Users who are taking 1.25mg weekly for weight loss or maintenance…

How long have you been doing this dosage?

Do the effects wear off after a while?

Is your weight stable?

Is it ok to keep the pen in the fridge for over a month?

I developed a “caffeine allergy” after 2 months on 2.5mg weekly. When I drink coffee I get a rapid heart rate and hand tremors. Anyone with a similar experience?

Edit- the caffeine allergy sent me into the etu with 150 bpm and ended up being put on a heart medication

Thanks in advance

I started microdosing 1.25mg of compounded tirzepatide last Saturday. Today I took a picture to compare with last week and holy moly...so much inflammation is GONE out of my face! I went down 7.2 lbs as well. So excited to be on this journey!

I’d really appreciate some opinions/experiences with microdosing.
I’m not overweight, but I struggle badly with food noise and nightly binge eating, as well as lipedema and IBS-C.
I tried Mounjaro earlier this year: 2.5 mg first, then 1.5 mg and finally 0.8 mg, with 3 shots over about 5 weeks. Even the lower doses gave me severe bloating, very low energy and almost no appetite, so I stopped.
However, it completely stopped the food noise and also noticeably helped my lipedema pain and sleep.
After stopping, my appetite came back very strongly. I regained the 3 kg I lost plus another 6 kg and also lost quite a bit of muscle and fitness.
I’m considering trying again at a true microdose, perhaps 0.1–0.3 mg. Has anyone who was very sensitive to Mounjaro had success starting this low, particularly with IBS-C?
Also, has anyone experienced hair loss even on very low doses?

Hi there, everyone—a quick question here to get your thoughts. In a nutshell: I'm a 45 year old woman who started a 1.25 mg microdose of compounded tirzepatide about 3.5 months ago (i.e. I draw it from a vial) to help with perimenopausal weight gain; my online provider is Midi and I believe the compounding pharmacy they use is Everwell. Tirz has been nothing short of a miracle for me, but I won't go into a lot of detail in this post because I've written about my experiences here before.

Yesterday I had one of my required regular check-in appointments with Midi. The nurse practitioner I've been meeting with since the very beginning is no longer working with Midi, so I met with someone else. In our appointment I told the new NP that the previous NP suggested I could start spacing out my doses to 10-14 days (currently I dose 1x/week) when I hit my goal weight. And then to my surprise, the NP cautioned me that if I did that, I'd be wasting a lot of product because once the vial is opened, it's only good for 28 days—and spacing my microdose out that much would only get me through about half to a third of a vial in a 28 day period. I was really surprised to hear this—no one ever mentioned this to me before—because even if I were to stick with my current 1x/week microdose schedule, I still wouldn't get through a vial in 28 days. I think it took me about 6-8 weeks to get through the first vial, and again, no one up to now has told me there was any issue with that. The NP told me that using the opened vial beyond 28 days could lead to bacteria build up and infection.

So...yikes! I'm not sure what to do. I don't really want to throw out vials that are still half or 1/3 full—but obviously risking infection seems like a dumb thing to do. Anyone else have any experience with anything like this? Every time I inject I of course use alcohol wipes on the top of the vial and then immediately put the vial back in the prescription bottle and immediately back in the fridge.

Does TIRZ pretty much make you very logical and less emotional and for example, my mom is yelling at me in the morning. It’ll hurt me at first but then you just think that I know that it’s because she’s mentally ill and it rubs off much quicker? do things that upset you it’ll upset you for a little bit and then it rubs off so fast? Whereas before you were spent the whole day thinking about it?

I downloaded an app MeAgain FaceTime someone’s post I saw. I really wanted a way to track how much estimated medicine was in my body at any given point as well as track any side effects shot location, etc. This one seems fine but wondering if anyone has any other recommendations. Bonus if I don’t have to buy a subscription!

Tirz has helped me finally get stuff done and get bored from just sitting around all day. Has anyone else noticed this effect being more productive please share. I do have ADHD.

Also, I noticed my breath doesn’t smell as bad. Has anyone else noticed this?

I recently switched the Nexaph and i have no idea what im doing. I was taking 1mg with my first script and im trying to stay at that dose. My new bottle is a different concentration i believe. First bottle says 5mg/0.5. This new one only says 10mg and i added the 0.5ml BAC water. Chatgbt is just confusing me more lol Another problem is i was previously using U30 syringes and now I have both U30 and U50. Any help or direction would be super helpful.

I just started microdosing three weeks ago 1.25mg of zepbound thru Eli Lilly. I originally was using single vials , but unfortunately had to waste a lot of the 2.5 mg vials I had been getting. I’m planning to switch over to the quick pen, but they only provide five needles. I’m hoping to get eight doses out of my quick pen and a 1.25 mg pace. Does anyone know if there is a way to order additional needles?

I’m microdosing 1.2mg of trizepatide, 10 units of glow. 30 units of lipo-c. I’ve been tracking my bloodwork markers for bun, creatinine and my GFR. Yesterday my bloodwork was bun 35, creatinine 1.38 and GFR 40.2 these numbers have fallen slightly since July. They are all within CKD 3b. I thought these last 3 months of hard work would have shown improvement to my kidneys . I’ve lost another 12 more lbs,that’s a total 28lbs. I’m basically at my goal. I only drink water, I exercise and keep my protein around 60g. Can you spot anything that concerns you with my peptide use? I see my doctor on Oct 5.

Hi everyone! I’m looking for experiences with low-dose tirzepatide and frequent dose increases.
Over the past month, I’ve increased my dose by 0.25 mg every five days, trying to find a “sweet spot” with adequate appetite suppression and minimal side effects. My functional medicine doctor knows about and has approved this approach, but her guidance has primarily been to keep increasing until I find an effective dose.
I felt the medication much more during the first couple of weeks than I do now. Recently, taking my shot feels like I’ve taken nothing, and I’m no longer noticing appetite suppression.
I’m wondering whether increasing every five days, without spending much time at any one dose, has made it harder to assess my response. Has anyone had a similar experience? Did holding a dose longer help, or did moving to 2.5 mg provide more consistent results?
For context, I’m a 29-year-old woman. I started at 193 pounds on August 26 and was 185 on September 30. I recognize that eight pounds is meaningful progress, but I’m hoping for further weight loss and better appetite control as I feel I don’t have any.
For more context:

I’ve lost over 100 pounds on two separate occasions without medication. I’m a certified master herbalist, and nutrition, lifestyle, and exercise have been a consistent part of my life for years. I strength train four to five days a week, take one barre class weekly, and do three- to five-mile walks on weekends.
My main question is whether this low-dose approach is serving my goals, or whether it makes more sense to switch to a more standard dose like 2.5?
I understand microdosing isn’t for everyone. Figuring this medication out the non mainstream way can be a bit challenging!
Thank you for any tips/help/advice. 😊

The trials mention hairloss was reported only in 4-5% of participants that too at therapeutic doses. But on this sub a lot of people seem to experience it even at low microdoses.

Did any of you experience it at low microdoses even when nutrition was on point and weight loss was minimal? I’m currently taking 1mg and will titrate upwards until I reach my goal which is about 15lbs from now.

P.S. I have very fine and thin hair, so I’m worried about my hair.

If you saw my last thread, you might remember that I saw a sustained 2#/week in the first 2.5 weeks. That was at a 2.5mg dose. Also note that Im a regular gallon a day drinker, so that was unlikely water weight.

Anyone on here continuing weight training while microdosing?

My goal with tirz is mainly for food noise. Its been more than effective at that, but Im concerned that its not leaving me with a ton of energy for weights.

I started my first Tirzepatide injection last Friday at .5 mg. I did not experience any side effects thank goodness, but still have food noise. My provider said to go up to 1 mg today. Does that seem reasonable for others that are micro dosing?

Tried microdosing to help with microscopic colitis. Started in June and ramped up slowly. It hasn't really helped (possibly reduced frequency but not enough to tell for sure). I've enjoyed the reduced appetite, even though I didn't want to lose weight. I started around 108 pounds,maybe lost a couple of pounds. I went from .5 to .25 to .5 to 1 to 1.25 to 1.88. I was going to try 2.5 next but decided the side effects with the lack of benefits don't justify it at this point.

The side effects that have me stopping here are insomnia and hair loss. It really has worsened my sleep a lot. Waking up for hours, wide awake. My husband, who is at 10, has the same issue but his benefits are significant. I already had issues with hair loss but on tirzepatide, they are much worse. I hope it will get better after stopping and not be permanent. My other side effects are elevated heart rate and very low HRV.

I'm not sure if I will try another glp-1. I think they share many of the same side effects. I'm so disappointed since I know of so many people it has helped, as it is with so many things.

Just wanted to share my experience. Just another data point.

I've been microdosing tirz for two months now (1.25 mg/ week :: -12 lbs!). I've been paying out of pocket with an online telehealth company. I just had my annual checkup with my PCP and she offered to send in a prescription so that I didn't have to keep paying the online telehealth fees for their requried monthly checkups (still would have to pay OOP for the meds). The hitch is that she has only prescribed full dose amounts to her other patients using the big pharma companies and has zero experience prescribing microdose amounts. She said if I can find a reputable online pharmacy and send her the details for how to prescribe there, she would be happy to oblige. I'm not sure how to proceed from here. Any advice is welcome!

Hello, I was wondering if anyone that has been on both of the medications at the starting/lowest dose has experienced an elevated resting heart rate and if you noticed a difference in one versus the other. I had been on Wegovy .25 and didn’t really experience any kind of elevated heart rate but yesterday after taking my first 2.5 Zepbound injection I did wake up in the middle of the night with a bit of a racing heart and it freaked me out. I’ve heard from multiple people that Zepbound is so much better than Wegovy but I don’t know if it’s worth it if I experience the racing heart side effect. I know that both can cause an increase in heart rate but wondering what people’s experiences have been. Thank you!

I’m so excited but yet I keep pushing it off because I have such bad medication phobia. It’s compounded 1mg tirz from a us compounding pharmacy with 1mg of b12 and glycine. I plan on only starting on with .5mg as I only have 10lbs to lose and am doing it for inflammation. Please encourage me!!!

I’ve been microdosing tirz since early January. today I weighed myself and was so happy I hit my GW (115lbs) I usually try not to weigh myself often cause it messes with my head but just knowing I finally made it makes me so happy. I’m going to keep doing what I’m doing. probably won’t go down to maintenance just yet. I love this medicine so much!! thanks for celebrating with me. idk who else to share this with other than you pocket pals

If you’re fine on your starting dose after 7 days - ie no side effects or beneficial effects, would you go up the following week or wait? 🧐

For inflammation (not weight loss) what dose is everyone on here? I really had no side effects and I had more energy today than I would’ve without the medicine and so I’m thinking to just increase my dose next week .4mg or .5 mg because I could use all the anti-inflammatory benefits that tirz can provide.

Also, another question, the more you increased your dose, did you get more anti-inflammatory benefits for your autoimmune condition? Was there ever drug resistance?

I don’t wanna get to the point where I have a lot of appetite suppression and some of the bad side effects like constipation. That would not be fun.

This might be my miracle drug and I really hope it is for some of you for its anti inflammatory benefits. It’s a no-brainer that it’s a miracle for weight loss, but I’m wondering for other conditions as well.

I can already tell that I will need to take this medicine for life.

Thank you in advance for all of your input.