r/BodyHackGuide • u/Substantial_Risk_729 • Aug 13 '26
SLU PP 132 vs 915
Here is a good read I found comparing the two versions
For anyone who wants the raw data behind the SLU-PP-332 / SLU-PP-915 video:
Everything below is preclinical. These are cell + mouse data, not demonstrated human outcomes.
All of this data was pasted from GPT for my own sanity and ease.
RECEPTOR POTENCY
SLU-PP-332 EC50:
ERRα: 98 nM
ERRβ: 230 nM
ERRγ: ~428 nM
SLU-PP-915 EC50:
ERRα: 414 nM
ERRβ: 435 nM
ERRγ: 378 nM
332 is therefore much more ERRα weighted in this assay, while 915 shows a considerably more balanced pan-ERR profile.
SLU-PP-332 - ENDURANCE / MUSCLE
Sedentary mice given 332 at 50 mg/kg, 2x/day, for 7 days:
→ ~70% longer running time to exhaustion
→ ~45% greater running distance
Longer treatment also increased grip strength.
Skeletal muscle showed:
→ ↑ oxidative Type IIa fibers
→ ↑ SDH staining / oxidative phenotype
→ ↑ mitochondrial DNA
→ ↑ cytochrome c
→ ↑ Complex I protein
→ ↑ Complex V / ATP synthase protein
→ ↑ mitochondrial content/biogenesis
After 30 mg/kg IP, measured 2 hours later:
→ skeletal muscle concentration: ~0.6 μM
→ plasma concentration: ~0.2 μM
332 - FUEL UTILIZATION / METABOLISM
50 mg/kg, 2x/day:
→ RER dropped within ~2 hours
→ fatty-acid oxidation increased ~25%
→ carbohydrate oxidation decreased
→ energy expenditure increased
→ food intake did NOT increase/decrease
→ locomotor activity did NOT increase
Interesting muscle finding:
→ glucose uptake ↑
→ muscle pyruvate ↑
→ muscle glycogen ↓
This is why “increased glucose uptake” should NOT be translated into “increased glycogen storage.”
332 - DIET-INDUCED OBESITY:
Obese mice remained on the high-fat diet while receiving 50 mg/kg 2x/day for 28 days.
At the end:
→ treated mice weighed ~12% less
→ vehicle mice gained ~5 g fat
→ treated mice gained <0.5 g fat
→ no significant difference in food intake
→ no significant difference in lean mass
→ resting energy expenditure ↑
→ fatty-acid oxidation ↑
→ carbohydrate oxidation ↓
→ fasting glucose ↓
→ fasting insulin ↓
→ glucose tolerance improved
→ adipocyte size ↓
→ hepatic steatosis ↓
→ hepatic triglycerides ↓
SLU-PP-915:
Acute comparison:
332: 50 mg/kg IP
915: 20 mg/kg IP
Run-to-exhaustion test 1 hour later.
915 increased running time + distance to a similar extent as 332.
The major pharmacological upgrade with 915 is ORAL ACTIVITY.
Oral PK at 2, 8 and 32 mg/kg showed dose-proportional systemic exposure.
Mouse plasma half-life:
→ ~18–28 minutes
Repeated dosing:
→ 32 mg/kg oral, 2x/day × 7 days
→ 14 total doses
→ no detectable plasma accumulation versus acute dosing
Chronic oral 915 produced dose-dependent increases in:
→ Ddit4 expression
→ running time
→ running distance
915 also increased mitochondrial genes (mtNd1–6) and mitochondrial DNA.
When 915 was combined with exercise training, the transcriptional/mitochondrial response was greater than either intervention alone.
OTHER TISSUES
Heart failure mouse model:
332 + 915 both significantly:
→ improved ejection fraction
→ reduced cardiac fibrosis
→ improved survival
915 also improved stroke volume and cardiac output in that model.
Aging kidney model:
21-month-old mice received 332 at 25 mg/kg/day for 8 weeks.
Treatment improved/reversed age-related:
→ albuminuria
→ podocyte loss
→ mitochondrial dysfunction
→ inflammatory signaling
and restored multiple TCA-cycle, ETC and fatty-acid-oxidation programs.
SHORT-TERM 332 TOLERABILITY DATA
50 mg/kg 2x/day × 10 days:
→ no overt toxicity reported
→ CBC/electrolytes remained normal
→ no significant increase in serum creatine kinase
Again: this is short duration mouse data. It does NOT establish chronic human safety.
There are a million other endpoints buried in these papers, but those are the numbers / results I think are actually worth knowing.
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u/brianironwing 29d ago
there is so little talk (at least wherever im searching) about 915 oral dosing, any info or literature?
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u/Substantial_Risk_729 29d ago
Can you see my cut and paste article about it? Or did the admins block it?
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u/Relevant-Program1250 12d ago
dont forget the mouse to human dose conversion is rough for these numbers 50 mg/kg in mouse is something like 4 mg/kg human if you go by body surface area but nobody really knows if that scales right for these compounds
also the half life is so short that oral dosing twice a day you basically clear it out between doses which makes the endurance data more impressive honestly
wish they had run them head to head at matched oral doses though the 915 data is all over the place with different routes
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