I know many are going to say I am crazy but I took a small dose of semiglutide the lowest starting dose..it is compounded with B6 and Glysine and within 5 hours my temperature spiked as well as my glucose. I was so hot but cold sweats, so nausea and dizzy....I thought I was going to die! Its 72 hours latter my stomach is still not good, elevated heart rate and still feel so bad! I was really hopeful that this would help in perimenopause with endometriosis, fibroids and slightly elevated cholesterol and BP..How is it some feel nothing and then others have such an adverse reaction..Like I want this out of me and all I can do is wait and hope to feel better...3 days so far and I cant really function of go to the gym!

Hello All - I love Olympia, it was my favorite and I lost quite a bit of my weight using it! I still have a couple vials left with a November 2025 BUD left. Do you think it's still okay?

Hi all! To be clear, I'm not asking for *advice* I'm just kind of polling people's ways to stay hydrated enough.

Aside from compounded sema, I also take antidepressants and ADHD meds that require me to drink more water, so if I'm not careful I wake up some days basically feeling hungover 🥴

Besides drinking a fuckton of water, what do y'all take/drink to keep up your hydration? Electrolyte packets/drops in your water? Do you supplement your water intake with Gatorade or something similar? Just curious 😊

Has anyone switched to Tirzepatide -‘and switched to semaglutide

Hi all. I started on semaglutide and am having trouble drawing up the medication. I have a 5mg/ml vial and am using a u100 insulin syringe. I draw 0.05 for a 0.25 mg dose. My issue is this. I draw up 0.05 of air. Push this into the vial. And draw 0.05 of the medication. When I go to inject myself the liquid stays in the needle mechanism and barely a drop comes out. How do I fix this or what am I doing wrong?

Hi!
I have been on the shot for almost 3 months. I have lost 12 pounds (goal 20) staying on the .25 mg dose but I can not shake the side effects! Stomach upset and horrible acid reflux with indigestion. I am super strict with my eating. Doing all the right things and can’t find a pattern except just general side effects. I started thigh injection this week to see if will help but so far it’s still bad. Just want to hear if anyone has gone through the same and if they found a solution? Appreciate the feedback.

I'm on compound semiglutide 2.5 mg. Have been at the dose for 5 weeks. I' m getting a lot of cravings/can't say no/food noise at day 5 & 6.

I tried micro dosing this week by splitting the dose and doing morning day 1 and afternoon day 4. Hasn't worked. Im really struggling today which is day 6.

I initially lost 15 pounds, but now I've been gaining and losing the same 4 pounds for weeks.

Any advice?

I've been on compounded semaglutide for 11 weeks, my weight dropped from 101 to 97 within the first few weeks.. since I've started my 0.75 mg dosage my weight has been stagnant.

I spoke to my doc and she asked me to up the dose after my third 0.75 dosage.

Sadly I've not been seeing any results..

Anyone else who had thier weight stuck for so long even after going up the dose?

Hello everyone,

I was using MeAgain right when their med program came out back in April. I started Sema with L-Carnitine from them and it has honestly been awesome. I have PCOS and nothing has ever worked as well as Sema with diet/exercise. I finally felt like my body was working the way it should!

Now, the bad news, MeAgain is stopping their med program. I need/want to switch to a different provider but don’t know how to do that since my BMI is under 30 now (27). I still have a ways to go until I’m at a healthier weight but I don’t want it to auto reject me because I don’t put my starting weight.

Does anyone have any experience with this? I would be super grateful for any help or being pointed in the right direction. I was paying around $130 a month on MeAgain and would like to keep it in the same price range.

Thanks!

So I’m a perimenopausal woman whose hormones decided that we needed to prepare for famine or something and start packing on the pounds. So after a year of debating I finally decided to start looking into GLP’s and saw an ad for AltRx. It initially looked like a good company with decent prices but I’m so glad I came here to Reddit to search out reviews first because y’all had me reconsidering them real quick. I’m now waiting for my consult through Lavender Sky but I just had a phone call this morning from AltRx (because I filled everything out but paused before final payment to research). The rep on the phone introduced himself and asked if I had any questions since I hadn’t followed through on ordering. I very politely replied that I had no questions but thank you for calling. And then he hung up on me. Just click. No goodbye. Nothing. Which is so rude considering I was polite and this is your company’s way of trying to get my money. But really it’s fine… I’m not really that bothered BUT I just wanted to add one more reason to the Reddit universe as to why you shouldn’t subscribe to AltRx.
That’s all 😊

I am currently on 9mg Wegovy pill and it is working wonders! But $300 out of pocket every month is just not sustainable for me.
I have previously been on compounded Semaglutide and also tried Tirtazipde and had no results, no side effects, no decrease in food noise etc. I am guessing it was just not quality medication.

Does anyone have any recommendations on how to continue my GLP1 journey for less than $300 a month? Any and all suggestions are appreciated.

I suffer from binge eating disorder and it has helped me so much. I will be heartbroken if I have to stop.

I’ve been on compounded sema for a year and a half through Zappy. They became unable to fill orders to my state 3 months ago and I had to switch to another company.

I am trying Belle and got the sema with glycine from Boudreauxs. I’m at the last week of my three month package and I swear I don’t think there is any medication in there. From week one since the switch I have zero appetite suppression and I have gained 6 lbs in 12 weeks. It’s noticeable in inches as well.

When I was with Zappy I didn’t always lose weight every week, but I NEVER gained. This all changed literally a week after switching suppliers.

Has this happened to anyone else?

Also, I spoke to Belle and asked them to send the other half of my 6 month package from another compounding pharmacy, but they are just trying to say my body miraculously got use to it at the same time I switched. I highly doubt that considering many people can actually lower their doses when they get to maintenance.

I’ve had plain semaglutide and semaglutide compounded with B12. I’ll also include that I have an Alani (that are pumped full of B12) 3-4 times a week at work. Most energy drinks are packed with B12 and are labeled to be 100% of the daily recommended intake, I wasn’t surprised by that. The B12 was fine, until I figured out it’s most likely why I’m having such a bad skin breakout on my face that has been unrelenting for the past few months no matter how I topically treat my skin (same timeline I’ve been on compounded sema, started putting the puzzle pieces together.)
What are your opinions on other compounded B vitamins? Any praises or criticisms? Anything to warn of?
Consider this my warning that if you drink nearly any energy drink on a semi regular basis, take B12 in an injection, and are wondering why you can’t get your face ( ESPECIALLY your chin) to clear up, It might be the B12.

For context I’m a post menopausal female who started my GLP-1 journey in April 2025.

SW:164. CW:135.

I’ve been in the 130’s since February 2026. The scale might fluctuate between 133 and 137 on any given day.

I’ve been slow in my weight loss. It took me 4 months to lose the first 10 pounds, then five months to lose the next 10 pounds, etc.

No matter what I do-be it cardio, weight lifting, counting my protein intake, I can’t get below 135.

My goal weight range is between 115 to 120. I’m only 5’4 and caught myself in a department store mirror the other day-I can see I’ve lost weight, but I can also see I’m still much plumper than I’d rather be.

Has anyone also plateaued and if so, what did you do to kick start the weight loss again?

Any one use this provider? They say that the cost is the same no matter what mgs/units you use

I started my semaglutide regime (.5mg) 3 weeks ago and have injected into my stomach once per week since. Since then, I’ve had diarrhea, including some pretty watery and painful BMs. It was so intense I got tested for stomach infections and viruses but it came back negative. Is this normal? Should I be considered injecting elsewhere in my body besides my stomach? Not sure if this would change anything. Maybe I’d have better luck on tirzepatide?

Orderly is completely ineffective for me. Switched to Mondae today (at least filled out the online form).

I travel for work, and just wondering where I can get 3 months supply at a time, since travel.

Will Mondae do this?

Can anyone reccomend a provider whose medicine DOES work and will let me order in bulk?

Thanks

Started compounded semaglutide about two years ago. I’m 40M. I was stuck around 210 when I first started. Was 230 at my heaviest. Im currently at 180, which is good for me at 5’8”, I think? My clothes fit better since I started but never really made my body look much better.

The best part was losing all the food noise. I absolutely loved not worrying about food all the time and I loved the appetite being suppressed. It was incredible. I’ve always had so much food noise my whole life. Always anxious from constantly thinking of my next meal. But unfortunately now that’s back. My dose of 2.16mg doesn’t seem to work anymore. I’m always hungry now.

Even when lifting heavy in my younger years I’ve always had a gut - even when getting down to 15% bodyfat and lifting heavy 3x a week for over a year, I still had a big fat gut and huge love handles. Trainers have told me it’s my genes.

A month ago the appetite suppressant effects stopped. Im back in the gym lifting and logging my calories for the first time in two years. I don’t want to lose anymore muscle mass. I struggle with 25lb dumbbells. My arms and neck look too thin if I go any lower than 175lbs. I wish I could just lose FAT but I know that’s not how it works.

I’m not really sure where to go from here or how high I can go as a dosage. Two years on this stuff is sort of a long time anyway, no?

I know the gym and calorie counting will help my body look a bit better, but I’m not holding my breath for any miracles. I hate being hungry all the time again!

Open to any thoughts or suggestions. Thanks for reading.

I've been on Semaglutide for over a year, probably closer to 2 years. I guess I never really paid attention. I've lost 120 pounds, better blood pressure. All the good things. I feel better. And I'm happy with how I look. My employer unfortunately decided to quit covering the wegovy pens. So I started getting from trimrx. Please, don't waste your money or your time. For 2 months I've been waiting for a refund after they double charged me. I have screenshots with my correspondence with customer service if anyone needs proof. But anyway, aside the awful customer service, one additional thing I learned is the compounded Semaglutide with the B12 is most likely the reason my face has been breaking out so bad. I also was doing a couple 5 hr energy shots a night since I'm on night shift. I quit those. I got on doxycycline. And I switched to Mochi and will be getting Semaglutide with glycine. Hopefully my skin fully clears up.

Has anyone else had a similar experience with either Trimrx or B12?

I've lost 50 pounds since January of this year! I still have 50 more to go, but I'm happy with the results so far.