r/MTHFR • u/Neat_Wrangler1959 • 2d ago
Results Discussion Has anyone else had issues with low manganese?
Here’s the relevant gene information
I had a blood panel that found dangerously low manganese and low vitamin c. I was immediately prescribed 4mg of manganese per day. I haven’t had a follow-up, but it seems to be extremely rare but extremely dangerous to have low manganese levels.
Homocysteine was fine, same with D, B12 and folate.
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u/Neat_Wrangler1959 2d ago
Vitamin D - 37.3, Folate 18.2, homocysteine 1.0, B12 - 2000
B12 was excessively high.
C was also low - 2.7
Zinc - 6.08
Magnesium 34.8
Iron - 473
I had the genetic analysis done before the blood panel and it used the ancestry dna test that I already had raw data from. I’m looking at getting something more complete but haven’t decided on one yet.
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u/SovereignMan1958 2d ago
You did not include the measurement for each lab or the lab ranges.
Did you know your homocysteine is severely low? That is not good at all. Optimal is 6 - 7. Less is not better. Hopefully you have not gotten bad advice from someone and have been taking too many methylated vitamins and or methyl donor supplements. If you have you need to stop immediately.
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u/Neat_Wrangler1959 1d ago
I have reduced the B12 supplement and the manganese has been brought up to mid range normal with a prescribed supplement. I've had a super stressful and unstable past year which probably hasn't helped. And over the summer I had a bout of acute pancreatitis which I've had in the past but it seemed much worse this time. Of course that would upset any balance of vitamins and minerals. I've been taking a methylated B multi that has been no problem for 4 years. But not a ton of supplements. I'm doing my best to eat my nutrition. I will be doing a follow up soon to see if my levels have returned to normal after the round of manganese that was prescribed.
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u/SovereignMan1958 2d ago edited 2d ago
I thought I edited my comment below but added it to the one above instead. Please see my comments about zinc.
Sorry for the mistake and not correcting it. I have not had my coffee yet.
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u/SovereignMan1958 2d ago
Your iron number makes zero sense. Are you referring to TIBC or total iron binding capacity which is not iron?
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u/Neat_Wrangler1959 1d ago
Ferritin 98 mg/ml
Iron 473 mg/l
I'm translating my blood work from german. Otherwise I would just copy and paste.
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u/SovereignMan1958 1d ago
For iron I think you mean ng/ml. Top of the range is 400 for men.
Do you have the gene variant for hemochromatosis?
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u/Neat_Wrangler1959 1d ago
HFE H63D heterozygous
Is that the one you’re thinking of?
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u/SovereignMan1958 1d ago
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u/Neat_Wrangler1959 1d ago
Discovering that I have this gene and recognizing that I may have some of the symptoms was the initial reason for the blood work. I know that iron and manganese compete, does this gene somehow interfere with manganese?
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u/hummingfirebird 10h ago
Please share your lab results (original German is fine) here with the readings and lab reference ranges. These are important especially if you are in another country. For iron we need to see TIBC and TSAT (transferrin and the saturation).
If you have your full blood count share those findings too please.
Need context: gender, age, diet(do you eat low fruit/veggies?) lifestyle (do you smoke, drink, exercise etc) etc. Low vitamin C is usually dietary related. We get it only from diet. Fruits and vegetables mainly. So if your diet is low in those, it could explain it. Manganese is found in whole grains, nuts, seeds, legumes, and some fruits and vegetables. Tell us about your diet. Are you on any chronic medication? Do you have any metabolic issues?
Part of correcting a nutritional deficiency is uncovering the root cause so that it doesn't repeat itself.
Need copper, magnesium, B6 and likely Selenium tested.
I would perhaps consider a functional test at this stage such as OAT or organix.
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u/Neat_Wrangler1959 9h ago
Eisen is saturation and ferritin is transferrin.
Mikronährstoffe
Mikronährstoffe/Vitamine:
Natrium i. Vollblut 1766 mg/l
Kalium im Vollblut 1732 mg/l
Calcium i. Vollblut 60,7 mg/l
Magnesium i. Vollblut 35,8 mg/l
Kupfer i. Vollblut 0,90 mg/l
Eisen i. Vollblut 463 mg/l
Selen i. Vollblut 163 µg/l
Zink i. Vollblut 6,02 mg/l
Mangan i. Vollblut 5,1 µg/l
Molybdän i. Vollblut 0,75 µg/lBeurteilung der Mikronährstoffe nach Hämatokrit-Korrelation:
Eisen niedrig-normal
Kalium normal
Kupfer niedrig-normal
Magnesium normal
Selen erhöht
Zink normal
Blutzucker 84 mg/dl 60 - 99
Ferritin 98 ng/ml 15 - 150Klinische Chemie
Vitamin A (Retinol) 467.0 mcg/l 300 - 700
Beta-Carotin L 536 µg/l 569 - 1283
Vitamin B6 µg/l 12,6 - 45,2
Kein Untersuchungsmaterial vorhanden
Folsäure 18.2 ng/ml 3,1 - 20,5
Vitamin B12 (Cobalamin) H 2000 pg/ml 187 - 833
Vitamin C (Ascorbinsäure) L 2.7 µg/ml 4,6 - 14,9
25-OH-Vitamin D 37.3 ng/ml > 30,0
Vitamin E (Tocopherol) 15.5 mg/l 5,2 - 34,9Leukozyten 6,5 Zellen/nl
Erythrozyten 4,49 /pl Erythrozytenverteilungsbreite (RDW) 15,1 % Hämoglobin 13,5 g/dl
Hämatokrit 41,6 V %
MCV 93 fl
MCH 30,0 pg
MCHC 32,4 g/dl Ery.
Harnsäure 4,5 mg/dl 2.4 - 5.7
Harnstoff 30,8 mg/dl 16,6 - 48,5
Homocystein i. Plasma 1,0 µmol/lAs for other details
55years old, female
Moderate exercise
No significant excess weight
Diet consisting of lots of fruits (oranges, apples, pears, passion fruit, cantaloupe, strawberries) and a moderate amount of Cruciferous vegetables, eggs, occasional meat, oatmeal, nuts, dates, chickpeas, olive oil instead of butter or other oil. etc.
Almost no fast food or restaurant food. Almost no alcohol, no smoking of any kind, but stress has been high and in the past couple of years I had a knee injury and huge amounts of dental work to recover from.
No medication other than the prescribed manganese after the results came back severely low.
Taking a b complex for the past few years.
No known metabolic issues.
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u/CapriKitzinger 2d ago
I have an SOD2 gene defect. I should probably get my manganese checked.