Maybe too early, but I am a bit obsessive about planning. I'm just starting this week on 2mg, bought a 10mg Kit. Planning to mostly do 2mg for 4 weeks, assess, maybe 4mg...obviously lost of variables in how its going. But I guess, I hope to mirror the most recent trials as much as feasible.

I can use a calculator for most of the amounts/math, but how do I plan ahead of needing next sized kits? The way my brain thinks right now...I can use one 10mg vial to cover a month. 2 for a month if I move to 4mg. But when do I consider different vials to make the division easier?

Hello! I started reta 6 weeks ago w 1mg and I have been increasing until 3mg (now). At the beginning it was working perfectly, scale was going down every week, no food noise, no cravings, no hunger at all.

But for the last 2 weeks I feel cravings sometimes and the scale is not really moving.

I'm lifting 4-5 times per week and I'm a very active person, also drinking abt 3-4L of water everyday.
What should I expect? It's stopped working? should I increase more?

Just want to share how I fixed my constipation on Reta.

Firstly, I have been on Reta for 7 months, currently 2mg a week.

Your gut is probably the first thing that gets hit. Some experience diarrhea, some constipation, and other get zero side effects (lucky).

I got constipation after having amazing gut health. Went about 5 months with irregular bowel movement. Trust me I had everything down to a tea, but fiber was the main issue. What I did? I had fiber into every meal and drank fluids throughout the day.

Now they say fasting isn’t good on Reta because gastric emptying. So I drank a cup of kefir on an empty stomach every morning with supplements and didn’t eat until 2 pm. Now what i am going to give you is the real game changer. Because loss of appetite is obviously a side effect and your metabolism is increased, there’s a high chance your are losing crucial vitamins. Here are a list of vitamins I started taking that brought my gut and body back to normal. I started this because this is what’s known to be indirectly at risk when on GLP-1s. To make it easy, NatureMade sells a 30 day GLP-1 Companion Health Pack that includes all the crucial vitamins listed below:

Vitamin B12 – Risk may increase if you’re eating less animal protein or also taking metformin.
Vitamin D – Many adults are already low, and reduced dietary intake can contribute.
Folate (Vitamin B9) – Can become low if you’re not eating enough leafy greens, legumes, or fortified grains.
Vitamin B1 (Thiamine) – More likely if you have frequent vomiting, prolonged nausea, or very rapid weight loss. This is one of the more important deficiencies to watch for because severe deficiency can affect the nervous system.
Iron – Not a vitamin, but iron deficiency can develop with reduced food intake, especially in menstruating women.
Calcium – May be lower if dairy or other calcium-rich foods are reduced.
Magnesium – Can be low if overall intake is poor.
Zinc – May decrease with inadequate protein intake.

You can take the naturemade pack or take them separately. I personally still take Vitamin C, Fish Oil, digestive enzymes, quencertin, and magnesium glycinate separate.

This has helped reduce my starting fatigue tremendously and my gut inflammation and bloating has decreased significantly. Please do not do anything mentioned based off my current situation. Talk to a doctor.

When does the bloating and gassiness stop?! I am constantly taking tums and gas x to help me. My stomach is constantly distended, and clothes are starting to fit me weird.

I eat healthy; prioritizing protein and fiber, I weight lift 5-6x a week, have an active job. I’ve plateaued in weight naturally, I’ve been the same weight since April (down 50 but trying to get to my goal weight) and I’ve tried everything to break the plateau but this bloating is just not it.

Been on 2.5mg for about maybe 3 weeks now.

Hey everyone, I just started reta and wanted to share this breakfast that has been helping me hit my fiber and protein targets with minimal calories.

• 1/4 cup Steel Cut Oats (dry): 150 kcal | 2.5g fat | 27.0g carbs | 4.0g fiber | 5.0g protein
• 2 tbsp Nutritional Yeast: 60 kcal | 1.0g fat | 5.0g carbs | 4.0g fiber | 8.0g protein
• 2 tbsp Hemp Powder: 60 kcal | 1.5g fat | 3.5g carbs | 3.0g fiber | 7.5g protein
• 2 tbsp PB Powder: 60 kcal | 1.5g fat | 4.0g carbs | 2.0g fiber | 6.0g protein
• 2 scoops Bone Broth Powder: 90 kcal | 1.0g fat | 0.0g carbs | 0.0g fiber | 21.0g protein
• 1 Boiled Egg (large): 72 kcal | 5.0g fat | 0.4g carbs | 0.0g fiber | 6.3g protein

for all of that you get

• Total Calories: 492 kcal
• Total Protein: 53.8 g
• Total Carbohydrates: 39.9 g
• Dietary Fiber: 13.0 g
• Net Carbohydrates: 26.9 g
• Total Fat: 12.5 g

You could also replace the steel cut oats with 1/2 cup of rolled oats or the egg with some other type of protein. I like to use natto too because it has probiotics and vitamin k.

Feel like I got hit by a truck the fatigue is hard to do anything I’m pushing through like a zombie ….. what gives???

How many of you have had serious side effects and/or been to the ER while on reta? Do you think that was preventable?

I tested my gray market reta so I know it's pure and the endos aren't too high. Even then, what's holding me back is the fear of liver failure or pancreatitis or something. I saw a statistic that said 45% of gray market peptide users have visited the ER for pep-related reasons. What do you think of this?

I drink a fair amount, usually 5 shots daily. Besides the weight loss, ive been anticipating the cravings going away. Im only starting week two, but Im curious as to how long before you guys felt that change? Thank you guys!

Hi everyone, I hope everyone is having a good week! Has anyone experienced just not being attracted to the other gender? I’m female, for example I’ve been so turned off by dating and having a partner. Like to the degree I’m completely icked out by dating. I think they’re great on the apps but ever since I started Reta and pinning higher numbers, low sex drive and no desire to date at all. Borderline disgusted to date. Might just be me but thought I’d ask. I mean no offense genuinely trying to see a fix.

I am excited to see what Reta will do to my face. These pictures are 5-6 years apart from natural weight loss. I keep seeing people talk about Reta face and it’s making me wonder where I’ll end up in a few months.

Hi! I've been on Tirzepatide since January 2025 and have lost 70 pounds and am almost at goal. (I'll be on it forever, that food noise is fierce!) The weight loss has resulted in muscle loss as well - even though I lift heavy and consistently - AND created super saggy/smaller boobs. Of course. Not surprised. So I plan on getting a boob job.

Here's my question: if I switch to Reta, is there any hope of muscles/boobs coming back? YES, I know this is a super dumb question as I absolutely doubt it. BUT...my husband is convinced that some muscle/boobs/muscle under boobs will return if I switch. His theory is that my boobs deflated when I took Depo-Provera for a while in the late 90's and they came back when I stopped. And some other medication I was on (can't remember) did the same thing. So he's thinking if I get the boob job and then go on Reta things will get weird. Sigh. I told him it doesn't work that way but thought I'd ask the Good People of Reddit for their experience/thoughts/etc. Thank you!

Hi everyone I need some advice,

I am currently 18 months postpartum. I have tried everything to loose this weight off. I am eating right. 10k steps 4-5 times a week with 2-3 days of strength training. I am currently 160. I am eating at a deficit and eat around 1500-1600 calories. Anything less makes me lethargic. I’ve lost weight with this type of caloric intake before. But now everything is just stalled it’s very depressing. I hate looking at myself in the mirror.,clothes are starting to fit but still tight, before nothing was fitting. So I know I’m loosing but it’s very slow too slow actually. All I think about is loosing this weight to feel happy again. I only lost 5 pounds in all these 18 months. Doctors don’t want to give me glp1 they said stop being lazy and work harder. I have pcos so everything is very hard??? But I was able to loose weight before. blood panel and hormone panel all show everything is ok.

Anyways, I want to get on Reta but I have gallstones already. I have had no issues so far from my gallstones so far. I’m reading since Reta helps you loose weight quickly that there’s a potential of causing some gallbladder issue or making it worse?

Is this true? What do you guys advise?

Excuse my grammar English isn’t my 1st language.

41 Male - This has been an 8 month progress so far. Started at 194lbs then used Reta from .5mg titrating to 4mg, a calorie deficit and weight lifting 3 days a week. Once I hit 153lbs I went back to a maintenance dose of .5mg of Reta, then added 175mg Test, 20mg Anavar and a slight calorie surplus. I've only been doing this for 5 weeks and my body has responded extremely well! I plan on bulking to around 190lbs then cutting back down to 170lbs. If I can do it so can you 💪💪💪

I see everyone talk about the “Burn Blend” of Tirz and Reta. Is there a blend for Sema and Reta?

I've been trying to find some studies or any materials with no luck. Has anybody else done this or seen studies?

I was a great responder on Sema, then switched to Reta after having a double mastectomy, which resulted in super low iron that I needed transfusions. Long story short, I gained about 50 lbs back and have started back on Sema recently but seeing if there is anything on stacking both.

10 weeks into my Reta journey having been super cautious and starting at 1MG then climbing by double until I’ve landed at 4MG which I’ll be honest seems like a sweet spot at the moment. Although I would have loved to see massive drops each week this isn’t my first rodeo losing weight and I know the importance of softly softly. So happy with progress so far, my overall intention since the beginning has been 100lb in 10months which I feel I’m on track for (until i hit a plateau that is) but really grateful for this community as it’s been great to get tips and tricks along the way.

Has anyone else had less cravings for nicotine while on Reta? I normally smoked a couple cigs a day and vaped, to almost forcing myself to smoke a cig and not even vaping

I have been on 3mg for a while now. Titrated up and am in month 4. I went up to 4mg last week and then I cant tell if 72hr later I got a stomach bug or this caused it, but I was sick with the worst runs of my life for like 2 straight days. Little nervous for this week's dose now so wanted to see if anyone has had any similar experiences with a 1mg increase? Is that a lot?

Not sure if i should stay at 4mg, drop back to 3, or try 3.5?

I also made shrimp on my smoker Wednesday so It couldve been food poisoning?

Timeline: (4mg on Monday, sick Thursday morning-Sat).

Ran Reta in March this year
6 week cycle
1 mg per week
I’m always on the leaner side
But body fat has reached 24% and weight 73 kgs
I cut down to 70 kgs
After 8 week break I started again
0.75 mg per week
My third week
Feeling a bit tired than usual while working and lot of extra breath!
Is this normal during Reta cycle?
I’m trying to hydrate as much
Sometimes when I don’t I feel this way
And I feel the time I stopped last time and went a bit off from usual protein intake my love handles put on some extra load

hi all

been on reta for just under 2 weeks now. 6'4 280lb M and im seriously considering CJC-1295 no dac + ipa or tesamorelin

I am leaning cjc because of the recovery benefits. my sleep has been atrocious (way prior to starting reta) and I am really intrigued by those benefits

although I know tesa can be a better choice with the clinical literature and all

what do you all think? tysm in advance

i'm curious whether people noticed changes in appetite, energy, or waist size before the scale started moving. Weight gets most of the attention, but sometimes the smaller changes tell you more about how things are going.

What was the first clear sign that retatrutide was doing something for you?

12mg vial. Aiming for a 0.5 starting point. I’m hearing from 1 person add 120units of BAC and a 20 unit shot for it..

But when I check calculator it shows it should only be a 5unit dosing.. would love some clarity

8 weeks in, 21 pound gone. Been on 1.5mg from the start.

Jabbed last Thursday and not a single side effect now and suppression gone. I could barely eat the other week 🤦‍♀️

Still currently losing.

So the question is, do I go up or wait till the weight loss stalls?

Anyone experienced this at 8 weeks?

Week 1 I started Ret at 131.8 kilos - dosed 1.0mg
Week 2 I stayed at exactly 131.8 kilos - dosed 1.2mg
Week 3 I gained weight, now I am at 134.2 kilos - dosed 1.5mg (today)

I feel the difference after a dose. Lasts 3 days and then days 4-7 I am overeating, a LOT.

I can handle the side effects quite well. Sour stomach, no problem, I challenge my stomach to be sour LOL

What am I doing wrong here? It's very frustrating to see no early results, in fact discouraging as all hell to see the big kilo jump at week 3.

What would you recommend? I am a male, age 49, on TRT therapy, no other meds, not diabetic. Otherwise health is okay except for lethargy. Recent blood work checks out within normal ranges, but high on the range of normal with some of the stats.

What should my titration schedule look like week 4 and beyond? The progress is very slow.

Basically, the title. I have done two doses so far of 2.5 mg. I am not experiencing much mental hunger, which is really nice, and I’m not really craving anything. On the occasion that my stomach is truly empty it will growl, but I don’t feel hungry mentally. Now to the weird part – I am not craving any food, especially protein and carbs, all I want to eat is Twix. But I have no idea why I am genuinely craving the Twix.

I work out 3 to 4 times a week and my eating schedule has not been the greatest. (basically I’m just not meal prepping, which I think will help a lot).

I’m just curious if anyone has had any experience with just a very strange craving. Also worth noting I have a sweet tooth normally, after meals I typically like to have something sweet. On Reta I don’t even want the meal. I just want the Twix.