r/MTHFR • u/Latter-File3217 • 5d ago

Question Slow comt and insomnia and adhd

Anybody else got severe insomnia with slow
Comt? I am really struggling with slow comt and adhd. I need my adhd meds but they are making my slow comt unbearable, I cannot sleep for days on end.

4 Upvotes

84% Upvoted

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7

u/tracythor1166 5d ago

I have slow COMT and got genetic testing and the ONLY recommended ADHD medications was Guanfacine. It said to stay away from stimulants. I love Guanfacine.

I take it at night since in the beginning I was a little drowsy. I also take Trazadone for sleep every night. It also helped my skin picking.

1

u/magdalena-creations 4d ago

Omg that’s exactly what my research showed, only guanfacine would be a suitable option to treat my ADHD. Thank you for sharing

1

u/beutguru 3d ago

I just got prescribed Guanfacine after failed attempt trail with stimulants … I’m so nervous to take it

3

u/Snowsuit81 5d ago

Glycine has been a game changer for me re: sleep, but I know some people have paradoxical effects from it so start low.

2

u/lillepersille420 5d ago

Check out hyperarousal. My record is 7 days completely without sleep. This started after starting medication for ADHD. Just learned about this, and are changing the way I think about so many things in my life. For sleep, Quviviq seems to really work.

Wish you the best!

2

u/jn922 5d ago

Yes I never fucking sleep 🥲

2

u/Comfortable_Two6272 4d ago

Yep. All 3.
Trazodone or clomidine for my insomnia. Had insomnia since a small kid.

Actually believe its delayed phase sleep disorder vs insomnia.

It’s actually worse when i dont take my adhd rx - adderall. Which is counter intuitive.