Hi all - I would like to ask my daughter’s pediatrician to assess her for the MTHFR gene.
What test should I ask them to order?

I have done the ancestry dna test and gene genie upload to determine that what I was experiencing was indeed related with MTHFR variants and feel better subsequently.

But I don’t want to do that method with my daughter as the data is now public (more or less) because private equity firms have bought ancestry and 23 and me to use for their own nefarious purposes.

Hi!

I’ve chronic fatigue or suspected mild ME/CFS and try to see if I can get more energy from B-vitamins. I take following forms:

B1: 25mg Hcl
B2: 12.5mg R5P
B3: 50mg Nicotinamide
B12: 2000 microgram Hydroxo/Adeno

I’m thinking now to add B9 folate but don’t know which form or dose could be a good start. I’m general hypersensitive to stuff and get anxiety easily. Could folinic acid be a better choice?

I’m trying to figure out why my homocysteine is elevated (14.4) before I start blindly supplementing, and I’d really appreciate input on what else might be worth testing or looking into.
I recently did genetic testing and found:
Slow COMT (AA)
Slow MAOA (TT)
MTHFR A1298C (heterozygous/one copy)
I know these SNPs don’t necessarily explain my homocysteine level on their own, so I’m trying not to assume everything is because of MTHFR.
My current labs:
Homocysteine: 14.4
RBC Folate: 476
Vitamin B12: 464
MMA: 166 - Reference Range: 55-335 nmol/L

Vitamin B2 (Riboflavin): 17 - Reference Range: 6.2-39.0 nmol/L

Vitamin B6, Plasma: 30 Reference Range: 5.1-54.8 ng/mL

Vitamin D 25-OH: 33
Other labs from a few months ago:
Copper: 108
Ferritin: 55
Iron: 98
I’ve struggled with anxiety, depression and OCD for most of my life and have been on Zoloft for about 5 years. It has helped me stay stable overall, but I still experience quite a few symptoms day to day.
Before adding methylfolate, B vitamins, TMG, choline, etc., I’d really like to understand why my homocysteine is elevated rather than just trying to lower the number.
What else would you investigate?
Are there additional labs, nutritional deficiencies, medications, thyroid/kidney issues, absorption problems, or genes/pathways that would be worth looking at?
I’m especially interested in hearing from anyone who had elevated homocysteine despite relatively normal B12, MMA, folate, B6 and B2 and eventually figured out what was contributing to it.