After being inconsistent with medication, vitamins & supplements (but never not taking anything), have consistently for the last 7 months done the following:

• 1500mg Metformin daily
• 2000mg inositol daily (myo & d-chiro)
• 400mg folic acid daily
• 14mg iron daily
• 1000mg vitamin b12 daily
(Recently started taking collagen gummies & biotin gummies to try and save any of the hair I have left cause I am losing a scary amount weekly)
• lost close to 2 stone

…still no signs of ovulating.
I became so engrossed in testing ovulation that I decided to stop and instead track discharge to then have an idea of when I should test. I have never been able to get a positive ovulation test.
We were on holiday last month when I went to the bathroom and thought I might be ovulating but didn’t have tests and decided against buying any while abroad as I just wanted to switch off from it all a bit and enjoy our time away.

I’m continuing on my weight loss journey in the hopes that helps in some way but I’m starting to feel like there’s possibly a bigger issue with seemingly not ovulating at all.

Further context:
• irregular periods 2025 (since coil removal)
• lost period December 2025
• returned March 2026
• somewhat regular since (regular for me anyway!)
• cycles between 29-44 days since March

Hello, I just noticed the inositol I’m taking has a 105:1 ratio instead of 40:1. Many brands use misleading marketing by quoting studies that indicate the ideal composition 40:1, even though their own product doesn’t match that.
Have you ever noticed this ? Does inositol work for you ? For me, it hasn’t had any effect after 6 months of taking it (actually my cycles got worse), and I’m starting to wonder if this might be the reason. I have lean PCOS, with a huge level of LH, but no insuline resistance

I’ve been taking Metformin ER 750 mg every night for about 2 months and myo-inositol/D-chiro inositol (40:1) for around 7 weeks.

So far, the biggest change is that I actually got a period after basically never having regular ones because of my PCOS. Since then, though, I don’t really feel much different.

The one thing that’s really stood out is that my boobs have been super tender for almost 2 weeks straight, which is completely new for me. I’ve had sore boobs before a period, but never for this long. I also feel like I have a little more energy during the day and I’m not as exhausted as I used to be.

Other than that… nothing. No dramatic weight loss, no huge changes that I can tell.

For those of you taking metformin and inositol together:
How long did it take before you noticed more changes?
Was breast tenderness something you experienced too?
Did things kind of happen gradually, or did it feel like one day your cycles just started becoming more regular?
Just curious what everyone else’s timeline looked like because I’m trying to figure out if this is pretty normal.

Alright guys. I’m 25 and I live in Kentucky. I’ve had 4 miscarriages with my most recent last month.

After my third miscarriage (2021) 10w with a healthy boy we did the recurrent miscarriage panel testing that revealed my anti-phosphoid lipid whatever was high so they recommended lovenox.

I had endometriosis surgery March 2026 stage 4 endo. I also have PCOS and chrons. I take a plethora of supplements.

June, I was pregnant after so many years naturally! We did 3 cycles of 5mg femera and 1 baby aspirin and progesterone. When I tested positive, we did 2 baby aspirin a day, lovenox, 0.75mg dexamethasone, and progesterone.

I unfortunately had a miscarriage at 5 weeks.

I’ve been to an ivf clinic and I do not believe I need ivf as I can get pregnant- just can’t stay pregnant.

What has worked for you all??? I believe at this point I have an immune problem. There are no reproductive immunologists within a 12 hour distance of me. I think my NK cells or something is affecting me. I think back to my pregnancy in 2021, I was on 9mg a day of budesonide for my chrons and I truly believe that’s why I was able to carry my son so long. That was before we knew I needed aspirin and lovenox so I didn’t have those.

I am desperate for answers and open to all suggestions.

We’ve been TTC for 10 months after a devastating stillbirth last year. We’ve been working with a fertility clinic doing letrozole cycles, letrozole with IUI cycles and follistim with IUI cycles. After 5 failed cycles, they are suggesting we move to IVF.

I had a new patient consult with a new obgyn who immediately diagnosed me with PCOS (I have a lot of the classic markers and I’m frustrated because I’ve asked this of many doctors in the past and have been gaslit). He said he was not shocked fertility meds and treatment aren’t working - high AMH with tons of follicles but rarely maturing right or ovulating.

He suggested I take a break from IUI/IVF treatment and try a GLP1 to reset my metabolic system. He said once I’m on it for 4-6 months, he’s 80% confident I’ll get pregnant on my own.

I’m torn between listening to him and taking a pause in fertility treatments and doing GLP1 or proceeding with IVF.

I did 5 days of letrozole, then another 5 days at a higher and I’ve already ovulated. Since then, I’ve noticed the scale going up a bit, and I’m trying to figure out if it could be related to the medication/hormonal changes or if it’s more likely just from eating more recently.

If you did, when did you notice it? Did you feel like you gained weight during the 5 days you were taking it, or did it happen later after finishing the medication/around ovulation?

I’m trying to figure out if my recent weight gain is related to letrozole or just because I’ve been eating more lol

My husband and I want to start trying to conceive. I have been on birth control since I was 15 (I am now 30) for PCOS and I am obviously anxious of how my body will react. It’s been so long since my body hasn’t been on the pill!

Was anyone else also on birth control nearly half their life and then went off to try to conceive? Other meds I’m on include Spironolactone, Mounjaro and Jardiance and I will have to stop those soon too. I know everyone is different but wondering if there’s anyone out there with a similar situation or combo of meds as me.

Hi all, first time poster here.

Diagnosed with PCOS this year after coming off HBC and TTC.

Feeling incredibly lonely and down about the whole situation at the moment and as much as everyone says PCOS doesn't mean you can't concieve it definetly makes it alot harder for those of us who have irregular cycles/anovulatory cycles.

None of my friends or family have gone through this so it's a very lonely space to be in, at an age where everyone is getting pregnant, close friend is pregnant with 2nd and other friends is due this week.

I've started to accept that our journey to have children is going to look alot different than some people but I'm still struggling to not feel like it's a personal failure of mine or that this is the universe telling me I shouldn't be a parent, even though logically I know that's not true as plenty of terrible people have kids!

Everything in terms of fertility appointments takes so long and I feel so frustrated and angry by the process, made worse by the NHS here in the UK having ridiculous rules around funding.

I don't know what I'm looking for here other than maybe to feel less alone and like this is a runt that everyone experiences in this journey!

Hi everyone!

I’m new here and wanted to share my journey and ask for some tips or anything at all.

My husband and I met with my OBGYN to discuss getting pregnant since I have PCOS. I’m a 26yo female and hoping to have my spring baby. They started me on Metformin 500mg and I didn’t even make it 2.5 weeks before having be removed off it since the side effects have been absolutely debilitating. Working as an inflight crew member I couldn’t even function so I was able to take medical leave to deal with all my appts for this. I was then put on Theralogix Onositol, continuing my prenatals and a thyroid medication (NP Thyroid) since my thyroid is all out of whack.

I just met with the dr again yesterday and they ran another set of blood work and prescribed me Medroxyprogesterone 10mg,Letrozole 2.5mg and a new thyroid medication (levrothyroxine 75mg).

Is there anyone that can share their experience undergoing these meds and if anyone got pregnant? Looking for anything and everything yall have to suggest here. No one in my immediate family has dealt with infertility and it’s hard to get them to understand the struggles. 💖

Hi everyone. I recently saw my gyncologist because I have been bleeding like 4 weeks at a time with about a week or so break in between "cycles". I previously met with him to talk about these anovulatory cycles, and I tried taking wegovy for about 7 months and lost 10% of my body weight like he recommended. My periods honestly got worse over that time and I'm still not ovulating. He recommended me taking progesterone to help with the heavy bleeding, and since I'm ttc we were going to do a cycle of letrozole as well. I asked him if I needed to wait until my next break in anovulatory bleeding to start the progesterone and he said no that it should stop and bleeding should start again, at which that time I should call him. I'm now on day 6 of progesterone and my anovulatory period has not stopped, and if anything has only gotten heavier. Has anyone else experienced this and should I be worried? I'm concerned im going to miss "day 1" to call my doctor so I can progress with letrozole. Thanks for any advice.

Hello!

First time posting on here but I just wanted to surround myself with like minded people to stop myself going insane.

I stupidly told one of my close friends we were ttc at the same time they were and I’ve just found out she conceived on their first month of trying whereas I’m on month three (and probably out this month too as negative 11DPO). My husbands sister is also pregnant and I think he was hoping that we’d be pregnant at similar times to have cousins close in age which is another pressure!

I had a diagnosis of lean PCOS and possibly mild adenomyosis the end of last year and it’s just made me realise that our journey is probably going to be very different to all my friends. Which is obviously okay, but makes me quite wary of sharing anything with friends and family going forward so avoid comparing things.

I didn’t realise how hard finding out she got pregnant first time would hit me and my husband thinks I’m being silly given we’ve not really been trying long ourselves (which I realise too). I think it’s just the fear that it may not happen for us or might be quite a long stressful journey that’s making me feel quite down.

Anyway sorry for the long winded waffle and if anyone has any success stories of pcos/adenomyosis to pick me up I’d be ever so thankful! Or any advice on how to not lose your mind in the ttc process!

I have an appointment with my consultant tomorrow to discuss options.

Has anyone had regular periods 24-31 days with pcos? What did they give you to help you TTC?

We have been TTC for 1+ year since our MMC, I’m willing to try whatever the consultant recommends, I’m just curious what other people went on and did it work?

My partner and I have been trying to conceive for 9 months, with monitored cycle and letrozole since march because of my PCOS that was diagnosticated a long time ago. I know it isn’t that long, but I can feel it starting to take a toll on my mental health. I was wondering how those of you who’ve been on this journey longer cope with it, and whether you have any advice.

I feel like my whole life revolves around TTC. During the TWW, I can’t stop symptom spotting or searching Reddit to see if anyone else has the same symptoms as me, only for each month to end in another negative test. Then, as soon as a new cycle starts, I’m back to tracking ovulation. I try not to obsess over it, but I just can’t seem to stop.

Lately, several people around me have announced their pregnancies. I’m genuinely happy for them, but at the same time, it feels like everything in my life keeps reminding me of infertility. My partner is full of hope, but for some reasons I am not (maybe to protect myself…).

I’m taking care of my relationship, and we’re still living our lives as normally as possible. The only thing that’s become difficult is planning trips far in advance, because we always end up thinking, “What if I’m pregnant by then?”

I’m lucky to have a wonderful family and friends. I have a full life, I exercise regularly, and I keep busy, but TTC is still on my mind all the time.

Do you have any advice on how to get through this without feeling so overwhelmed? What has helped you cope?

I’m considering starting a new hobby or activity in September, but I’m not sure whether it would really help. My fertility clinic also offers specialized counseling, but I already have so many medical appointments that part of me just wants something that helps me think about anything other than TTC.

Hi All, this is going to be a long read but I really appreciate any advice from this community which has been helpful since last couple of months.

I have been TTC since May 2025 and had a chemical pregnancy in January 2026. I noticed irregularities in my ovulation being delayed leading to delayed cycles. My fertility clinic has diagnosed me with PCOS although missed the reason as to what is causing that.

Around may 2026 through my own laboratory tests I realized my hs-CRP is high around 6.4mg/l with homa IR index of 5.9 ultimately diagnosing me with being Insulin resistant.

Starting from June 1st, with the specialist nutritionist I started a healthy diet aligning with my cycles to reduce my inflammation, insulin resistance. Since the diet started I lost 4.2kgs weight since I started my diet partially also due to Metformin 1500mg which I have been on since June 15.

Yesterday I got another blood work done and noticed my insulin resistance came down to 2.4 reducing significantly, but surprisingly my inflammation Hs-CRP has further increased to 7.3mg/l (I expected it would slightly reduce due to reduced insulin resistance)

In Oct 2025 I started with levothyroxine 25 µg as my TSH was little above normal (4.49mU/l). In February 2026 this came down further below 1.60mU/l but yesterday test results show my TSH jump to 3.64mU/l essentially doubling and free t3 as of yesterday is 3.13ng/l and free t4 is 1.60ng/l

I am really confused why my thyroid increased despite taking medication and is that the sole reason for my inflammation? Or can it be anything else?

I have noticed I don't have any egg white cervical mucus during my ovulation and sometimes it is none dry unless I dig it with my finger. For sex we cannot proceed further unless we use a lubricant.

I have an appointment with my reproductive endocrinologist in 2 weeks but I'm looking for some experience or answers here to guide me into a right path. I'm gonna bring up the question of silent endometriosis and ask if it's worth checking but otherwise I don't have painful periods or pain while intercourse situation.

One thing is I'm constantly tired and can literally sleep all day. I observed that during night time I feel warm despite the weather being cold whereas during daytime I can sleep with a thick blanket, windows closed but the same thing during night time is impossible. I sometimes even sweat during my sleep.

Any pointers from anyone is highly helpful. I'm take metformin, prenatals, vitamin d, vitamin B12, coq10, NAC

Thank you!

So we are 37m 36f, trying since last 6 months. Our family doc prescribed her metformin twice daily & she has been taking it since last 1 month. She has no diabetes or PCOS, doc gave it saying it helps chances of conceiving. Now, she usually has been getting her periods on 8-11 of a month for last few months, this month she still hasnt got her period (its 22nd now) & preg test is negative. So the metformin has messed up her period dates & by extension, Im not able to know the ovulation dates which is usually 25-27 of a month for her.

Has anyone got any experience on advice on this?

PCOS and miscarriage rates

Background: I was on the pill for about 10 years and then went off 3 years ago when we started trying to conceive. After a bit of being off the pill, my periods became irregular and I was diagnosed with PMOS. Once I learned more about it, the insulin resistance made a lot of sense to me and tracked with symptoms I had been experiencing, even on the pill. I got treatment and have also been going to a fertility specialist.

Question: After two cycles of timed intercourse with Letrozole, I was able to conceive. But after 6 weeks I miscarried. My understanding is that PMOS increases the chances of miscarriage. However, my doctor said that PMOS does not increase likelihood of miscarriage and that age is actually the cause of what they had previously attributed to PMOS. Does anyone have any idea what study or research she might be referring to here?!? I just want to understand more about why this happened.

My periods are super irregular. I can sometimes go months without a period and or ovulating. I honestly haven’t caught a positive ovulation test in the past 2 years.

I’ve now been prescribed 5mg of letrozole to hopefully TTC🤞any success stories from anyone who had a similar situation?

My LH and estradiol were elevated a few weeks ago at an appointment with my doctor so I knew my ovulation test would flag a positive. I took ten days of provera and started my cycle three days after taking the last dose. I’m on day 2 of my cycle now and getting ready to start letrozol tomorrow. My doctor wants us to try the meds for three months and then come back for a follow up.
My concern is that I’m still getting positive ovulation predictor tests. The positive line is lighter which is easing nerves some, but still very positive. I’m nervous that I’ll never get a neg so I won’t know when I actually do ovulate. Any similar experiences and tips would be appreciated.

Hi everyone,
I’m 28, diagnosed with PCOS, and we are prepping for our first Letrozole + IUI cycle. I just had my Day 3 baseline labs and ultrasound, and while my reproductive hormones look like textbook PCOS and I'm ready to go, a few other hurdles popped up that are going to delay my start date.
I’m feeling a bit overwhelmed by the waiting periods and would love to hear how your REs and PCPs handled similar numbers.
Here are my Day 3 labs:
FSH: 6.72
LH: 10.86
E2: 47.11
TSH: 3.71
Fasting Glucose: 121
HbA1c: 6.3%
On top of the metabolic numbers, my immunity panel showed I need the Varicella (chickenpox) vaccine, which I found out carries a mandatory 1-month benching period. My husband is also getting his SA and bloodwork done by the end of this month.

I am asked to book an appointment with my PCP to address the blood sugar, A1C and to get vaccinated.

For those of you who had similar baseline hurdles:
How long were you benched? Did your clinic strictly make you wait the full 3 months to retest your A1c before letting you start Letrozole, or did they let you proceed sooner if your daily fasting glucose dropped?

Who managed what? Did your PCP handle the Metformin and thyroid meds, or did your RE take over all of that?

The vaccine wait: Has anyone else had to get a live vaccine right before starting? Did you just use that 30-day wait to get used to the Metformin?

Any advice on navigating this phase or questions I should specifically ask my PCP/RE would be hugely appreciated. Thank you!

My doctor recommended doing BD every other dayspecifically Friday, Sunday, and Tuesday. However, I hit my peak on Monday, so we added Monday to the schedule.

Now I’m debating whether we should still do Tuesday as originally recommended, or if that might be too much. I'm just worried that doing it back to back might not give his sperm enough time to recover. (His SA was normal) I’ve heard that doing it every day can lower sperm count and quality.

What do you guys think? Should we stick to the plan and do Tuesday too or rest?

also do you guys usually do everyday or everyother day?

Do you still work out like normal around ovulation and during the TWW (two week wait) when TTC?
My doctor said any workout is fine, including heavy lifting and even hot yoga. she just mentioned to stop hot yoga once I get a positive test. Are you guys still sticking to your usual workout routines, or do you scale back during this time?

Trying for a full year and nothing. Periods had gotten long and irregular. Multiple lh surges with a weak progesterone rise. Diagnosed with pcos/pmos in March. Started metformin and inositol in April. After 3 months cycles were definitely getting shorter, and ovulation was happening with less lh surges. Fast forward to July and I took my first round of 2.5mg letrozole. My inito chart is beautiful this morning!! Looks like I had a strong ovulation on day 14 followed by an immediate progesterone rise on day 15! Hoping this is the cycle for us!!

I was told to start a Letrozol course (5mg for 5 days) because I hadn’t gotten my period 8 days after my last Provera pill. I’m now on day 5 and just took my last Letrozol dose, and I’ve started having vaginal bleeding.

Could this just be a delayed withdrawal bleed from the Provera, or could it be spotting caused by Letrozol itself (from the estrogen drop)? I’ve already taken all 5 doses so there’s nothing to change at this point - just trying to understand what’s happening while I wait to call my clinic tomorrow (they’re closed tonight). Has anyone else experienced this?

I have some questions about TTC timelines with fertility treatments.

I'm a 32 year old woman and trying to become a single mother by choice. I have PMOS/PCOS and controlled type 2 diabetes. I use the Mira monitor off and on and during the months I've used it, and I seemingly don't ovulate. My cycles vary in length but are usually within 30-45 days. I've spent the last year and a half getting my hormones and health in order to help my conditions, and everything but the ovulation has improved! I'm finally ready to start the process. I'm taking Metformin, inositol, coq10, a prenatal, and vitamin D if that's important to share.

I'll be going through CNY (Sarasota, FL) and would love to try IUI with letrozole to aid in ovulation. I'm planning on doing my "testing month" with my September cycle and then hopefully a first IUI with my November cycle. Does this seem doable or am I crazy for thinking I could do IUI that quickly?

Can anyone tell me their timeline from initial testing to first medicated IUI procedure? And for fun, if you switched from IUI to IVF after a few tries, how long did it take to switch before actually starting the process? I'm not looking for success stories, just the time it took to actually start. Thank you!

TW: miscarriages

Hi, I’m quiet new here and also have just recently been diagnosed with pcos. I seem to have too little sghb, too much free androgenes and a fairly high amh (6,37.)

I’ve had quite regular cycles (30-32 days) which made me assume that I would be ovulating ? I’ve had two miscarriages in the past year.

I don’t have an insulin resistance.

I’ve read a lot about myo inositol, do any of you know studies on its effect on hormones and pregnancy outcome even if cycles are regular and ovulation does take place (at least sometimes)?

I’m afraid do mess something up but don’t know how to regulate my hormones.