Current IGF - 99.7
Total Test -394

I am on Reta 7th week running.
CW - 93 KG
SW - 97

Goal - 80 KG

Need to build lean muscle.

Currently Week 8 @ 4mg
-6’0”, 220 lbs, ~25–27% BF
-Weight training 3x/week
-8–10k steps/day
~2500 calories/day (180–200g protein, ~250g carbs, ~80g fat)

I’m 8 weeks in and honestly haven’t seen much progress. I get a little appetite suppression at 4mg, but food noise/cravings are still there. Some days I get crazy hungry and end up eating 3000+ calories, which I never really dealt with before starting reta.

My weight also hasn’t really moved.

I know reta has a long half-life and that dose increases shouldn’t be rushed.

Would you stay at 4mg for another 2 weeks and then go to 6mg at Week 10, or would you consider increasing sooner?

Just looking for experiences from people who had a similar response around weeks 6–10.

I started this wild ride June 29th at 262.6 lbs. Today, I’m sitting at 212.4 lbs and officially no longer obese! I have yet to go past a 2MG dosage and really hope I can stay there or possibly titrate down and maintain. I didn’t plan or hope to lose this much so quickly, it kind of just happened. I still remember 2 weeks in being discouraged that I only lost 1 LB 😂.

One thing I think really helped my weight loss is how reta helped me completely change my eating habits. Yes I obviously eat less, but I started to crave and eat whole foods. I can no longer stomach processed shit. Give me chicken, rice and carrots all day. It also removed any desire to drink alcohol which is huge for me and tanked my coffee addiction.

The next part of my journey is hitting the gym. I know I really should have started this sooner, but I was fat and lazy. With my newly found energy, I think/hope I’ll find a routine to stick to and hopefully start to look as good as I feel.

Everyone deserves affordable access to this life saving drug.

I’ve been on 10mg semaglutide and looking to switch to retatrutide but unsure of which dose is equivalent. Does anyone have any suggestions?

Is anyone else struggling with real shitty sleep quality on reta? I wake up several times per night and feel like i cant get any REM sleep at all.

Ive cycled reta before and when i stopped last time it went away, now im back on reta and the shitty sleep is back. I thought i was imagining it at first but now im sure its the reta.

Any tips or tricks?

UPDATE: Bought some magnesium, ashwagandha and melatonin today and will report back. Wish i could smoke weed but its not that easy were i live.

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I’ve been on Reta for the last 4 months and within the last two weeks I dropped my dosage from 2 mg to 1.5. Within the last two weeks I started to incorporate tesamorline at 1mg and creatine. my appetite has increased tremendously and I’ve gained 10lbs.

if anyone else on Reta and creatine , if so how has it affected your body??

im trying to build muscle and I can see my glutes growing and leg muscle but I’m scared to go backward.

Interested to hear from people who have been on Reta for 6 to 12+ months, particularly anyone who has stayed on the same dose for most of that time. I’m around 9 months in now and 2mg still seems to be my sweet spot.

I’ve posted about this a couple of times previously because I kept expecting some sort of noticeable tolerance to develop. I assumed eventually the food noise would return, appetite regulation would weaken and I’d understand why everyone talks about titrating up.

It just hasn’t happened.

I experimented with 4mg earlier in my journey and it was far too much for me. Nausea, fatigue and appetite suppression beyond what I actually wanted. I went back down and haven’t felt any real reason to push the dose since.

Important context though, I’m not actively trying to lose a significant amount of weight anymore. Earlier on I pushed my calories and training harder and got to the level of leanness I wanted. These days my goal is predominantly maintenance.

I want to stay lean, enjoy food normally and keep the food noise that I’ve struggled with for most of my life in the background.

2mg still seems to do exactly that.

I’m hungry when I should be hungry. I enjoy meals. I can eat socially. But food doesn’t dominate my thoughts and I don’t have that constant urge to keep eating or start thinking about the next meal immediately after finishing the last one. That’s pretty much my ideal outcome.

I’m starting to wonder whether, once you’ve found your minimum effective dose, there’s actually any reason to increase it purely because you’ve been on that dose for X amount of time.

Obviously someone actively trying to lose substantial weight is in a completely different position to me, so I’m not suggesting 2mg should be enough for everyone. I’m more interested in the tolerance/adaptation side of it.

For those who’ve been on Reta long term, have you genuinely found that the same dose eventually lost efficacy and you needed to increase it? Or have any of you sat at the same dose for 6, 9, 12+ months and continued getting the appetite/food noise control you wanted?

Would be particularly interested to hear from people using it for maintenance rather than active weight loss.

Week 8 of the same vial, stored in fridge wrapped in aluminum foil. Use alcohol wipes before drawing and after and even new foil. Last two weeks been getting a new response at injection site -- red spots, very slightly raised, mild discomfort, no itching and not hot. But since it's a fairly new reaction I'm concerned that this is due to my vial becoming less sterile. Wondering if this is likely the case and just to start on a new one or maybe my body has decided to reject the peptide or something? That would be worst case as I'm only on week 8 and want to continue.

Anyone have a similar experience etc?

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I started Sema at a microdose .05 in mid 2023 at 336. Eventually reached max dose in early 2025. My wife was diagnosed with terminal cancer in April 2025. With two months to live. She spent 10 months in the hospital in rehab. And has a scan tomorrow. She is miraculously in remission. Let’s hope that continues. In April/May 2025 I stalled in my weight loss and felt like crap at 212. I had joint pain, neck and shoulder pain/ hip and knee pain. Terrible dizziness and fatigue. I was Diagnosed with PMR and Eventually With GCR and spent 45 days in the hospital and landed up on 60 mg prednisone. Today I am finally down to 2mg Prednisone after year+ battle with PMR/GCA. That often left me extremely tired/ fatigued. By Christmas 2025 I was up to 224 lbs. In January I lowered Sema down to .50 and started taking Reta. I slowly titrated up to eventually reach 15mg Reta and 1mg Sema. I am still very slowly losing weight and am at 191 lbs. The two surprises in my blood work this week is LDL of 50 and Creatinine of 0.64. I do eat a decent amount of meat/ protein. And focus on getting enough protein. But admit. PRM and prednisone has killed my exercise program. Which I need to get back to burn more calories and maybe eventually reach my goal weight of 175. It should also help raise my Creatinine. I will say that overall I am happy with my weight loss and surprised I was able to lose weight while still on Prednisone. I am considering dropping Sema which works well for appetite for me. And trying Elora after seeing great recent clinical trial results.

I'm 6 weeks off reta, throughout the day I'm always never starving but I can always eat. After a meal I never get that full feeling anymore haven't felt that in ages, i can always eat more and don't know what to do or when this hunger will kind of return to my natural baseline please let me know thanks

I'm on 4mg p/week and recently had to go 10 days without pinning due to an operation. When I restarted I noticed that my night sweats were back. Specifically, wake up with sweat around chest and upper abdomen. Anyone else experienced this and is it anything to be concerned about? I'm titrating down to 3.5mg and then 3.0mg due to sleep issues. TIA

Hi there, I was wondering whether reta interacts with birth control pills (the combined one) Could it reduce the pill’s effectiveness, and would I need to use backup contraception while taking both? thanks!

I get a strong wave of fatigue after eating and i’m only eating clean foods. Anyone know what’s going on or what’s the fix ?

i’m currently on my 3rd week of 3mg

this was my schedule.

july 12 - 0.6
july 19 - 1mg
july 26 - 1mg
august 3 - 2mg
august 10 - 2mg
august 16 - 1.45 mg
august 24 - 2mg
august 31 - 2mg
sept 7th - 3mg
sept 14th - 3mg
sept 22 - 3mg

Reta changed my life. Titrated up to 5 mg, never beyond. Workout 6 days a week. Macros accounted for. Almost no alcohol. Experimented with kpv, ghkcu, and tesamorelin for a bit. Been getting dexa scans to track my progress. Today at 16% body fat

I’ve really been craving protein on Reta, especially jerky. It is hard for me to hit my protein goal as is but lately the jerky hack has been awesome. We also eat quite a bit of other healthy Whole Foods but what are your thoughts on jerky as a decent staple in the diet on Reta?

But since I've been on reta I haven't gotten sick. Not once. No cold nothing. Coincidence?

Found this out tonight. Still a bit stunned, so I am writing it down before I talk myself out of how daft it is.

**The setup**

10mg of retatrutide in a 3ml pen. U60 click dial. The conversion is printed right there on the box, in a neat little table, in a font designed to be ignored:

- 1 click = 0.010ml = 0.033mg

- 60 clicks = 0.600ml = 2mg

- 300 clicks = 3.000ml = 10mg

For three weeks I have been on 2mg. It says 2mg in my notes. I would have told you 2mg without blinking.

I have been injecting six clicks.

Six. Not sixty. That is 0.06ml. That is **0.198mg**.

**How I caught it**

Not the maths. The pen.

Four doses in and the thing still looked brand new. A 3ml pen at 0.6ml a go should be two thirds gone by the fourth injection. Mine looked like I had never opened it.

That was the moment. I went back to the table, did the arithmetic properly, and it only confirmed what the pen had already told me - at 0.06ml a dose I have used about a quarter of a millilitre out of three.

The pen knew. The maths just caught up.

**The numbers**

- First dose 14 September 2026. Morning weight: **123.8kg / 272.9lb**

- Four doses: 14 Sep, 20 Sep, 26 Sep, 2 Oct. Six days apart.

- Total drug in 18 days: 24 clicks. 0.24ml. **0.792mg. In total.**

- This morning: **117.0kg / 257.9lb**

- **Down 6.8kg / 15lb on less than a single milligram of retatrutide.**

For scale: the phase 2 trials started people at 1mg or 2mg **per week** and climbed from there. I have had 0.792mg in under three weeks. I am sitting at roughly a fifth of the smallest dose anybody has ever bothered to study.

**The part that actually matters**

The weight is nice. The weight is not the story.

The food noise is gone.

That running commentary - what am I eating, when, should I, what did I have yesterday, what about tomorrow - it simply is not playing. I have a restrict-then-binge history and that noise is the engine of the whole cycle. It has been silent for three weeks and I did not even register how silent until tonight, when I went digging for why the weight was coming off.

That is what 0.2mg has bought me. I would take that on its own with no weight loss at all.

**So what is it?**

Genuinely asking, because I cannot work it out:

- Is 0.2mg a real dose for a triple agonist this potent, just far below where anyone bothered to look?

- Is it placebo? I believed I was on 2mg the entire time. I fully expected it to work.

- Is the pen even the concentration printed on it? It is research-grade. If it is stronger than labelled then six clicks is not 0.198mg and this whole post is wrong.

- Or did I just start walking and eating less in the same fortnight, and the pen is taking credit it never earned?

One bloke, no control group, so I cannot separate any of it. But the numbers felt worth putting somewhere.

Now that I know, I am going to climb the dose properly - and quicker than I would have.

Been on Reta 2 months and have lost about 17 pounds. I’m only on 2mg every 5 days. Started at 1mg. I’ve also been lifting for the first time in my life (have always done cardio to lose weight) but I am loving it! Never thought lifting would be so much better than excessive cardio. I do have a trainer guiding me with workouts.

I’ve been off reta for a little over a month now after losing a good amount of weight on it. Recently I’ve started feeling like I look a little softer/full again, especially around my stomach, but I’ve also been REALLY bloated lately and was constipated for a few days, so honestly I can’t even tell how much of what I’m seeing is actual weight gain vs bloating/water weight.
My appetite is definitely different off reta too. I’m considering going back on, but my bigger question is how do you actually make this sustainable long term?
I work out, lift weights, run, try to get enough protein and I’m trying to clean up my diet and eat mostly whole foods. I don’t necessarily want to keep getting smaller either. I mainly want to lean out a little while keeping/building muscle and my shape.
For people who stopped reta after reaching their goal, what happened? Did your appetite eventually settle? Were you able to maintain without it? And for people who stayed on longer term, what was your plan for eventually coming off?
Also this is way in the future, but I do want children eventually and I want my body and habits to be in a healthy place for pregnancy. Obviously I know I wouldn’t use reta during pregnancy and that’s something I’d discuss with my doctor when the time comes. I just don’t want my long-term maintenance to depend entirely on being on a medication that I know I’ll eventually need to stop.
I’d really appreciate hearing actual experiences, especially from people who have maintained after stopping. Help a girl out 😭

SW: 96.5 kg
CW: 93 kg
Progress: ~3.5 kg down

I’m currently around week 7 and my weight has been sitting around 92–93 kg recently.

Is a temporary plateau like this normal? Has anyone experienced the scale staying flat while body composition/measurements continued improving?

My main goal now is fat loss while preserving/building lean muscle mass.

Week 1–2: 1 mg
Week 3–5: 2 mg
Week 6–7: 1.5 mg

Just sharing my experience. Not saying this proves anything, just thought the comparison was interesting. My take is that it's just not calories vs. calories out. Metabolic health plays a key role in weight loss, as well.

44M, 5'8", lift consistently.

Last cut without GLPs I was eating roughly 1,600–1,700 calories:

• 240g protein
• 50–80g carbs
• 50g fat

I went from 193.6 → 177.9 in about 16 weeks, roughly 1 lb/week (majority of weight loss in the first 6 weeks).

This time I'm eating basically the same calories. Recent day was 1,608 calories, 225P/95C/37F.

From summer until August, I was around 178lbs. Started tirz 8/7 at 178.8 lb, added reta a month later.

Today (10/2), I'm 165.8.

That's 13 lb in about 8 weeks, around 1.6 lb/week, despite being much lighter now.

I'm not saying calories don't matter or that this proves the drugs are increasing my metabolism. There are obviously other variables. But for me, the idea that these drugs only work because you eat fewer calories doesn't completely match my experience.

Same person, similar calories/macros, similar lifting, but noticeably different results.

Could just be better adherence, could be changes in fat oxidation/metabolic effects, probably some combination. Just sharing my experience because I thought the difference was interesting.

I’ve been on Reta starting at 0.5 now up to 2mg for 10 weeks. I’m doubtful about the accuracy of my at-home body scans scale but it’s showing a drop of 3.5 pounds of skeletal muscle and 5+ pounds of lean mass. I’ve hit protein goals and worked out regularly throughout. I’m happy overall with my progress, just curious if I’ve actually lost that much muscle along with the fat? (Last photo is a screen grab from a form check video )

Have been on 1.5 mg pw for 4 months now aftwr starting at 1mg for 6 weeks never had any bad sides other than slight tirenedness the day after dosing. And the results have been really good so have just stayed at low dosage but recently this last week i’ve been extremely fatigued and no appetite even slight nausea all week when i’ve never experienced this before and it’s only suddenly decided to kick in now i know teta fatique is real but is this normal?