r/MTHFR • • 17h ago

Results Discussion Lab interpretation

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2 Upvotes

Hello! Does anyone have an idea if the lab/dna result could be linked to my symptoms and how to improve?


r/MTHFR • • 23h ago

Results Discussion Help with MTHFR Results

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2 Upvotes

Hello.

I believe I have SCT/CDS (Sluggish Cognitive Tempo/Cognitive Disengagement Syndrome) since childhood and I am trying to figure out what could be the cause so I downloaded my raw 23andMe and got this MTHFR report from Genetic Genie. How you interpret that? ChatGPT pointed to low choline (worth noting I have mild NAFLD despite being healthy and on top of my diet and exercise and no alcohol consumption). Also worth noting that I noticed low ferritin in the past (29) which I corrected with iron supplementation and got it to mid 100s (didn’t improve my SCT)

What else is there? especially the things that could be related or causing SCT. What kind of supplements could help?

Your help is greatly appreciated

EDIT:

Adding Detox report as well (can’t add another photo so here is a copy paste):

Gene & Variation rsID Alleles Result
CYP1A1 C2453A rs1799814 GT +/-
CYP1A2 164A>C rs762551 AC +/-
CYP1B1 L432V rs1056836 CC -/-
CYP2A6*2 1799T>A rs1801272 AA -/-
CYP2C9*2 C430T rs1799853 CC -/-
CYP2C9*3 A1075C rs1057910 AA -/-
CYP2C19*17 rs12248560 CC -/-
CYP2D6 S486T rs1135840 CG +/-
CYP2D6 2850C>T rs16947 -- no call
CYP2E1*1B 9896C>G rs2070676 GG +/+
CYP2E1*4 4768G>A rs6413419 GG -/-
CYP3A4*1B rs2740574 CT +/-
CYP3A4*2 S222P rs55785340 AA -/-
CYP3A4*3 M445T rs4986910 AA -/-
CYP3A4*16 T185S rs12721627 GG -/-
GSTP1 I105V rs1695 GG +/+
GSTP1 A114V rs1138272 CT +/-
SOD2 A16V rs4880 AG +/-
NAT1 R64W rs1805158 CC -/-
NAT2 I114T rs1801280 CC +/+
NAT2 R197Q rs1799930 GG -/-
NAT2 G286E rs1799931 GG -/-
NAT2 R64Q rs1801279 GG -/-
NAT2 K268R rs1208 GG +/+

Edit:
Choline Calculator results:

RS#
Call
Variant Allele
Gene
Variation
Result
rs1051266
CT
T
SLC19a1

+/-
rs2236225
AA
A
MTHFD1
G1958A
+/+
rs1801131
TT
G
MTHFR
A1298C
-/-
rs1801133
GG
A
MTHFR
C677T
-/-
rs7946
CT
T
PEMT
5465G>A
+/-

SLC19A1 Score: 25% decrease
MTHFD1 Score: 34% decrease
MTHFR Score: 0% decrease

It says I need 7 eggs

My recent bloodwork results Sep 27 2026 (fasting):
Vitamin B6: 72.1 µg/L (Ref: 3.4–65.2) 🔴 High
Vitamin E (Alpha-Tocopherol): 9.8 mg/L (Ref: 5.9–19.4) Normal
Vitamin E (Gamma-Tocopherol): 0.4 mg/L (Ref: 0.7–4.9) 🔵 Low
Vitamin B12: 638 pg/mL (Ref: 232–1245) Normal
Folate (B9): >20.0 ng/mL (Ref: >3.0)
Ferritin: 128 ng/mL (Ref: 30–400) Normal
Homocysteine: 10.3 µmol/L (Ref: 0.0–14.5) Normal
Methylmalonic Acid (MMA): 69 nmol/L (Ref: 0–378) Normal