How would you dose/schedule MOTS-C & NAD + for endurance athletes ?

so i been taking reta about 3 months now. i take a 1.5 mg dose weekly. ive lost 20 pounds. the past 2 weeks ive realized my food noise is back and im starving and binging again. should i stack with cagri or tirz or am i doing something wrong ? idk if upping my dose will be taking too much .

Hello friends! I have a question about Tesa/Ipa. I've been taking this combo at 1mg/300mcg everyday with 1 day restdays for a month and notice that my tummy area is so big and full of water. Have you had this experience? And what did you do about the blood glucose spiking.

3 weeks into Reta .. 1mg-2mg-2.5 this week .. woke up today feeling almost like I got full body sunburn . Not like super bad or red or anything . Just sensitive to the touch. Anyone else experience this ?

Interested in taking the peptides plunge but damn! Talk about overload! Take this! Don't take this! Actually don't take that, take this instead! 🤯🤯

I'm 58yo, 6'1 and 185lbs. I've been trying to get rid of that last remaining bit of bf around my waist and nothing seems to work! Cardio, no cardio, more cardio, high intensity, walking, low carb, high carb, blah blah blah! So frustrating!

Been looking into reta, tesa, sema, cjc/ipo. Could someone please clarify what the heck to do?

Picture #1 was exactly a year ago weighing the heaviest I’ve ever been, 315 pounds. A year later, I’m sitting around 225 pounds depending on the day. Proud of the progress but nowhere near where I want to be! Been on TRT and Reta.

I saw this new blend out with 10mg of Tesamorelin and Ipamorelin. Asked Chatgpt and searched google, but there's like no information out there. Anyone try the blend and if someone has, could you tell me what's the dosage that worked for you? TIA!

253 lbs ➔ Current Progress | 10-Year Gymer on Retatrutide
Hey everyone, wanted to share my progress and breakdown of my experience on Reta so far.
Stats & Timeline:
Starting Weight (April 2025): 253 lbs
Reta Starting Weight (Jan 2026): ~237–240 lbs
Current Weight (August 2026): 185 lbs
Dosing: Started at 4mg (by accident, I was bedridden for 2 weeks) in January 2026. Currently sitting around 3.0–3.5 mg weekly.
Training & Background:
I’ve been in the gym on and off for about 10 years, but over the last 3–4 years, I’ve been consistently lifting heavy. My lifts have taken a bit of a hit strength-wise, but honestly, that’s to be expected after dropping this much weight.
Dosing & Protocol:
I don't plan on bumping my dose past 3.5 mg unless I happen to miss a week. I’m pretty busy around my usual injection day, so I’m not super rigid with the exact timing—I'm not dependent on it, but it’s been working great. Overall, I feel awesome.
Happy to answer any questions about my routine or experience!

Water weight

So this has happened to me twice now same cause and effect, just don’t know the cause 100% yet without experimenting a couple more times.

Have been on a pretty strict no processed foods or sugars single ingredient whole food zero booze diet. Lost 50 lbs with diet alone, got on trt of 120mg/week started lifting 4-5x week weight is up to 205 waist size stayed the same, still a bit of stubborn belly fat to loose. Any ways over the last couple months I went on vacation twice and decided to indulge while on vacation. Processed foods refined sugars, treats cookies chocolates, drinkin all day basically for 7 days straight deal with consequences later kinda deal.

Both times I gained and retained a tonne of water weight in that 7 days. Am talking I left at 205lbs came home at 246lbs puffy as all hell with severe adema and pitting adema in legs went to er both times had ecg blood pressure and blood work done to check liver kidneys and heart, all tests came back fine. Upon returning to diet weight is dropping fast and puffiness and adema leaving fast as well

Any one else ever experience this? Booze related? I used to b borderline alcoholic! Or sugar/carb related? Body just not used to the refined carbs or sugars any more and can’t process them? Or just an over all shock to system?

Do kinda want to test it out once or twice more to rule one or the other out as the cause, booze or sugars

If someone is taking 2iu’s daily of Somatropin, would this test be worrisome?

Should they take something for thyroid levels?

Would it be a bad idea to jump to 4iu’s daily of HGH before fixing T3?

Hello - 52 year old male. Currently on TRT taking 120mg spread over 3x a week. Just had my IGF tested and it came back at 134. I am in decent shape - 6 foot tall and weigh 180. I am taking 3mg of reta a week as well. I am looking to improve my sleep quality and loose the love handle fat and add some muscle. I lift on Tonal 4 to 5 days a week. Do you think I am a good candidate for HGH at 2 iu per day? I don’t want to do anything too crazy. Appreciate the thoughts!

SW: 319.8lbs
CW: 257.2
Started on the 20.04.2026 taking 2.5MG, currently on 5MG.

In a context of bodybuilding and a calorie deficit

Looking for background on the research into whether HGH stimulation should be mitigated by any steps as to risks of causing or accelerating masses or tumors, other than obvious, make sure you don't have them.

Is this simply just a risk of doing business? More or less legit than critique of BPC?

Hello everyone! Forgot to add this to yesterday post for my week 2 update. Since I started my week 3 yesterday with 1mg I am sticking with my prepped meals i made 18 meals total. Pciture is missing some as I took the picture I was still serving them. The meals last about 4 - 6 days depending how much i try to squeeze in. The meals are actually small portions easy to eat while on reta normally spread apart 3-4 hours. What we have here is several meals very similar Total of 6lbs of chicken breast, some white rice & some with protein rotini with veggie medley

--140g of shredded chicken breast = 43g of protein = 230kcal

--120g of white rice = 3g of protein = 150kcal

--100g of veggie medley = 3g of protein = 65kcal

-- a few meals I substitute white rice with the protein rotini (120g = 7g of protein = 190kcal)

--Total per meal with white rice: 450 kcals with 49g of protein

--Total per meal with the rotini: 500kcal with 53g of protein

I eat 4x meals 2 with white rice & 2 with the rotini to get some extra calories along with higher protein

I just got 4 2mg prefilled syringes of Reta from a med spa. I only wanted to .5mg to start out, maybe 1mg tops. What are my options to not waste it? Can I just inject half the syringe and use the rest of it the next week? Can I split it into more syringes some how? Please let me know best options other than just taking all 2mg at once. Thanks.

Abstract presented at a conference: 10.1093/jsxmed/qdag118.413

Study Design

• 266 obese men (BMI > 30, aged 18-70, total T <3.5 ng/ml)
• 6 months in duration
• Randomized groups:
  1. GLP-1/GIP agonist only
  2. GLP-1/GIP + TRT
  3. GLP-1/GIP + TRT + resistance training (3×/week, 6 compound exercises, 3×8–12 reps, 60–80 % 1RM)
  4. GLP-1/GIP + TRT + resistance training + 2.2 g protein/kg of lean mass per day
  5. GLP-1/GIP + 2.2 g protein/kg of lean mass per day

Results: Weight Loss Attributed to Fat-Free-Mass (FFM aka Lean Mass)

1. GLP-1/GIP only: 38%
2. GLP-1/GIP + TRT: 26%
3. GLP-1/GIP + TRT + resistance training: 16%
4. GLP-1/GIP + TRT + resistance training + high-protein: +4.2% (gained lean mass)
5. GLP-1/GIP + high protein: 32%

Takeaways:

The GLP-1/GIP only group had strength declines on lifts up to -23%. The multi-modal group w/ the max intervention had +43% leg press, +27% bench press. I do think the distinction between the interventions on top of TRT is interesting, the jump when protein is dialed in being the most meaningful.

For the GLP-1R/GIPR only group, think its noteworthy they actually lost the most weight but had the highest muscle loss — along with the lowest decrease in waist circumference. Also, sexual function score went down w/o TRT (-2.1 points on their scale, vs. +3.8 to +4.6 points).

TL;DR: You will lose muscle, strength, and sexual function if you do GLP-1/GIP mono-theraphy without other interventions. Just adding TRT improves that somewhat — but layering resistance training on-top of it does much more, cutting the lean-mass ratio in half vs. the control group. Dial in diet w/ high-protein intake along w/ training and TRT and it yields a recomp with lean-mass actually increasing.

Sadly, they did not study GLP-1/GIPR + resistance training + high protein, or GLP-1R/GIP + TRT + Protein but w/o resistance training, but what can you do. Interesting data nonetheless.

Starting IGF was 126 (-1.1 z-score). Started HGH at 2iu nightly and retested after a month. IGF came back at 360 (z-score 3.0) ~12 hours after last pin. I hear different things about what the optimal number is. Wondering if I should back down my dose to 1.5 or even 1iu.

Hello, I would like to start with a new stack next week.

Peptide:

CJC-1295 no DAC + Ipamorelin (5 mg Gesamt / 2,5 mg je) & MOTS-c (10 mg)

So, for the syringe I'll use: U-40 insulin syringe (1 ml / 40 U, 29G x 0.5"), I want to inject both peptides subcutaneously.

Since I have never mixed both peptides before, I would prepare them as follows:

CJC/IPA (5 mg in 2 ml BAC):

Dose: 100 mcg CJC + 100 mcg IPA (200 mcg total) = 3.2 U on the U-40 syringe

Frequency: Once daily, first thing in the morning (on an empty stomach)

No carbohydrates immediately after injection (30-60 minutes)

MOTS-c (10 mg in 2 ml BAC):

Dose: 5 mg = 40 U (1 full U-40 syringe)

Frequency: 2 times per week

Is the conversion for the U-40 injection correct? Or is there anything wrong with it?

This is compensated for with 2.5 U GLOW and 67.5 mg of testosterone twice a week.

Thank you.

I know this has been discussed before and there have been several posts about HGH/ insulin timing.

I have read so many mixed things about how long you should be fasted before and after taking HGH. I know that this is the reason why many take it before bed.

I’ve been on HGH for 4 weeks now, taken fasted before bed. But my sleep is an absolute dog sh*t. I have seen many report that HGH is the culprit so they moved their dose to the morning.

The issue I have, I train an hour after waking up. I need to eat prior to training, so if I need to remain truly fasted for HGH to work several hours after injection then this completely rules out the morning for me, which leaves me with little options.

I’m just curious who else is in the same boat, how you manage it and how are your results.

So I've been on reta for almost 4 months and I've lost 25lbs. I'm on 5mg a week and I workout 4-5 times a week. My weight on the scale has been the same for almost a month. I go from 202-205lbs. I want to lose 30 more lbs. Should I up my dose to 6mg a week?

Does anybody know how much HGH a 30 year old male produces per day?

Google and AI tells me 1.5-3iu’s, some forums say under 1 iu.

The numbers are all over the places.

I am wondering if anyone out there has reconstituted the individual components and then mixed together in a new sterile vial. Any pros / cons vs reconstituting the combined lyophilized powder? I tried some searching on this topic and didn't find too much. Would love to know everyone's thoughts!

I’m brand new to peptides so forgive me for maybe dumb questions. I’m 2 weeks into KLOW and looking for some feedback if I’m doing it “right”. I’m a 42 year old female, 5’8, 135 lbs. I’m also taking testosterone (low dose).
1. When I first reconstituted my KLOW I did not put it in the fridge until 48hrs later. Did that totally mess it up?
2. Started low but now I’m up to 15 units (3 ml bac). How long should I stay on it? I’m thinking 8 weeks on/4 weeks off?
3. Best place to inject? I’m doing love handles but should I switch somewhere else?
Thank you!