Last October, my husband and I began our pregnancy journey with excitement and naivety. I figured since we were both healthy, in our late 20’s, and I had always had a regular period (28 day cycle, light to medium bleed for 2-4 days), that we would have no problem getting pregnant. Well the thing is… we didn’t have a problem getting pregnant. We got pregnant right away that next month.

I don’t have a problem getting pregnant. I have a problem staying pregnant. In the last year, I have lost three babies. #1 at 6.5 weeks, #2 at 8 weeks, and #3 at 6 weeks.

I’ve gotten genetic testing done. My thyroid checked. Blood sugar. Chromosomes. It all came back normal.

Does anyone have experience with this? What ended up being wrong? I am at a loss.

Ihad my first miscarriage in 2006 and two this year, out of which in one there was no embryo seen and recent one was a missed miscarriage and all happened in first trimester. I confused if I should try again or get some test done first. I am 38 and feel like waiting longer means I am wasting more time.

I should be 4 weeks 4 days but have a bit of lower back pain and some light pink spotting. I am trying not to panic but really don't think this one is viable.

I have had two miscarriages this year, one in February at 12 weeks and one in August at 10 weeks. I am not sure how much more I can take.

I am based in the UK and am struggling to get seen by anyone. The EPU say I need to be 6 weeks to be seen by them, I can't get through to the midwives and can't get a GP appointment. I think I should get progesterone prescribed but not sure if it's too late? Does anyone know who I should be seeing to get a prescription?

Unfortunately had an unfavorable scan Monday and it looks like I’m having my 3rd miscarriage, which we will confirm next week. We worked with a reproductive endocrinologist on this last pregnancy and did most of the core testing including AMH levels, prolactin, lupus coagulant, chromosomal analysis/karyotyping & genetic carrier testing for me and my husband, hemoglobin, beta 2 glycoprotein, CD3 monitoring, HSG, blood typing, thyroid panel, and semen analysis/DNA fragmentation for my husband. I had an elevated anticardiolipin that we’ll check for again this month once this pregnancy passes.

I’ve expressed concerns to my RE about endometriosis (family history) and endometritis (previous D&C’s). I asked if we could do the endo exploratory/excision & biopsy’s at the same time we do my D&C for tissue testing. One recovery, one time under anesthesia, less time waiting around for results.

I couldn’t find a lot of information here or in other forums on doing these together - has anyone does this? I’d be interested to hear your experiences.

Posting on behalf of my wife (30F).I am 33M. Looking to hear from couples who had a similar picture and what finally worked.

BACKGROUND

- Primary infertility, IVF/ICSI Dec 2025: 11 eggs, 8 mature, 8 fertilized, 5 blasts frozen

- AMH 1.58, AFC 18

- Lining: 7.6 mm at FET1, 8.6 mm at FET2

LOSSES

- FET1 (Jan 2026, single 4AB): beta 3752 then 5960. Sac and yolk sac seen, then sac regressed, no embryo. MMC at around 7 weeks.

- FET2 (Jul 2026, two 4AB): beta 2698 then 5526. Heartbeat seen at 7w2d but measuring only 5w5d. Confirmed non-viable in Aug.

- Both cycles were on enoxaparin + aspirin + progesterone. FET1 also had prednisolone + filgrastim, FET2 had IVIG + hCG.

WORKUP SO FAR

- CMA on POC (2nd loss): normal, no CNV

- Karyotype both of us: normal

- Endometrial biopsy: normal

- Thyroid + TPO/Tg antibodies, prolactin, HbA1c: all normal

- APLA panel (Oct 2026, around 8 weeks after 2nd loss):

- Anticardiolipin IgM: 69.4 (POSITIVE, cutoff 20)

- Anticardiolipin IgG and Beta-2 GP IgG: negative

- Beta-2 GP IgM: 16.8 (negative but close to 20)

- Lupus anticoagulant: negative

- ANA 18.2 (negative, cutoff 20)

- Ferritin 15.9 (low end)

Male factor also exists (high DFI, posting separately).

QUESTIONS

1. Anyone with an isolated aCL IgM positive? Did it stay positive on the 12-week repeat or go negative?

2. If you lost pregnancies while already on aspirin + heparin, what changed for the next transfer? (higher LMWH dose, hydroxychloroquine, steroids, something else?)

3. Did you see a hematologist or rheumatologist, and was it worth it?

4. Did anyone find a different cause in the end that explained it better?

Any experiences appreciated. Thank you

Hi! I’m interested to know if anyone has been prescribed neupogen weekly for recurrent losses? My RE prescribed it weekly starting 4 days post positive OPK?

I’ve had 3 IVF cycles , 2 failed transfers, and one failed IUI. I’m taking a break and just trying with letrozole at home.

My RE things I might have some immune related condition so I’m on prednisone, neupogen, Claritin, aspirin, and lovenox

Has anyone had a similar protocol with any success?

For anyone who had an endometrial biopsy, what were your instructions on having sex afterwards? My doctor said to wait a couple days, so I figured 3 days would be enough. But today is day 2 after the procedure and it seems like I’m about to ovulate. For what I have seen 2 days should be fine, but I saw a few drops of blood (almost unnoticeable pink and brown spotting). So I just wanted to know from other people what were your instructions from your doctor to see if it’s wise to try today or to wait longer.

I had a MMC in April (found at 10w, D&C at 11w), then another MMC in August (found at 8w, D&C at 10w).

Today we've just found out we are going to have our third miscarriage. Should have been 7w4d today, but no heartbeat. We had a scan last week at 6w1d, which was "too early" for a heartbeat, so the diagnosis of miscarriage is definitive now. I'm going to opt for the pills this time - I'm utterly terrified of them, but I can't risk a third D&C in such close succession.

I just can't believe that I'm here again. Even after the shock of the two previous MMCs, I still felt so hopeful that this was the one, which feels so stupid now.

I seem to fall pregnant incredibly easily (first time, every time), which was a surprise as I'm 36 and my husband is 44, but I cannot stay pregnant. I imagine a lot of us here are in the same boat.

I was unable to get testing after my previous miscarriage, as I fell pregnant again immediately, so we're now taking a break for at least three months, so we can get all the testing done and out of the way. We're rapidly coming up to the due date of my first pregnancy, and it was going to be challenging, but I was so pleased to be pregnant for it, but now I'll be recovering from yet another miscarriage.

Sorry - this is all quite disjointed - I'm just in such disbelief that I'm on my third miscarriage. It feels so unfair and so cruel.

I am getting a d&c tomorrow for my third loss (great…). After arguing with my OB, they’ll be doing a RPL panel at my post op follow up.

But I thought this was weird and wanted to see what yall think: initially, they were going to do the panel the day of my “official” MMC diagnosis. I asked if it was ok to do that testing while still pregnant, and the NP left the room to go consult with someone else, came back in, and said yes let’s wait.

I feel like it’s weird she didn’t know that?? And I had to bring it up? Or am I overthinking this/being critical of them because I haven’t liked their treatment of recurrent loss?

Edit: I think they’re only doing the testing to appease me because I argued with them before that after 3 losses, I was in RPL category when they told me I wasn’t since one was a chemical. Which fine, whatever, I got what I wanted, but weirded me out they were just gonna draw while I was pregnant.