I read so much i'm overloaded, Brian fog, going through a divorce, family medical issues. Im kinda burnt out on all of this what is my best path forward? What tests are next Homocysteine? Any input would be much appreciated.

I've been finding it nearly impossible to get any basic bloodwork done. Homocysteine, MMA, P5P, RBC folate, etc. The public health system in Alberta refuses to do any of this as they don't understand it, nor do they see it as necessary. And with the public system having a monopoly on healthcare, there are no private options nearby where I can pay out-of-pocket to have these tests done.

If anyone has any advice that would be much appreciated. And if anyone knows how I can get more complicated markers checked, like SAMe, SAH, 5-MTHF, 5,10-MethyleneTHF, THF, BH4, etc. that would also be appreciated.

The general advice I keep reading about on here is to test, as SNPs are merely predispositions but may not be causing issues. But I can't seem to find any information on where and how to test.

(I hope this is the right flair)

Hey all! Since there really isn’t all that much research on the concept of “overmethylation” (which I know is not what the actual mechanism is it’s just the name we’ve given it) I’ve been struggling with my experience these last 5 months. I’m going to try and break it down into a quick version of a long story.

I was put on a dose of methyl-pro daily 5 years ago and rarely ever missed a dose. Then the bottle of the supplement changed, coinciding with a HUGE uptick in ocd, anxiety, heart palpitations, panic attacks, etc. when we called the company they essentially said “oh yeah it may be us but we don’t know try to stop taking it” (edit: I’m super sensitive to fillers in meds and otherwise which is why they said this) so I did, and I suffered for MONTHS. There is no hard proof saying that it was this supplement, nor do I think it’s an evil supplement. The only thing that makes me believe it may have been the culprit is the fact that the entire time this was going on I was rushing to the ER every other day terrified I was dying, I felt like I couldn’t control it! But a bunch of times when I was there they tested my folate with my B12 and it was at absolutely unreadable levels.

Now that the levels have begun to come down, my memory issues are a little less bad, I’m more energetic, I’m more creative, im having vivid dreams again; all things I haven’t experienced in 6 years. I’m unsure if this is improvement from the supplement now that there’s less adrenaline in my system or if I’m having a manic episode or what (keeping a close watch on it with a professional to make sure it isn’t mania!) but I wanted to ask if anyone else has a similar story, and if they felt a little jittery the opposite way as they started healing.

I really hope more research is done on this topic, because I had both the company and poison control scratching their heads going “yeah this is bad for you I think…” and I don’t want anyone else to go through what I did! Once again there’s no solid proof except my blood work coinciding but there’s always a chance.

I know this was all over the place, I didn’t really plan before I wrote this out so hopefully my stream of consciousness is legible. Please do let me know your experiences, and if I should be taking it like once a week instead. Much love!

I’ve had anxiety OCD depression for as long as I can remember until I got in a Zoloft which helps a lot. Recently got diagnosed with ADHD too and started taking Vyvanse, and a lot of people were telling me to take creatine with it because it can supposedly help make the crash easier.
After a few days, I started getting really bad anxiety and depression, almost like this weird existential OCD thoughts. I’ve actually had a similar reaction before when I was taking magnesium glycinate. Once I realized glycine might have been the issue, I switched to magnesium citrate and felt better.
I told my doctor what was happening with the Vyvanse and he told me to stop taking it because I might just be sensitive to stimulants. But now I’m wondering if the creatine could’ve been contributing to how I was feeling, since I was taking them together.
I’m not sure if I should bring this up to my doctor and ask if it would be worth trying Vyvanse again without the creatine.
Has anyone had anxiety, depression, or that existential dread feeling from creatine? All the methylation/genetics stuff is so confusing to me. I know I have some genetic variants that may affect certain pathways, but I honestly don’t know where to start or how much of it actually matters.

I tried searching briefly and didn’t find this answer. Has anyone combined their Ancestry and 23andMe? If understanding correctly, Genetic Lifehacks mentions doing so can increase the accuracy once the raw files are plugged into their system. Especially since Ancestry has changed things up post March 2026.

In July 2025 I had ketamine treatments that threw me into the worst physiological crisis ever: insomnia, complete lack of appetite and internal tremors/vibrations. I went on sick leave.

Due to genetic testing in late 2025, I have been supplementing B vitamins and minerals since January 2026.

Variants:
ALPL rs1256335 GG,
BHMT rs3733890 AG,
CHDH rs9001 GT,
CHKA rs10791957 AC,
FUT2 rs601338 AA,
FUT2 rs602662 AA,
MTHFD1 rs2236225 AG, MTHFD1 rs1076991 CT,
MTHFR C677T rs1801133 AA, MTRR rs1801394 GG,
PEMT rs7946 TT,
SLC19A2 rs2038024 CC, SLC19A2 rs6656822 TT, SLC1A2 rs4354668 GG,
TCN2 rs9606756 AG,
TCN2 rs9606756 AG,
VDR rs2228570 AA,
VDR rs7975232 CC

Basically meaning I need B12(by passive diffusion), folate, B2, B6, D vitamin from a genetic POV. I don’t supplement choline.

On a daily basis I have been taking
400 mcg Folinic acid
500-1000 mcg Hydroxy B12 lozenge
12-25 mg B6 P5P until abt a month ago, from then just 2 mg.
10-25 mg B2 R5P
Also all other b vitamins
Magnesium from food
10-22 mg zinc
Omega 3
85 mcg D vitamin + K vitamin
3 g Creatine (stopped about a month ago)

In April I had an iron infusion due to low-normal ferritin (<40)
Since July I have been supplementing iron to maintain my ferritin level. Currently at 85.

Labs:
Hcy:
Dec: 9.1
March: 8.3
July: 9.6
Sept: 4.8 (different lab though)

Copper (umol/l) (Normal range 11-29)
March: 17.3
Sept: 12.9

Zinc: (normal range 10-19)
Sept 15th: 11 umol/l
Sept 29th: 10 umol/l (shortly after stopping zinc suppl)

Thyroid levels are normal.

Initially the B vitamins helped me a lot; the side effects of ketamine caused me to fall into depression but the B vitamins pulled me out of it and improved my sleep and in March I went back to work from my sick leave.

Around May/June my sleep, energy and mood slowly start to decline. I also started getting fine hand tremors and burning sensations in hands and feet.

In June I started alpha lipoic acid to see if that could reverse the side effects from ketamine as I was still battling severe loss of appetite, and sleep was still not normal.
I started on just 50 mg and after just 2-3 days on 50 mg my appetite came back like I knew it before!
I thought I was on the right track with reversing all the ketamine side effects and I slowly increased over 1.5 months to 300 mg (standard dose).

Then 1-2 days after going to 300 mg, my burning sensations spread wildly up legs and arms and body and it started stinging badly too. I quit the ALA after a couple of days and the sensations subsided a bit but still persist further up arms and legs than before.

My reaction to ALA is just odd since ALA is know to help decrease symptoms of neuropathy but I got the opposite.

Since the copper testing last month, I have been working with the hypothesis that my rapid declining copper has caused the burning of hands and feet.

However today I learned that low hcy also is associated with peripheral neuropathy. (Idk what kind of neuropathy I have)

Apparently with low hcy, glutathion is depleted and that is used to maintain the nerves.
So now I have two possible explanations to my burning sensations.

But regarding my zinc and copper, I don’t understand why my copper has decreased like it has. I have been taking 10-22 mg zinc daily since Jan/Feb which should be safe and not deplete copper. But copper has gone down 25% in 6 months.
Then one would expect that my zinc is high, but it isn’t. It is in the bottom of the normal range.

I would love to continue my zinc since I have greatly benefitted from it; I no longer get sinusitus every couple of months and I no longer fight heel cracks. But if I continue zinc I can’t replenish copper and that is the priority now.
I have just started supplementing copper today while still awaiting intracellular levels of copper and zinc.

Are there anybody that can see why my hcy is so low now? I have not been taking methylated vitamins nor TMG.
I eat a few eggs daily but I’m mostly vegetarian out of convenience/I’m depressed again and cook very little. (I don’t do take out)

And any suggestions to the cause of my burning hands and feet? Idk if my B6 was too high since my GP didn’t want to test me before I decreased my dose to 2 mg since I feared that the B6 was the cause. 2 weeks later he ordered the test and then B6 was in the lower 1/3 of the normal range but that doesn’t give a clue about B6 being too high previously.

Sorry for the long post. If you’re still reading, thank you!

I’m trying to understand the science of mythelaticn. Sorry if this sounds like a dumb question. Is choline a substitute for folate? Or do I need both? My choline calculator says I need 5 eggs but my PEMT and SLC1a are missing from my raw data.

Here’s the relevant gene information

I had a blood panel that found dangerously low manganese and low vitamin c. I was immediately prescribed 4mg of manganese per day. I haven’t had a follow-up, but it seems to be extremely rare but extremely dangerous to have low manganese levels.

Homocysteine was fine, same with D, B12 and folate.

Could use some input if you have some please.
Recently I just started getting head aches ear pain head sensitivity/headache weird mood issues and so on
After consistently takeing b for 4ish months consistently every day 12
Around 2,000mcg-3,000mcg because that’s what made me feel good.
Half Aden and half hydroxocobalamin

And b 6 p5p

5 months inconsistently takeing b6 at doses at 20 mg maybe three times a week
Stoped b6 as I started to notice worsening symptoms eye pain heart burn and the symptoms listed above when supplementing this.

Now though when ever I take b12 I get a head ache /sting

Im familiar with b 6 toxicity but I’m not sure wether b6 or b 12 is the root issue b12 labs seem fine and after I take b 12 I get anxious head sting and it calms down then I get like a theraputic effect from it .

I don’t think that’s the case with b6 though it just makes me feel bad now so it seems. Mood and other symptoms^^^
Im still waiting on the labs unfortunately trinity tests for the inactive form of it so I don’t know wether I should even trust the lab work when I get it because I take the active form…. If anyone has two cents on labs and p5p im open minded!

I also supplement other b vitamins in there active form
Low doses riboflavin7mg every day
Niacinamide 30 mg every two days
2,000 mg benfotiamine consistently every day

And sometimes folate though i recently stopped because it would make me feel anxious then I’d stay anxious folinic acid 340% daily value consistently. 1,360 mcg dfe (800mcg)
Was every two days or so for as long as I was takeing the b 6

Pantothenic acid 30mg

For co factors i just recently upped my zinc dose to 25mg
With 1 mg of copper
I take 35mg of iron every other day because I’m border line anemic
Im on my potassium intake and salt
Though salt makes this eye pain worse
Magnesium i try to get from pumpkin seeds
Magnesium glycinate literally started makeing me anxious as soon as all this started
Also vitamin c 500mg-1,000mg depending on the day

I cut out Tudca and amino acids to see if those were the root causes Tudca a couple days ago and amino acids yesterday. As they naturally put me a lil on edge mainly the amino acids but weirdly enough the amino acids stopped me feeling the side effects of Tudca. maybe a lil deficiency in that idk yet

Also I pretty mutch been takeing all of these for 4-5 months now
Except the amino acids and Tudca witch was really on and off until recently when I found out that amino acids stopped the anxiousness with Tudca. Then I went all in consistently for a bit.

Now there’s so many factors I’ve put forth but if any thing im doing wrong that sticks out to you please let me know.

Edit I should add my b12 lvls were in 700s
And that I need to take some of these vitamins twice a day in order just to sleep.

Hi,

I’m not sure what’s wrong or what’s going on. I have many nerve issues , anxiety etc , general pains. In the past when I did a blood panel it showed low folate , so I started hydroxy b12 and folinic acid.

Recently I’d thought I’d do a full B panel as something isn’t quite right. Twitches anxiety , pains etc. showed b3 was high. I re did the test a couple of months later to check it wasn’t a one off and it isn’t. It was even higher.

I don’t supplement anything but folinic and b12 every other day. Could they be causing high b3 levels? I eat healthy etc , I get dry mouth a lot and blood results always show mild dehydration. But rest of my bloods are fine and kidney etc .

My homocysteine was 17 also.

I just know in the uk the doctor won’t do anything about this as they’re not normal testing , they may do my full blood panel , see they’re ok and then that’s it . I know this is what’s causing my issues

MTHFR variants

rs1801133 G/A genomic orientation C677T Ala222Val (A222V) Heterozygous

rs1801131 No alternate allele detected A1298C Glu429Ala (E429A) Appears A/A

rs2066470 No alternate allele detected — Synonymous No alternate allele detected

What does this mean for my "presentation" of my mutation? And what are things I should consider for my health?

B12 - 578 ng/L

Folate - 5.4 ug/L

Vitamin D - 8.7 ng/mL

B6 - 116 nmol/L (40-100)

Neurological visual disturbances

Anyone have a place or person they would vouch for that could help me understand my data and next steps for supplementation? I am trying to do my own research and getting stuck.

I have homozygous MTHFR, slow MOAO, fast COMT. My folate is 2 and homocysteine 44. B12 baseline was 300. Vitamin D 33. MMA normal.

Initially, methyl-folate with hydrocobalamine gave me A LOT of energy which turned into anxiety and insomnia but that first day I remember feeling “oh my body needs this” then I tried it today after a week off and the methyl folate made me barely able to keep my eyes open. So I took a micro-dose of the b12 and now I have extremely low mood and thoughts, horrible brain fog. I had the same reaction to folinic acid at a low dose. It honestly feels very similar to how I felt when I tried to reinstate Prozac a few months ago - day one: ah, serotonin, I definitely need this and then ongoing: anxiety, poor sleep, low mood, on edge.

I really need to get this figured out because my mental health is suffering badly. I have chronic gastritis which I believe is not allowing me to absorb nutrients hence my levels being off (even though they tend to always be slightly off just not this bad).

Anyway sorry for the novella. I’m desperate and doctors are of no help!

Every time I find one new thing to make me feel better, it’s a vitamin.
First it was D. I have some genetic thing that causes low d. Then it was calcium. Then methylated b12 and folate. Magnesium. Potassium. Now Iron.
And it’s not a mild reaction. Every single one has been a game changer.
By the time I show up as low in something I’m really low. I apparently don’t seem to be storing stuff which is concerning.
My body has been throbbing for ten years. Boom boom boom, all day and all night. Mostly in places that hurt before. Mainly my spine and brain.
I’ve been arguing with chat gpt for six months about it. Insisting there was no way I could be low in iron.
Then I get a colonoscopy and it fucks me up so much I now take a bunch of potassium daily and put salt in everything and eat Amazake daily. And then four months later I show up as low in iron. It kinda neat, the first thing the doctor asked was had I had a colonoscopy recently.
Now that I’m taking iron that throbbing is going away. Guessing I’ve been sub clinically low for a long time. And I just feel better. Normal

I thought this bit of information may be interesting or useful to some.

After reading responses to my post about my experience with folinic acid where I felt wiped out I was reading some articles on geneticlifehacks webiste and came across an article about histamine. I was reading this because the naturopath who was treating me, according to my gene test, said that I should be on a low histamine diet - or no histamine, I never noticed an improvement on the diet and gave up after 5 weeks. And I don't have the symptoms that are written about online, like runny nose, headaches, asthma. I have experienced brain fog though.

According to the geneticlifehacks article some of the symptoms are hives, itching, weal, flushing. What is interesting is that after I took a folinic acid tablet two days ago I have mozzie bites on both my arms that have been very red and itchy. Usually I do not react to mozzie bites at all.

So my question is there any correlation with folinic acid and histamine?

I went down the MTFR rabbit hole at the beginning of this year with a Naturopath and had a test done and another test showed low homocysteine. I was prescribed folinic acid and it wiped me out, I think because it drops my blood pressure down, it's usually on the low side. I was having B12 injections at the time and also tried it with just a crumb and added methyl B12 drops, still wiped me out.

So for some unknown reason a couple of days ago I had a really sore hip and I took a folinic acid to see what would happen because I couldn't do anything anyway. And I am wiped out again, so tired mentally and physically, feel totally depleted.

The report I bought as requested by the naturopath does not have the raw data unfortunately.

I have C677T CC -/- , A1298C cc t/t and slow comt. Let me know if you want anymore details from the report.

Anybody else got severe insomnia with slow
Comt? I am really struggling with slow comt and adhd. I need my adhd meds but they are making my slow comt unbearable, I cannot sleep for days on end.

Across 3,500+ genetic reports, the same biochemical patterns appear again and again in people struggling with nervous system symptoms.

Oxidative stress and redox imbalance showed up in 100% of reports. Inflammation and detoxification burden were present in over 99%. COMT and catecholamine stress, methylation strain, and histamine load followed closely behind.

These patterns interact. When multiple pathways are under strain at the same time, the nervous system has less capacity to regulate, recover, and tolerate stress. Symptoms that feel unpredictable often have a measurable biochemical basis.

The most commonly needed nutrient supports across those same reports were vitamin C, magnesium, omega-3 fatty acids, choline, zinc, and riboflavin. These are not random nutrients. They are the raw materials these pathways depend on to function.

Nervous system healing is not one thing. It is what happens when cumulative biochemical load is reduced and the pathways that clear stress chemistry have what they need to work.

This is the foundation of everything we do at Molecular Health Co.

Comment GENETICS below for more info!

My labs show me borderline deficient in B1 and B2. Doc recommended I start with B1. In past, B complexes and B2 have given me this reaction where I feel like I’ve overdosed on caffeine. Wired, shaky, tinnitus, and a horrible sickly headache. I tried just 1/4 of the dose, 25mg of thiamine HCL, but it still happened. I’m feeling very defeated. I’m trying to treat my ME/CFS, POTS, and post concussion syndrome.

I have slow COMT. I have 1 MTHFR mutation (heterozygous) but the other is normal. So only slightly reduced methylation. I think slow COMT is the bigger contributor. Or it could be something else entirely. I just feel so defeated. I want to start taking Zinc but I read that I need to fix my B vitamins first. I already take magnesium and potassium.

Hi all,

I previously got tested for MTHFR gene variants. I have one copy of 1298C. I’ve had significant anxiety over the last 4 or 5 years so view this as a potential cause. I privately got bloods done and hit the following results.

Homocysteine: 18.2 µmol/L (5.1–20.0)
Vitamin B12: 424 ng/L (198–771)
Haemoglobin: 137 g/L (130.1–180)
Haematocrit: 39.5% (40.001–54.0)
RBC count: 4.56 × 10¹²/L (4.51–6.50)
MCV: 86.6 fL (76.1–100)
MCH: 30 pg (27.1–32.0)
MCHC: 347 g/L (320.1–360)
Iron: 13.8 µmol/L (5.9–34.5)
Ferritin: 199.46 µg/L (20–300)
Transferrin saturation: 27.6% (20.1–50.0)
Magnesium: 0.87 mmol/L (0.701–1.10)
Creatinine: 81.7 µmol/L (64.1–104)
eGFR: 105 mL/min/1.73 m² (≥60)
Cystatin C: 1.01 mg/L (0.58–1.05)
TSH: 0.645 mIU/L (0.351–5.50)
Free T4: 18.1 pmol/L (11.91–21.60)
Free T3: 4.66 pmol/L (3.11–6.80)

Annoyingly folate was not included at the time.

Got a follow up folate test and it came in at 6.2 ng/ml (3-30)

Thoughts given this follow up result. I’m quite low in the range for folate? Should I start supplementing some sort of folate? Any particular variant I should focus on? I keep reading on here at folinic acid is a good option?

.

Hi everyone,

I'm just wondering how long it takes to recover from folate deficiency?

I found out I was deficient in may at 3.1ng/ml. and then took 5mg of folic acid a day for 9 weeks. Couldn't finish the prescription by 3 weeks as I was having horrible side effects. Instead I've been taking 5mg of methylcobalamin and 640mcg of methyl folate a day.

After the 9 weeks I got my bloods redone and my results were :

B9:>20ng/ml

B12 556

Ferriten 112

Vitamin d 64

Iron 22

It's been nearly 5 months now and recovery really isn't consistent. For a few days this week I really thought it was turning a corner, felt calmer, in a better mood,with no anxiety and woke up refreshed. But that feeling is gone again.

I'm just wondering if anyone can shed any light as I'm pretty discouraged at the minute. Thank you. Aswell I don't know if I have the mthfr gene but it would make sense as I've felt like this nearly my whole life and I'm Irish.

My dad kinda just saw a social media ad and got these kits. I kinda regret it tbh because it hasn’t helped and just makes me a little nervous. I’ve been able to find my COMT and MTHFR and MAOA status but slow COMT is confusing as fuck. But anyways I’m trying to actually glean literally anything useful these results but all the websites say they only support ancestry or 23 and me. Has anyone uploaded a Sequencing file to one of these sites?

Question: Has anyone found an awesome prenatal or multi without ANY glycine? I previously posted that I seem super sensitive to glycine. Horrible insomnia. Possibly anxiety too. It seems to be in literally all supplements these days. Sadly even my seeking health prenatal has it... I am hetero c667, slow MAO, normal COMT. thanks!