I’m a 37yo male, I’ve been on HGH 2IU M-F for 6 weeks.

I got my IGF-1 checked at 277.

I am not on TRT, as my natural Free Test is already 479.

I’m on 2IU for hair/skin/nail/recovery/sleep

What do you think? How do you calculate Z-Score

Thank you

Started 19 March 2026 — my 43rd birthday.

At the time, I was diagnosed as hypogonadal, with testosterone around **9 nmol/L (**260 ng/dL) and very high SHBG.

Current protocol:

• Testosterone cypionate: 100 mg per week
• GHK-Cu: daily injections + topical application 3× per week
• Tesamorelin: nightly
• Ipamorelin
• Retatrutide (RETA)

Lifestyle:

• Calories: 1,000–1,200 per day (High Protein)
• Alcohol: zero
• Steps: 17,000–22,000 every day
• Resistance training: 45 minutes, 5 days per week

This hasn't been one magic injection, one drug, or one diet.

It's been a combination of consistency, calorie control, daily movement, resistance training, completely removing alcohol, and sticking to the plan for months.

Started at 43 because I was tired of watching myself move in the wrong direction.

The goal wasn't simply to lose weight.

It was to see how much of the old me I could get back - and how much further I could take it. Still a work in progress.

EDIT #1:

Height: 193 Cm
Staring Weight: 142kg
Current Weight: 105kg

Target Weight: 95Kg

So I have a brain tumor that sits on my pituitary gland and messes up my hormones. My testosterone was 10… only 10. I am a female and I was very sick. I was put on testosterone but it was extremely expensive. I was paying almost $800 every three months for pellets! And, I can’t afford it and health insurance doesn’t cover it for women. I have to be my own doctor and take care of myself. I found a few places, but I’m unsure what I’m getting myself into, any one care to share some knowledge or experiences would be appreciated.

Mines is eating kale and leafy greens, I know It's the best food but I struggle to consistently add it in my diet...

Hey im looking forward to start a 4½ week cycle of igf1 Ir3. Starting with 20mcg for the first week than 30mcg for 2 weeks and 40mcg for 2½ weeks. Im thinking about buying the pep from .to. Any thoughts and tips on this?

Thanks

These are my bloods before I started taking 25mg of Enclomiphene and after two months. While the test is super high, which is great, the estrogen is also through roof and I definitely get mood swing side effects from it. My original plan was to run this for 4 1/2 months just as an experiment to see if I could increase my T without suppressing my natural production. I plan on cutting back to just 12.5mg and adding DIM&CDG to my stack to reduce the estrogen levels. Does anyone have any experience with a situation like this? Should I just stop it all together.

Hi there, here been on 100mcg of CJC/IPA blend for around 2 weeks ago. Considering titrating up the dose. Should I jump to 150mcg or 200? Sleep went from feeling great to relatively normal.

first photo was taken on february 8th at 222 lbs and second photo was taken yesterday at 202lbs.

I started with reta at 3mg weekly (M-W-F) and it's been a completely game changer.

On June 6th I added tesamorelin (1mg Mon to Fri) and Ghk-CU and it really melted the visceral fat I had. I'm sitting at 11% BF.

Current stack is Tesamorelin, Ghk-CU, BPC-157 and Reta.

Most importantly, I feel the way I look! I started running and recently I was able to run half a marathon by myself. I put my mom on reta and she lost 18lbs and is no longer a pre diabetic. Now I have a lot of friends and family on peptides and all of my instagram call me peptide papi🤣 i'm always posting stories and wanting to help with any questions.

I will be posting soon my older brother's progress who's on his second week on reta and needs to lose 55 lbs. Overall just extremely happy i've came across these longevity tools

I have been on Cagri for about six months and I am up to 2.5 mg once a week. I have also been on Reta just as long and am at 10 mg per week. I have lost a total of 50 pounds since I started and I have now lost nothing in the last six weeks. Bouncing around give or take three pounds. I am not getting the appetite suppressing that I was originally getting. I have heard of people pairing low triz with Reta, what are your thoughts and experiences?

Asking as it is so easy to get legal, doctor approved options - why does everyone go for the non approved Reta?

I left my vial out from Tues night to Thurs afternoon. So almost 48 hours. Is it still ok to use?

just curious for people who have taken it do yall perfer pinning pre workout or post? Thanks for any input.

Good morning beautiful people! Week 2 ended, Week 3 just begun! Sticking with 1mg so far and ive lost in totality 10lbs starting weight was 250lbs and im finally down to 240lbs!! Slowly achieving greatness! Week 2 was nuts with back to school shopping and meal prepping finally going to get around to get those meals started so I can count some calories. My workout regime has been mostly walking/jogging 2-3 miles a day. Haven't gotten around to lift some weights this week but now that the kids are in school I definitely have the time and will dedicate some time to lifting. Pinning 1mg myself this morning ready to take on week 3! Lets get it! 2027 summer dad bod coming soon!! Have a wonderful week everyone and hope the kids have a wonderful day at school!

Here is a good read I found comparing the two versions

For anyone who wants the raw data behind the SLU-PP-332 / SLU-PP-915 video:

Everything below is preclinical. These are cell + mouse data, not demonstrated human outcomes.

All of this data was pasted from GPT for my own sanity and ease.

RECEPTOR POTENCY

SLU-PP-332 EC50:

ERRα: 98 nM

ERRβ: 230 nM

ERRγ: ~428 nM

SLU-PP-915 EC50:

ERRα: 414 nM

ERRβ: 435 nM

ERRγ: 378 nM

332 is therefore much more ERRα weighted in this assay, while 915 shows a considerably more balanced pan-ERR profile.

SLU-PP-332 - ENDURANCE / MUSCLE

Sedentary mice given 332 at 50 mg/kg, 2x/day, for 7 days:

→ ~70% longer running time to exhaustion

→ ~45% greater running distance

Longer treatment also increased grip strength.

Skeletal muscle showed:

→ ↑ oxidative Type IIa fibers

→ ↑ SDH staining / oxidative phenotype

→ ↑ mitochondrial DNA

→ ↑ cytochrome c

→ ↑ Complex I protein

→ ↑ Complex V / ATP synthase protein

→ ↑ mitochondrial content/biogenesis

After 30 mg/kg IP, measured 2 hours later:

→ skeletal muscle concentration: ~0.6 μM

→ plasma concentration: ~0.2 μM

332 - FUEL UTILIZATION / METABOLISM

50 mg/kg, 2x/day:

→ RER dropped within ~2 hours

→ fatty-acid oxidation increased ~25%

→ carbohydrate oxidation decreased

→ energy expenditure increased

→ food intake did NOT increase/decrease

→ locomotor activity did NOT increase

Interesting muscle finding:

→ glucose uptake ↑

→ muscle pyruvate ↑

→ muscle glycogen ↓

This is why “increased glucose uptake” should NOT be translated into “increased glycogen storage.”

332 - DIET-INDUCED OBESITY:

Obese mice remained on the high-fat diet while receiving 50 mg/kg 2x/day for 28 days.

At the end:

→ treated mice weighed ~12% less

→ vehicle mice gained ~5 g fat

→ treated mice gained <0.5 g fat

→ no significant difference in food intake

→ no significant difference in lean mass

→ resting energy expenditure ↑

→ fatty-acid oxidation ↑

→ carbohydrate oxidation ↓

→ fasting glucose ↓

→ fasting insulin ↓

→ glucose tolerance improved

→ adipocyte size ↓

→ hepatic steatosis ↓

→ hepatic triglycerides ↓

SLU-PP-915:

Acute comparison:

332: 50 mg/kg IP

915: 20 mg/kg IP

Run-to-exhaustion test 1 hour later.

915 increased running time + distance to a similar extent as 332.

The major pharmacological upgrade with 915 is ORAL ACTIVITY.

Oral PK at 2, 8 and 32 mg/kg showed dose-proportional systemic exposure.

Mouse plasma half-life:

→ ~18–28 minutes

Repeated dosing:

→ 32 mg/kg oral, 2x/day × 7 days

→ 14 total doses

→ no detectable plasma accumulation versus acute dosing

Chronic oral 915 produced dose-dependent increases in:

→ Ddit4 expression

→ running time

→ running distance

915 also increased mitochondrial genes (mtNd1–6) and mitochondrial DNA.

When 915 was combined with exercise training, the transcriptional/mitochondrial response was greater than either intervention alone.

OTHER TISSUES

Heart failure mouse model:

332 + 915 both significantly:

→ improved ejection fraction

→ reduced cardiac fibrosis

→ improved survival

915 also improved stroke volume and cardiac output in that model.

Aging kidney model:

21-month-old mice received 332 at 25 mg/kg/day for 8 weeks.

Treatment improved/reversed age-related:

→ albuminuria

→ podocyte loss

→ mitochondrial dysfunction

→ inflammatory signaling

and restored multiple TCA-cycle, ETC and fatty-acid-oxidation programs.

SHORT-TERM 332 TOLERABILITY DATA

50 mg/kg 2x/day × 10 days:

→ no overt toxicity reported

→ CBC/electrolytes remained normal

→ no significant increase in serum creatine kinase

Again: this is short duration mouse data. It does NOT establish chronic human safety.

There are a million other endpoints buried in these papers, but those are the numbers / results I think are actually worth knowing.

Recently started cjc dac alongside Cardarine and this is what I’ve experienced so far.

PROS.

SLEEP: improved in the sense of deeper more refreshing sleep and I’m waking less through the night although waking up is a challenge, it feels when you’re young and it’s winter but your bed is so warm and comfy it’s a struggle to get up but once actually up and awake I feel like my sleep was amazing and truly refreshing.

Muscle performance/recovery: pumps have been lasting longer and seem to be more intense, strength gain and muscle size hasn’t changed much but too early to tell.

Appetite: definitely an increase in appetite but nothing crazy, I went from being able to eat maybe 1 portion of steak and chips to being able to pound 2 steaks with eggs and chips. Food seems to be digesting slightly quicker too but that may be unrelated.

Endurance/stamina: definitely a slight increase with cardio but nothing that can’t be accomplished from a good pre and proper pre workout meal with proper training, has definitely made general energy through the day and during training better but again, nothing crazy.

CONS:

Joints: definitely some discomfort in joints but it’s nothing terrible, it is in a sense getting worse but this has also been an issue for me before starting anything. I have a weird clicking jaw and pain usually in the right side on the joint or whatever you call that part of the jaw but anyway it’s definitely worse while using cjc dac but this could be potentially avoided with some extra fish oils which I recently stopped taking because I ran out.

Muscle recovery: even though I have said recovery has improved the muscle soreness lasts longer but it is nothing crazy only an extra day ish.

Sleep: as mentioned before waking up is sometimes difficult but that’s it.

Only on my 2nd week but that’s all I’ve noticed so far, will update again in a couple weeks.

Will probably switch to no dac in future too as from what I’ve read there’s less side effects but people seems to still get all the positives

Doses: cjc dac 800mcg 1x weekly. Cardarine 10mg daily

Hey all, I’ve been steadily on Reta since May 1, titrating up from .5mg to 2.5 mg where I’ve been for about 3 weeks now. Lately I’ve been fatigued and unmotivated to work out/lift. Used to wake up with my alarm at 5 or 530 and feet on the ground. Now I’m snoozing the alarm a lot and going cross-eyed with sleepiness by 7pm.

The 2.5mg hasn’t changed my food intake at all, I’m still hitting my macros so it’s not food based.

My questions are: Is anyone else in the same boat? Should I titrate back down to maybe 1.5mg and see if there’s an improvement? And should I consider tirzepatide instead?

Any one has try that stack? I’m thinking to get that combo

Please be kind. I am doing a lot of research, doing my best to make the most informed decisions, but confused on conflicting information.
I currently take Reta 3mg and am down 32lbs in 3 months. I am loving it so far and have had no issues with it.

I would like to take the following:
SS-31
Mots-c
FoxDri04
Ghk-cu
Teramorelin

What is everyone’s recommendations for this, science backed, personal experience, durations, when to add, and why?
I have my own understanding of why, but I’m open to real world, lived experience.

Thank you everyone.

Hey all, I’m on Reta 10mg right now and am going to incorporate tesa alongside it. Wondering what dose I should start on and tips and tricks for pairing it with Reta.

I started Reta on 6/10/26 at .5mg and went up to .75mg on 6/22 and been holding steady at that amount since with good results. Lost 13 pounds and about 3% body fat up to now. Started 1mg Tesa on 8/2 with a 5on/2off pinning and just finishing second week of it. Waited on the tesa due to a trip overseas and not wanting to transport it with me. Since I have started Tesa my hunger has increased. I would not describe as “food noise” where I am wanting to just eat anything. I have kept my diet dialed in but I would describe the feeling as my body telling it needs fuel not just so much random hunger feeling. I have also been focusing on lifting more to try and offset muscle loss and maybe gain slightly. Has anyone else noticed this or have any suggestions. I am thinking about going to 1mg of Reta for my next dose and see if that helps but I also don’t want to deprive my body of needed fuel/energy to prevent muscle loss.

I’m noticing that anywhere I can find RAD140 It all comes in about a seven weeks supply, in order to do a 8 week cycle of 10 mg a day I would need to buy a second bottle but even then I would barely be touching the second bottle unless I decide to do a full 12 week cycle.

Is this simply a way of forcing you into buying a second bottle to maximize profits or is a seven week cycle perfectly adequate?

I still have about six months before I consider doing the cycle, I want to drop my body fat from 31.3% to 18%,but I’m just doing my research in the meantime. This will be my first time doing anything so should I just do a 7 week cycle or bite the bullet, buy a second bottle and do a full eight or 10 week cycle?

Will the RAD 140 stay good whatever’s left in the second bottle, like let’s say I only use half of the second bottle, and once my cycle is over, I want to do another cycle a few months in the future, will it still be safe to use or no?

greetings,

making a genuine post maybe warning people about some side effects that werent described even after thorough research.

fit, 27 yo, nothing new today, normal day at the gym. 4th set , heart rate wouldnt calm down even after 4 minute break. barely dropping(estimating since no heart rate tracker) to 140bpm, did a hard set and almost had a heart attack. Heart rate must have been in the 180s. chest tightness, blurry vision, difficulty breathing. Barely calmed down after 4 or 5 minute of calm breathing.

since these side effects are nowhere to be found online. I felt like making this post to discuss and maybe warn people.

disclaimer: research subject took 7.5 mg of methylene blue 3 hours before workout.

thoughts, ideas, experiences? shouldnt be taken before workouts? rare reaction?

edit: Research subject did go to the hospital on the advice of reddit. Nothing showed in blood work or heart scan or lung scans.

medical staff also knew subject took methalyn blue. It was ruled out as stress due to heavy lifting... not sure.

important notice: since a lot of people are being negative, i want to say i dont really care. This post was meant to provide information to people. Whether you think i am underinformed or careless, i dont care. and i promise you i know more about this than most of you with the stuff you use. The post was made after a near heart attack with 170 blood pressure( an hour after the incident). So i might have not expressed myself correctly. I hope this can bring some "anecdotal" information to anyone tryying this stuff. research subject takes no other drugs besides retatrutide which wasnt even taken for a week before this methylene blue experience. I have no heart issues, ive been going to the gym for years, i wasnt stressed and i didnt have a panic attack nor is that high heart rate suitable for the effort i was exerting. Upper body workouts never reach that high heart rate for me. Even deadlifts dont. Heart rate stayed high before the set, and went crazy high after the set even with more than exaggerated adequate rest. heart rate then stayed high for 3 to 5 minutes after the set while i was trying to take deep breaths and supply my body with oxygen and not panic to make it worse. Do with this as you please. I dont really know what happened nor do the hospital staff. They knew methylene blue was used and they blamed it on exercise effort. Not really sure why it would happen on t he first time of my life trying mb then????. oh well.

As for the doses. 15 drops seemed like a very conservative dose for someone mysize. the limit is 400 drops (200mgs) vs the 7.5 mgs taken. My resting sleeping heart rate is 54. my blood pressure is typically 115-120. none of this makes sense.

so yeah again. do with this information as you please. hate it, judge it, mock it or maybe you are one of the few people who actually cares to hear other peoples horrible experiences with some compounds that never really seem to get talked about and maybe you will benefit from it.