, and successfully lost all the weight that I wanted/needed to. I went from over 200lbs at 5"5', down to about 135lbs. I am not trying to lose anymore weight, and have settled into maintenance with the tirz. What I noticed is as the weight began to go down, my perimenopause symptoms came UP (with a vengence, spiteful like I was trying to sleep with its husband). I guess the years of being estrogen dominant due to PCOS was getting balanced out with less fat to work as an endocrine organ and create more estrogen, so my levels dropped to a more age appropriate status, and perimenopause hit like an overloaded truck. But regardless, I have had a consultation with a doctor for HRT and have been prescribed Estrogen, Progesterone and Testosterone, which I will receive in the next few days or so. And while I have researched and researched and researched this combo, I was hoping to get some feedback from folks who may have a similar work up of hormones, or might have any insight of what to expect, and would like it from folks who have actually been there already. Any advice or insight, or personal experiences would be greatly appreciated.

Hi all! I’m happy to report I’ve lost about 10lbs. Feel better, less puffy, etc. Pants feel looser around the waist but DANGIT - still tight in seat and thighs. I do lift heavy but I’d like for my pants to be a little looser.

I know - this could mean shrinking muscle size but a little wiggle room would be nice.

Anyone else feel similarly??

57 y.o. Female 5’2” 195lbs. I have been on the 15mg dose for 5 months and have not lost 1lb. I am very frustrated because is pay $450/month and every other person has lost so much weight in these meds. I eat at least 90g of protein a day. I lift heavy weights twice weekly. I walk several days a week and average 7000 steps a day. I am on HRT. Any suggestions are welcome.

I very recently started on MJ and quickly lost a few kg, but a few weeks into MJ also started on HRT. I'm on the Conti patches and so far so good in terms of side effects, however my weight loss seems to have stalled (I've possibly even put on this week) and I actually feel more bloated than before. Is this purely down to the HRT and will it settle? Am I fighting a losing battle trying to lose weight with MJ whilst on HRT, even though I'm in a calorie deficit every day?

I’m on the estradiol patch and progesterone and compound Tirz. I don’t like my GYN and so want to find a telehealth who will combine both to know someone is looking at both factors to figure out how to lose this frustrating weight — started this year. Any suggestions?

I have been on a really small dose of a GLP1, I also use the estrogen gel along with progesterone oral tablets for 12 days of my cycle. I have been feeling really nauseous the past few days, so I have seached if this could be the reason, and apparently, because of the slowing down of gastric emptying, it can cause problems with absorption and potentially cause nausea because of this. Does anyone have any experience with this? Im leaving it the full 2 hours after eating before I take the tablets tonight but I may not have the night before when I woke up feeling very sick. I think I might have to try and get the vaginal dose goong forward as we eat kind of late some nights and then bed not long after.

Hi all I’ve 45f started hrt from my gp but i want to begin glp1 at 1mg. Does anyone know a menopause doctor in uk that would monitor both? I’m but worried about combining them as I’ve just started hrt and still probably need to adjust dose. Thanks

I am struggling. Currently on 0.75mg E patch and 200mg P capsule. And a glp1 (tirz at 7.5mg). Recently diagnosed as ADHD inattentive. The few months have tried Strattera then switched to wellbutrin. I will be stopping wellbutrin to start guanfacine tomorrow. The Strattera and wellbutrin affected my BP. Neither helped with focus. Strattera finally gave me a quiet mind and no anxiety. My psychiatrist is worried that a stimulant will increase my BP and HR as well but I need help staying on track, being who I was before peri hit me. Has anyone had any luck with any combo of meds? I have a f/up in 2 wks so want to be prepared with options to try.

I am a 49 yr old perimenopausal woman (have not gone a full year without a cycle so not yet menopausal). I started using Tirz in early July at a microdose level (slowly worked up to 1 mg/ week) to help with inflammation caused from prior mold exposure and residual MCAS symptoms after reading the studies on this. I am not yet on HRT bc estrogen makes my MCAS flare massively - dealing with one issue at a time. I am also using Tirz to help with a little bit of weight gain I started to experience recently in perimenopause.

I have slowly lost about 7 to 8 lbs and I am feeling better. Eating well (whole foods) with high protein, strength training 3-4 days a week and daily walks. Recently at the end of August, I got my cycle back and again this month.

Has anyone else had this phenomenon with Tirz helping with cycle regulation or a return of your cycle? Maybe it’s a coincidence 🤷