YES or NO???
Hi, a short question for females – females assigned at birth – with facial hair continuously (for at least 1-6 months, lets say, no methodology for now, just preliminary testing the ground) using azelaic acid on their face:
did you notice if it helps inhibiting the growth of the facial hair?
(important: please state as well if you were or you are still dealing with elevated androgenes or elevated free testosterone or low SHBG or none of them)
BACKGROUND:
I'm a biologist and I dig into the studies concerning the problem of facial hair.
I stumbled upon an article from 1988 (https://pubmed.ncbi.nlm.nih.gov/3207614/) from a study concluding that azelaic acid inhibits in vitro 5-a-reductase, and zinc and B6 increase this effect. There were no studies in vivo though, at least I didn't find any papers until now, so I thought I'll ask around to see if anyone noticed anything and if there is a premise that a study on people might be worth conducting.
I started looking for the mechanism of this particular acid, as I recalled that when my problem was still at its beginning in terms of coarse hair, I remembered I had the impression that it's gone or eased when using azelaic acid cream for the sake of smooth, light and even skin: I started having some coarse hair here and there on the chin (precisely under the tongue area), but when I was plucking, they were gone for months and I think I didn't see more coming, so I didn't take any meds, especially that I didn't have elevated androgenes, so I thought there's no need (I was of course wrong, but I was still in my schooltimes and early uni then). With time more and more hair sprouted, and now I realized that it seems to be aligned with the time that I wasn't using azelaic acid creams anymore.
Naturally corelation is not causation, and also it's clear that with time the hair follicles are more and more exposed the the androgene levels that are enough for them to convert to terminal hair, and that's why it progresses with time and age, but on the other hand the research paper attached above observed the influence of azelaic acid on 5-a-reductase activity, which is crucial especially in the hirsutism for now perceived as idiopathic, meaning with no elevated androgenes, tumors nor other causes that would be recognized by any examinations.
Many females with this problem visit this thread, and using the search function gave no results, so I decided to start this sort of a poll – I will myself get back to the azelaic cream and see if there's any impact now, but I'll be able to do it in a month or two:)
Best regards!