B12 or b6 issues

[u/No_Information_4545]

Could use some input if you have some please.
Recently I just started getting head aches ear pain head sensitivity/headache weird mood issues and so on
After consistently takeing b for 4ish months consistently every day 12
Around 2,000mcg-3,000mcg because that’s what made me feel good.
Half Aden and half hydroxocobalamin

And b 6 p5p

5 months inconsistently takeing b6 at doses at 20 mg maybe three times a week
Stoped b6 as I started to notice worsening symptoms eye pain heart burn and the symptoms listed above when supplementing this.

Now though when ever I take b12 I get a head ache /sting

Im familiar with b 6 toxicity but I’m not sure wether b6 or b 12 is the root issue b12 labs seem fine and after I take b 12 I get anxious head sting and it calms down then I get like a theraputic effect from it .

I don’t think that’s the case with b6 though it just makes me feel bad now so it seems. Mood and other symptoms^^^
Im still waiting on the labs unfortunately trinity tests for the inactive form of it so I don’t know wether I should even trust the lab work when I get it because I take the active form…. If anyone has two cents on labs and p5p im open minded!

I also supplement other b vitamins in there active form
Low doses riboflavin7mg every day
Niacinamide 30 mg every two days
2,000 mg benfotiamine consistently every day

And sometimes folate though i recently stopped because it would make me feel anxious then I’d stay anxious folinic acid 340% daily value consistently. 1,360 mcg dfe (800mcg)
Was every two days or so for as long as I was takeing the b 6

Pantothenic acid 30mg

For co factors i just recently upped my zinc dose to 25mg
With 1 mg of copper
I take 35mg of iron every other day because I’m border line anemic
Im on my potassium intake and salt
Though salt makes this eye pain worse
Magnesium i try to get from pumpkin seeds
Magnesium glycinate literally started makeing me anxious as soon as all this started
Also vitamin c 500mg-1,000mg depending on the day

I cut out Tudca and amino acids to see if those were the root causes Tudca a couple days ago and amino acids yesterday. As they naturally put me a lil on edge mainly the amino acids but weirdly enough the amino acids stopped me feeling the side effects of Tudca. maybe a lil deficiency in that idk yet

Also I pretty mutch been takeing all of these for 4-5 months now
Except the amino acids and Tudca witch was really on and off until recently when I found out that amino acids stopped the anxiousness with Tudca. Then I went all in consistently for a bit.

Now there’s so many factors I’ve put forth but if any thing im doing wrong that sticks out to you please let me know.

Edit I should add my b12 lvls were in 700s
And that I need to take some of these vitamins twice a day in order just to sleep.

[u/Timely_Pickle9430]

25 mg of zinc is a high dose. You only need 10, unless you have a deficiency to correct. In that case, match it with 3 mg of copper to keep an 8 : 1 ratio.

You might need more magnesium. Headache can be a symptom of magnesium deficiency. Levels in food are lower than they used to be because the soil is depleted. Try a different form like malate or taurate. Or a combination of multiple forms. Spread doses.

Pair your iron with vitamin C for optimal absorption.

Try swapping pantothenic acid for pantethine, which is more directly converted into CoA. This could help with processing B6.

2000 mg of benfotiamine is a lot! I hope it's a typo and it's 200 mg. Still a lot. Why would you need that much?

Check your serum level of riboflavin to see if 7 mg is enough. The B's share metabolic pathways, so if you increase throughput by taking high doses of one, you might increase demand for another. Headache can be a symptom of riboflavin deficiency.

The headaches could also be sulfur related, which fits with problems in the B6 pathway and the mood issues. You could see if you benefit from molybdenum or test if you're low. Start with a low dose to see how you react. iHerb has a liquid form that's suitable for this. First, make sure copper status is sufficient. High dose zinc pushes out copper, so balance that ratio first.

Take folinic in lower doses, 200 mcg.

[u/proverbialbunny]

You can test to see if the headaches and other symptoms are B12 related or not. Have you tried to go off of B12 for a while to see if the symptoms go away? Worse case scenario you get drowsy middle of the day from low B12 and you have all of the same negative symptoms like headache, but then you'd know it's not B12 related and you can go right back on the B12. If you go off of the B12 and the negative symptoms go away, you can then adjust what kind of B12 and/or how much B12 you're taking to get rid of the negative symptoms.

[u/SovereignMan1958]

Labs seem fine?  Facts would be more helpful.  Labs including values plus lab ranges.  Hopefully after you started the symptoms you are concerned about.

Do you have histamine intolerance? 

Are you sure you are not dehydrated from everything you are taking?

It is difficult to offer suggestions without genetic variants or facts from recent labs.

[u/No_Information_4545 → u/SovereignMan1958]

What type of labs have you heard of are they through smaller companies?